The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 279,619 1,951,284 SH   SOLE   1,951,284 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 44,996 1,613,330 SH   SOLE   1,613,330 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 2,220 1,032,715 SH   SOLE   1,032,715 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 26,517 1,289,719 SH   SOLE   1,289,719 0 0
ALCOBRA LTD SHS M2239P109 306 272,788 SH   SOLE   272,788 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 125,435 1,030,942 SH   SOLE   1,030,942 0 0
ALIGN TECHNOLOGY INC COM 016255101 33,493 223,107 SH   SOLE   223,107 0 0
ALIMERA SCIENCES INC COM 016259103 4,189 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 61,541 3,344,620 SH   SOLE   3,344,620 0 0
AMICUS THERAPEUTICS INC COM 03152W109 79,964 7,940,788 SH   SOLE   7,940,788 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 216,580 2,384,719 SH   SOLE   2,384,719 0 0
CELGENE CORP COM 151020104 38,343 295,240 SH   SOLE   295,240 0 0
CEMPRA INC COM 15130J109 1,565 340,320 SH   SOLE   340,320 0 0
CLOVIS ONCOLOGY INC COM 189464100 311,749 3,329,581 SH   SOLE   3,329,581 0 0
CYTOKINETICS INC COM NEW 23282W605 1,497 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 1,588 500,913 SH   SOLE   500,913 0 0
EPIZYME INC COM 29428V104 86,044 5,698,296 SH   SOLE   5,698,296 0 0
EXACT SCIENCES CORP COM 30063P105 15,318 433,076 SH   SOLE   433,076 0 0
GILEAD SCIENCES INC COM 375558103 24,886 351,600 SH   SOLE   351,600 0 0
HISTOGENICS CORP COM 43358V109 542 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 1,060 616,355 SH   SOLE   616,355 0 0
IMMUNOMEDICS INC COM 452907108 26,582 3,010,466 SH   SOLE   3,010,466 0 0
INSMED INC COM PAR $.01 457669307 96,470 5,621,816 SH   SOLE   5,621,816 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 31,382 3,467,575 SH   SOLE   3,467,575 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 30,210 1,787,576 SH   SOLE   1,787,576 0 0
PROTHENA CORP PLC SHS G72800108 58,122 1,073,955 SH   SOLE   1,073,955 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 10,524 3,855,024 SH   SOLE   3,855,024 0 0
SAGE THERAPEUTICS INC COM 78667J108 82,270 1,033,025 SH   SOLE   1,033,025 0 0
SHIRE PLC SPONSORED ADR 82481R106 21,518 130,200 SH   SOLE   130,200 0 0
SOLENO THERAPEUTICS INC COM 834203101 212 423,738 SH   SOLE   423,738 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 543 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 38,114 3,529,070 SH   SOLE   3,529,070 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 3,139 1,162,473 SH   SOLE   1,162,473 0 0
TREVENA INC COM 89532E109 785 341,300 SH   SOLE   341,300 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 242,247 1,867,315 SH   SOLE   1,867,315 0 0
VANDA PHARMACEUTICALS INC COM 921659108 68,513 4,203,270 SH   SOLE   4,203,270 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 73,574 2,676,393 SH   SOLE   2,676,393 0 0
ZOGENIX INC COM NEW 98978L204 428 29,500 SH   SOLE   29,500 0 0