The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALIMERA SCIENCES INC Common 016259103 6,106 6,241,581 SH   SOLE   6,241,581 0 0
ALNYLAM PHARMACEUTICALS INC Common 02043Q107 68,953 700,100 SH   SOLE   700,100 0 0
AMICUS THERAPEUTICS INC Common 03152W109 146,346 9,369,150 SH   SOLE   9,369,150 0 0
ARGENX SE Sponsored ADR 04016X101 64,801 782,053 SH   SOLE   782,053 0 0
ARROWHEAD PHARMACEUTICALS INC Common 04280A100 6,120 450,000 SH   SOLE   450,000 0 0
ASCENDIS PHARMA Sponsored ADR 04351P101 137,253 2,063,336 SH   SOLE   2,063,336 0 0
ASSEMBLY BIOSCIENCES INC Common 045396108 37,776 963,427 SH   SOLE   963,427 0 0
AVROBIO INC Common 05455M100 2,856 100,000 SH   SOLE   100,000 0 0
BIODELIVERY SCIENCES INTL Common 09060J106 16,041 5,437,779 SH   SOLE   5,437,779 0 0
BIOMARIN PHARMACEUTICAL INC Common 09061G101 152,865 1,622,770 SH   SOLE   1,622,770 0 0
CATALYST PHARMACEUTICALS INC Common 14888U101 14,031 4,497,042 SH   SOLE   4,497,042 0 0
CLOVIS ONCOLOGY INC Common 189464100 52,128 1,146,436 SH   SOLE   1,146,436 0 0
CYMABAY THERAPEUTICS INC Common 23257D103 17,209 1,282,374 SH   SOLE   1,282,374 0 0
DERMIRA INC Common 24983L104 16,945 1,841,823 SH   SOLE   1,841,823 0 0
ENDOCYTE INC Common 29269A102 78,594 5,695,200 SH   SOLE   5,695,200 0 0
FENNEC PHARMACEUTICALS INC Common 31447P100 10,700 1,022,666 SH   SOLE   1,022,666 0 0
GLOBAL BLOOD THERAPEUTICS INC Common 37890U108 31,665 700,548 SH   SOLE   700,548 0 0
HORIZON PHARMA PLC Common G4617B105 92,631 5,593,683 SH   SOLE   5,593,683 0 0
IMMUNOMEDICS INC Common 452907108 419,301 17,714,461 SH   SOLE   17,714,461 0 0
INTEC PHARMA LTD Common M53644106 11,311 2,570,705 SH   SOLE   2,570,705 0 0
IOVANCE BIOTHERAPEUTICS INC Common 462260100 104,675 8,177,720 SH   SOLE   8,177,720 0 0
MADRIGAL PHARMACEUTICALS INC Common 558868105 136,918 489,536 SH   SOLE   489,536 0 0
MEDICINES CO Common 584688105 35,290 961,574 SH   SOLE   961,574 0 0
MIRATI THERAPEUTICS INC Common 60468T105 236,546 4,798,101 SH   SOLE   4,798,101 0 0
ONCOBIOLOGICS INC Common 68235M105 578 683,531 SH   SOLE   683,531 0 0
ONCOBIOLOGICS INC - WARRANT A Warrant 68235M113 12 233,333 SH   SOLE   233,333 0 0
ONCOSEC MEDICAL INC Common 68234L207 5,531 4,007,696 SH   SOLE   4,007,696 0 0
PACIRA PHARMACEUTICALS INC Common 695127100 46,813 1,460,610 SH   SOLE   1,460,610 0 0
PERNIX THERAPEUTICS HOLDINGS INC Convertible Debt 71426VAK4 2,618 6,000,000 PRN   SOLE   6,000,000 0 0
PTC THERAPEUTICS INC Common 69366J200 77,406 2,294,877 SH   SOLE   2,294,877 0 0
PUMA BIOTECHNOLOGY INC Common 74587V107 61,183 1,034,375 SH   SOLE   1,034,375 0 0
SAREPTA THERAPEUTICS INC Common 803607100 126,751 958,928 SH   SOLE   958,928 0 0
SESEN BIO INC Common 817763105 13,260 6,800,000 SH   SOLE   6,800,000 0 0
SPECTRUM PHARMACEUTICALS INC Common 84763A108 71,679 3,419,818 SH   SOLE   3,419,818 0 0
TELIGENT INC Common 87960W104 18,336 5,299,431 SH   SOLE   5,299,431 0 0
TG THERAPEUTICS INC Common 88322Q108 65,093 4,950,031 SH   SOLE   4,950,031 0 0
TRICIDA INC Common 89610F101 32,763 1,095,764 SH   SOLE   1,095,764 0 0
VANDA PHARMACEUTICALS INC Common 921659108 53,344 2,800,191 SH   SOLE   2,800,191 0 0
VIKING THERAPEUTICS INC Common 92686J106 42,433 4,471,300 SH   SOLE   4,471,300 0 0
SPDR SERIES TRUST - S&P BIOTECH ETF 78464A870 1,875 750,000 SH Put SOLE   750,000 0 0
SPDR SERIES TRUST - S&P BIOTECH ETF 78464A870 1,575 500,000 SH Put SOLE   500,000 0 0
SPDR SERIES TRUST - S&P BIOTECH ETF 78464A870 1,850 500,000 SH Put SOLE   500,000 0 0
XENON PHARMACEUTICALS INC Common 98420N105 11,059 1,202,118 SH   SOLE   1,202,118 0 0
ZOGENIX INC Common 98978L204 66,446 1,503,313 SH   SOLE   1,503,313 0 0