The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
58.Com Inc Adr SPON ADR REP A 31680Q104 51,868 748,028 SH   DFND 1 748,028 0 0
58.Com Inc Adr SPON ADR REP A 31680Q104 99,083 1,428,938 SH   SOLE 0 1,383,404 0 45,534
58.Com Inc Adr SPON ADR REP A 31680Q104 177,990 2,566,910 SH   DFND 2 2,013,172 0 553,738
ABIOMED COM 003654100 269,606 659,102 SH   DFND 1 659,102 0 0
ABIOMED COM 003654100 346,315 846,632 SH   DFND 2 600,559 0 246,073
ABIOMED COM 003654100 245,670 600,586 SH   SOLE 0 589,079 0 11,507
AJ Gallagher & Co COM 363576109 78,910 1,208,800 SH   DFND 1 1,208,800 0 0
AJ Gallagher & Co COM 363576109 245,445 3,759,876 SH   DFND 2 2,961,478 0 798,398
AJ Gallagher & Co COM 363576109 140,575 2,153,415 SH   SOLE 0 2,087,299 0 66,116
Acacia Reasearch Corp ACACIA TCH COM 003881307 596 143,640 SH   DFND 1 143,640 0 0
Acacia Reasearch Corp ACACIA TCH COM 003881307 922 222,180 SH   SOLE 0 222,180 0 0
Activision Blizzard Inc COM 00507V109 28,953 379,357 SH   DFND 1 379,357 0 0
Activision Blizzard Inc COM 00507V109 44,408 581,870 SH   DFND 2 330,414 0 251,456
Activision Blizzard Inc COM 00507V109 12,130 158,937 SH   SOLE 0 158,937 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 15,416 1,298,734 SH   DFND 1 1,298,734 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 12,272 1,033,830 SH   DFND 2 411,665 0 622,165
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 8,317 700,697 SH   SOLE 0 700,697 0 0
Aduro Biotechnology COM 00739L101 7,590 1,084,342 SH   DFND 1 1,084,342 0 0
Aduro Biotechnology COM 00739L101 4,097 585,293 SH   SOLE 0 585,293 0 0
Aduro Biotechnology COM 00739L101 7,986 1,140,873 SH   DFND 2 444,298 0 696,575
Advanced Micro Devices COM 007903107 115,968 7,736,381 SH   DFND 2 6,026,066 0 1,710,315
Advanced Micro Devices COM 007903107 35,096 2,341,327 SH   DFND 1 2,341,327 0 0
Advanced Micro Devices COM 007903107 65,228 4,351,441 SH   SOLE 0 4,213,732 0 137,709
Aerovironment COM 008073108 16,313 228,383 SH   DFND 2 88,953 0 139,430
Aerovironment COM 008073108 22,546 315,638 SH   DFND 1 315,638 0 0
Aerovironment COM 008073108 15,755 220,567 SH   SOLE 0 220,567 0 0
Agios Pharmaceuticals COM 00847X104 31,977 379,640 SH   DFND 1 379,640 0 0
Agios Pharmaceuticals COM 00847X104 7,076 84,005 SH   DFND 2 2,519 0 81,486
Agios Pharmaceuticals COM 00847X104 13,726 162,958 SH   SOLE 0 162,958 0 0
Albemarle Corp COM 012653101 125,962 1,335,338 SH   DFND 2 1,061,616 0 273,722
Albemarle Corp COM 012653101 43,753 463,834 SH   DFND 1 463,834 0 0
Albemarle Corp COM 012653101 77,179 818,177 SH   SOLE 0 795,959 0 22,218
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 648,496 3,495,368 SH   DFND 1 3,495,368 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 5,949,281 32,066,408 SH   DFND 2 12,489,770 0 19,576,638
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 1,695,726 9,139,900 SH   SOLE 0 7,619,303 0 1,520,597
Align Technology Inc COM 016255101 4,683 13,688 SH   DFND 2 13,688 0 0
Alnylam Pharmaceuticals COM 02043Q107 112,787 1,145,159 SH   DFND 1 1,145,159 0 0
Alnylam Pharmaceuticals COM 02043Q107 168,112 1,706,898 SH   DFND 2 1,135,620 0 571,278
Alnylam Pharmaceuticals COM 02043Q107 135,899 1,379,824 SH   SOLE 0 1,362,436 0 17,388
Alphabet Inc Class A CAP STK CL A 02079K305 14,854 13,155 SH   DFND 2 12,713 0 442
Alphabet Inc Class A CAP STK CL A 02079K305 25,235 22,348 SH   DFND 1 22,348 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 89,410 79,181 SH   SOLE 0 79,181 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 436,895 391,606 SH   DFND 1 391,606 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 1,401,641 1,256,345 SH   DFND 2 658,798 0 597,547
Alphabet Inc Class C CAP STK CL C 02079K107 781,550 700,533 SH   SOLE 0 558,377 0 142,156
Amazon.Com COM 023135106 1,133,554 666,875 SH   DFND 1 666,875 0 0
Amazon.Com COM 023135106 5,303,927 3,120,324 SH   DFND 2 1,197,434 0 1,922,890
Amazon.Com COM 023135106 2,788,629 1,640,563 SH   SOLE 0 1,383,582 0 256,981
Ambarella SHS G037AX101 4,645 120,300 SH   DFND 1 120,300 0 0
Ambarella SHS G037AX101 4,206 108,942 SH   DFND 2 42,697 0 66,245
Ambarella SHS G037AX101 3,769 97,605 SH   SOLE 0 97,605 0 0
Ameren COM 023608102 15,018 246,800 SH   DFND 1 246,800 0 0
Ameren COM 023608102 958 15,740 SH   DFND 2 15,740 0 0
American Express COM 025816109 32,956 336,287 SH   DFND 1 336,287 0 0
American Express COM 025816109 23,883 243,700 SH   DFND 2 180,120 0 63,580
American Express COM 025816109 16,487 168,230 SH   SOLE 0 168,230 0 0
Analog Devices COM 032654105 13,547 141,230 SH   DFND 1 141,230 0 0
Analog Devices COM 032654105 16,596 173,019 SH   SOLE 0 173,019 0 0
Anthem Inc COM 036752103 182,742 767,728 SH   DFND 1 767,728 0 0
Anthem Inc COM 036752103 616,673 2,590,735 SH   DFND 2 2,032,861 0 557,874
Anthem Inc COM 036752103 345,527 1,451,610 SH   SOLE 0 1,405,644 0 45,966
Apache Corp COM 037411105 187,381 4,008,154 SH   DFND 1 4,008,154 0 0
Apache Corp COM 037411105 612,689 13,105,644 SH   DFND 2 10,287,954 0 2,817,690
