The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 365 39,000 SH   DFND 1 0 0 39,000
ABBOTT LABS COM 002824100 34,694 568,850 SH   DFND 1 0 0 568,850
ABIOMED INC COM 003654100 11,077 27,081 SH   DFND 1 0 0 27,081
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 711 59,935 SH   DFND 1 0 0 59,935
AETNA INC NEW COM 00817Y108 1,303 7,100 SH   DFND 1 0 0 7,100
AGIOS PHARMACEUTICALS INC COM 00847X104 2,427 28,811 SH   DFND 1 0 0 28,811
AKCEA THERAPEUTICS INC COM 00972L107 8,993 379,301 SH   DFND 1 0 0 379,301
ALDER BIOPHARMACEUTICALS INC COM 014339105 11,992 758,964 SH   DFND 1 0 0 758,964
ALEXION PHARMACEUTICALS INC COM 015351109 20,327 163,730 SH   DFND 1 0 0 163,730
ALIGN TECHNOLOGY INC COM 016255101 44,840 131,058 SH   DFND 1 0 0 131,058
ALKERMES PLC SHS G01767105 1,344 32,650 SH   DFND 1 0 0 32,650
ALLERGAN PLC SHS G0177J108 1,667 10,000 SH   DFND 1 0 0 10,000
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 10,194 103,500 SH   DFND 1 0 0 103,500
AMERISOURCEBERGEN CORP COM 03073E105 20,367 238,853 SH   DFND 1 0 0 238,853
AMGEN INC COM 031162100 8,842 47,900 SH   DFND 1 0 0 47,900
ANGIODYNAMICS INC COM 03475V101 1,684 75,700 SH   DFND 1 0 0 75,700
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 1,231 75,000 SH   DFND 1 0 0 75,000
ANTHEM INC COM 036752103 50,826 213,527 SH   DFND 1 0 0 213,527
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,370 31,417 SH   DFND 1 0 0 31,417
AURIS MED HLDG AG COM H0381L104 151 193,125 SH   DFND 1 0 0 193,125
BAXTER INTL INC COM 071813109 15,506 210,000 SH   DFND 1 0 0 210,000
BECTON DICKINSON & CO COM 075887109 19,456 81,215 SH   DFND 1 0 0 81,215
BEIGENE LTD SPONSORED ADR 07725L102 1,768 11,500 SH   DFND 1 0 0 11,500
BELLICUM PHARMACEUTICALS INC COM 079481107 664 90,020 SH   DFND 1 0 0 90,020
BIOGEN INC COM 09062X103 11,419 39,345 SH   DFND 1 0 0 39,345
BIOMARIN PHARMACEUTICAL INC COM 09061G101 4,665 49,519 SH   DFND 1 0 0 49,519
BLUEBIRD BIO INC COM 09609G100 2,025 12,900 SH   DFND 1 0 0 12,900
BOSTON SCIENTIFIC CORP COM 101137107 26,833 820,596 SH   DFND 1 0 0 820,596
BRISTOL MYERS SQUIBB CO COM 110122108 14,435 260,849 SH   DFND 1 0 0 260,849
CARDINAL HEALTH INC COM 14149Y108 879 18,000 SH   DFND 1 0 0 18,000
CASTLIGHT HEALTH INC CL B 14862Q100 1,221 287,340 SH   DFND 1 0 0 287,340
CELGENE CORP COM 151020104 42,315 532,800 SH   DFND 1 0 0 532,800
CELLECTIS S A SPONSORED ADS 15117K103 1,431 50,600 SH   DFND 1 0 0 50,600
CENTENE CORP DEL COM 15135B101 20,114 163,247 SH   DFND 1 0 0 163,247
CERNER CORP COM 156782104 3,462 57,900 SH   DFND 1 0 0 57,900
CIGNA CORPORATION COM 125509109 21,453 126,234 SH   DFND 1 0 0 126,234
CLOVIS ONCOLOGY INC COM 189464100 784 17,250 SH   DFND 1 0 0 17,250
COHERUS BIOSCIENCES INC COM 19249H103 2,770 197,835 SH   DFND 1 0 0 197,835
COOPER COS INC COM NEW 216648402 4,544 19,300 SH   DFND 1 0 0 19,300
COTIVITI HLDGS INC COM 22164K101 1,093 24,774 SH   DFND 1 0 0 24,774
CVS HEALTH CORP COM 126650100 515 8,000 SH   DFND 1 0 0 8,000
DANAHER CORP DEL COM 235851102 21,558 218,465 SH   DFND 1 0 0 218,465
DENTSPLY SIRONA INC COM 24906P109 3,287 75,093 SH   DFND 1 0 0 75,093
DEXCOM INC COM 252131107 25,730 270,897 SH   DFND 1 0 0 270,897
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 1,400 91,800 SH   DFND 1 0 0 91,800
EAGLE PHARMACEUTICALS INC COM 269796108 2,497 33,000 SH   DFND 1 0 0 33,000
