The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 326,292 1,935,300 SH   SOLE   1,935,300 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 61,818 1,641,030 SH   SOLE   1,641,030 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 4,750 1,032,715 SH   SOLE   1,032,715 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 32,072 1,293,764 SH   SOLE   1,293,764 0 0
ALCOBRA LTD SHS M2239P109 276 272,788 SH   SOLE   272,788 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 789 64,400 SH   SOLE   64,400 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 151,561 1,080,342 SH   SOLE   1,080,342 0 0
ALIGN TECHNOLOGY INC COM 016255101 41,558 223,107 SH   SOLE   223,107 0 0
ALIMERA SCIENCES INC COM 016259103 4,069 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 63,491 3,441,233 SH   SOLE   3,441,233 0 0
AMICUS THERAPEUTICS INC COM 03152W109 111,898 7,420,288 SH   SOLE   7,420,288 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 226,953 2,438,519 SH   SOLE   2,438,519 0 0
BIOVERATIV INC COM 09075E100 12,059 211,300 SH   SOLE   211,300 0 0
CELGENE CORP COM 151020104 43,052 295,240 SH   SOLE   295,240 0 0
CEMPRA INC COM 15130J109 1,106 340,320 SH   SOLE   340,320 0 0
CLOVIS ONCOLOGY INC COM 189464100 274,357 3,329,581 SH   SOLE   3,329,581 0 0
CYTOKINETICS INC COM NEW 23282W605 1,793 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 2,880 500,913 SH   SOLE   500,913 0 0
EPIZYME INC COM 29428V104 121,888 6,398,296 SH   SOLE   6,398,296 0 0
EXACT SCIENCES CORP COM 30063P105 20,407 433,076 SH   SOLE   433,076 0 0
GILEAD SCIENCES INC COM 375558103 14,251 175,900 SH   SOLE   175,900 0 0
HISTOGENICS CORP COM 43358V109 600 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 1,374 616,355 SH   SOLE   616,355 0 0
IMMUNOMEDICS INC COM 452907108 42,086 3,010,466 SH   SOLE   3,010,466 0 0
INSMED INC COM PAR $.01 457669307 192,622 6,171,816 SH   SOLE   6,171,816 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 38,414 3,498,585 SH   SOLE   3,498,585 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 33,207 1,794,998 SH   SOLE   1,794,998 0 0
PROTHENA CORP PLC SHS G72800108 70,966 1,095,655 SH   SOLE   1,095,655 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 9,792 3,855,024 SH   SOLE   3,855,024 0 0
SAGE THERAPEUTICS INC COM 78667J108 49,046 787,251 SH   SOLE   787,251 0 0
SHIRE PLC SPONSORED ADR 82481R106 19,939 130,200 SH   SOLE   130,200 0 0
SOLENO THERAPEUTICS INC COM 834203101 220 84,748 SH   SOLE   84,748 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 530 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 43,663 3,507,052 SH   SOLE   3,507,052 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 2,255 1,162,473 SH   SOLE   1,162,473 0 0
TREVENA INC COM 89532E109 870 341,300 SH   SOLE   341,300 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 206,565 1,762,650 SH   SOLE   1,762,650 0 0
VANDA PHARMACEUTICALS INC COM 921659108 74,386 4,155,670 SH   SOLE   4,155,670 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 69,238 2,676,393 SH   SOLE   2,676,393 0 0
ZOGENIX INC COM NEW 98978L204 1,034 29,500 SH   SOLE   29,500 0 0