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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 31,452 1,984,364 SH   SOLE   1,984,364 0 0
Ablynx NV SPONSORED ADR 00372Y105 103,986 4,161,118 SH   SOLE   4,161,118 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 819,845 27,228,338 SH   SOLE   27,228,338 0 0
Acceleron Pharma Inc. COM 00434H108 6,956 163,900 SH   SOLE   163,900 0 0
Achaogen, Inc. COM 004449104 1,315 122,482 SH   SOLE   122,482 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 8,227 2,856,637 SH   SOLE   2,856,637 0 0
Acorda Therapeutics, Inc. COM 00484M106 4,418 205,966 SH   SOLE   205,966 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 5,850 172,630 SH   SOLE   172,630 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 668 100,000 SH   SOLE   600,000 0 0
Advanced Accelerator Applications S.A. SPONSORED ADS 00790T100 4,499 55,125 SH   SOLE   110,250 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 6,156 1,137,872 SH   SOLE   1,137,872 0 0
Aerie Pharmaceuticals, Inc. COM 00771V108 17,887 299,356 SH   SOLE   299,356 0 0
Aevi Genomic Medicine, Inc. COM 00835P105 4,866 4,055,142 SH   SOLE   4,055,142 0 0
Affimed N.V. COM N01045108 520 400,000 SH   SOLE   400,000 0 0
Agios Pharmaceuticals, Inc. COM 00847X104 7,356 128,666 SH   SOLE   128,666 0 0
Aimmune Therapeutics, Inc. COM 00900T107 25,487 673,908 SH   SOLE   673,908 0 0
Akari Therapeutics Plc SPONSORED ADR 00972G108 3,018 696,901 SH   SOLE   69,690,100 0 0
Albireo Pharma, Inc. COM 01345P106 5,120 200,000 SH   SOLE   200,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 1,022,957 8,553,864 SH   SOLE   8,553,864 0 0
Alkermes plc SHS G01767105 8,223 150,251 SH   SOLE   150,251 0 0
Amarin Corporation plc SPONSORED ADR NEW 023111206 90,905 22,669,509 SH   SOLE   22,669,509 0 0
AnaptysBio, Inc. COM 032724106 18,269 181,386 SH   SOLE   181,386 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 128,586 10,934,154 SH   SOLE   10,934,154 0 0
Arbutus Biopharma Corporation COM 03879J100 912 180,582 SH   SOLE   180,582 0 0
argenx SE SPONSORED ADR 04016X101 60,725 961,754 SH   SOLE   961,754 0 0
Array BioPharma Inc. COM 04269X105 72,399 5,656,196 SH   SOLE   5,656,196 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 104,910 2,618,818 SH   SOLE   2,618,818 0 0
Assembly Biosciences, Inc. COM 045396108 14,603 322,727 SH   SOLE   322,727 0 0
AveXis, Inc. COM 05366U100 85,769 775,000 SH   SOLE   775,000 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 376,147 3,849,231 SH   SOLE   50,040,003 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 42,322 5,032,313 SH   SOLE   5,032,313 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 68,726 13,997,172 SH   SOLE   13,997,172 0 0
BioDelivery Sciences International, Inc. COM 09060J106 620 210,021 SH   SOLE   210,021 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 676,184 7,583,084 SH   SOLE   7,583,084 0 0
BioTime, Inc. *W EXP 10/1/201 09066L162 2 20,084 SH   SOLE   20,084 0 0
bluebird bio, Inc. COM 09609G100 35,620 200,000 SH   SOLE   200,000 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 22,882 5,852,153 SH   SOLE   5,852,153 0 0
Cellectis S.A. SPONSORED ADS 15117K103 1,458 50,000 SH   SOLE   50,000 0 0
Cerus Corporation COM 157085101 32,939 9,745,209 SH   SOLE   9,745,209 0 0
ChemoCentryx, Inc. COM 16383L106 292 49,064 SH   SOLE   49,064 0 0