Apache Corp COM 037411105 344,843 7,376,331 SH   SOLE 0 7,145,720 0 230,611
Apollo Senior Floating Rate COM 037636107 2,838 173,769 SH   DFND 1 173,769 0 0
Apple COM 037833100 10,155 54,859 SH   DFND 1 54,859 0 0
Apple COM 037833100 12,640 68,282 SH   SOLE 0 68,282 0 0
Aslan Pharmaceuticals ADR ADS 04522R101 1,384 157,248 SH   SOLE 0 157,248 0 0
Aslan Pharmaceuticals ADR ADS 04522R101 2,577 292,885 SH   DFND 1 292,885 0 0
Atlassian Corp Plc CL A G06242104 324,567 5,191,417 SH   DFND 2 1,909,042 0 3,282,375
Atlassian Corp Plc CL A G06242104 61,424 982,464 SH   DFND 1 982,464 0 0
Atlassian Corp Plc CL A G06242104 121,911 1,949,958 SH   SOLE 0 1,027,449 0 922,509
Autohome Inc - ADR SP ADR RP CL A 05278C107 51,940 514,254 SH   DFND 1 514,254 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 183,101 1,812,883 SH   DFND 2 1,417,321 0 395,562
Autohome Inc - ADR SP ADR RP CL A 05278C107 103,711 1,026,843 SH   SOLE 0 995,204 0 31,639
Avangrid COM 05351W103 17,440 329,500 SH   DFND 1 329,500 0 0
Avangrid COM 05351W103 1,226 23,170 SH   DFND 2 23,170 0 0
BRF SA-ADR SPONSORED ADR 10552T107 889 189,964 SH   DFND 1 189,964 0 0
BRF SA-ADR SPONSORED ADR 10552T107 6,843 1,462,132 SH   DFND 2 436,962 0 1,025,170
Baidu.com Sponsored ADR SPON ADR REP A 056752108 320,639 1,319,501 SH   DFND 1 1,319,501 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 3,615,434 14,878,328 SH   DFND 2 5,467,176 0 9,411,152
Baidu.com Sponsored ADR SPON ADR REP A 056752108 981,150 4,037,653 SH   SOLE 0 3,240,897 0 796,756
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 13,008 1,896,192 SH   DFND 1 1,896,192 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 107,106 15,613,110 SH   DFND 2 6,421,902 0 9,191,208
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 13,067 238,887 SH   DFND 1 238,887 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 16,318 298,323 SH   DFND 2 117,960 0 180,363
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 10,579 193,400 SH   SOLE 0 193,400 0 0
Beigene Ltd SPONSORED ADR 07725L102 2,624 17,069 SH   DFND 1 17,069 0 0
Beigene Ltd SPONSORED ADR 07725L102 10,200 66,350 SH   DFND 2 0 0 66,350
Benefitfocus Inc COM 08180D106 9,198 273,748 SH   DFND 1 273,748 0 0
Benefitfocus Inc COM 08180D106 8,193 243,848 SH   DFND 2 79,615 0 164,233
Benefitfocus Inc COM 08180D106 6,000 178,568 SH   SOLE 0 178,568 0 0
BitAuto Holdings Ltd - ADR SPONSORED ADS 091727107 1,382 58,113 SH   SOLE 0 58,113 0 0
BlackRock Floating Rate Income COM 091941104 12,524 958,251 SH   DFND 1 958,251 0 0
Blackline COM 09239B109 9,633 221,805 SH   DFND 1 221,805 0 0
Blackline COM 09239B109 8,099 186,483 SH   DFND 2 73,419 0 113,064
Blackline COM 09239B109 6,044 139,175 SH   SOLE 0 139,175 0 0
Blackstone/GSO Strategic Credit Fund COM SHS BEN IN 09257R101 3,293 208,300 SH   DFND 1 208,300 0 0
Blackstone/GSO Strategic Credit Fund COM SHS BEN IN 09257R101 993 62,820 SH   DFND 2 62,820 0 0
Blue Capital Reinsurance Holdings Fund (USD) COM G1190F107 6,955 629,438 SH   DFND 1 629,438 0 0
Bluebird Bio Inc COM 09609G100 71,747 457,131 SH   DFND 1 457,131 0 0
Bluebird Bio Inc COM 09609G100 386,517 2,462,678 SH   DFND 2 960,876 0 1,501,802
Bluebird Bio Inc COM 09609G100 301,907 1,923,590 SH   SOLE 0 1,496,063 0 427,527
British Amer.Tobacco - ADR SPONSORED ADR 110448107 4,886 96,840 SH   DFND 1 96,840 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 1,519 30,117 SH   SOLE 0 30,117 0 0
CEVA Inc COM 157210105 4,741 156,980 SH   DFND 1 156,980 0 0
CEVA Inc COM 157210105 3,837 127,064 SH   DFND 2 50,471 0 76,593
CEVA Inc COM 157210105 2,492 82,500 SH   SOLE 0 82,500 0 0
CH Robinson Worldwide COM NEW 12541W209 77,243 923,302 SH   DFND 1 923,302 0 0
CH Robinson Worldwide COM NEW 12541W209 215,390 2,574,582 SH   DFND 2 2,052,466 0 522,116
CH Robinson Worldwide COM NEW 12541W209 132,370 1,582,240 SH   SOLE 0 1,539,303 0 42,937
CarMax Inc COM 143130102 5,313 72,906 SH   DFND 1 72,906 0 0
CarMax Inc COM 143130102 23,380 320,845 SH   DFND 2 320,845 0 0
CarMax Inc COM 143130102 5,207 71,451 SH   SOLE 0 71,451 0 0
Celgene COM 151020104 30,316 381,718 SH   DFND 1 381,718 0 0
Celgene COM 151020104 23,400 294,640 SH   DFND 2 217,928 0 76,712
Celgene COM 151020104 14,576 183,528 SH   SOLE 0 183,528 0 0
Cemex ADR SPON ADR NEW 151290889 32,701 4,984,856 SH   DFND 1 4,984,856 0 0
Cemex ADR SPON ADR NEW 151290889 166,886 25,439,973 SH   DFND 2 5,679,450 0 19,760,523
Cemex ADR SPON ADR NEW 151290889 8,367 1,275,421 SH   SOLE 0 1,275,421 0 0
Chegg COM 163092109 54,682 1,967,675 SH   DFND 1 1,967,675 0 0
Chegg COM 163092109 22,895 823,875 SH   DFND 2 216,897 0 606,978
Chegg COM 163092109 52,020 1,871,889 SH   SOLE 0 1,871,889 0 0
China Biologic Products Holdings Inc COM G21515104 20,935 210,762 SH   DFND 1 210,762 0 0
China Biologic Products Holdings Inc COM G21515104 71,772 722,558 SH   DFND 2 567,663 0 154,895
China Biologic Products Holdings Inc COM G21515104 41,119 413,962 SH   SOLE 0 401,148 0 12,814