EDWARDS LIFESCIENCES CORP COM 28176E108 29,938 205,660 SH   DFND 1 0 0 205,660
ENDO INTL PLC SHS G30401106 934 99,092 SH   DFND 1 0 0 99,092
ESPERION THERAPEUTICS INC NEW COM 29664W105 12,287 313,520 SH   DFND 1 0 0 313,520
EXPRESS SCRIPTS HLDG CO COM 30219G108 3,436 44,500 SH   DFND 1 0 0 44,500
FITBIT INC CL A 33812L102 13,438 2,057,900 SH   DFND 1 0 0 2,057,900
FOUNDATION MEDICINE INC COM 350465100 1,142 8,357 SH   DFND 1 0 0 8,357
GENMARK DIAGNOSTICS INC COM 372309104 7,570 1,186,502 SH   DFND 1 0 0 1,186,502
GILEAD SCIENCES INC COM 375558103 11,356 160,300 SH   DFND 1 0 0 160,300
GLOBUS MED INC CL A 379577208 3,736 74,045 SH   DFND 1 0 0 74,045
GW PHARMACEUTICALS PLC ADS 36197T103 1,002 7,179 SH   DFND 1 0 0 7,179
HCA HEALTHCARE INC COM 40412C101 1,949 19,000 SH   DFND 1 0 0 19,000
HEALTHCARE SVCS GRP INC COM 421906108 648 15,000 SH   DFND 1 0 0 15,000
SCHEIN HENRY INC COM 806407102 3,731 51,368 SH   DFND 1 0 0 51,368
HILL ROM HLDGS INC COM 431475102 15,694 179,689 SH   DFND 1 0 0 179,689
HMS HLDGS CORP COM 40425J101 3,158 146,069 SH   DFND 1 0 0 146,069
HOLOGIC INC COM 436440101 14,385 361,894 SH   DFND 1 0 0 361,894
HORIZON PHARMA PLC SHS G4617B105 3,173 191,578 SH   DFND 1 0 0 191,578
HUMANA INC COM 444859102 25,849 86,850 SH   DFND 1 0 0 86,850
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 10,023 332,536 SH   DFND 1 0 0 332,536
IDEXX LABS INC COM 45168D104 1,526 7,000 SH   DFND 1 0 0 7,000
ILLUMINA INC COM 452327109 39,372 140,971 SH   DFND 1 0 0 140,971
INCYTE CORP COM 45337C102 3,675 54,850 SH   DFND 1 0 0 54,850
INOGEN INC COM 45780L104 1,120 6,011 SH   DFND 1 0 0 6,011
INSMED INC COM PAR $.01 457669307 10,029 424,051 SH   DFND 1 0 0 424,051
INSPIRE MED SYS INC COM 457730109 1,710 47,953 SH   DFND 1 0 0 47,953
INSULET CORP COM 45784P101 1,543 18,000 SH   DFND 1 0 0 18,000
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 3,746 58,161 SH   DFND 1 0 0 58,161
INTELLIA THERAPEUTICS INC COM 45826J105 458 16,734 SH   DFND 1 0 0 16,734
INTERCEPT PHARMACEUTICALS IN COM 45845P108 2,068 24,648 SH   DFND 1 0 0 24,648
INTERSECT ENT INC COM 46071F103 3,297 88,028 SH   DFND 1 0 0 88,028
INTRA CELLULAR THERAPIES INC COM 46116X101 1,412 79,900 SH   DFND 1 0 0 79,900
INTUITIVE SURGICAL INC COM NEW 46120E602 41,981 87,739 SH   DFND 1 0 0 87,739
IONIS PHARMACEUTICALS INC COM 462222100 13,442 322,586 SH   DFND 1 0 0 322,586
IRHYTHM TECHNOLOGIES INC COM 450056106 3,726 45,921 SH   DFND 1 0 0 45,921
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 28,418 164,933 SH   DFND 1 0 0 164,933
JOHNSON & JOHNSON COM 478160104 2,427 20,000 SH   DFND 1 0 0 20,000
K2M GROUP HLDGS INC COM 48273J107 13,791 612,941 SH   DFND 1 0 0 612,941
LABORATORY CORP AMER HLDGS COM NEW 50540R409 13,508 75,240 SH   DFND 1 0 0 75,240
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 2,501 12,070 SH   DFND 1 0 0 12,070
LIVANOVA PLC SHS G5509L101 10,973 109,924 SH   DFND 1 0 0 109,924
MACROGENICS INC COM 556099109 12,326 596,913 SH   DFND 1 0 0 596,913
MASIMO CORP COM 574795100 1,445 14,800 SH   DFND 1 0 0 14,800
MATERIALISE NV SPONSORED ADS 57667T100 510 39,329 SH   DFND 1 0 0 39,329
MCKESSON CORP COM 58155Q103 1,581 11,850 SH   DFND 1 0 0 11,850
MEDICINES CO COM 584688105 626 17,050 SH   DFND 1 0 0 17,050
MEDIDATA SOLUTIONS INC COM 58471A105 375 4,649 SH   DFND 1 0 0 4,649
