The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 21,284 1,853,998 SH   DFND 1 1,853,998 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 29,033 741,016 SH   DFND 1 741,016 0 0
ACCELERON PHARMA INC COM 00434H108 24,047 615,000 SH   DFND 1 615,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 48,105 2,745,705 SH   DFND 1 2,745,705 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 2,448 422,000 SH   DFND 1 422,000 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 13,186 16,600,000 PRN   DFND 1 16,600,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 26,260 484,055 SH   DFND 1 484,055 0 0
AETNA INC NEW COM 00817Y108 27,885 165,000 SH   DFND 1 165,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 29,931 366,000 SH   DFND 1 366,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 22,606 710,210 SH   DFND 1 710,210 0 0
ALBIREO PHARMA INC COM 01345P106 3,908 120,000 SH   DFND 1 120,000 0 0
ALIMERA SCIENCES INC COM 016259103 6,235 6,052,935 SH   DFND 1 6,052,935 0 0
ALLSCRIPTS HEALTHCARE SOLUTN NOTE 1.250% 7/0 01988PAD0 9,708 9,671,000 PRN   DFND 1 9,671,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 17,389 146,000 SH   DFND 1 146,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 7,305 913,100 SH   DFND 1 913,100 0 0
ANAPTYSBIO INC COM 032724106 82,675 794,338 SH   DFND 1 794,338 0 0
ANTHEM INC COM 036752103 41,963 191,000 SH   DFND 1 191,000 0 0
ARALEZ PHARMACEUTICALS INC COM 03852X100 2,467 1,644,583 SH   DFND 1 1,644,583 0 0
ARDELYX INC COM 039697107 13,144 2,602,733 SH   DFND 1 2,602,733 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 27,539 697,194 SH   DFND 1 697,194 0 0
ARGENX SE SPONSORED ADR 04016X101 25,734 319,920 SH   DFND 1 319,920 0 0
ARMO BIOSCIENCES INC COM 04225U104 7,053 188,525 SH   DFND 1 188,525 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 31,553 482,467 SH   DFND 1 482,467 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 41,603 1,384,470 SH   DFND 1 1,384,470 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 27,618 3,788,540 SH   DFND 1 3,788,540 0 0
AVEXIS INC COM 05366U100 93,402 755,798 SH   DFND 1 755,798 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 35,138 7,366,460 SH   DFND 1 7,366,460 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 22,385 869,000 SH   DFND 1 869,000 0 0
BIOSCRIP INC COM 09069N108 7,685 3,124,000 SH   DFND 1 3,124,000 0 0
BLUEBIRD BIO INC COM 09609G100 7,001 41,000 SH   DFND 1 41,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 34,750 378,950 SH   DFND 1 378,950 0 0
CATALYST BIOSCIENCES INC COM NEW 14888D208 21,430 830,605 SH   DFND 1 830,605 0 0
CENTENE CORP DEL COM 15135B101 62,840 588,000 SH   DFND 1 588,000 0 0
CVS HEALTH CORP COM 126650100 34,216 550,000 SH   DFND 1 550,000 0 0
CVS HEALTH CORP COM 126650100 35,261 566,800 SH Call DFND 1 566,800 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 15,759 1,213,181 SH   DFND 1 1,213,181 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 21,432 753,322 SH   DFND 1 753,322 0 0
DAVITA INC COM 23918K108 32,075 486,427 SH   DFND 1 486,427 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 66,903 2,900,000 SH   DFND 1 2,900,000 0 0
DEPOMED INC NOTE 2.500% 9/0 249908AA2 22,006 27,019,000 PRN   DFND 1 27,019,000 0 0
DEXCOM INC COM 252131107 48,130 649,000 SH   DFND 1 649,000 0 0
DFB HEALTHCARE ACQUISTION CO UNIT 01/30/2023 23291E208 25,125 2,500,000 SH   DFND 1 2,500,000 0 0
EDITAS MEDICINE INC COM 28106W103 38,416 1,158,841 SH   DFND 1 1,158,841 0 0
EGALET CORP COM 28226B104 2,041 3,239,237 SH   DFND 1 3,239,237 0 0
EHEALTH INC COM 28238P109 14,751 1,030,802 SH   DFND 1 1,030,802 0 0
ENDOCYTE INC COM 29269A102 23,884 2,627,540 SH   DFND 1 2,627,540 0 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 34,899 40,500,000 PRN   DFND 1 40,500,000 0 0
EPIZYME INC COM 29428V104 17,057 960,970 SH   DFND 1 960,970 0 0
EXACT SCIENCES CORP DBCV 1.000% 1/1 30063PAA3 11,083 12,500,000 PRN   DFND 1 12,500,000 0 0
EYENOVIA INC COM 30234E104 2,745 300,000 SH   DFND 1 300,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 3,458 674,002 SH   DFND 1 674,002 0 0
G1 THERAPEUTICS INC COM 3621LQ109 13,820 373,000 SH   DFND 1 373,000 0 0
GALAPAGOS NV SPON ADR 36315X101 12,969 130,000 SH   DFND 1 130,000 0 0
GLAUKOS CORP COM 377322102 50,655 1,643,031 SH   DFND 1 1,643,031 0 0
GLAXOSMITHKLINE PLC SPONSORED ADR 37733W105 31,647 810,000 SH   DFND 1 810,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 25,402 225,452 SH   DFND 1 225,452 0 0
HOMOLOGY MEDICINES INC COM 438083107 97,746 5,227,035 SH   DFND 1 5,227,035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 91,055 99,100,000 PRN   DFND 1 99,100,000 0 0
HORIZON PHARMA PLC SHS G4617B105 93,860 6,609,894 SH   DFND 1 6,609,894 0 0
