The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC Common 004225108 363 500,000 SH Call SOLE   500,000 0 0
ACADIA PHARMACEUTICALS INC Common 004225108 7,125 317,100 SH   SOLE   317,100 0 0
AGENUS INC Common 00847G705 3,318 704,554 SH   SOLE   704,554 0 0
ALIMERA SCIENCES INC Common 016259103 6,429 6,241,581 SH   SOLE   6,241,581 0 0
AMICUS THERAPEUTICS INC Common 03152W109 142,962 9,505,447 SH   SOLE   9,505,447 0 0
AMICUS THERAPEUTICS INC Common 03152W109 3,760 2,350,100 SH Call SOLE   2,350,100 0 0
APELLIS PHARMACEUTICALS INC Common 03753U106 7,454 396,635 SH   SOLE   396,635 0 0
ARGENX SE Sponsored ADR 04016X101 69,442 863,275 SH   SOLE   863,275 0 0
ARMO BIOSCIENCES INC Common 04225U104 45,173 1,207,500 SH   SOLE   1,207,500 0 0
ARRAY BIOPHARMA INC Common 04269X105 31,378 1,922,655 SH   SOLE   1,922,655 0 0
ASCENDIS PHARMA Sponsored ADR 04351P101 134,942 2,063,336 SH   SOLE   2,063,336 0 0
ASSEMBLY BIOSCIENCES INC Common 045396108 53,756 1,093,934 SH   SOLE   1,093,934 0 0
ASTRAZENECA PLC Sponsored ADR 046353108 26,238 750,300 SH   SOLE   750,300 0 0
AVEO PHARMACEUTICALS INC Common 053588109 9,372 3,231,893 SH   SOLE   3,231,893 0 0
AVEXIS INC Common 05366U100 83,449 675,262 SH   SOLE   675,262 0 0
BIODELIVERY SCIENCES INTL Common 09060J106 12,235 5,437,779 SH   SOLE   5,437,779 0 0
BIOMARIN PHARMACEUTICAL INC Common 09061G101 138,710 1,710,995 SH   SOLE   1,710,995 0 0
BIOMARIN PHARMACEUTICAL INC Common 09061G101 73 42,500 SH Call SOLE   42,500 0 0
BIOMARIN PHARMACEUTICAL INC Common 09061G101 141 120,000 SH Call SOLE   120,000 0 0
CATALYST BIOSCIENCES INC Common 14888D208 26,422 1,024,124 SH   SOLE   1,024,124 0 0
CATALYST PHARMACEUTICALS INC Common 14888U101 11,215 4,692,343 SH   SOLE   4,692,343 0 0
CLOVIS ONCOLOGY INC Common 189464100 61,559 1,165,884 SH   SOLE   1,165,884 0 0
DERMIRA INC Common 24983L104 27,385 3,427,378 SH   SOLE   3,427,378 0 0
DOVA PHARMACEUTICALS INC Common 25985T102 3,390 125,000 SH   SOLE   125,000 0 0
DYNAVAX TECHNOLOGIES CORP Common 268158201 32,766 1,650,700 SH   SOLE   1,650,700 0 0
ENDOCYTE INC Common 29269A102 51,769 5,695,200 SH   SOLE   5,695,200 0 0
FENNEC PHARMACEUTICALS INC Common 31447P100 3,284 272,666 SH   SOLE   272,666 0 0
GLOBAL BLOOD THERAPEUTICS INC Common 37890U108 85,276 1,765,548 SH   SOLE   1,765,548 0 0
GLOBAL BLOOD THERAPEUTICS INC Common 37890U108 1,444 152,000 SH Call SOLE   152,000 0 0
HORIZON PHARMA PLC Common G4617B105 73,253 5,158,683 SH   SOLE   5,158,683 0 0
IMMUNOMEDICS INC Common 452907108 247,486 16,939,461 SH   SOLE   16,939,461 0 0
INTEC PHARMA LTD Common M53644106 13,943 2,195,705 SH   SOLE   2,195,705 0 0
IOVANCE BIOTHERAPEUTICS INC Common 462260100 136,527 8,078,505 SH   SOLE   8,078,505 0 0
JOUNCE THERAPEUTICS INC Common 481116101 11,693 523,174 SH   SOLE   523,174 0 0
KARYOPHARM THERAPEUTICS INC Common 48576U106 7,524 560,658 SH   SOLE   560,658 0 0
MEDICINES CO Common 584688105 53,884 1,635,817 SH   SOLE   1,635,817 0 0
MACROGENICS INC Common 556099109 62 11,400 SH Call SOLE   11,400 0 0
MACROGENICS INC Common 556099109 10 3,100 SH Call SOLE   3,100 0 0
MIRATI THERAPEUTICS INC Common 60468T105 135,022 4,398,101 SH   SOLE   4,398,101 0 0
ONCOBIOLOGICS INC Common 68235M105 608 683,531 SH   SOLE   683,531 0 0
ONCOBIOLOGICS INC - WARRANT A Warrant 68235M113 5 233,333 SH   SOLE   233,333 0 0
ONCOBIOLOGICS INC - WARRANT B Warrant 68235M121 12 233,333 SH   SOLE   233,333 0 0
ONCOSEC MEDICAL INC Common 68234L207 7,534 4,007,696 SH   SOLE   4,007,696 0 0
PACIRA PHARMACEUTICALS INC Common 695127100 53,424 1,715,072 SH   SOLE   1,715,072 0 0
PERNIX THERAPEUTICS HOLDINGS INC Convertible Debt 71426VAK4 2,772 6,000,000 PRN   SOLE   6,000,000 0 0
PUMA BIOTECHNOLOGY INC Common 74587V107 56,166 825,368 SH   SOLE   825,368 0 0
SOLID BIOSCIENCES INC Common 83422E105 2,063 275,000 SH   SOLE   275,000 0 0
STEMLINE THERAPEUTICS INC Common 85858C107 8,022 524,321 SH   SOLE   524,321 0 0
TANDEM DIABETES CARE INC Common 875372203 3,888 783,910 SH   SOLE   783,910 0 0
TELIGENT INC Common 87960W104 17,806 5,299,431 SH   SOLE   5,299,431 0 0
TG THERAPEUTICS INC Common 88322Q108 74,261 5,229,619 SH   SOLE   5,229,619 0 0
UNIQURE NV Shares N90064101 1,592 67,758 SH   SOLE   67,758 0 0
VANDA PHARMACEUTICALS INC Common 921659108 46,762 2,775,191 SH   SOLE   2,775,191 0 0
VERACYTE INC Common 92337F107 665 119,680 SH   SOLE   119,680 0 0
VIEWRAY INC Common 92672L107 4,044 730,161 SH   SOLE   730,161 0 0
VIVEVE MEDICAL INC Common 92852W204 5,612 1,533,276 SH   SOLE   1,533,276 0 0
SPDR SERIES TRUST - S&P BIOTECH ETF 78464A870 998 750,000 SH Put SOLE   750,000 0 0
ZOGENIX INC Common 98978L204 47,628 1,189,213 SH   SOLE   1,189,213 0 0