MEDTRONIC PLC SHS G5960L103 34,405 401,881 SH   DFND 1 0 0 401,881
MERCK & CO INC COM 58933Y105 759 12,500 SH   DFND 1 0 0 12,500
MIRATI THERAPEUTICS INC COM 60468T105 1,257 25,500 SH   DFND 1 0 0 25,500
MOLINA HEALTHCARE INC COM 60855R100 5,116 52,240 SH   DFND 1 0 0 52,240
MYLAN N V SHS EURO N59465109 18,155 502,350 SH   DFND 1 0 0 502,350
NEKTAR THERAPEUTICS COM 640268108 1,685 34,500 SH   DFND 1 0 0 34,500
NEUROCRINE BIOSCIENCES INC COM 64125C109 4,278 43,550 SH   DFND 1 0 0 43,550
NEURONETICS INC COM 64131A105 1,320 50,000 SH   DFND 1 0 0 50,000
NEVRO CORP COM 64157F103 2,060 25,798 SH   DFND 1 0 0 25,798
OMNICELL INC COM 68213N109 3,354 63,945 SH   DFND 1 0 0 63,945
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 1,426 110,661 SH   DFND 1 0 0 110,661
PENUMBRA INC COM 70975L107 1,938 14,027 SH   DFND 1 0 0 14,027
PFIZER INC COM 717081103 1,059 29,200 SH   DFND 1 0 0 29,200
PORTOLA PHARMACEUTICALS INC COM 737010108 1,567 41,500 SH   DFND 1 0 0 41,500
PRA HEALTH SCIENCES INC COM 69354M108 12,081 129,400 SH   DFND 1 0 0 129,400
QIAGEN NV SHS NEW N72482123 2,778 76,838 SH   DFND 1 0 0 76,838
QUANTERIX CORP COM 74766Q101 2,376 165,480 SH   DFND 1 0 0 165,480
QUOTIENT LTD SHS G73268107 2,568 319,814 SH   DFND 1 0 0 319,814
REGENERON PHARMACEUTICALS COM 75886F107 5,955 17,260 SH   DFND 1 0 0 17,260
REGENXBIO INC COM 75901B107 1,708 23,800 SH   DFND 1 0 0 23,800
RESMED INC COM 761152107 8,514 82,200 SH   DFND 1 0 0 82,200
SAGE THERAPEUTICS INC COM 78667J108 1,894 12,100 SH   DFND 1 0 0 12,100
SEATTLE GENETICS INC COM 812578102 3,286 49,500 SH   DFND 1 0 0 49,500
SHIRE PLC SPONSORED ADR 82481R106 11,021 65,292 SH   DFND 1 0 0 65,292
STRYKER CORP COM 863667101 20,056 118,770 SH   DFND 1 0 0 118,770
SUPERNUS PHARMACEUTICALS INC COM 868459108 19,547 326,600 SH   DFND 1 0 0 326,600
SYNEOS HEALTH INC CL A 87166B102 1,250 26,656 SH   DFND 1 0 0 26,656
TABULA RASA HEALTHCARE INC COM 873379101 4,296 67,306 SH   DFND 1 0 0 67,306
TANDEM DIABETES CARE INC COM NEW 875372203 2,510 114,006 SH   DFND 1 0 0 114,006
TELADOC INC COM 87918A105 33,095 570,110 SH   DFND 1 0 0 570,110
TELEFLEX INC COM 879369106 3,755 14,000 SH   DFND 1 0 0 14,000
TESARO INC COM 881569107 1,123 25,250 SH   DFND 1 0 0 25,250
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 2,189 90,000 SH   DFND 1 0 0 90,000
THERMO FISHER SCIENTIFIC INC COM 883556102 6,034 29,131 SH   DFND 1 0 0 29,131
ULTRAGENYX PHARMACEUTICAL INC COM 90400D108 3,009 39,150 SH   DFND 1 0 0 39,150
UNITEDHEALTH GROUP INC COM 91324P102 23,731 96,729 SH   DFND 1 0 0 96,729
UNIQURE NV SHS N90064101 764 20,200 SH   DFND 1 0 0 20,200
VALEANT PHARMACEUTICALS INTL COM 91911K102 3,021 130,000 SH   DFND 1 0 0 130,000
VARIAN MED SYS INC COM 92220P105 716 6,300 SH   DFND 1 0 0 6,300
VEEVA SYS INC CL A COM 922475108 791 10,296 SH   DFND 1 0 0 10,296
VERTEX PHARMACEUTICALS INC COM 92532F100 7,188 42,294 SH   DFND 1 0 0 42,294
VOYAGER THERAPEUTICS INC COM 92915B106 331 16,922 SH   DFND 1 0 0 16,922
WALGREENS BOOTS ALLIANCE INC COM 931427108 13,564 226,018 SH   DFND 1 0 0 226,018
WELLCARE HEALTH PLANS INC COM 94946T106 5,430 22,050 SH   DFND 1 0 0 22,050
WRIGHT MED GROUP NV ORD SHS 0.03 PAR N96617118 14,805 570,301 SH   DFND 1 0 0 570,301
ZIMMER BIOMET HLDGS INC COM 98956P102 7,957 71,401 SH   DFND 1 0 0 71,401