IGI LABORATORIES INC NOTE 3.750%12/1 449575AB5 10,750 11,600,000 PRN   DFND 1 11,600,000 0 0
IMMUNOMEDICS INC COM 452907108 13,594 930,448 SH   DFND 1 930,448 0 0
INFLARX NV COM N44821101 2,552 88,500 SH   DFND 1 88,500 0 0
INSULET CORP COM 45784P101 14,822 171,000 SH   DFND 1 171,000 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 28,596 36,000,000 PRN   DFND 1 36,000,000 0 0
INTERSECT ENT INC COM 46071F103 32,717 832,500 SH   DFND 1 832,500 0 0
INVITAE CORP COM 46185L103 8,919 1,901,788 SH   DFND 1 1,901,788 0 0
INVUITY INC COM NEW 46187J205 8,997 2,336,889 SH   DFND 1 2,336,889 0 0
ISIS PHARMACEUTICALS INC DEL NOTE 1.000%11/1 464337AJ3 45,283 45,700,000 PRN   DFND 1 45,700,000 0 0
K2M GROUP HLDGS INC NOTE 4.125% 8/1 48273JAB3 23,444 20,000,000 PRN   DFND 1 20,000,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 57,250 75,000,000 PRN   DFND 1 75,000,000 0 0
LANNET INC COM 516012101 43,994 2,741,077 SH   DFND 1 2,741,077 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 124,838 8,621,383 SH   DFND 1 8,621,383 0 0
MANNKIND CORP COM NEW 56400P706 3,380 1,482,601 SH   DFND 1 1,482,601 0 0
MCKESSON CORP COM 58155Q103 21,131 150,000 SH   DFND 1 150,000 0 0
MELINTA THERAPEUTICS INC COM 58549G100 23,146 3,127,846 SH   DFND 1 3,127,846 0 0
MENLO THERAPEUTICS INC COM 586858102 16,037 426,749 SH   DFND 1 426,749 0 0
MIRATI THERAPEUTICS INC COM 60468T105 6,048 197,000 SH   DFND 1 197,000 0 0
MOLINA HEALTHCARE INC COM 60855R100 13,638 168,000 SH   DFND 1 168,000 0 0
MYLAN N V SHS EURO N59465109 104,906 2,548,111 SH   DFND 1 2,548,111 0 0
MYOKARDIA INC COM 62857M105 52,152 1,068,680 SH   DFND 1 1,068,680 0 0
NATERA INC COM 632307104 29,479 3,180,000 SH   DFND 1 3,180,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 7,179 864,906 SH   DFND 1 864,906 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 31,273 27,600,000 PRN   DFND 1 27,600,000 0 0
NUVASIVE INC NOTE 2.250% 3/1 670704AG0 11,001 10,000,000 PRN   DFND 1 10,000,000 0 0
OBALON THERAPEUTICS INC COM 67424L100 1,531 446,284 SH   DFND 1 446,284 0 0
ORTHOPEDIATRICS CORP COM 68752L100 877 58,247 SH   DFND 1 58,247 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 17,978 1,444,000 SH   DFND 1 1,444,000 0 0
PFENEX INC COM 717071104 9,957 1,659,501 SH   DFND 1 1,659,501 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 16,330 500,000 SH Call DFND 1 500,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 16,330 500,000 SH Put DFND 1 500,000 0 0
PROTEON THERAPEUTICS INC COM 74371L109 3,062 1,224,899 SH   DFND 1 1,224,899 0 0
RA PHARMACEUTICALS INC COM 74933V108 2,032 382,700 SH   DFND 1 382,700 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 21,134 21,000,000 PRN   DFND 1 21,000,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 7,999 390,000 SH   DFND 1 390,000 0 0
RECRO PHARMA INC COM 75629F109 11,120 1,010,000 SH   DFND 1 1,010,000 0 0
REGENXBIO INC COM 75901B107 7,651 256,300 SH   DFND 1 256,300 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 11,582 582,010 SH   DFND 1 582,010 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 7,500 400,000 SH   DFND 1 400,000 0 0
SCYNEXIS INC COM 811292101 1,367 1,020,000 SH   DFND 1 1,020,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 32,051 1,858,000 SH   DFND 1 1,858,000 0 0
SIENTRA INC COM 82621J105 1,063 110,000 SH   DFND 1 110,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 3,653 1,764,889 SH   DFND 1 1,764,889 0 0
STEADYMED LTD SHS M84920103 4,611 1,418,787 SH   DFND 1 1,418,787 0 0
SYNLOGIC INC COM 87166L100 12,805 1,365,143 SH   DFND 1 1,365,143 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 16,471 1,268,945 SH   DFND 1 1,268,945 0 0
TACTILE SYS TECHNOLOGY INC COM 87357P100 2,894 91,020 SH   DFND 1 91,020 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 1,577 318,000 SH   DFND 1 318,000 0 0
TELIGENT INC NEW COM 87960W104 1,609 479,000 SH   DFND 1 479,000 0 0
TESARO INC COM 881569107 2,451 42,893 SH   DFND 1 42,893 0 0
TRINITY BIOTECH INVT LTD NOTE 4.000% 4/0 89643QAB4 38,550 48,000,000 PRN   DFND 1 48,000,000 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 31,023 262,000 SH   DFND 1 262,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 2,211 117,647 SH   DFND 1 117,647 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 23,307 356,000 SH   DFND 1 356,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 10,754 268,174 SH   DFND 1 268,174 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 12,579 634,000 SH   DFND 1 634,000 0 0
WRIGHT MED GROUP N V NOTE 2.250%11/1 98236JAB4 35,763 31,500,000 PRN   DFND 1 31,500,000 0 0
XENCOR INC COM 98401F105 26,456 882,462 SH   DFND 1 882,462 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 13,194 121,000 SH   DFND 1 121,000 0 0