The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 3,149 | 64,800 | SH | DFND | 1 | 64,800 | 0 | 0 | |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 7,290 | 150,000 | SH | Call | DFND | 1 | 150,000 | 0 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 8,719 | 74,208 | SH | DFND | 1 | 74,208 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 5,714 | 1,632,449 | SH | DFND | 1 | 1,632,449 | 0 | 0 | |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 2,126 | 141,000 | SH | DFND | 1 | 141,000 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 30,265 | 1,770,940 | SH | DFND | 1 | 1,770,940 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 10,387 | 3,205,900 | SH | DFND | 1 | 3,205,900 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 31,784 | 5,184,942 | SH | DFND | 1 | 5,184,942 | 0 | 0 | |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 37,465 | 3,568,122 | SH | DFND | 1 | 3,568,122 | 0 | 0 | |
| BAXTER INTL INC | COM | 071813109 | 4,098 | 65,300 | SH | DFND | 1 | 65,300 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 13,012 | 4,410,866 | SH | DFND | 1 | 4,410,866 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 17,369 | 6,892,500 | SH | DFND | 1 | 6,892,500 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 6,645 | 820,403 | SH | DFND | 1 | 820,403 | 0 | 0 | |
| COGENTIX MED INC | COM | 19243A104 | 2,571 | 1,004,352 | SH | DFND | 1 | 1,004,352 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 3,010 | 2,711,561 | SH | DFND | 1 | 2,711,561 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 49,159 | 4,436,726 | SH | DFND | 1 | 4,436,726 | 0 | 0 | |
| EGALET CORP | NOTE 5.500% 4/0 | 28226BAB0 | 4,800 | 10,000,000 | SH | DFND | 1 | 10,000,000 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 55,810 | 3,455,710 | SH | DFND | 1 | 3,455,710 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM NEW | 45168K306 | 5,419 | 2,429,937 | SH | DFND | 1 | 2,429,937 | 0 | 0 | |
| IGNYTA INC | COM | 451731103 | 18,456 | 1,494,402 | SH | DFND | 1 | 1,494,402 | 0 | 0 | |
| INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 3,963 | 78,500 | SH | DFND | 1 | 78,500 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 19,279 | 2,487,622 | SH | DFND | 1 | 2,487,622 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 36,802 | 1,058,138 | SH | DFND | 1 | 1,058,138 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 29,142 | 2,490,801 | SH | DFND | 1 | 2,490,801 | 0 | 0 | |
| NATUS MEDICAL INC DEL | COM | 639050103 | 7,665 | 204,400 | SH | DFND | 1 | 204,400 | 0 | 0 | |
| NOVELION THERAPEUTICS INC | COM NEW | 67001K202 | 13,698 | 1,948,554 | SH | DFND | 1 | 1,948,554 | 0 | 0 | |
| NUVASIVE INC | COM | 670704105 | 4,880 | 88,000 | SH | DFND | 1 | 88,000 | 0 | 0 | |
| OVASCIENCE INC | COM | 69014Q101 | 781 | 550,000 | SH | DFND | 1 | 550,000 | 0 | 0 | |
| OWENS & MINOR INC NEW | COM | 690732102 | 3,904 | 133,700 | SH | DFND | 1 | 133,700 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 10,196 | 406,207 | SH | DFND | 1 | 406,207 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DBCV 4.250% 4/0 | 71426VAK4 | 5,983 | 15,000,000 | SH | DFND | 1 | 15,000,000 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 27,839 | 3,100,086 | SH | DFND | 1 | 3,100,086 | 0 | 0 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 5,368 | 4,294,505 | SH | DFND | 1 | 4,294,505 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 42,735 | 1,716,958 | SH | DFND | 1 | 1,716,958 | 0 | 0 | |
| STRATA SKIN SCIENCES INC | COM NEW | 86272A206 | 85 | 47,825 | SH | DFND | 1 | 47,825 | 0 | 0 | |
| TELIGENT INC NEW | COM | 87960W104 | 9,565 | 1,425,415 | SH | DFND | 1 | 1,425,415 | 0 | 0 | |
| TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 6,156 | 900,000 | SH | DFND | 1 | 900,000 | 0 | 0 | |
| VERACYTE INC | COM | 92337F107 | 8,953 | 1,020,832 | SH | DFND | 1 | 1,020,832 | 0 | 0 | |
| ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 5,737 | 49,000 | SH | DFND | 1 | 49,000 | 0 | 0 | |
| ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 23,418 | 200,000 | SH | Call | DFND | 1 | 200,000 | 0 | 0 |
| ZOGENIX INC | COM NEW | 98978L204 | 4,940 | 140,954 | SH | DFND | 1 | 140,954 | 0 | 0 | |
| ENDO INTL PLC | SHS | G30401106 | 25,792 | 3,011,323 | SH | DFND | 1 | 3,011,323 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 39,282 | 3,097,964 | SH | DFND | 1 | 3,097,964 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 19,919 | 2,886,795 | SH | DFND | 1 | 2,886,795 | 0 | 0 | |
| MEDIWOUND LTD | ORD SHS | M68830104 | 2,675 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |