The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Armo Biosciences Inc COM 04225U104 13,969 413,892 SH   SOLE 1 413,892 0 0
OraSure Technologies Inc COM 68554V108 1,981 117,291 SH   SOLE 1 117,291 0 0
Agenus Inc COM NEW 00847G705 43,867 9,313,556 SH   SOLE 1 9,313,556 0 0
Arbutus Biopharma Corp COM 03879J100 25,758 5,151,615 SH   SOLE 1 5,151,615 0 0
PTC Therapeutics Inc COM 69366J200 111,973 4,137,960 SH   SOLE 1 4,137,960 0 0
Dicerna Pharmaceuticals Inc COM 253031108 48,082 5,029,462 SH   SOLE 1 5,029,462 0 0
Viewray Inc COM 92672L107 8,737 1,358,711 SH   SOLE 1 1,358,711 0 0
Myokardia Inc COM 62857M105 12,672 259,670 SH   SOLE 1 259,670 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 33,429 1,122,540 SH   SOLE 1 1,122,540 0 0
Uniqure NV SHS N90064101 9,557 406,667 SH   SOLE 1 406,667 0 0
CORIUM INTL INC COM 21887L107 21,914 1,910,522 SH   SOLE 1 1,910,522 0 0
MOTUS GI HLDGS INC COM 62014P108 531 118,478 SH   SOLE 1 118,478 0 0
Homology Medicines Inc COM 438083107 4,208 225,000 SH   SOLE 1 225,000 0 0
ARGENX SE SPONSORED ADR 04016X101 2,048 25,457 SH   SOLE 1 25,457 0 0
Avexis Inc COM 05366U100 29,217 236,425 SH   SOLE 1 236,425 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 5,248 1,104,940 SH   SOLE 1 1,104,940 0 0
Nuvectra Corp COM 67075N108 6,602 507,061 SH   SOLE 1 507,061 0 0
CareDx Inc COM 14167L103 4,468 560,600 SH   SOLE 1 560,600 0 0
Adverum Biotechnologies Inc COM 00773U108 1,016 175,208 SH   SOLE 1 175,208 0 0
Novus Therapeutics Inc COM 67011N105 1,512 300,000 SH   SOLE 1 300,000 0 0
VIVEVE MED INC COM NEW 92852W204 9,361 2,557,559 SH   SOLE 1 2,557,559 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 22,069 456,921 SH   SOLE 1 456,921 0 0
Regenxbio Inc COM 75901B107 56,051 1,877,767 SH   SOLE 1 1,877,767 0 0
LivaNova PLC SHS G5509L101 12,390 140,000 SH   SOLE 1 140,000 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 69,346 1,096,386 SH   SOLE 1 1,096,386 0 0
Edwards Lifesciences Corp COM 28176E108 20,265 145,246 SH   SOLE 1 145,246 0 0
Vericel Corp COM 92346J108 20,576 2,067,916 SH   SOLE 1 2,067,916 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 29,326 246,229 SH   SOLE 1 246,229 0 0
Novavax Inc COM 670002104 5,726 2,726,504 SH   SOLE 1 2,726,504 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 50,074 13,496,902 SH   SOLE 1 13,496,902 0 0
Bovie Medical Corp COM 10211F100 5,738 1,931,948 SH   SOLE 1 1,931,948 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 21,028 2,916,561 SH   SOLE 1 2,916,561 0 0
Sarepta Therapeutics Inc COM 803607100 50,994 688,271 SH   SOLE 1 688,271 0 0
Masimo Corp COM 574795100 20,404 232,000 SH   SOLE 1 232,000 0 0
Odonate Therapeutics Inc COM 676079106 5,303 274,544 SH   SOLE 1 274,544 0 0
Rocket Pharmaceuticals Inc COM 77313F106 258,228 14,969,744 SH   SOLE 1 14,969,744 0 0
Solid Biosciences Inc COM 83422E105 4,612 675,771 SH   SOLE 1 675,771 0 0
VIVUS INC NOTE 4.500% 5/0 928551AB6 2,500 4,000,000 SH   SOLE 1 4,000,000 0 0