The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 16,859 1,873,276 SH   DFND 1 1,873,276 0 0
AMAG PHARMACEUTICALS INC NOTE 3.250% 6/0 00163UAD8 21,759 25,250,000 PRN   DFND 1 25,250,000 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 24,179 741,016 SH   DFND 1 741,016 0 0
ACCELERON PHARMA INC COM 00434H108 26,101 615,000 SH   DFND 1 615,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 55,076 2,233,416 SH   DFND 1 2,233,416 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 13,195 16,600,000 PRN   DFND 1 16,600,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 28,922 484,055 SH   DFND 1 484,055 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 15,035 262,984 SH   DFND 1 262,984 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108 1,082 249,785 SH   DFND 1 249,785 0 0
ALIMERA SCIENCES INC COM 016259103 8,050 6,052,935 SH   DFND 1 6,052,935 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 6,087 605,100 SH   DFND 1 605,100 0 0
ALLSCRIPTS HEALTHCARE SOLUTN NOTE 1.250% 7/0 01988PAD0 10,351 9,671,000 PRN   DFND 1 9,671,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 10,227 913,100 SH   DFND 1 913,100 0 0
ANAPTYSBIO INC COM 032724106 81,833 812,484 SH   DFND 1 812,484 0 0
ANTHEM INC COM 036752103 29,251 130,000 SH   DFND 1 130,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 11,132 513,000 SH   DFND 1 513,000 0 0
ARALEZ PHARMACEUTICALS INC COM 03852X100 2,335 1,644,583 SH   DFND 1 1,644,583 0 0
ARDELYX INC COM 039697107 16,299 2,469,580 SH   DFND 1 2,469,580 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 51,722 1,522,566 SH   DFND 1 1,522,566 0 0
ARGENX SE SPONSORED ADR 04016X101 23,107 365,961 SH   DFND 1 365,961 0 0
ARSANIS INC COM 042873109 1,679 131,548 SH   DFND 1 131,548 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 31,607 789,000 SH   DFND 1 789,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 37,204 1,190,516 SH   DFND 1 1,190,516 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 32,435 3,955,494 SH   DFND 1 3,955,494 0 0
AVEXIS INC COM 05366U100 83,644 755,798 SH   DFND 1 755,798 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 35,418 7,213,393 SH   DFND 1 7,213,393 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 9,200 341,000 SH   DFND 1 341,000 0 0
BIOSCRIP INC COM 09069N108 9,091 3,124,000 SH   DFND 1 3,124,000 0 0
BLUEBIRD BIO INC COM 09609G100 14,248 80,000 SH   DFND 1 80,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 29,862 396,000 SH   DFND 1 396,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 15,903 753,322 SH   DFND 1 753,322 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 51,787 2,105,180 SH   DFND 1 2,105,180 0 0
DAVITA INC COM 23918K108 30,706 425,000 SH   DFND 1 425,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 7,617 336,009 SH   DFND 1 336,009 0 0
DEPOMED INC NOTE 2.500% 9/0 249908AA2 22,776 27,019,000 PRN   DFND 1 27,019,000 0 0
DEXCOM INC COM 252131107 88,048 1,534,211 SH   DFND 1 1,534,211 0 0
EDITAS MEDICINE INC COM 28106W103 52,530 1,709,400 SH   DFND 1 1,709,400 0 0
EHEALTH INC COM 28238P109 17,612 1,013,916 SH   DFND 1 1,013,916 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 4,185 300,000 SH   DFND 1 300,000 0 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 36,112 40,500,000 PRN   DFND 1 40,500,000 0 0
ENVISION HEALTHCARE CORP COM 29414D100 23,363 676,000 SH   DFND 1 676,000 0 0
EPIZYME INC COM 29428V104 12,670 1,009,526 SH   DFND 1 1,009,526 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 9,880 450,728 SH   DFND 1 450,728 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 3,011 501,000 SH   DFND 1 501,000 0 0
GALAPAGOS NV SPON ADR 36315X101 12,189 130,000 SH   DFND 1 130,000 0 0
GLAUKOS CORP COM 377322102 85,749 3,343,045 SH   DFND 1 3,343,045 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 44,775 339,180 SH   DFND 1 339,180 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 68,886 74,100,000 PRN   DFND 1 74,100,000 0 0
