The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Achillion Pharmaceuticals In COM 00448Q201 35,201 7,839,766 SH   SOLE 1 7,839,766 0 0
Agenus Inc COM NEW 00847G705 18,604 4,218,520 SH   SOLE 1 4,218,520 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 73,236 623,338 SH   SOLE 1 623,338 0 0
Arbutus Biopharma Corp COM 03879J100 32,651 5,266,280 SH   SOLE 1 5,266,280 0 0
argenx SE SPONSORED ADR 04016X101 563 24,906 SH   SOLE 1 24,906 0 0
Atara Biotherapeutics Inc COM 046513107 10,857 656,018 SH   SOLE 1 656,018 0 0
Avexis Inc COM 05366U100 45,237 467,667 SH   SOLE 1 467,667 0 0
BioCryst Pharmaceuticals COM 09058V103 17,421 3,324,705 SH   SOLE 1 3,324,705 0 0
bluebird bio Inc COM 09609G100 14,295 104,078 SH   SOLE 1 104,078 0 0
Bovie Medical Corp COM 10211F100 3,852 1,139,600 SH   SOLE 1 1,139,600 0 0
Bristol Myers Squibb Co COM 110122108 52,746 827,512 SH   SOLE 1 827,512 0 0
Corium Intl Inc COM 21887L107 18,564 1,675,479 SH   SOLE 1 1,675,479 0 0
Dicerna Pharmaceuticals Inc COM 253031108 11,954 2,078,991 SH   SOLE 1 2,078,991 0 0
Global Blood Therapeutics In COM 37890U108 817 26,310 SH   SOLE 1 26,310 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 36,321 1,044,307 SH   SOLE 1 1,044,307 0 0
Masimo Corp COM 574795100 10,465 120,900 SH   SOLE 1 120,900 0 0
Myokardia Inc COM 62857M105 10,882 253,962 SH   SOLE 1 253,962 0 0
OraSure Technologies Inc COM 68554V108 12,053 535,707 SH   SOLE 1 535,707 0 0
Oxford Immunotec Global PLC ORD SHS G6855A103 17,344 1,032,370 SH   SOLE 1 1,032,370 0 0
PTC Therapeutics Inc COM 69366J200 69,938 3,495,143 SH   SOLE 1 3,495,143 0 0
Regenxbio Inc COM 75901B107 50,710 1,539,005 SH   SOLE 1 1,539,005 0 0
SENSUS HEATLHCARE INC *W EXP 06/08/201 81728J117 90 155,000 SH   SOLE 1 155,000 0 0
Spring Bk Pharmaceuticals In COM 849431101 4,195 249,095 SH   SOLE 1 249,095 0 0
Tactile Sys Technology Inc COM 87357P100 10,932 353,216 SH   SOLE 1 353,216 0 0
Viewray Inc COM 92672L107 5,878 1,020,462 SH   SOLE 1 1,020,462 0 0
Viveve Med Inc COM NEW 92852W204 7,719 1,473,028 SH   SOLE 1 1,473,028 0 0
Zynerba Pharmaceuticals Inc COM 98986X109 1,672 200,000 SH   SOLE 1 200,000 0 0