The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 17,372 1,853,998 SH   DFND 1 1,853,998 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 30,315 741,016 SH   DFND 1 741,016 0 0
ACCELERON PHARMA INC COM 00434H108 54,672 1,126,800 SH   DFND 1 1,126,800 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 54,832 2,745,705 SH   DFND 1 2,745,705 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 10,707 16,600,000 PRN   DFND 1 16,600,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 32,698 484,055 SH   DFND 1 484,055 0 0
AETNA INC NEW COM 00817Y108 42,022 229,000 SH   DFND 1 229,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 29,481 350,000 SH   DFND 1 350,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 18,097 673,000 SH   DFND 1 673,000 0 0
ALBIREO PHARMA INC COM 01345P106 4,260 120,000 SH   DFND 1 120,000 0 0
ALIMERA SCIENCES INC COM 016259103 5,922 6,052,935 SH   DFND 1 6,052,935 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 14,380 146,000 SH   DFND 1 146,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 6,912 913,100 SH   DFND 1 913,100 0 0
ANAPTYSBIO INC COM 032724106 39,995 562,989 SH   DFND 1 562,989 0 0
ANTHEM INC COM 036752103 45,464 191,000 SH   DFND 1 191,000 0 0
ARALEZ PHARMACEUTICALS INC COM 03852X100 576 1,644,583 SH   DFND 1 1,644,583 0 0
ARDELYX INC COM 039697107 12,920 3,491,922 SH   DFND 1 3,491,922 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 17,361 398,194 SH   DFND 1 398,194 0 0
ARGENX SE SPONSORED ADR 04016X101 37,041 447,029 SH   DFND 1 447,029 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 32,094 482,467 SH   DFND 1 482,467 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 40,061 1,048,430 SH   DFND 1 1,048,430 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 6,698 250,000 SH   DFND 1 250,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 16,687 2,722,241 SH   DFND 1 2,722,241 0 0
AVROBIO INC COM 05455M100 5,712 200,000 SH   DFND 1 200,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 34,744 6,063,496 SH   DFND 1 6,063,496 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 15,729 398,000 SH   DFND 1 398,000 0 0
BIOSCRIP INC COM 09069N108 6,842 2,335,000 SH   DFND 1 2,335,000 0 0
BLUEBIRD BIO INC COM 09609G100 17,735 113,000 SH   DFND 1 113,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 30,150 474,950 SH   DFND 1 474,950 0 0
BROOKDALE SR LIVING INC COM 112463104 20,959 2,305,773 SH   DFND 1 2,305,773 0 0
CENTENE CORP DEL COM 15135B101 39,986 324,536 SH   DFND 1 324,536 0 0
CVS HEALTH CORP COM 126650100 35,393 550,000 SH   DFND 1 550,000 0 0
CVS HEALTH CORP COM 126650100 36,474 566,800 SH Call DFND 1 566,800 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 18,025 1,343,181 SH   DFND 1 1,343,181 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 16,687 729,948 SH   DFND 1 729,948 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 55,941 2,900,000 SH   DFND 1 2,900,000 0 0
DEPOMED INC NOTE 2.500% 9/0 249908AA2 21,952 27,019,000 PRN   DFND 1 27,019,000 0 0
DEXCOM INC COM 252131107 15,688 165,175 SH   DFND 1 165,175 0 0
DFB HEALTHCARE ACQUISTION CO UNIT 01/30/2023 23291E208 25,375 2,500,000 SH   DFND 1 2,500,000 0 0
EDITAS MEDICINE INC COM 28106W103 41,521 1,158,841 SH   DFND 1 1,158,841 0 0
EHEALTH INC COM 28238P109 24,419 1,104,952 SH   DFND 1 1,104,952 0 0
EIDOS THERAPEUTICS INC COM 28249H104 6,586 323,807 SH   DFND 1 323,807 0 0
ELECTROCORE INC COM 28531P103 7,017 425,000 SH   DFND 1 425,000 0 0
ENDOCYTE INC COM 29269A102 32,075 2,324,299 SH   DFND 1 2,324,299 0 0
ENDOLOGIX INC NOTE 3.250%11/0 29266SAB2 38,243 40,500,000 PRN   DFND 1 40,500,000 0 0
EPIZYME INC COM 29428V104 22,208 1,639,000 SH   DFND 1 1,639,000 0 0
EYENOVIA INC COM 30234E104 1,890 300,000 SH   DFND 1 300,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 3,377 674,002 SH   DFND 1 674,002 0 0
FORTY SEVEN INC COM 34983P104 9,600 600,000 SH   DFND 1 600,000 0 0
G1 THERAPEUTICS INC COM 3621LQ109 12,473 287,000 SH   DFND 1 287,000 0 0
GALAPAGOS NV SPON ADR 36315X101 15,210 165,000 SH   DFND 1 165,000 0 0
GLAUKOS CORP COM 377322102 30,652 754,222 SH   DFND 1 754,222 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 32,513 233,000 SH   DFND 1 233,000 0 0
HOMOLOGY MEDICINES INC COM 438083107 106,632 5,227,035 SH   DFND 1 5,227,035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 94,914 99,100,000 PRN   DFND 1 99,100,000 0 0
HORIZON PHARMA PLC SHS G4617B105 109,460 6,609,894 SH   DFND 1 6,609,894 0 0
IGI LABORATORIES INC NOTE 3.750%12/1 449575AB5 3,476 3,733,000 PRN   DFND 1 3,733,000 0 0
