The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 28,718 1,684,364 SH   SOLE   1,684,364 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 972,631 25,819,768 SH   SOLE   25,819,768 0 0
Acceleron Pharma Inc. COM 00434H108 6,117 163,900 SH   SOLE   163,900 0 0
Achaogen, Inc. COM 004449104 61,996 3,886,878 SH   SOLE   3,886,878 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 8,336 1,856,637 SH   SOLE   1,856,637 0 0
Acorda Therapeutics, Inc. COM 00484M106 12,286 519,500 SH   SOLE   519,500 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 3,655 172,630 SH   SOLE   172,630 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 819 100,000 SH   SOLE   600,000 0 0
Advanced Accelerator Applications S.A. SPONSORED ADS 00790T100 151,689 2,243,262 SH   SOLE   4,486,524 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 5,609 1,137,872 SH   SOLE   1,137,872 0 0
Aerie Pharmaceuticals, Inc. COM 00771V108 14,549 299,356 SH   SOLE   299,356 0 0
Aevi Genomic Medicine, Inc. COM 00835P105 5,728 4,546,426 SH   SOLE   4,546,426 0 0
Affimed N.V. COM N01045108 900 400,000 SH   SOLE   400,000 0 0
Agios Pharmaceuticals, Inc. COM 00847X104 8,588 128,666 SH   SOLE   128,666 0 0
Aimmune Therapeutics, Inc. COM 00900T107 16,706 673,908 SH   SOLE   673,908 0 0
Akari Therapeutics plc SPONSORED ADR 00972G108 3,051 496,901 SH   SOLE   49,690,100 0 0
Albireo Pharma, Inc. COM 01345P106 4,190 200,000 SH   SOLE   200,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 1,200,022 8,553,864 SH   SOLE   8,553,864 0 0
Alkermes plc SHS G01767105 7,639 150,251 SH   SOLE   150,251 0 0
Amarin Corporation plc SPONSORED ADR NEW 023111206 79,343 22,669,509 SH   SOLE   22,669,509 0 0
AnaptysBio, Inc. COM 032724106 3,893 111,386 SH   SOLE   111,386 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 155,156 10,934,154 SH   SOLE   10,934,154 0 0
Arbutus Biopharma Corporation COM 03879J100 1,120 180,582 SH   SOLE   180,582 0 0
argenx SE SPONSORED ADR 04016X101 2,261 100,000 SH   SOLE   100,000 0 0
Array BioPharma Inc. COM 04269X105 64,126 5,213,528 SH   SOLE   5,213,528 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 85,145 2,348,840 SH   SOLE   2,348,840 0 0
Assembly Biosciences, Inc. COM 045396108 8,730 250,000 SH   SOLE   250,000 0 0
AveXis, Inc. COM 05366U100 74,966 775,000 SH   SOLE   775,000 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 403,332 3,898,431 SH   SOLE   50,679,603 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 58,123 5,032,313 SH   SOLE   5,032,313 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 73,346 13,997,172 SH   SOLE   13,997,172 0 0
BioDelivery Sciences International, Inc. COM 09060J106 620 210,021 SH   SOLE   210,021 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 549,641 5,905,673 SH   SOLE   5,905,673 0 0
BioPharmX Corporation COM 09072X101 171 598,758 SH   SOLE   598,758 0 0
BioTime, Inc. *W EXP 10/1/201 09066L162 4 20,084 SH   SOLE   20,084 0 0
bluebird bio, Inc. COM 09609G100 33,162 241,441 SH   SOLE   241,441 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 12,857 5,102,153 SH   SOLE   5,102,153 0 0
Cellectis S.A. SPONSORED ADS 15117K103 1,423 50,000 SH   SOLE   50,000 0 0
Cerus Corporation COM 157085101 26,604 9,745,209 SH   SOLE   9,745,209 0 0
ChemoCentryx, Inc. COM 16383L106 364 49,064 SH   SOLE   49,064 0 0