HORIZON PHARMA PLC SHS G4617B105 92,592 6,341,894 SH   DFND 1 6,341,894 0 0
IMMUNOMEDICS INC COM 452907108 21,015 1,300,448 SH   DFND 1 1,300,448 0 0
INFLARX NV COM N44821101 3,666 175,000 SH   DFND 1 175,000 0 0
INSULET CORP COM 45784P101 48,685 705,573 SH   DFND 1 705,573 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 28,879 36,000,000 PRN   DFND 1 36,000,000 0 0
INTERSECT ENT INC COM 46071F103 47,574 1,468,341 SH   DFND 1 1,468,341 0 0
INVITAE CORP COM 46185L103 15,645 1,723,000 SH   DFND 1 1,723,000 0 0
INVUITY INC COM NEW 46187J205 7,299 1,177,229 SH   DFND 1 1,177,229 0 0
ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 48,392 45,700,000 PRN   DFND 1 45,700,000 0 0
K2M GROUP HLDGS INC NOTE 4.125% 8/1 48273JAB3 22,847 20,000,000 PRN   DFND 1 20,000,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 45,750 75,000,000 PRN   DFND 1 75,000,000 0 0
LANNET INC COM 516012101 63,041 2,717,287 SH   DFND 1 2,717,287 0 0
LOXO ONCOLOGY INC COM 548862101 14,226 169,000 SH   DFND 1 169,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 130,081 5,766,000 SH   DFND 1 5,766,000 0 0
MCKESSON CORP COM 58155Q103 61,569 394,801 SH   DFND 1 394,801 0 0
MCKESSON CORP COM 58155Q103 6,737 43,200 SH Call DFND 1 43,200 0 0
MIMEDX GROUP INC COM 602496101 1,892 150,000 SH   DFND 1 150,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 6,844 375,000 SH   DFND 1 375,000 0 0
MOLINA HEALTHCARE INC COM 60855R100 43,554 568,000 SH   DFND 1 568,000 0 0
MYLAN N V SHS EURO N59465109 105,928 2,503,611 SH   DFND 1 2,503,611 0 0
MYOKARDIA INC COM 62857M105 42,129 1,000,680 SH   DFND 1 1,000,680 0 0
NATERA INC COM 632307104 26,258 2,920,856 SH   DFND 1 2,920,856 0 0
NEOS THERAPEUTICS INC COM 64052L106 7,607 745,767 SH   DFND 1 745,767 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 28,890 27,600,000 PRN   DFND 1 27,600,000 0 0
NUCANA PLC SPONSORED ADR 67022C106 835 82,637 SH   DFND 1 82,637 0 0
OBALON THERAPEUTICS INC COM 67424L100 2,950 446,284 SH   DFND 1 446,284 0 0
ORTHOPEDIATRICS CORP COM 68752L100 1,118 58,247 SH   DFND 1 58,247 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 17,658 1,264,000 SH   DFND 1 1,264,000 0 0
PFENEX INC COM 717071104 2,208 830,216 SH   DFND 1 830,216 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 14,533 298,545 SH   DFND 1 298,545 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 4,680 225,000 SH   DFND 1 225,000 0 0
PROTEON THERAPEUTICS INC COM 74371L109 2,327 1,224,899 SH   DFND 1 1,224,899 0 0
RA PHARMACEUTICALS INC COM 74933V108 673 79,150 SH   DFND 1 79,150 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 11,045 390,000 SH   DFND 1 390,000 0 0
RECRO PHARMA INC COM 75629F109 17,591 1,901,685 SH   DFND 1 1,901,685 0 0
REGENXBIO INC COM 75901B107 8,522 256,300 SH   DFND 1 256,300 0 0
REVANCE THERAPEUTICS INC COM 761330109 35,750 1,000,000 SH   DFND 1 1,000,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 16,913 582,010 SH   DFND 1 582,010 0 0
SELECT MED HLDGS CORP COM 81619Q105 32,794 1,858,000 SH   DFND 1 1,858,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 6,569 1,761,092 SH   DFND 1 1,761,092 0 0
STEADYMED LTD SHS M84920103 5,250 1,418,787 SH   DFND 1 1,418,787 0 0
SYNLOGIC INC COM 87166L100 8,246 850,143 SH   DFND 1 850,143 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 12,347 1,268,945 SH   DFND 1 1,268,945 0 0
TESARO INC COM 881569107 3,555 42,893 SH   DFND 1 42,893 0 0
TRINITY BIOTECH INVT LTD NOTE 4.000% 4/0 89643QAB4 39,492 48,000,000 PRN   DFND 1 48,000,000 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 14,962 132,000 SH   DFND 1 132,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 1,953 117,647 SH   DFND 1 117,647 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 10,530 145,000 SH   DFND 1 145,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 11,045 314,674 SH   DFND 1 314,674 0 0
XENCOR INC COM 98401F105 11,442 522,000 SH   DFND 1 522,000 0 0