China Rapid Finance ADR SPONSORED ADR 16953Q105 651 300,000 SH   SOLE 0 300,000 0 0
CoStar Group COM 22160N109 53,421 129,464 SH   DFND 1 129,464 0 0
CoStar Group COM 22160N109 12,179 29,516 SH   DFND 2 869 0 28,647
CoStar Group COM 22160N109 23,083 55,940 SH   SOLE 0 55,940 0 0
Coca Cola COM 191216100 16,840 383,944 SH   DFND 1 383,944 0 0
Coca Cola COM 191216100 20,445 466,140 SH   SOLE 0 466,140 0 0
Codexis COM 192005106 15,614 1,084,273 SH   DFND 1 1,084,273 0 0
Codexis COM 192005106 13,858 962,332 SH   DFND 2 381,093 0 581,239
Codexis COM 192005106 8,635 599,635 SH   SOLE 0 599,635 0 0
Consolidated Edison COM 209115104 14,605 187,290 SH   DFND 1 187,290 0 0
Consolidated Edison COM 209115104 856 10,972 SH   DFND 2 10,972 0 0
Copa Holdings S A CL A P31076105 6,395 67,590 SH   DFND 1 67,590 0 0
Copa Holdings S A CL A P31076105 26,288 277,829 SH   SOLE 0 277,829 0 0
Copa Holdings S A CL A P31076105 242,860 2,566,686 SH   DFND 2 1,568,685 0 998,001
Credicorp COM G2519Y108 12,748 56,626 SH   DFND 1 56,626 0 0
Credicorp COM G2519Y108 357,717 1,589,007 SH   DFND 2 750,008 0 838,999
Credicorp COM G2519Y108 26,226 116,497 SH   SOLE 0 116,497 0 0
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 188,181 3,950,899 SH   DFND 1 3,950,899 0 0
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 1,846,978 38,777,627 SH   DFND 2 15,935,757 0 22,841,870
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 553,466 11,620,104 SH   SOLE 0 9,373,083 0 2,247,021
CyberArk Software Ltd SHS M2862V108 6,560 104,200 SH   DFND 2 40,600 0 63,600
CyberArk Software Ltd SHS M2862V108 5,049 80,200 SH   DFND 1 80,200 0 0
CyberArk Software Ltd SHS M2862V108 5,068 80,500 SH   SOLE 0 80,500 0 0
Denali Therapeutics COM 24823R105 22,670 1,486,533 SH   DFND 1 1,486,533 0 0
Denali Therapeutics COM 24823R105 5,110 335,088 SH   DFND 2 9,661 0 325,427
Denali Therapeutics COM 24823R105 53,726 3,523,012 SH   SOLE 0 3,523,012 0 0
Dexcom Inc COM 252131107 66,146 696,416 SH   DFND 1 696,416 0 0
Dexcom Inc COM 252131107 310,698 3,271,199 SH   DFND 2 1,215,502 0 2,055,697
Dexcom Inc COM 252131107 116,868 1,230,452 SH   SOLE 0 681,213 0 549,239
Digimarc COM 25381B101 2,492 93,000 SH   DFND 1 93,000 0 0
Digimarc COM 25381B101 2,184 81,500 SH   SOLE 0 81,500 0 0
Digimarc COM 25381B101 6,733 251,236 SH   DFND 2 99,501 0 151,735
Dolby Laboratories 'A' COM 25659T107 6,058 98,204 SH   DFND 1 98,204 0 0
Dolby Laboratories 'A' COM 25659T107 7,394 119,854 SH   SOLE 0 119,854 0 0
Dropbox Inc Class A Common Stock CL A 26210C104 23,883 736,666 SH   SOLE 0 736,666 0 0
Dropbox Inc Class B Common Stock CL A 26210C104 46,985 1,449,275 SH   SOLE 0 1,449,275 0 0
EOG Resources COM 26875P101 97,196 781,128 SH   DFND 1 781,128 0 0
EOG Resources COM 26875P101 343,241 2,758,510 SH   DFND 2 2,217,999 0 540,511
EOG Resources COM 26875P101 176,824 1,421,069 SH   SOLE 0 1,377,898 0 43,171
Eaton Vance Senior Income Trust SH BEN INT 27826S103 6,699 1,050,000 SH   DFND 1 1,050,000 0 0
Ecolab COM 278865100 1,229 8,758 SH   DFND 1 8,758 0 0
Ecolab COM 278865100 1,073 7,644 SH   DFND 2 7,644 0 0
Edison International COM 281020107 12,654 200,000 SH   DFND 1 200,000 0 0
Edison International COM 281020107 800 12,640 SH   DFND 2 12,640 0 0
Ellie Mae COM 28849P100 58,902 567,241 SH   DFND 1 567,241 0 0
Ellie Mae COM 28849P100 19,848 191,138 SH   DFND 2 34,771 0 156,367
Ellie Mae COM 28849P100 28,139 270,988 SH   SOLE 0 270,988 0 0
Embraer ADR SP ADR REP 4 COM 29082A107 6,256 251,259 SH   DFND 1 251,259 0 0
Embraer ADR SP ADR REP 4 COM 29082A107 70,261 2,821,729 SH   DFND 2 225,926 0 2,595,803
Estee Lauder 'A' COM 518439104 27,462 192,461 SH   DFND 2 192,461 0 0
Eversource Energy COM 30040W108 14,002 238,900 SH   DFND 1 238,900 0 0
Eversource Energy COM 30040W108 1,127 19,223 SH   DFND 2 19,223 0 0
Evolent Health Inc A CL A 30050B101 6,602 313,618 SH   DFND 2 123,375 0 190,243
Evolent Health Inc A CL A 30050B101 6,508 309,180 SH   DFND 1 309,180 0 0
Evolent Health Inc A CL A 30050B101 5,166 245,416 SH   SOLE 0 245,416 0 0
Exact Sciences COM 30063P105 15,046 251,651 SH   DFND 1 251,651 0 0
Exact Sciences COM 30063P105 9,367 156,658 SH   DFND 2 62,131 0 94,527
Exact Sciences COM 30063P105 7,494 125,335 SH   SOLE 0 125,335 0 0
Exelon Corporation COM 30161N101 17,207 403,930 SH   DFND 1 403,930 0 0
Exelon Corporation COM 30161N101 1,032 24,215 SH   DFND 2 24,215 0 0
Facebook Cl.A CL A 30303M102 576,906 2,968,847 SH   DFND 1 2,968,847 0 0
Facebook Cl.A CL A 30303M102 2,094,689 10,779,585 SH   DFND 2 4,804,780 0 5,974,805
Facebook Cl.A CL A 30303M102 1,049,489 5,400,830 SH   SOLE 0 3,837,804 0 1,563,026
Faro Technologies COM 311642102 3,598 66,200 SH   DFND 1 66,200 0 0
Faro Technologies COM 311642102 7,366 135,520 SH   DFND 2 53,627 0 81,893
Faro Technologies COM 311642102 5,863 107,880 SH   SOLE 0 107,880 0 0
Fastenal COM 311900104 16,244 337,512 SH   DFND 1 337,512 0 0
Fastenal COM 311900104 11,776 244,676 SH   DFND 2 244,676 0 0
Fastenal COM 311900104 19,097 396,789 SH   SOLE 0 396,789 0 0
Ferrari NV COM N3167Y103 1,655,010 12,167,441 SH   DFND 2 3,888,458 0 8,278,983
Ferrari NV COM N3167Y103 311,039 2,286,725 SH   SOLE 0 2,286,725 0 0
Fiat Chrysler Automobiles SHS N31738102 175,792 9,217,859 SH   SOLE 0 8,922,277 0 295,582
Fiat Chrysler Automobiles SHS N31738102 95,379 5,001,364 SH   DFND 1 5,001,364 0 0
Fiat Chrysler Automobiles SHS N31738102 1,172,259 61,468,887 SH   DFND 2 29,802,007 0 31,666,880
First Republic Bank COM 33616C100 262,493 2,711,982 SH   DFND 2 2,044,074 0 667,908
First Republic Bank COM 33616C100 162,667 1,680,619 SH   SOLE 0 1,643,079 0 37,540
First Republic Bank COM 33616C100 164,499 1,699,548 SH   DFND 1 1,699,548 0 0
Foamix Pharmaceuticals SHS M46135105 557 111,200 SH   SOLE 0 111,200 0 0
Foamix Pharmaceuticals SHS M46135105 542 108,200 SH   DFND 1 108,200 0 0
Fortive Corp COM 34959J108 25,255 327,520 SH   DFND 2 201,599 0 125,921
Fortive Corp COM 34959J108 47,870 620,807 SH   DFND 1 620,807 0 0
Fortive Corp COM 34959J108 22,485 291,600 SH   SOLE 0 291,600 0 0
Foundation Medicine COM 350465100 10,225 74,800 SH   DFND 1 74,800 0 0
Foundation Medicine COM 350465100 31,367 229,460 SH   DFND 2 90,449 0 139,011
Foundation Medicine COM 350465100 13,670 100,000 SH   SOLE 0 100,000 0 0
Glaukos Corp COM 377322102 30,017 738,613 SH   DFND 1 738,613 0 0
Glaukos Corp COM 377322102 7,193 176,993 SH   DFND 2 25,426 0 151,567
Glaukos Corp COM 377322102 12,032 296,057 SH   SOLE 0 296,057 0 0
Grubhub Inc COM 400110102 287,923 2,744,478 SH   DFND 1 2,744,478 0 0
Grubhub Inc COM 400110102 383,897 3,659,303 SH   DFND 2 2,438,819 0 1,220,484
Grubhub Inc COM 400110102 304,291 2,900,500 SH   SOLE 0 2,850,507 0 49,993
HDFC Bank ADR ADR REPS 3 SHS 40415F101 78,119 743,848 SH   SOLE 0 743,848 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 60,393 575,066 SH   DFND 2 416,994 0 158,072
HEICO COM 422806109 11,324 155,274 SH   DFND 1 155,274 0 0
HEICO COM 422806109 7,184 98,503 SH   SOLE 0 98,503 0 0
HEICO 'A' CL A 422806208 26,224 430,254 SH   DFND 2 308,991 0 121,263
HEICO 'A' CL A 422806208 17,979 294,987 SH   DFND 1 294,987 0 0
HEICO 'A' CL A 422806208 4,082 66,975 SH   SOLE 0 66,975 0 0
Himax Technologies Adr SPONSORED ADR 43289P106 5,041 675,800 SH   DFND 2 0 0 675,800
Howard Hughes COM 44267D107 33,685 254,225 SH   DFND 1 254,225 0 0
Howard Hughes COM 44267D107 119,284 900,258 SH   DFND 2 704,684 0 195,574
Howard Hughes COM 44267D107 68,238 515,004 SH   SOLE 0 498,376 0 16,628
Hutchison China Meditech SPONSORED ADR 44842L103 1,767 58,613 SH   DFND 1 58,613 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 4,402 146,050 SH   DFND 2 0 0 146,050
ICICI Bank ADR ADR 45104G104 156,639 19,506,695 SH   DFND 2 16,513,165 0 2,993,530
ICICI Bank ADR ADR 45104G104 47,534 5,919,507 SH   DFND 1 5,919,507 0 0
ICICI Bank ADR ADR 45104G104 142,892 17,794,828 SH   SOLE 0 17,794,828 0 0
IPG Photonics Corp COM 44980X109 22,855 103,591 SH   DFND 2 40,953 0 62,638
IPG Photonics Corp COM 44980X109 13,433 60,886 SH   DFND 1 60,886 0 0
IPG Photonics Corp COM 44980X109 16,246 73,636 SH   SOLE 0 73,636 0 0
Illumina COM 452327109 450,605 1,613,393 SH   DFND 1 1,613,393 0 0
Illumina COM 452327109 2,768,853 9,913,901 SH   DFND 2 2,920,045 0 6,993,856
Illumina COM 452327109 1,399,106 5,009,510 SH   SOLE 0 3,958,345 0 1,051,165
Infosys Ltd ADR SPONSORED ADR 456788108 7,094 365,098 SH   DFND 1 365,098 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 3,657 188,220 SH   DFND 2 176,311 0 11,909
Interactive Brokers Group COM 45841N107 105,770 1,642,134 SH   DFND 1 1,642,134 0 0
Interactive Brokers Group COM 45841N107 188,501 2,926,580 SH   DFND 2 2,257,321 0 669,259
Interactive Brokers Group COM 45841N107 110,790 1,720,082 SH   SOLE 0 1,679,496 0 40,586
Intuitive Surgical COM NEW 46120E602 120,609 252,067 SH   DFND 1 252,067 0 0
Intuitive Surgical COM NEW 46120E602 628,319 1,313,156 SH   DFND 2 479,643 0 833,513
Intuitive Surgical COM NEW 46120E602 383,932 802,399 SH   SOLE 0 566,705 0 235,694
Invesco Senior Income Trust COM 46131H107 39,441 9,215,099 SH   DFND 1 9,215,099 0 0
Invesco Senior Income Trust COM 46131H107 2,378 555,601 SH   DFND 2 555,601 0 0
Ionis Pharmaceuticals COM 462222100 47,430 1,138,223 SH   DFND 1 1,138,223 0 0
Ionis Pharmaceuticals COM 462222100 93,511 2,244,074 SH   SOLE 0 1,181,822 0 1,062,252
Ionis Pharmaceuticals COM 462222100 245,746 5,897,433 SH   DFND 2 2,160,324 0 3,737,109
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 265,944 25,620,779 SH   DFND 2 8,590,971 0 17,029,808
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 13,020 1,254,318 SH   DFND 1 1,254,318 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 13,791 1,328,635 SH   SOLE 0 1,328,635 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 71,585 1,837,879 SH   DFND 1 1,837,879 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 370,659 9,516,273 SH   DFND 2 4,977,334 0 4,538,939
JD.Com Inc - ADR SPON ADR CL A 47215P106 25,487 654,364 SH   SOLE 0 654,364 0 0
Jefferies Financial Group Inc COM 47233W109 49,307 2,168,307 SH   DFND 1 2,168,307 0 0
Jefferies Financial Group Inc COM 47233W109 166,749 7,332,838 SH   DFND 2 5,733,762 0 1,599,076
Jefferies Financial Group Inc COM 47233W109 94,780 4,168,006 SH   SOLE 0 4,038,264 0 129,742
Jianpu Technology Inc- ADR ADR 47738D101 6,145 929,638 SH   DFND 1 929,638 0 0
Jianpu Technology Inc- ADR ADR 47738D101 6,397 967,818 SH   SOLE 0 967,818 0 0
Johnson & Johnson COM 478160104 14,987 123,511 SH   DFND 1 123,511 0 0
Johnson & Johnson COM 478160104 18,448 152,039 SH   SOLE 0 152,039 0 0
Kirby COM 497266106 40,682 486,631 SH   DFND 1 486,631 0 0
Kirby COM 497266106 138,444 1,656,027 SH   DFND 2 1,297,672 0 358,355
Kirby COM 497266106 75,667 905,106 SH   SOLE 0 877,432 0 27,674
Korea Electric Power ADR SPONSORED ADR 500631106 936 65,300 SH   DFND 2 65,300 0 0
LendingTree COM 52603B107 57,663 269,703 SH   DFND 1 269,703 0 0
LendingTree COM 52603B107 134,793 630,461 SH   DFND 2 428,877 0 201,584
LendingTree COM 52603B107 91,917 429,922 SH   SOLE 0 421,913 0 8,009
Liberty Media Corp DEB 4.00011/1 530715AG6 8,471 12,852,000 SH   DFND 1 12,852,000 0 0
Liberty Media Corp DEB 4.00011/1 530715AG6 1,025 1,555,000 SH   DFND 2 1,555,000 0 0
Lincoln Electric Hdg. COM 533900106 30,792 350,868 SH   DFND 1 350,868 0 0
Lincoln Electric Hdg. COM 533900106 56,014 638,258 SH   SOLE 0 617,597 0 20,661
Lincoln Electric Hdg. COM 533900106 108,219 1,233,130 SH   DFND 2 977,419 0 255,711
Lindblad Expeditions Holdings COM 535219109 14,213 1,072,701 SH   SOLE 0 1,072,701 0 0
Line Corp Sponsored Adr SPONSORED ADR 53567X101 20,308 494,467 SH   DFND 2 11,916 0 482,551
Luxoft Holding ORD SHS CL A G57279104 3,572 96,930 SH   DFND 2 0 0 96,930
M&T Bank COM 55261F104 17,745 104,293 SH   DFND 2 104,293 0 0
MakeMyTrip SHS V5633W109 93,136 2,576,385 SH   DFND 2 1,939,420 0 636,965
Markel Corp COM 570535104 124,072 114,421 SH   DFND 1 114,421 0 0
Markel Corp COM 570535104 302,392 278,869 SH   DFND 2 217,757 0 61,112
Markel Corp COM 570535104 170,639 157,365 SH   SOLE 0 153,069 0 4,296
MarketAxess Holdings COM 57060D108 294,017 1,485,987 SH   DFND 2 1,028,255 0 457,732
MarketAxess Holdings COM 57060D108 222,511 1,124,589 SH   DFND 1 1,124,589 0 0
MarketAxess Holdings COM 57060D108 212,177 1,072,359 SH   SOLE 0 1,054,282 0 18,077
Martin Marietta Materials COM 573284106 110,492 494,746 SH   DFND 1 494,746 0 0
Martin Marietta Materials COM 573284106 242,113 1,084,105 SH   DFND 2 841,801 0 242,304
Martin Marietta Materials COM 573284106 142,454 637,862 SH   SOLE 0 620,907 0 16,955
Mastercard Inc-Class A CL A 57636Q104 246,196 1,252,779 SH   DFND 1 1,252,779 0 0
Mastercard Inc-Class A CL A 57636Q104 547,454 2,785,743 SH   DFND 2 2,147,180 0 638,563
Mastercard Inc-Class A CL A 57636Q104 314,750 1,601,620 SH   SOLE 0 1,558,492 0 43,128
McDonald's COM 580135101 10,545 67,296 SH   DFND 1 67,296 0 0
McDonald's COM 580135101 12,843 81,962 SH   SOLE 0 81,962 0 0
MercadoLibre COM 58733R102 49,314 164,968 SH   DFND 1 164,968 0 0
MercadoLibre COM 58733R102 1,422,426 4,758,393 SH   DFND 2 1,810,336 0 2,948,057
MercadoLibre COM 58733R102 76,687 256,539 SH   SOLE 0 256,539 0 0
Mettler-Toledo COM 592688105 47,194 81,561 SH   DFND 1 81,561 0 0
Mettler-Toledo COM 592688105 265,136 458,214 SH   DFND 2 339,904 0 118,310
Mettler-Toledo COM 592688105 28,183 48,706 SH   SOLE 0 48,706 0 0
Microchip Technology COM 595017104 7,518 82,660 SH   DFND 2 82,660 0 0
Microsoft COM 594918104 14,084 142,827 SH   DFND 1 142,827 0 0
Microsoft COM 594918104 32,901 333,643 SH   DFND 2 333,643 0 0
Microsoft COM 594918104 17,062 173,026 SH   SOLE 0 173,026 0 0
Mindbody Cl A COM CL A 60255W105 5,253 136,090 SH   DFND 1 136,090 0 0
Mindbody Cl A COM CL A 60255W105 4,695 121,628 SH   SOLE 0 121,628 0 0
Mindbody Cl A COM CL A 60255W105 7,898 204,619 SH   DFND 2 80,939 0 123,680
Moody's Corp COM 615369105 175,075 1,026,473 SH   DFND 1 1,026,473 0 0
Moody's Corp COM 615369105 610,252 3,577,934 SH   DFND 2 2,829,903 0 748,031
Moody's Corp COM 615369105 329,325 1,930,846 SH   SOLE 0 1,870,125 0 60,721
Myriad Genetics Inc COM 62855J104 191,433 5,122,639 SH   DFND 2 4,005,612 0 1,117,027
Myriad Genetics Inc COM 62855J104 56,793 1,519,747 SH   DFND 1 1,519,747 0 0
Myriad Genetics Inc COM 62855J104 105,114 2,812,799 SH   SOLE 0 2,721,157 0 91,642
NVIDIA COM 67066G104 231,561 977,463 SH   DFND 1 977,463 0 0
NVIDIA COM 67066G104 1,052,732 4,443,781 SH   DFND 2 1,722,765 0 2,721,016
NVIDIA COM 67066G104 596,748 2,518,987 SH   SOLE 0 1,781,155 0 737,832
National Instruments Corp COM 636518102 11,724 279,280 SH   DFND 1 279,280 0 0
National Instruments Corp COM 636518102 7,042 167,758 SH   DFND 2 66,221 0 101,537
National Instruments Corp COM 636518102 13,358 318,202 SH   SOLE 0 318,202 0 0
NetEase.com ADR SPONSORED ADR 64110W102 102,985 407,586 SH   DFND 1 407,586 0 0
NetEase.com ADR SPONSORED ADR 64110W102 195,972 775,605 SH   SOLE 0 508,160 0 267,445
NetEase.com ADR SPONSORED ADR 64110W102 457,112 1,809,125 SH   DFND 2 820,126 0 988,999
Netflix Inc COM 64110L106 488,549 1,248,113 SH   DFND 1 1,248,113 0 0
Netflix Inc COM 64110L106 1,010,769 2,582,248 SH   SOLE 0 2,032,418 0 549,830
Netflix Inc COM 64110L106 1,483,450 3,789,823 SH   DFND 2 1,662,193 0 2,127,630
New Oriental Education & Technology Sponsored ADR SPON ADR 647581107 720,985 7,616,578 SH   DFND 2 2,648,928 0 4,967,650
New Relic COM 64829B100 45,231 449,654 SH   DFND 1 449,654 0 0
New Relic COM 64829B100 18,753 186,429 SH   SOLE 0 186,429 0 0
New Relic COM 64829B100 9,993 99,342 SH   DFND 2 2,927 0 96,415
Novocure Ltd ORD SHS G6674U108 16,961 541,894 SH   DFND 2 109,979 0 431,915
Novocure Ltd ORD SHS G6674U108 52,014 1,661,781 SH   DFND 1 1,661,781 0 0
Novocure Ltd ORD SHS G6674U108 27,848 889,720 SH   SOLE 0 889,720 0 0
Now Inc/DE COM 67011P100 86,524 6,490,940 SH   DFND 2 4,836,174 0 1,654,766
Now Inc/DE COM 67011P100 46,806 3,511,351 SH   DFND 1 3,511,351 0 0
Now Inc/DE COM 67011P100 57,869 4,341,268 SH   SOLE 0 4,243,772 0 97,496
Nucana Plc ADR SPONSORED ADR 67022C106 7,666 403,450 SH   DFND 1 403,450 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 4,788 252,000 SH   SOLE 0 252,000 0 0
Nuveen Credit Strategies Income Fund COM SHS 67073D102 968 121,700 SH   DFND 2 121,700 0 0
Nuveen Credit Strategies Income Fund COM SHS 67073D102 2,864 360,300 SH   DFND 1 360,300 0 0
Nuveen Senior Income Fund COM 67067Y104 8,724 1,400,331 SH   DFND 1 1,400,331 0 0
PG&E Corp COM 69331C108 10,649 250,200 SH   DFND 1 250,200 0 0
PG&E Corp COM 69331C108 720 16,909 SH   DFND 2 16,909 0 0
Pacira Pharmaceuticals COM 695127100 5,911 184,430 SH   DFND 1 184,430 0 0
Pacira Pharmaceuticals COM 695127100 8,665 270,370 SH   DFND 2 106,800 0 163,570
Pacira Pharmaceuticals COM 695127100 4,077 127,200 SH   SOLE 0 127,200 0 0
Penumbra Inc COM 70975L107 46,956 339,889 SH   DFND 1 339,889 0 0
Penumbra Inc COM 70975L107 16,373 118,516 SH   DFND 2 22,575 0 95,941
Penumbra Inc COM 70975L107 22,514 162,966 SH   SOLE 0 162,966 0 0
Pepsico COM 713448108 11,029 101,305 SH   DFND 1 101,305 0 0
Pepsico COM 713448108 13,433 123,387 SH   SOLE 0 123,387 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 14,720 1,467,550 SH   DFND 1 1,467,550 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 153,243 15,278,429 SH   DFND 2 3,528,901 0 11,749,528
Petrobras Pref ADR SP ADR NON VTG 71654V101 3,137 354,904 SH   DFND 1 354,904 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 14,258 1,612,849 SH   DFND 2 841,362 0 771,487
Pioneer Floating Rate Trust COM 72369J102 8,994 804,500 SH   DFND 1 804,500 0 0
PriceSmart COM 741511109 99,112 1,095,158 SH   DFND 2 799,026 0 296,132
PriceSmart COM 741511109 13,414 148,222 SH   SOLE 0 148,222 0 0
Procter & Gamble COM 742718109 12,908 165,356 SH   DFND 1 165,356 0 0
Procter & Gamble COM 742718109 15,884 203,485 SH   SOLE 0 203,485 0 0
RPM Inc. COM 749685103 9,409 161,336 SH   SOLE 0 161,336 0 0
RPM Inc. COM 749685103 7,991 137,020 SH   DFND 1 137,020 0 0
Redfin COM 75737F108 9,694 419,841 SH   DFND 2 13,543 0 406,298
Redfin COM 75737F108 44,862 1,942,912 SH   DFND 1 1,942,912 0 0
Redfin COM 75737F108 21,273 921,319 SH   SOLE 0 921,319 0 0
Resmed Inc COM 761152107 78,996 762,658 SH   DFND 1 762,658 0 0
Resmed Inc COM 761152107 270,314 2,609,710 SH   DFND 2 2,046,442 0 563,268
Resmed Inc COM 761152107 150,655 1,454,483 SH   SOLE 0 1,409,529 0 44,954
Restaurant Brands International COM 76131D103 184,007 3,052,359 SH   DFND 2 1,888,318 0 1,164,041
Restaurant Brands International COM 76131D103 20,274 336,312 SH   SOLE 0 336,312 0 0
Restorbio Inc COM 76133L103 3,777 412,832 SH   DFND 1 412,832 0 0
Restorbio Inc COM 76133L103 4,368 477,384 SH   SOLE 0 477,384 0 0
Rio Tinto Spn.Adr 1:1 SPONSORED ADR 767204100 3,918 70,626 SH   DFND 2 70,626 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 40,148 1,176,663 SH   DFND 1 1,176,663 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 197,626 5,792,087 SH   DFND 2 4,539,016 0 1,253,071
Ritchie Bros Auctioneers (USA) COM 767744105 72,868 2,135,651 SH   SOLE 0 2,067,759 0 67,892
Ritchie Bros. Auctioneers COM 767744105 58,721 1,722,668 SH   DFND 2 748,200 0 974,468
Ritchie Bros. Auctioneers COM 767744105 13,531 396,943 SH   SOLE 0 396,943 0 0
Royal Crbn.Cruises COM V7780T103 91,487 883,080 SH   DFND 1 883,080 0 0
Royal Crbn.Cruises COM V7780T103 309,814 2,990,486 SH   DFND 2 2,349,128 0 641,358
Royal Crbn.Cruises COM V7780T103 173,480 1,674,522 SH   SOLE 0 1,621,564 0 52,958
Ryanair ADR SPONSORED ADR NE 783513203 673,008 5,891,694 SH   DFND 2 4,071,981 0 1,819,713
Ryanair ADR SPONSORED ADR NE 783513203 5,171 45,268 SH   SOLE 0 45,268 0 0
SEA Ltd ADR ADR 81141R100 5,184 345,621 SH   DFND 1 345,621 0 0
SEA Ltd ADR ADR 81141R100 42,259 2,817,236 SH   DFND 2 0 0 2,817,236
SEA Ltd ADR ADR 81141R100 9,617 641,104 SH   SOLE 0 641,104 0 0