Clementia Pharmaceuticals Inc. COM ADDED 185575107 4,223 250,000 SH   SOLE   250,000 0 0
ContraFect Corporation COM 212326102 7,940 7,153,076 SH   SOLE   7,153,076 0 0
Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 98 13,253 SH   SOLE   13,253 0 0
CymaBay Therapeutics, Inc. COM 23257D103 24,114 2,991,775 SH   SOLE   2,991,775 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 233,826 5,509,560 SH   SOLE   2,754,780 0 0
Dimension Therapeutics, Inc. COM 25433V105 7,511 1,251,881 SH   SOLE   1,251,881 0 0
Dynavax Technologies Corporation COM NEW 268158201 1,613 75,000 SH   SOLE   75,000 0 0
Epizyme, Inc. COM 29428V104 4,429 232,481 SH   SOLE   232,481 0 0
Exelixis, Inc. COM 30161Q104 50,447 2,082,012 SH   SOLE   2,082,012 0 0
Five Prime Therapeutics, Inc. COM 33830X104 787 19,247 SH   SOLE   19,247 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 13,690 2,466,702 SH   SOLE   2,466,702 0 0
Fulgent Genetics, Inc. COM 359664109 599 125,000 SH   SOLE   125,000 0 0
Galapagos NV SPONSORED ADR 36315X101 26,444 259,894 SH   SOLE   259,894 0 0
Genomic Health, Inc. COM 37244C101 442,215 13,780,480 SH   SOLE   13,780,480 0 0
GlycoMimetics, Inc. COM 38000Q102 7,881 563,312 SH   SOLE   563,312 0 0
GW Pharmaceuticals plc ADS 36197T103 7,612 75,000 SH   SOLE   900,000 0 0
Halozyme Therapeutics, Inc. COM 40637H109 27,469 1,581,424 SH   SOLE   1,581,424 0 0
Heron Therapeutics, Inc. COM 427746102 45,026 2,787,992 SH   SOLE   2,787,992 0 0
Idera Pharmaceuticals, Inc. COM NEW 45168K306 22,984 10,306,757 SH   SOLE   10,306,757 0 0
Ignyta, Inc. COM 451731103 16,045 1,299,199 SH   SOLE   1,299,199 0 0
Immune Design Corp. COM 45252L103 1,541 148,937 SH   SOLE   148,937 0 0
ImmunoGen, Inc. COM 45253H101 20,567 2,688,489 SH   SOLE   2,688,489 0 0
Incyte Corporation COM 45337C102 3,996,048 34,230,323 SH   SOLE   34,230,323 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 772 580,400 SH   SOLE   580,400 0 0
Insmed Incorporated COM PAR $.01 457669307 21,847 700,000 SH   SOLE   700,000 0 0
Intellia Therapeutics, Inc. COM 45826J105 26,394 1,062,120 SH   SOLE   1,062,120 0 0
Intra-Cellular Therapies, Inc. COM 46116X101 9,613 609,166 SH   SOLE   609,166 0 0
Invitae Corporation COM 46185L103 68,292 7,288,300 SH   SOLE   7,288,300 0 0
InVivo Therapeutics Holdings Corp. COM NEW 46186M209 580 400,000 SH   SOLE   400,000 0 0
Jounce Therapeutics, Inc. COM 481116101 1,558 100,000 SH   SOLE   100,000 0 0
Karyopharm Therapeutics Inc. COM 48576U106 2,383 216,990 SH   SOLE   216,990 0 0
Krystal Biotech, Inc. COM ADDED 501147102 1,994 200,000 SH   SOLE   200,000 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 5,380 154,675 SH   SOLE   154,675 0 0
Ligand Pharmaceuticals Incorporated COM NEW 53220K504 9,992 73,386 SH   SOLE   73,386 0 0
Loxo Oncology, Inc. COM 548862101 8,849 96,062 SH   SOLE   96,062 0 0
MacroGenics, Inc. COM 556099109 6,721 363,676 SH   SOLE   363,676 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 2,598 57,762 SH   SOLE   57,762 0 0
MediWound Ltd. ORD SHS M68830104 1,209 226,000 SH   SOLE   226,000 0 0
Merus N.V. COM N5749R100 23,049 1,160,014 SH   SOLE   1,160,014 0 0
Mirati Therapeutics, Inc. COM 60468T105 26,549 2,269,198 SH   SOLE   2,269,198 0 0
Molecular Templates, Inc. COM ADDED 608550109 505 72,412 SH   SOLE   72,412 0 0
