The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 391,865 1,346,660 SH   SOLE   1,346,660 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 37,093 1,650,780 SH   SOLE   1,650,780 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 43,178 1,356,514 SH   SOLE   1,356,514 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 23,493 1,849,832 SH   SOLE   1,849,832 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 126,601 1,135,845 SH   SOLE   1,135,845 0 0
ALIGN TECHNOLOGY INC COM 016255101 54,924 218,707 SH   SOLE   218,707 0 0
ALIMERA SCIENCES INC COM 016259103 3,104 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 67,317 3,340,806 SH   SOLE   3,340,806 0 0
AMICUS THERAPEUTICS INC COM 03152W109 92,463 6,147,829 SH   SOLE   6,147,829 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 206,362 2,545,482 SH   SOLE   2,545,482 0 0
CELGENE CORP COM 151020104 33,823 379,140 SH   SOLE   379,140 0 0
CLOVIS ONCOLOGY INC COM 189464100 208,859 3,955,660 SH   SOLE   3,955,660 0 0
CYTOKINETICS INC COM NEW 23282W605 891 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 4,789 500,913 SH   SOLE   500,913 0 0
EPIZYME INC COM 29428V104 122,388 6,895,075 SH   SOLE   6,895,075 0 0
EXACT SCIENCES CORP COM 30063P105 12,612 312,719 SH   SOLE   312,719 0 0
GILEAD SCIENCES INC COM 375558103 13,261 175,900 SH   SOLE   175,900 0 0
HISTOGENICS CORP COM 43358V109 833 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 1,134 616,355 SH   SOLE   616,355 0 0
IMMUNOMEDICS INC COM 452907108 70,070 4,796,008 SH   SOLE   4,796,008 0 0
INSMED INC COM PAR $.01 457669307 161,234 7,159,590 SH   SOLE   7,159,590 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 49,385 3,679,978 SH   SOLE   3,679,978 0 0
MELINTA THERAPEUTICS INC COM 58549G100 375 50,689 SH   SOLE   50,689 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 33,222 1,830,435 SH   SOLE   1,830,435 0 0
PROTHENA CORP PLC SHS G72800108 40,430 1,101,338 SH   SOLE   1,101,338 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 14,040 3,966,087 SH   SOLE   3,966,087 0 0
SAGE THERAPEUTICS INC COM 78667J108 131,809 818,331 SH   SOLE   818,331 0 0
SHIRE PLC SPONSORED ADR 82481R106 28,563 191,200 SH   SOLE   191,200 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 496 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 52,028 3,515,385 SH   SOLE   3,515,385 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 3,162 1,162,473 SH   SOLE   1,162,473 0 0
TREVENA INC COM 89532E109 560 341,300 SH   SOLE   341,300 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 182,319 1,622,631 SH   SOLE   1,622,631 0 0
VANDA PHARMACEUTICALS INC COM 921659108 70,023 4,155,670 SH   SOLE   4,155,670 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 54,606 2,752,294 SH   SOLE   2,752,294 0 0
ZOGENIX INC COM NEW 98978L204 1,181 29,500 SH   SOLE   29,500 0 0