The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U Inc Common Stock 90214J101 14,179 188,571 SH   OTR   142,150 0 46,421
3D Systems Corp Common Stock 88554D205 3,447 182,377 SH   SOLE   182,377 0 0
3M Co Common Stock 88579Y101 67 319 SH   SOLE   319 0 0
Adobe Inc Common Stock 00724F101 11,662 43,201 SH   SOLE   43,201 0 0
Advanced Micro Devices Inc Common Stock 007903107 19,775 640,180 SH   SOLE   640,180 0 0
Aerovironment Inc Common Stock 008073108 11,601 103,426 SH   OTR   41,919 0 61,507
Alibaba Group Holding Ltd ADR 01609W102 22,340 135,592 SH   OTR   85,434 5,329 44,829
Align Technology Inc Common Stock 016255101 4,688 11,982 SH   SOLE   11,982 0 0
Allegheny Technologies Inc Common Stock 01741R102 71 2,412 SH   SOLE   2,412 0 0
Alphabet Inc Common Stock 02079K107 18,492 15,494 SH   OTR   11,242 0 4,252
Amazon.com Inc Common Stock 023135106 76,226 38,056 SH   OTR   29,764 1,144 7,148
AMETEK Inc Common Stock 031100100 662 8,369 SH   SOLE   8,369 0 0
ANSYS Inc Common Stock 03662Q105 4,013 21,497 SH   SOLE   21,497 0 0
Apple Inc Common Stock 037833100 60,359 267,382 SH   OTR   203,661 8,923 54,798
Aptiv PLC Common Stock G6095L109 51,413 612,785 SH   OTR   452,598 30,231 129,956
AquaBounty Technologies Inc Common Stock 03842K200 794 247,432 SH   SOLE   247,432 0 0
Arconic Inc Common Stock 03965L100 668 30,341 SH   SOLE   30,341 0 0
Arcturus Therapeutics Ltd Common Stock M1492T105 6,840 773,772 SH   SOLE   773,772 0 0
Arkema SA Common Stock F0392W125 65 525 SH   SOLE   525 0 0
Arrk Corp Common Stock J0198N101 598 595,101 SH   SOLE   595,101 0 0
ASX Ltd Common Stock Q0604U105 69 1,579 SH   SOLE   1,579 0 0
athenahealth Inc Common Stock 04685W103 43 320 SH   SOLE   320 0 0
Attunity Ltd Common Stock M15332121 842 44,600 SH   SOLE   44,600 0 0
AudioCodes Ltd Common Stock M15342104 692 68,833 SH   SOLE   68,833 0 0
Autodesk Inc Common Stock 052769106 5,839 37,402 SH   SOLE   37,402 0 0
Baidu Inc ADR 056752108 139,363 609,422 SH   OTR   455,235 24,303 129,884
Bayer AG Common Stock D0712D163 35 390 SH   OTR   0 390 0
BeiGene Ltd ADR 07725L102 3,480 20,207 SH   SOLE   20,207 0 0
Bellicum Pharmaceuticals Inc Common Stock 079481107 3,636 590,214 SH   SOLE   590,214 0 0
Bertrandt AG Common Stock D1014N107 549 5,947 SH   SOLE   5,947 0 0
Bezeq The Israeli Telecommunic Common Stock M2012Q100 584 503,466 SH   SOLE   503,466 0 0
Biogen Inc Common Stock 09062X103 7,949 22,498 SH   SOLE   22,498 0 0
Bitcoin Investment Trust Open-End Fund 09173T108 14,345 1,806,723 SH   OTR   540,935 544,031 721,757
Bluebird Bio Inc Common Stock 09609G100 58,494 400,644 SH   OTR   294,186 17,666 88,792
Bristol-Myers Squibb Co Common Stock 110122108 3,432 55,283 SH   SOLE   55,283 0 0
Camtek Ltd/Israel Common Stock M20791105 583 68,052 SH   SOLE   68,052 0 0
Carpenter Technology Corp Common Stock 144285103 67 1,139 SH   SOLE   1,139 0 0
Cboe Global Markets Inc Common Stock 12503M108 51 535 SH   SOLE   535 0 0
Celgene Corp Common Stock 151020104 13,239 147,935 SH   SOLE   147,935 0 0
Cellcom Israel Ltd Common Stock M2196U109 654 94,696 SH   SOLE   94,696 0 0
Cellectis SA ADR 15117K103 11,120 394,042 SH   OTR   364,877 29,165 0
Ceragon Networks Ltd Common Stock M22013102 482 143,143 SH   SOLE   143,143 0 0
Cerus Corp Common Stock 157085101 46,858 6,499,032 SH   OTR   4,800,353 57,406 1,641,273
Charles Schwab Corp/The Common Stock 808513105 184 3,738 SH   SOLE   3,738 0 0
Check Point Software Technolog Common Stock M22465104 577 4,901 SH   SOLE   4,901 0 0
Cognex Corp Common Stock 192422103 3,366 60,296 SH   SOLE   60,296 0 0
Compugen Ltd Common Stock M25722105 26,583 6,904,667 SH   OTR   6,711,954 49,584 143,129