MyoKardia, Inc. COM 62857M105 15,223 355,264 SH   SOLE   355,264 0 0
Nabriva Therapeutics plc SHS G63637105 7,684 938,235 SH   SOLE   938,235 0 0
Natera, Inc. COM 632307104 2,948 228,676 SH   SOLE   228,676 0 0
Neurocrine Biosciences, Inc. COM 64125C109 37,790 616,682 SH   SOLE   616,682 0 0
NeuroDerm Ltd. ORD SHS M74231107 22,238 571,667 SH   SOLE   571,667 0 0
Newlink Genetics Corporation COM 651511107 10,254 1,007,273 SH   SOLE   1,007,273 0 0
Novavax, Inc. COM 670002104 2,280 2,000,000 SH   SOLE   2,000,000 0 0
Ovid Therapeutics Inc. COM 690469101 2,857 333,333 SH   SOLE   333,333 0 0
Progenics Pharmaceuticals, Inc. COM 743187106 23,190 3,150,808 SH   SOLE   3,150,808 0 0
Proteon Therapeutics, Inc. COM 74371L109 597 298,591 SH   SOLE   298,591 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 2,598 177,952 SH   SOLE   177,952 0 0
Rigel Pharmaceuticals, Inc. COM NEW 766559603 6,398 2,518,882 SH   SOLE   2,518,882 0 0
Ritter Pharmaceuticals, Inc. COM 767836109 980 2,800,000 SH   SOLE   2,800,000 0 0
Sage Therapeutics, Inc. COM 78667J108 25,262 405,485 SH   SOLE   405,485 0 0
Sangamo Therapeutics, Inc. COM 800677106 31,701 2,113,376 SH   SOLE   2,113,376 0 0
Seattle Genetics, Inc. COM 812578102 2,487,928 45,725,556 SH   SOLE   45,725,556 0 0
Selecta Biosciences, Inc. COM 816212104 5,289 289,809 SH   SOLE   289,809 0 0
Spark Therapeutics, Inc. COM 84652J103 123,409 1,384,130 SH   SOLE   1,384,130 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 6,284 373,144 SH   SOLE   373,144 0 0
Stemline Therapeutics, Inc. COM 85858C107 7,032 633,497 SH   SOLE   633,497 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 1,439 741,665 SH   SOLE   741,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 8,462 574,835 SH   SOLE   574,835 0 0
T2 Biosystems, Inc. COM 89853L104 420 100,000 SH   SOLE   100,000 0 0
Tenax Therapeutics, Inc. COM 88032L100 126 348,374 SH   SOLE   348,374 0 0
Tetraphase Pharmaceuticals, Inc. COM 88165N105 6,395 935,000 SH   SOLE   935,000 0 0
Tonix Pharmaceuticals Holdings Corp. COM 890260409 3,190 699,500 SH   SOLE   699,500 0 0
Trevena, Inc. COM 89532E109 2,423 950,000 SH   SOLE   950,000 0 0
Trillium Therapeutics Inc. COM NEW 89620X506 2,131 413,697 SH   SOLE   413,697 0 0
Vanda Pharmaceuticals Inc. COM 921659108 7,588 423,884 SH   SOLE   423,884 0 0
Versartis, Inc. COM 92529L102 3,521 1,437,214 SH   SOLE   1,437,214 0 0
Voyager Therapeutics, Inc. COM 92915B106 4,880 237,014 SH   SOLE   237,014 0 0
Xencor, Inc. COM 98401F105 19,988 872,072 SH   SOLE   872,072 0 0
Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 31,574 35,083,000 PRN   SOLE   35,083,000 0 0
Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 7,576 9,517,000 PRN   SOLE   9,517,000 0 0
Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 5,410 3,000,000 PRN   SOLE   3,000,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13,634 12,228,000 PRN   SOLE   12,228,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 ADDED 09061GAH4 15,193 15,000,000 PRN   SOLE   15,000,000 0 0
Inotek Pharmaceuticals Corporation NOTE 5.75% 8/1/2021 45780VAB8 3,904 5,000,000 PRN   SOLE   5,000,000 0 0
Novavax, Inc. NOTE 3.75% 2/1/2023 670002AB0 39,536 88,500,000 PRN   SOLE   88,500,000 0 0
Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2,576 3,423,000 PRN   SOLE   3,423,000 0 0