The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADMA BIOLOGICS INC | COM | 000899104 | 3,314 | 720,529 | SH | DFND | 1 | 720,529 | 0 | 0 | |
| AMAG PHARMACEUTICALS INC | COM | 00163U106 | 12,066 | 598,800 | SH | DFND | 1 | 598,800 | 0 | 0 | |
| ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 27,131 | 1,135,203 | SH | DFND | 1 | 1,135,203 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 6,257 | 2,078,799 | SH | DFND | 1 | 2,078,799 | 0 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 8,243 | 79,200 | SH | DFND | 1 | 79,200 | 0 | 0 | |
| ANGIODYNAMICS INC | COM | 03475V101 | 15,727 | 911,707 | SH | DFND | 1 | 911,707 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 10,281 | 4,673,247 | SH | DFND | 1 | 4,673,247 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 18,938 | 4,294,426 | SH | DFND | 1 | 4,294,426 | 0 | 0 | |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 19,134 | 2,624,663 | SH | DFND | 1 | 2,624,663 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 9,627 | 4,278,819 | SH | DFND | 1 | 4,278,819 | 0 | 0 | |
| CIGNA CORPORATION | COM | 125509109 | 7,146 | 42,600 | SH | DFND | 1 | 42,600 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 16,283 | 6,812,764 | SH | DFND | 1 | 6,812,764 | 0 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 1,503 | 375,816 | SH | DFND | 1 | 375,816 | 0 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 633 | 389,475 | SH | DFND | 1 | 389,475 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 35,782 | 3,119,645 | SH | DFND | 1 | 3,119,645 | 0 | 0 | |
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 6,277 | 86,786 | SH | DFND | 1 | 86,786 | 0 | 0 | |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 19,721 | 175,030 | SH | DFND | 1 | 175,030 | 0 | 0 | |
| GLAUKOS CORP | COM | 377322102 | 9,061 | 293,900 | SH | DFND | 1 | 293,900 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 43,647 | 1,581,416 | SH | DFND | 1 | 1,581,416 | 0 | 0 | |
| INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 16,515 | 298,424 | SH | DFND | 1 | 298,424 | 0 | 0 | |
| INVITAE CORP | COM | 46185L103 | 3,518 | 750,000 | SH | DFND | 1 | 750,000 | 0 | 0 | |
| INVUITY INC | COM NEW | 46187J205 | 1,150 | 298,800 | SH | DFND | 1 | 298,800 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 15,429 | 912,987 | SH | DFND | 1 | 912,987 | 0 | 0 | |
| KALA PHARMACEUTICALS INC | COM | 483119103 | 10,784 | 681,239 | SH | DFND | 1 | 681,239 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 49,337 | 1,656,720 | SH | DFND | 1 | 1,656,720 | 0 | 0 | |
| MERCK & CO INC | COM | 58933Y105 | 7,130 | 130,900 | SH | DFND | 1 | 130,900 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 44,329 | 1,443,948 | SH | DFND | 1 | 1,443,948 | 0 | 0 | |
| NATUS MEDICAL INC DEL | COM | 639050103 | 3,820 | 113,526 | SH | DFND | 1 | 113,526 | 0 | 0 | |
| NOVELION THERAPEUTICS INC | COM NEW | 67001K202 | 6,820 | 1,948,554 | SH | DFND | 1 | 1,948,554 | 0 | 0 | |
| NUVASIVE INC | COM | 670704105 | 13,485 | 258,292 | SH | DFND | 1 | 258,292 | 0 | 0 | |
| OVASCIENCE INC | COM | 69014Q101 | 442 | 545,282 | SH | DFND | 1 | 545,282 | 0 | 0 | |
| PACIRA PHARMACEUTICALS INC | COM | 695127100 | 5,186 | 166,500 | SH | DFND | 1 | 166,500 | 0 | 0 | |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 6,209 | 477,607 | SH | DFND | 1 | 477,607 | 0 | 0 | |
| PERNIX THERAPEUTICS HLDGS IN | DBCV 4.250% 4/0 | 71426VAK4 | 6,027 | 15,000,000 | SH | DFND | 1 | 15,000,000 | 0 | 0 | |
| PROGENICS PHARMACEUTICALS IN | COM | 743187106 | 3,730 | 500,000 | SH | Call | DFND | 1 | 500,000 | 0 | 0 |
| RECRO PHARMA INC | COM | 75629F109 | 24,619 | 2,236,025 | SH | DFND | 1 | 2,236,025 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 26,345 | 1,178,226 | SH | DFND | 1 | 1,178,226 | 0 | 0 | |
| SCYNEXIS INC | COM | 811292101 | 2,527 | 1,885,904 | SH | DFND | 1 | 1,885,904 | 0 | 0 | |
| STRATA SKIN SCIENCES INC | COM NEW | 86272A206 | 238 | 203,346 | SH | DFND | 1 | 203,346 | 0 | 0 | |
| TELIGENT INC NEW | COM | 87960W104 | 5,681 | 1,690,794 | SH | DFND | 1 | 1,690,794 | 0 | 0 | |
| TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 3,219 | 1,048,642 | SH | DFND | 1 | 1,048,642 | 0 | 0 | |
| VARIAN MED SYS INC | COM | 92220P105 | 3,680 | 30,000 | SH | DFND | 1 | 30,000 | 0 | 0 | |
| VERACYTE INC | COM | 92337F107 | 3,340 | 600,658 | SH | DFND | 1 | 600,658 | 0 | 0 | |
| VERICEL CORP | COM | 92346J108 | 6,556 | 658,900 | SH | DFND | 1 | 658,900 | 0 | 0 | |
| ZOGENIX INC | COM NEW | 98978L204 | 21,522 | 537,380 | SH | DFND | 1 | 537,380 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 36,411 | 2,564,175 | SH | DFND | 1 | 2,564,175 | 0 | 0 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 4,260 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 4,659 | 374,233 | SH | DFND | 1 | 374,233 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 24,725 | 2,793,752 | SH | DFND | 1 | 2,793,752 | 0 | 0 | |
| MEDIWOUND LTD | ORD SHS | M68830104 | 2,600 | 500,000 | SH | DFND | 1 | 500,000 | 0 | 0 | |
| SOL GEL TECHNOLOGIES | SHS | M8694L103 | 6,671 | 647,700 | SH | DFND | 1 | 647,700 | 0 | 0 | |