The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 297,122 1,585,413 SH   SOLE   1,585,413 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 49,411 1,641,030 SH   SOLE   1,641,030 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 43,358 1,146,419 SH   SOLE   1,146,419 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 21,071 1,840,246 SH   SOLE   1,840,246 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 133,659 1,117,642 SH   SOLE   1,117,642 0 0
ALIGN TECHNOLOGY INC COM 016255101 47,217 212,507 SH   SOLE   212,507 0 0
ALIMERA SCIENCES INC COM 016259103 4,008 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 46,285 3,493,220 SH   SOLE   3,493,220 0 0
AMICUS THERAPEUTICS INC COM 03152W109 86,427 6,006,022 SH   SOLE   6,006,022 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 222,729 2,497,806 SH   SOLE   2,497,806 0 0
BIOVERATIV INC COM 09075E100 14,256 264,400 SH   SOLE   264,400 0 0
CELGENE CORP COM 151020104 32,137 307,940 SH   SOLE   307,940 0 0
CLOVIS ONCOLOGY INC COM 189464100 231,389 3,402,781 SH   SOLE   3,402,781 0 0
CYTOKINETICS INC COM NEW 23282W605 1,008 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 4,523 500,913 SH   SOLE   500,913 0 0
EPIZYME INC COM 29428V104 86,104 6,860,843 SH   SOLE   6,860,843 0 0
EXACT SCIENCES CORP COM 30063P105 16,333 310,876 SH   SOLE   310,876 0 0
GILEAD SCIENCES INC COM 375558103 12,601 175,900 SH   SOLE   175,900 0 0
HISTOGENICS CORP COM 43358V109 621 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 1,301 616,355 SH   SOLE   616,355 0 0
IMMUNOMEDICS INC COM 452907108 77,152 4,774,261 SH   SOLE   4,774,261 0 0
INSMED INC COM PAR $.01 457669307 199,695 6,404,586 SH   SOLE   6,404,586 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 34,027 3,544,439 SH   SOLE   3,544,439 0 0
MELINTA THERAPEUTICS INC COM 58549G100 801 50,689 SH   SOLE   50,689 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 25,411 1,821,576 SH   SOLE   1,821,576 0 0
PROTHENA CORP PLC SHS G72800108 41,076 1,095,655 SH   SOLE   1,095,655 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 15,270 3,935,584 SH   SOLE   3,935,584 0 0
SAGE THERAPEUTICS INC COM 78667J108 133,548 810,806 SH   SOLE   810,806 0 0
SHIRE PLC SPONSORED ADR 82481R106 21,065 135,800 SH   SOLE   135,800 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 561 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 54,200 3,496,752 SH   SOLE   3,496,752 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 4,290 1,162,473 SH   SOLE   1,162,473 0 0
TREVENA INC COM 89532E109 546 341,300 SH   SOLE   341,300 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 237,645 1,606,250 SH   SOLE   1,606,250 0 0
VANDA PHARMACEUTICALS INC COM 921659108 63,166 4,155,670 SH   SOLE   4,155,670 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 60,746 2,736,293 SH   SOLE   2,736,293 0 0
ZOGENIX INC COM NEW 98978L204 1,181 29,500 SH   SOLE   29,500 0 0