The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AGNICO EAGLE MINES LTD COM 008474108 34,183 757,600 SH   DFND 1 757,600 0 0
ALBANY MOLECULAR RESH INC COM 012423109 6,818 314,200 SH   DFND 1 314,200 0 0
ALLERGAN PLC SHS G0177J108 657,211 2,703,570 SH   DFND 1 2,703,570 0 0
ALTABA INC COM ADDED 021346101 145,734 2,675,000 SH   DFND 1 2,675,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 12,556 103,200 SH   DFND 1 103,200 0 0
ALPHABET INC CAP STK CL C 02079K107 3,635 4,000 SH   DFND 1 4,000 0 0
ALEXION PHARMACEUTICALS INC CALL 015351109 24,334 200,000 SH Call DFND 1 200,000 0 0
AMAZON COM INC COM 023135106 7,550 7,800 SH   DFND 1 7,800 0 0
AMERICAN INTL GROUP INC COM NEW 026874784 258,881 4,140,763 SH   DFND 1 4,140,763 0 0
ANGLOGOLD ASHANTI LTD SPONSORED ADR 035128206 124,245 12,782,400 SH   DFND 1 12,782,400 0 0
APPLE INC COM 037833100 1,771 12,300 SH   DFND 1 12,300 0 0
ARADIGM CORP COM PAR 038505400 252 192,727 SH   DFND 1 192,727 0 0
ARCONIC INC COM 03965L100 20,328 897,500 SH   DFND 1 897,500 0 0
ATLASSIAN CORP PLC CL A G06242104 13,998 397,900 SH   DFND 1 397,900 0 0
BANK AMER CORP * W Exp 01/16/2019 060505146 75,413 6,263,526 SH   DFND 1 6,263,526 0 0
BANK AMER CORP * W Exp 10/28/2018 060505153 7,053 8,928,344 SH   DFND 1 8,928,344 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 1,943 349,500 SH   DFND 1 349,500 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 3,334 65,800 SH   DFND 1 65,800 0 0
BROOKDALE SR LIVING INC COM 112463104 73,350 4,986,400 SH   DFND 1 4,986,400 0 0
CAESARS ACQUISITION CO CL A 12768T103 249,898 13,117,998 SH   DFND 1 13,117,998 0 0
CAESARS ENTMT CORP COM 127686103 173,015 14,417,900 SH   DFND 1 14,417,900 0 0
COBALT INTL ENERGY INC COM NEW 19075F304 5,060 2,048,595 SH   DFND 1 2,048,595 0 0
COBALT INTL ENERGY INC NOTE 3.125% 5/15/2024 19075FAB2 43,846 219,229,000 SH   DFND 1 219,229,000 0 0
CORESITE RLTY CORP COM 21870Q105 5,073 49,000 SH   DFND 1 49,000 0 0
BARD C R INC COM 067383109 13,315 42,122 SH   DFND 1 42,122 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 457 28,500 SH   DFND 1 28,500 0 0
CTRIP COM INTL LTD AMERICAN DEP SHS 22943F100 9,329 173,200 SH   DFND 1 173,200 0 0
COMMUNITY HEALTH SYS INC NEW PUT 203668108 3,386 340,000 SH Put DFND 1 340,000 0 0
DEXCOM INC COM 252131107 13,416 183,400 SH   DFND 1 183,400 0 0
DISH NETWORK CORP CL A 25470M109 250,965 3,998,800 SH   DFND 1 3,998,800 0 0
DOVA PHARMACEUTICALS INC COM ADDED 25985T102 13,856 621,632 SH   DFND 1 621,632 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 5,352 554,600 SH   DFND 1 554,600 0 0
EDITAS MEDICINE INC COM 28106W103 839 50,000 SH   DFND 1 50,000 0 0
ENDO INTL PLC SHS G30401106 80,139 7,174,490 SH   DFND 1 7,174,490 0 0
ENTELLUS MED INC COM 29363K105 1,701 102,702 SH   DFND 1 102,702 0 0