SINA Corp ORD G81477104 4,508 53,230 SH   DFND 1 53,230 0 0
SINA Corp ORD G81477104 31,912 376,813 SH   DFND 2 130,693 0 246,120
Salesforce.com COM 79466L302 95,153 697,601 SH   DFND 1 697,601 0 0
Salesforce.com COM 79466L302 500,444 3,668,947 SH   DFND 2 1,341,553 0 2,327,394
Salesforce.com COM 79466L302 188,686 1,383,328 SH   SOLE 0 729,434 0 653,894
Schlumberger COM 806857108 7,985 119,127 SH   DFND 2 119,127 0 0
Seattle Genetics COM 812578102 146,313 2,203,839 SH   DFND 1 2,203,839 0 0
Seattle Genetics COM 812578102 539,167 8,121,205 SH   DFND 2 4,415,811 0 3,705,394
Seattle Genetics COM 812578102 258,571 3,894,721 SH   SOLE 0 3,016,662 0 878,059
Sherwin-Williams Co COM 824348106 4,236 10,393 SH   DFND 1 10,393 0 0
Sherwin-Williams Co COM 824348106 9,976 24,478 SH   DFND 2 24,478 0 0
Sherwin-Williams Co COM 824348106 4,322 10,604 SH   SOLE 0 10,604 0 0
Shopify 'A' CL A 82509L107 52,281 358,356 SH   DFND 1 358,356 0 0
Shopify 'A' CL A 82509L107 130,427 894,012 SH   DFND 2 771,104 0 122,908
Shopify 'A' CL A 82509L107 62,697 429,755 SH   SOLE 0 429,755 0 0
Siteone Landscape Supply COM 82982L103 51,788 616,748 SH   DFND 1 616,748 0 0
Siteone Landscape Supply COM 82982L103 177,571 2,114,699 SH   DFND 2 1,663,138 0 451,561
Siteone Landscape Supply COM 82982L103 99,477 1,184,675 SH   SOLE 0 1,148,032 0 36,643
Snap Inc CL A 83304A106 3,223 246,186 SH   DFND 2 246,186 0 0
Sohu.com COM 83410S108 4,277 120,486 SH   DFND 1 120,486 0 0
Sohu.com COM 83410S108 20,633 581,225 SH   DFND 2 206,222 0 375,003
Solarcity Corp NOTE 1.625 11/0 83416TAC4 48 51,000 SH   DFND 2 51,000 0 0
Solarcity Corp NOTE 1.625 11/0 83416TAC4 12,169 13,007,000 SH   DFND 1 13,007,000 0 0
Splunk Inc COM 848637104 7,517 75,840 SH   DFND 1 75,840 0 0
Splunk Inc COM 848637104 11,465 115,677 SH   DFND 2 45,754 0 69,923
Splunk Inc COM 848637104 5,697 57,484 SH   SOLE 0 57,484 0 0
Spotify Technology SA SHS L8681T102 109,762 652,412 SH   DFND 1 652,412 0 0
Spotify Technology SA SHS L8681T102 1,648,266 9,797,113 SH   DFND 2 3,907,942 0 5,889,171
Spotify Technology SA SHS L8681T102 423,967 2,520,011 SH   SOLE 0 2,131,797 0 388,214
Staar Surgical COM PAR $0.01 852312305 13,574 437,871 SH   DFND 2 172,547 0 265,324
Staar Surgical COM PAR $0.01 852312305 12,543 404,629 SH   DFND 1 404,629 0 0
Staar Surgical COM PAR $0.01 852312305 9,798 316,050 SH   SOLE 0 316,050 0 0
Stericycle Inc COM 858912108 90,723 1,389,546 SH   DFND 2 1,085,426 0 304,120
Stericycle Inc COM 858912108 27,274 417,743 SH   DFND 1 417,743 0 0
Stericycle Inc COM 858912108 49,038 751,076 SH   SOLE 0 726,207 0 24,869
Stitch Fix COM CL A 860897107 8,785 320,159 SH   DFND 2 9,319 0 310,840
Stitch Fix COM CL A 860897107 37,882 1,380,532 SH   DFND 1 1,380,532 0 0
Stitch Fix COM CL A 860897107 16,174 589,422 SH   SOLE 0 589,422 0 0
Stratasys SHS M85548101 4,331 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 5,990 312,936 SH   DFND 2 124,056 0 188,880
Stratasys SHS M85548101 2,768 144,600 SH   SOLE 0 144,600 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 7,465 9,022,000 SH   DFND 1 9,022,000 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 3,577 4,324,000 SH   DFND 2 4,324,000 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 93,393 2,537,860 SH   DFND 1 2,537,860 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 1,512,835 41,109,636 SH   DFND 2 10,592,972 0 30,516,664
TAL Education Group ADR ADS REPSTG COM 874080104 183,243 4,979,431 SH   SOLE 0 2,651,408 0 2,328,023
TD Ameritrade Holding Corp COM 87236Y108 106,972 1,953,112 SH   DFND 1 1,953,112 0 0
TD Ameritrade Holding Corp COM 87236Y108 245,066 4,474,465 SH   DFND 2 3,490,714 0 983,751
TD Ameritrade Holding Corp COM 87236Y108 139,030 2,538,436 SH   SOLE 0 2,470,893 0 67,543
TJX Companies COM 872540109 11,035 115,941 SH   DFND 1 115,941 0 0
TJX Companies COM 872540109 20,530 215,696 SH   DFND 2 215,696 0 0
TJX Companies COM 872540109 6,231 65,469 SH   SOLE 0 65,469 0 0
TSMC ADR SPONSORED ADR 874039100 194,333 5,315,443 SH   DFND 1 5,315,443 0 0
TSMC ADR SPONSORED ADR 874039100 1,100,062 30,089,223 SH   DFND 2 21,742,221 0 8,347,002
TSMC ADR SPONSORED ADR 874039100 327,975 8,970,857 SH   SOLE 0 8,675,059 0 295,798
Tableau Software Class A CL A 87336U105 59,330 606,961 SH   DFND 1 606,961 0 0
Tableau Software Class A CL A 87336U105 12,267 125,489 SH   DFND 2 4,143 0 121,346
Tableau Software Class A CL A 87336U105 96,214 984,286 SH   SOLE 0 984,286 0 0
Teladoc COM 87918A105 12,254 211,098 SH   DFND 1 211,098 0 0
Teladoc COM 87918A105 8,896 153,252 SH   SOLE 0 153,252 0 0
Teladoc COM 87918A105 14,472 249,294 SH   DFND 2 98,473 0 150,821
Teradyne COM 880770102 44,567 1,170,665 SH   DFND 1 1,170,665 0 0
Teradyne COM 880770102 201,732 5,298,967 SH   DFND 2 4,431,510 0 867,457
Teradyne COM 880770102 82,896 2,177,462 SH   SOLE 0 2,107,650 0 69,812
TerraForm Power CL A COM 88104R209 19,775 1,690,157 SH   DFND 1 1,690,157 0 0
TerraForm Power CL A COM 88104R209 1,973 168,647 SH   DFND 2 168,647 0 0