Cornerstone OnDemand Inc Common Stock 21925Y103 2,042 35,978 SH   SOLE   35,978 0 0
CRISPR Therapeutics AG Common Stock H17182108 64,467 1,453,590 SH   OTR   1,105,949 66,138 281,503
CyberArk Software Ltd Common Stock M2682V108 623 7,800 SH   SOLE   7,800 0 0
Daimler AG ADR 233825207 2,244 142,921 SH   SOLE   142,921 0 0
Danel Adir Yeoshua Ltd Common Stock M27013107 655 12,170 SH   SOLE   12,170 0 0
Dassault Systemes SE Common Stock F2457H472 1,819 12,165 SH   SOLE   12,165 0 0
Deere & Co Common Stock 244199105 2,589 17,222 SH   SOLE   17,222 0 0
DowDuPont Inc Common Stock 26078J100 62 968 SH   SOLE   968 0 0
Eastman Chemical Co Common Stock 277432100 61 636 SH   SOLE   636 0 0
Eastman Kodak Co Common Stock 277461406 52 16,866 SH   SOLE   16,866 0 0
Ebix Inc Common Stock 278715206 147 1,862 SH   SOLE   1,862 0 0
Editas Medicine Inc Common Stock 28106W103 88,900 2,793,854 SH   OTR   2,031,690 129,446 632,718
Elbit Systems Ltd Common Stock M3760D101 2,547 20,292 SH   SOLE   20,292 0 0
Evelo Biosciences Inc Common Stock 299734103 2,883 236,685 SH   SOLE   236,685 0 0
Evogene Ltd Common Stock M4119S104 754 242,570 SH   SOLE   242,570 0 0
Evonik Industries AG Common Stock D2R90Y117 59 1,642 SH   SOLE   1,642 0 0
ExOne Co/The Common Stock 302104104 19,169 2,022,084 SH   OTR   1,641,265 0 380,819
FANUC Corp Common Stock J13440102 42 220 SH   OTR   0 220 0
FARO Technologies Inc Common Stock 311642102 686 10,659 SH   SOLE   10,659 0 0
FirstRand Ltd Common Stock S5202Z131 59 13,580 SH   SOLE   13,580 0 0
Fiserv Inc Common Stock 337738108 154 1,873 SH   SOLE   1,873 0 0
Foamix Pharmaceuticals Ltd Common Stock M46135105 572 99,901 SH   SOLE   99,901 0 0
Galmed Pharmaceuticals Ltd Common Stock M47238106 487 35,846 SH   SOLE   35,846 0 0
General Electric Co Common Stock 369604103 478 42,376 SH   SOLE   42,376 0 0
General Motors Co Common Stock 37045V100 2,723 80,861 SH   SOLE   80,861 0 0
Gilat Satellite Networks Ltd Common Stock M51474118 539 61,247 SH   SOLE   61,247 0 0
GMO internet Inc Common Stock J1822R104 14 800 SH   SOLE   800 0 0
GrubHub Inc Common Stock 400110102 3,583 25,845 SH   SOLE   25,845 0 0
Guidewire Software Inc Common Stock 40171V100 344 3,407 SH   SOLE   3,407 0 0
HDFC Bank Ltd ADR 40415F101 122 1,297 SH   SOLE   1,297 0 0
Henkel AG & Co KGaA Common Stock D3207M102 53 499 SH   SOLE   499 0 0
Hexagon AB Common Stock W40063104 635 10,824 SH   SOLE   10,824 0 0
Hexcel Corp Common Stock 428291108 62 926 SH   SOLE   926 0 0
Hilan Ltd Common Stock M5299H123 603 24,021 SH   SOLE   24,021 0 0
Hortonworks Inc Common Stock 440894103 19,463 853,284 SH   OTR   578,853 0 274,431
HP Inc Common Stock 40434L105 3,094 120,077 SH   SOLE   120,077 0 0
HubSpot Inc Common Stock 443573100 13,718 90,881 SH   SOLE   90,881 0 0
Illumina Inc Common Stock 452327109 99,408 270,821 SH   OTR   202,793 11,022 57,006
Incyte Corp Common Stock 45337C102 4,396 63,643 SH   SOLE   63,643 0 0
Infineon Technologies AG ADR 45662N103 17 738 SH   SOLE   738 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 10,659 1,917,071 SH   OTR   1,894,675 22,396 0
Intec Pharma Ltd Common Stock M53644106 609 107,761 SH   SOLE   107,761 0 0
Intellia Therapeutics Inc Common Stock 45826J105 164,673 5,753,790 SH   OTR   4,546,249 285,407 922,134
Interactive Brokers Group Inc Common Stock 45841N107 335 6,048 SH   SOLE   6,048 0 0
Intercontinental Exchange Inc Common Stock 45866F104 5,162 68,927 SH   SOLE   68,927 0 0
Intuit Inc Common Stock 461202103 297 1,307 SH   SOLE   1,307 0 0
Intuitive Surgical Inc Common Stock 46120E602 2,072 3,609 SH   SOLE   3,609 0 0