ENZYMOTEC LTD SHS M4059L101 34,068 4,205,980 SH   DFND 1 4,205,980 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105 9,742 210,500 SH   DFND 1 210,500 0 0
EXTENDED STAY AMER INC UNIT 99/99/9999B 30224P200 34,938 1,804,652 SH   DFND 1 1,804,652 0 0
FACEBOOK INC CL A 30303M102 21,817 144,500 SH   DFND 1 144,500 0 0
FEDEX CORP COM 31428X106 16,387 75,400 SH   DFND 1 75,400 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 12,483 289,500 SH   DFND 1 289,500 0 0
GRIFOLS S A SP ADR REP B NVT 398438408 4,157 196,753 SH   DFND 1 196,753 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 1,424 111,100 SH   DFND 1 111,100 0 0
HCA HEALTHCARE INC COM 40412C101 7,848 90,000 SH   DFND 1 90,000 0 0
HERTZ GLOBAL HLDGS INC PUT 42806J106 29,325 2,550,000 SH Put DFND 1 2,550,000 0 0
HORIZON PHARMA PLC SHS G4617B105 58,584 4,935,500 SH   DFND 1 4,935,500 0 0
HUNTSMAN CORP COM 447011107 336 13,000 SH   DFND 1 13,000 0 0
IAMGOLD CORP COM 450913108 19,938 3,863,912 SH   DFND 1 3,863,912 0 0
IGNYTA INC COM 451731103 1,273 123,000 SH   DFND 1 123,000 0 0
IMMUNOGEN INC COM 45253H101 1,630 229,222 SH   DFND 1 229,222 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 778 48,600 SH   DFND 1 48,600 0 0
INTERSECT ENT INC COM 46071F103 15,596 558,000 SH   DFND 1 558,000 0 0
INSULET CORP COM 45784P101 1,283 25,000 SH   DFND 1 25,000 0 0
INTERNATIONAL SEAWAYS INC COM Y41053102 74,908 3,456,773 SH   DFND 1 3,456,773 0 0
INTERNATIONAL TOWER HILL MIN COM 46050R102 26,634 55,487,842 SH   DFND 1 55,487,842 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 9,541 10,200 SH   DFND 1 10,200 0 0
K2M GROUP HLDGS INC COM 48273J107 2,670 109,600 SH   DFND 1 109,600 0 0
KAMADA LTD SHS M6240T109 4,745 790,800 SH   DFND 1 790,800 0 0
LOXO ONCOLOGY INC COM 548862101 55,082 686,893 SH   DFND 1 686,893 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 308,802 6,891,372 SH   DFND 1 6,891,372 0 0
MERCADOLIBRE INC COM 58733R102 5,018 20,000 SH   DFND 1 20,000 0 0
MOBILEYE N V AMSTELVEEN ORD SHS N51488117 17,121 272,629 SH   DFND 1 272,629 0 0
MONEYGRAM INTL INC COM NEW 60935Y208 7,520 435,932 SH   DFND 1 435,932 0 0
MONSANTO CO NEW COM 61166W101 18,843 159,200 SH   DFND 1 159,200 0 0
MULESOFT INC CL A 625207105 1,072 43,000 SH   DFND 1 43,000 0 0
MYLAN N V SHS EURO N59465109 618,542 15,933,600 SH   DFND 1 15,933,600 0 0
MYLAN N V CALL N59465109 7,764 200,000 SH Call DFND 1 200,000 0 0
NEW RELIC INC COM 64829B100 15,195 353,300 SH   DFND 1 353,300 0 0
NOVAGOLD RES INC COM NEW 66987E206 100,288 21,992,896 SH   DFND 1 21,992,896 0 0
NXP SEMICONDUCTORS N V COM N6596X109 131,413 1,200,664 SH   DFND 1 1,200,664 0 0
OASIS PETE INC NEW COM 674215108 39,186 4,867,847 SH   DFND 1 4,867,847 0 0
OFFICE DEPOT INC COM 676220106 71,086 12,603,900 SH   DFND 1 12,603,900 0 0
OKTA INC CL A ADDED 679295105 171 7,500 SH   DFND 1 7,500 0 0
PALO ALTO NETWORKS INC COM 697435105 10,718 80,100 SH   DFND 1 80,100 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 2,404 27,500 SH   DFND 1 27,500 0 0
RANDGOLD RES LTD ADR 752344309 38,188 431,700 SH   DFND 1 431,700 0 0
REALOGY HLDGS CORP COM 75605Y106 129,800 4,000,000 SH   DFND 1 4,000,000 0 0
REYNOLDS AMERICAN INC COM 761713106 15,401 236,787 SH   DFND 1 236,787 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,807 662,056 SH   DFND 1 662,056 0 0
SANDRIDGE ENERGY INC COM NEW 80007P869 11,471 666,535 SH   DFND 1 666,535 0 0
SANOFI SPONSORED ADR 80105N105 2,491 52,000 SH   DFND 1 52,000 0 0
SEABRIDGE GOLD INC COM 811916105 7,560 700,000 SH   DFND 1 700,000 0 0
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 6,819 174,000 SH   DFND 1 174,000 0 0
SHIRE PLC SPONSORED ADR 82481R106 575,404 3,481,600 SH   DFND 1 3,481,600 0 0
SHIRE PLC CALL 82481R106 9,090 55,000 SH Call DFND 1 55,000 0 0
SHIRE PLC CALL 82481R106 11,569 70,000 SH Call DFND 1 70,000 0 0
SIENTRA INC COM 82621J105 776 79,800 SH   DFND 1 79,800 0 0
SNAP INC PUT 83304A106 10,307 580,000 SH Put DFND 1 580,000 0 0
SPDR GOLD TRUST GOLD SHS 78463V107 514,534 4,359,722 SH   DFND 1 4,359,722 0 0
SPECTRANETICS CORP COM 84760C107 9,120 237,500 SH   DFND 1 237,500 0 0
STERIS PLC SHS USD G84720104 10,717 131,500 SH   DFND 1 131,500 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 107,195 24,088,655 SH   DFND 1 24,088,655 0 0
SYNTHESIS ENERGY SYS INC COM 871628103 6,700 10,000,000 SH   DFND 1 10,000,000 0 0
T MOBILE US INC COM 872590104 366,793 6,050,700 SH   DFND 1 6,050,700 0 0
TANDEM DIABETES CARE INC COM 875372104 400 500,000 SH   DFND 1 500,000 0 0
TEGNA INC COM 87901J105 11,215 778,300 SH   DFND 1 778,300 0 0
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 224,036 6,744,000 SH   DFND 1 6,744,000 0 0
TIM PARTICIPACOES S A SPONSORED ADR 88706P205 82,149 5,550,600 SH   DFND 1 5,550,600 0 0
TIME INC NEW COM 887228104 12,731 887,200 SH   DFND 1 887,200 0 0
TIME WARNER INC COM NEW 887317303 299,870 2,986,455 SH   DFND 1 2,986,455 0 0
TREVENA INC COM 89532E109 938 407,626 SH   DFND 1 407,626 0 0
TRILOGY METALS INC NEW COM 89621C105 7,338 11,566,126 SH   DFND 1 11,566,126 0 0
VALEANT PHARMACEUTICALS INTL COM 91911K102 377,372 21,813,400 SH   DFND 1 21,813,400 0 0
VISTRA ENERGY CORP COM ADDED 92840M102 193,598 11,530,556 SH   DFND 1 11,530,556 0 0
VWR CORP COM 91843L103 88,308 2,675,200 SH   DFND 1 2,675,200 0 0
WEBMD HEALTH CORP COM 94770V102 3,794 64,688 SH   DFND 1 64,688 0 0
LYON WILLIAM HOMES CL A NEW 552074700 80,209 3,322,666 SH   DFND 1 3,322,666 0 0
WORKDAY INC CL A 98138H101 3,744 38,600 SH   DFND 1 38,600 0 0
XCERRA CORP COM 98400J108 24,655 2,523,571 SH   DFND 1 2,523,571 0 0
ZILLOW GROUP INC CL C CAP STK 98954M200 7,842 160,000 SH   DFND 1 160,000 0 0