Tesla Inc COM 88160R101 545,535 1,590,713 SH   DFND 1 1,590,713 0 0
Tesla Inc COM 88160R101 2,620,020 7,639,656 SH   DFND 2 2,546,282 0 5,093,374
Tesla Inc COM 88160R101 1,351,714 3,941,432 SH   SOLE 0 3,208,400 0 733,032
Thermo Fisher Scientific COM 883556102 77,479 374,040 SH   DFND 1 374,040 0 0
Thermo Fisher Scientific COM 883556102 266,606 1,287,080 SH   DFND 2 1,014,594 0 272,486
Thermo Fisher Scientific COM 883556102 148,534 717,070 SH   SOLE 0 694,601 0 22,469
Trupanion COM 898202106 11,342 293,839 SH   DFND 2 115,995 0 177,844
Trupanion COM 898202106 7,627 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 28,371 735,000 SH   SOLE 0 735,000 0 0
Under Armour Inc Class A CL A 904311107 51,998 2,313,074 SH   DFND 1 2,313,074 0 0
Under Armour Inc Class A CL A 904311107 274,364 12,204,812 SH   DFND 2 4,396,045 0 7,808,767
Under Armour Inc Class A CL A 904311107 137,646 6,123,037 SH   SOLE 0 3,931,994 0 2,191,043
Under Armour Inc Class C CL C 904311206 36,233 1,718,836 SH   DFND 1 1,718,836 0 0
Under Armour Inc Class C CL C 904311206 18,853 894,367 SH   DFND 2 564,279 0 330,088
Under Armour Inc Class C CL C 904311206 16,771 795,594 SH   SOLE 0 795,594 0 0
United Parcel Service CL B 911312106 10,180 95,830 SH   DFND 1 95,830 0 0
United Parcel Service CL B 911312106 12,452 117,216 SH   SOLE 0 117,216 0 0
Unity Biotechnology Inc COM 91381U101 3,735 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 53,539 3,555,014 SH   SOLE 0 3,555,014 0 0
Varian Medical Systems Inc COM 92220P105 13,348 117,375 SH   DFND 2 117,375 0 0
Veeco Instruments COM 922417100 4,627 324,730 SH   DFND 1 324,730 0 0
Veeco Instruments COM 922417100 2,786 195,479 SH   DFND 2 78,080 0 117,399
Veeco Instruments COM 922417100 10,990 771,205 SH   SOLE 0 771,205 0 0
Verisk Analytics COM 92345Y106 70,642 656,278 SH   DFND 1 656,278 0 0
Verisk Analytics COM 92345Y106 262,877 2,442,189 SH   DFND 2 1,964,220 0 477,969
Verisk Analytics COM 92345Y106 134,680 1,251,210 SH   SOLE 0 1,212,291 0 38,919
Vertex Pharmaceuticals COM 92532F100 47,279 278,179 SH   DFND 1 278,179 0 0
Vertex Pharmaceuticals COM 92532F100 20,177 118,718 SH   SOLE 0 118,718 0 0
Vertex Pharmaceuticals COM 92532F100 30,855 181,542 SH   DFND 2 119,732 0 61,810
Visa Inc-Class A Shares COM CL A 92826C839 128,222 968,082 SH   DFND 1 968,082 0 0
Visa Inc-Class A Shares COM CL A 92826C839 433,952 3,276,344 SH   DFND 2 2,574,164 0 702,180
Visa Inc-Class A Shares COM CL A 92826C839 238,951 1,804,084 SH   SOLE 0 1,746,935 0 57,149
Voya Prime Rate Trust SH BEN INT 92913A100 26,184 5,205,613 SH   DFND 1 5,205,613 0 0
Voya Prime Rate Trust SH BEN INT 92913A100 1,553 308,787 SH   DFND 2 308,787 0 0
WEC Energy Group COM 92939U106 13,234 204,700 SH   DFND 1 204,700 0 0
WEC Energy Group COM 92939U106 933 14,427 SH   DFND 2 14,427 0 0
Wabtec COM 929740108 106,585 1,081,208 SH   DFND 1 1,081,208 0 0
Wabtec COM 929740108 235,892 2,392,901 SH   DFND 2 1,842,435 0 550,466
Wabtec COM 929740108 133,641 1,355,663 SH   SOLE 0 1,318,482 0 37,181
Waters COM 941848103 78,389 404,924 SH   DFND 1 404,924 0 0
Waters COM 941848103 275,973 1,425,552 SH   DFND 2 1,149,010 0 276,542
Waters COM 941848103 140,442 725,463 SH   SOLE 0 702,614 0 22,849
Watsco Inc COM 942622200 80,450 451,254 SH   DFND 1 451,254 0 0
Watsco Inc COM 942622200 38,916 218,284 SH   DFND 2 126,254 0 92,030
Watsco Inc COM 942622200 36,899 206,972 SH   SOLE 0 206,972 0 0
Wayfair Inc Class A CL A 94419L101 159,782 1,345,421 SH   DFND 1 1,345,421 0 0
Wayfair Inc Class A CL A 94419L101 76,786 646,567 SH   DFND 2 164,705 0 481,862
Wayfair Inc Class A CL A 94419L101 83,692 704,717 SH   SOLE 0 704,717 0 0
Weibo Corp SPON ADR SPONSORED ADR 948596101 2,335 26,310 SH   DFND 2 0 0 26,310
Wipro Ltd ADR SPON ADR 1 SH 97651M109 149 31,095 SH   DFND 2 0 0 31,095
Wix Com SHS M98068105 260,309 2,595,301 SH   DFND 2 759,866 0 1,835,435
Workday Inc CL A 98138H101 82,730 683,040 SH   DFND 1 683,040 0 0
Workday Inc CL A 98138H101 432,236 3,568,662 SH   DFND 2 1,299,339 0 2,269,323
Workday Inc CL A 98138H101 288,798 2,384,392 SH   SOLE 0 1,744,961 0 639,431
Xylem COM 98419M100 1,523 22,608 SH   DFND 2 22,608 0 0
Xylem COM 98419M100 1,746 25,910 SH   DFND 1 25,910 0 0
Zillow Group Inc Class A CL A 98954M101 8,472 141,792 SH   DFND 1 141,792 0 0
Zillow Group Inc Class A CL A 98954M101 40,112 671,332 SH   DFND 2 472,303 0 199,029
Zillow Group Inc Class A CL A 98954M101 26,122 437,195 SH   SOLE 0 424,376 0 12,819
Zillow Group Inc Class C CL C CAP STK 98954M200 103,059 1,744,995 SH   DFND 1 1,744,995 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 312,388 5,289,338 SH   DFND 2 4,011,598 0 1,277,740
Zillow Group Inc Class C CL C CAP STK 98954M200 170,878 2,893,289 SH   SOLE 0 2,808,880 0 84,409
iRobot COM 462726100 11,578 152,810 SH   DFND 1 152,810 0 0
iRobot COM 462726100 25,561 337,352 SH   SOLE 0 337,352 0 0
iRobot COM 462726100 13,904 183,507 SH   DFND 2 70,952 0 112,555