Clementia Pharmaceuticals Inc. COM 185575107 4,745 250,000 SH   SOLE   250,000 0 0
ContraFect Corporation COM 212326102 7,225 7,153,076 SH   SOLE   7,153,076 0 0
Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 4,691 660,714 SH   SOLE   660,714 0 0
Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 92 13,253 SH   SOLE   13,253 0 0
CymaBay Therapeutics, Inc. COM 23257D103 27,524 2,991,775 SH   SOLE   2,991,775 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 135,535 5,509,560 SH   SOLE   2,754,780 0 0
Dynavax Technologies Corporation COM NEW 268158201 1,403 75,000 SH   SOLE   75,000 0 0
Endocyte, Inc. COM 29269A102 4,654 1,087,323 SH   SOLE   1,087,323 0 0
Epizyme, Inc. COM 29428V104 2,918 232,481 SH   SOLE   232,481 0 0
Erytech Pharma S.A. SPONSORED ADR 29604W108 68,043 3,090,069 SH   SOLE   3,090,069 0 0
Exelixis, Inc. COM 30161Q104 45,798 1,506,499 SH   SOLE   1,506,499 0 0
Five Prime Therapeutics, Inc. COM 33830X104 422 19,247 SH   SOLE   19,247 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 14,825 2,466,702 SH   SOLE   2,466,702 0 0
Fulgent Genetics, Inc. COM 359664109 548 125,000 SH   SOLE   125,000 0 0
Galapagos NV SPONSORED ADR 36315X101 24,368 259,894 SH   SOLE   259,894 0 0
Genomic Health, Inc. COM 37244C101 471,314 13,781,102 SH   SOLE   13,781,102 0 0
GlycoMimetics, Inc. COM 38000Q102 9,458 563,312 SH   SOLE   563,312 0 0
GW Pharmaceuticals plc ADS 36197T103 29,280 221,800 SH   SOLE   2,661,600 0 0
Halozyme Therapeutics, Inc. COM 40637H109 32,040 1,581,424 SH   SOLE   1,581,424 0 0
Heron Therapeutics, Inc. COM 427746102 55,398 3,060,641 SH   SOLE   3,060,641 0 0
Idera Pharmaceuticals, Inc. COM NEW 45168K306 38,646 18,315,802 SH   SOLE   18,315,802 0 0
Ignyta, Inc. COM 451731103 36,960 1,384,266 SH   SOLE   1,384,266 0 0
Immune Design Corp. COM 45252L103 581 148,937 SH   SOLE   148,937 0 0
ImmunoGen, Inc. COM 45253H101 16,432 2,563,489 SH   SOLE   2,563,489 0 0
Incyte Corporation COM 45337C102 3,241,973 34,230,523 SH   SOLE   34,230,523 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 1,178 580,400 SH   SOLE   580,400 0 0
InflaRx N.V. COM N44821101 4,190 200,000 SH   SOLE   200,000 0 0
Insmed Incorporated COM PAR $.01 457669307 21,826 700,000 SH   SOLE   700,000 0 0
Intellia Therapeutics, Inc. COM 45826J105 22,016 1,145,453 SH   SOLE   1,145,453 0 0
Intra-Cellular Therapies, Inc. COM 46116X101 8,821 609,166 SH   SOLE   609,166 0 0
Invitae Corporation COM 46185L103 66,178 7,288,300 SH   SOLE   7,288,300 0 0
InVivo Therapeutics Holdings Corp. COM NEW 46186M209 255 331,393 SH   SOLE   331,393 0 0
Jounce Therapeutics, Inc. COM 481116101 1,275 100,000 SH   SOLE   100,000 0 0
Karyopharm Therapeutics Inc. COM 48576U106 2,083 216,990 SH   SOLE   216,990 0 0
Krystal Biotech, Inc. COM 501147102 2,104 200,000 SH   SOLE   200,000 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 4,977 154,675 SH   SOLE   154,675 0 0
Ligand Pharmaceuticals Incorporated COM NEW 53220K504 10,049 73,386 SH   SOLE   73,386 0 0
MacroGenics, Inc. COM 556099109 6,910 363,676 SH   SOLE   363,676 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 56,514 615,684 SH   SOLE   615,684 0 0
MediWound Ltd. ORD SHS M68830104 1,006 226,000 SH   SOLE   226,000 0 0
Merus N.V. COM N5749R100 22,504 1,160,014 SH   SOLE   1,160,014 0 0
Mirati Therapeutics, Inc. COM 60468T105 46,528 2,549,461 SH   SOLE   2,549,461 0 0