IMMUNOMEDICS INC COM 452907108 26,624 1,124,800 SH   DFND 1 1,124,800 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 31,598 36,000,000 PRN   DFND 1 36,000,000 0 0
INTERSECT ENT INC COM 46071F103 38,199 1,020,000 SH   DFND 1 1,020,000 0 0
INVITAE CORP COM 46185L103 13,978 1,901,788 SH   DFND 1 1,901,788 0 0
INVUITY INC COM NEW 46187J205 9,114 2,336,889 SH   DFND 1 2,336,889 0 0
K2M GROUP HLDGS INC NOTE 4.125% 8/1 48273JAB3 26,036 20,000,000 PRN   DFND 1 20,000,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 55,438 75,000,000 PRN   DFND 1 75,000,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 21,287 1,226,890 SH   DFND 1 1,226,890 0 0
LANNET INC COM 516012101 24,498 1,801,353 SH   DFND 1 1,801,353 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 130,401 6,988,248 SH   DFND 1 6,988,248 0 0
MANNKIND CORP COM NEW 56400P706 2,771 1,458,537 SH   DFND 1 1,458,537 0 0
MELINTA THERAPEUTICS INC COM 58549G100 25,373 3,995,806 SH   DFND 1 3,995,806 0 0
MIRATI THERAPEUTICS INC COM 60468T105 64,108 1,300,365 SH   DFND 1 1,300,365 0 0
MOLINA HEALTHCARE INC COM 60855R100 16,454 168,000 SH   DFND 1 168,000 0 0
MORPHOSYS AG SPONSORED ADS 617760202 18,204 600,000 SH   DFND 1 600,000 0 0
MYLAN N V SHS EURO N59465109 62,960 1,742,111 SH   DFND 1 1,742,111 0 0
MYOKARDIA INC COM 62857M105 57,544 1,159,000 SH   DFND 1 1,159,000 0 0
NATERA INC COM 632307104 20,341 1,080,829 SH   DFND 1 1,080,829 0 0
NEOS THERAPEUTICS INC COM 64052L106 1,458 233,332 SH   DFND 1 233,332 0 0
NEURONETICS INC COM 64131A105 3,326 125,000 SH   DFND 1 125,000 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 29,913 27,600,000 PRN   DFND 1 27,600,000 0 0
NUVASIVE INC NOTE 2.250% 3/1 670704AG0 7,591 7,000,000 PRN   DFND 1 7,000,000 0 0
NUVECTRA CORP COM 67075N108 2,689 131,000 SH   DFND 1 131,000 0 0
ORTHOPEDIATRICS CORP COM 68752L100 2,152 80,783 SH   DFND 1 80,783 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 16,899 1,311,000 SH   DFND 1 1,311,000 0 0
PFENEX INC COM 717071104 6,112 1,129,684 SH   DFND 1 1,129,684 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 54,639 1,446,633 SH   DFND 1 1,446,633 0 0
PROTEON THERAPEUTICS INC COM 74371L109 3,001 1,224,899 SH   DFND 1 1,224,899 0 0
PROTHENA CORP PLC SHS G72800108 9,160 628,262 SH   DFND 1 628,262 0 0
RA PHARMACEUTICALS INC COM 74933V108 3,808 382,700 SH   DFND 1 382,700 0 0
RADIUS HEALTH INC NOTE 3.000% 9/0 750469AA6 19,342 21,000,000 PRN   DFND 1 21,000,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 21,316 609,554 SH   DFND 1 609,554 0 0
REGENXBIO INC COM 75901B107 8,969 125,000 SH   DFND 1 125,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 21,995 703,600 SH   DFND 1 703,600 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 5,496 280,000 SH   DFND 1 280,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 39,125 296,000 SH   DFND 1 296,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 33,723 1,858,000 SH   DFND 1 1,858,000 0 0
SIENTRA INC COM 82621J105 12,664 649,100 SH   DFND 1 649,100 0 0
SIERRA ONCOLOGY INC COM 82640U107 5,224 1,764,889 SH   DFND 1 1,764,889 0 0
SOLID BIOSCIENCES INC COM 83422E105 6,391 179,381 SH   DFND 1 179,381 0 0
STEADYMED LTD SHS M84920103 4,132 918,120 SH   DFND 1 918,120 0 0
SYNLOGIC INC COM 87166L100 13,419 1,365,143 SH   DFND 1 1,365,143 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 12,956 1,268,945 SH   DFND 1 1,268,945 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 56,664 2,573,305 SH   DFND 1 2,573,305 0 0
TELIGENT INC NEW COM 87960W104 2,453 708,873 SH   DFND 1 708,873 0 0
TELIGENT INC NEW NOTE 4.750% 5/0 87960WAA2 10,312 9,567,000 PRN   DFND 1 9,567,000 0 0
TRANSLATE BIO INC COM 89374L104 8,223 650,000 SH   DFND 1 650,000 0 0
TRINITY BIOTECH INVT LTD NOTE 4.000% 4/0 89643QAB4 35,398 43,000,000 PRN   DFND 1 43,000,000 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 29,197 262,000 SH   DFND 1 262,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 2,299 117,647 SH   DFND 1 117,647 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 31,868 531,000 SH   DFND 1 531,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 6,839 178,806 SH   DFND 1 178,806 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 9,074 349,539 SH   DFND 1 349,539 0 0
WRIGHT MED GROUP N V NOTE 2.250%11/1 98236JAB4 41,943 31,500,000 PRN   DFND 1 31,500,000 0 0
XENCOR INC COM 98401F105 1,790 48,366 SH   DFND 1 48,366 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 47,425 2,498,666 SH   DFND 1 2,498,666 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 13,484 121,000 SH   DFND 1 121,000 0 0