Molecular Templates, Inc. COM 608550109 726 72,412 SH   SOLE   72,412 0 0
MyoKardia, Inc. COM 62857M105 14,957 355,264 SH   SOLE   355,264 0 0
Nabriva Therapeutics plc SHS G63637105 5,611 938,235 SH   SOLE   938,235 0 0
Natera, Inc. COM 632307104 2,056 228,676 SH   SOLE   228,676 0 0
Nektar Therapeutics COM 640268108 10,268 171,934 SH   SOLE   171,934 0 0
Neurocrine Biosciences, Inc. COM 64125C109 77,949 1,004,624 SH   SOLE   1,004,624 0 0
NewLink Genetics Corporation COM 651511107 8,169 1,007,273 SH   SOLE   1,007,273 0 0
Novavax, Inc. COM 670002104 2,480 2,000,000 SH   SOLE   2,000,000 0 0
Ovid Therapeutics Inc. COM 690469101 3,290 333,333 SH   SOLE   333,333 0 0
Progenics Pharmaceuticals, Inc. COM 743187106 18,747 3,150,808 SH   SOLE   3,150,808 0 0
Proteon Therapeutics, Inc. COM 74371L109 567 298,591 SH   SOLE   298,591 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 1,513 177,952 SH   SOLE   177,952 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 59,545 2,049,020 SH   SOLE   2,049,020 0 0
Rigel Pharmaceuticals, Inc. COM NEW 766559603 9,773 2,518,882 SH   SOLE   2,518,882 0 0
Ritter Pharmaceuticals, Inc. COM 767836109 922 2,800,000 SH   SOLE   2,800,000 0 0
Sage Therapeutics, Inc. COM 78667J108 101,546 616,514 SH   SOLE   616,514 0 0
Sangamo Therapeutics, Inc. COM 800677106 34,659 2,113,376 SH   SOLE   2,113,376 0 0
Seattle Genetics, Inc. COM 812578102 2,446,317 45,725,556 SH   SOLE   45,725,556 0 0
Selecta Biosciences, Inc. COM 816212104 2,783 283,716 SH   SOLE   283,716 0 0
Spark Therapeutics, Inc. COM 84652J103 71,172 1,384,130 SH   SOLE   1,384,130 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 5,015 373,144 SH   SOLE   373,144 0 0
Stemline Therapeutics, Inc. COM 85858C107 9,883 633,497 SH   SOLE   633,497 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 2,737 741,665 SH   SOLE   741,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 5,593 574,835 SH   SOLE   574,835 0 0
T2 Biosystems, Inc. COM 89853L104 412 100,000 SH   SOLE   100,000 0 0
Tenax Therapeutics, Inc. COM 88032L100 171 348,374 SH   SOLE   348,374 0 0
Tetraphase Pharmaceuticals, Inc. COM 88165N105 5,891 935,000 SH   SOLE   935,000 0 0
Tonix Pharmaceuticals Holdings Corp. COM 890260409 2,413 699,500 SH   SOLE   699,500 0 0
Trevena, Inc. COM 89532E109 1,520 950,000 SH   SOLE   950,000 0 0
Trillium Therapeutics Inc. COM NEW 89620X506 2,968 409,323 SH   SOLE   409,323 0 0
uniQure N.V. SHS N90064101 9,453 482,557 SH   SOLE   482,557 0 0
Vanda Pharmaceuticals Inc. COM 921659108 6,443 423,884 SH   SOLE   423,884 0 0
Versartis, Inc. COM 92529L102 3,138 1,426,310 SH   SOLE   1,426,310 0 0
Xencor, Inc. COM 98401F105 19,116 872,072 SH   SOLE   872,072 0 0
Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 29,751 35,083,000 PRN   SOLE   35,083,000 0 0
Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 7,566 9,517,000 PRN   SOLE   9,517,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13,218 12,228,000 PRN   SOLE   12,228,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 14,928 15,000,000 PRN   SOLE   15,000,000 0 0
INOTEK Technologies Corp. NOTE 5.75% 8/1/2021 45780VAB8 4,009 5,000,000 PRN   SOLE   5,000,000 0 0
Novavax, Inc. Note 3.75% 2/1/2023 670002AB0 40,863 88,500,000 PRN   SOLE   88,500,000 0 0
Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2,576 3,423,000 PRN   SOLE   3,423,000 0 0