Invitae Corp Common Stock 46185L103 153,417 9,170,156 SH   OTR   7,456,586 86,832 1,626,738
Ionis Pharmaceuticals Inc Common Stock 462222100 11,828 229,318 SH   OTR   169,227 0 60,091
Iovance Biotherapeutics Inc Common Stock 462260100 4,779 424,820 SH   SOLE   424,820 0 0
Ituran Location and Control Lt Common Stock M6158M104 624 18,127 SH   SOLE   18,127 0 0
JD.com Inc ADR 47215P106 87,754 3,363,496 SH   OTR   2,698,552 119,248 545,696
K2M Group Holdings Inc Common Stock 48273J107 724 26,470 SH   SOLE   26,470 0 0
Kamada Ltd Common Stock M6240T109 606 97,391 SH   SOLE   97,391 0 0
Koninklijke DSM NV Common Stock N5017D122 64 606 SH   SOLE   606 0 0
Kratos Defense & Security Solu Common Stock 50077B207 1,095 74,101 SH   SOLE   74,101 0 0
LendingClub Corp Common Stock 52603A109 69,847 18,001,802 SH   OTR   14,610,649 146,305 3,244,848
LendingTree Inc Common Stock 52603B107 33,862 147,160 SH   OTR   121,027 5,547 20,586
magicJack VocalTec Ltd Common Stock M6787E101 537 64,357 SH   SOLE   64,357 0 0
Materialise NV ADR 57667T100 34,955 2,533,004 SH   OTR   2,312,953 10,716 209,335
Matrix IT Ltd Common Stock M6859E153 592 49,009 SH   SOLE   49,009 0 0
Mazor Robotics Ltd ADR 57886P103 6,141 105,304 SH   SOLE   105,304 0 0
Medidata Solutions Inc Common Stock 58471A105 58,951 804,133 SH   OTR   636,697 28,723 138,713
Medtronic PLC Common Stock G5960L103 648 6,588 SH   SOLE   6,588 0 0
Mellanox Technologies Ltd Common Stock M51363113 477 6,489 SH   SOLE   6,489 0 0
MercadoLibre Inc Common Stock 58733R102 41,655 122,347 SH   OTR   98,656 4,187 19,504
MGI Digital Graphic Technology Common Stock F4090S113 1,984 35,597 SH   SOLE   35,597 0 0
MGT Capital Investments Inc Common Stock 55302P202 309 2,804,453 SH   OTR   2,765,809 38,644 0
Microsoft Corp Common Stock 594918104 15,622 136,590 SH   SOLE   136,590 0 0
Moog Inc Common Stock 615394202 627 7,298 SH   SOLE   7,298 0 0
MSCI Inc Common Stock 55354G100 139 783 SH   SOLE   783 0 0
Nano Dimension Ltd ADR 63008G104 1,011 513,077 SH   SOLE   513,077 0 0
NanoString Technologies Inc Common Stock 63009R109 61,234 3,434,304 SH   OTR   3,349,399 84,905 0
Nasdaq Inc Common Stock 631103108 192 2,232 SH   SOLE   2,232 0 0
Netflix Inc Common Stock 64110L106 76,950 205,676 SH   OTR   161,332 9,944 34,400
Nice Ltd ADR 653656108 565 4,934 SH   SOLE   4,934 0 0
Nintendo Co Ltd Common Stock J51699106 62 171 SH   OTR   0 171 0
Nova Measuring Instruments Ltd Common Stock M7516K103 497 18,879 SH   SOLE   18,879 0 0
NVIDIA Corp Common Stock 67066G104 89,601 318,842 SH   OTR   249,525 9,258 60,059
NXP Semiconductors NV Common Stock N6596X109 2,910 34,038 SH   SOLE   34,038 0 0
Opera Ltd ADR 68373M107 5,681 631,887 SH   OTR   544,877 0 87,010
Orbotech Ltd Common Stock M75253100 512 8,620 SH   SOLE   8,620 0 0
Organovo Holdings Inc Common Stock 68620A104 20,644 17,951,107 SH   OTR   17,819,321 131,786 0
Pacific Biosciences of Califor Common Stock 69404D108 42,125 7,786,485 SH   OTR   7,708,358 78,127 0
Partner Communications Co Ltd Common Stock M78465107 729 137,612 SH   SOLE   137,612 0 0
PayPal Holdings Inc Common Stock 70450Y103 11,987 136,465 SH   SOLE   136,465 0 0
Pluristem Therapeutics Inc Common Stock 72940R102 3,760 2,892,231 SH   SOLE   2,892,231 0 0
Pointer Telocation Ltd Common Stock M7946T104 595 45,757 SH   SOLE   45,757 0 0
PolyOne Corp Common Stock 73179P106 60 1,362 SH   SOLE   1,362 0 0
Praxair Inc Common Stock 74005P104 62 388 SH   SOLE   388 0 0
Prodways Group SA Common Stock F7329W102 2,586 549,751 SH   SOLE   549,751 0 0
Proto Labs Inc Common Stock 743713109 13,076 80,843 SH   OTR   39,994 0 40,849
PTC Inc Common Stock 69370C100 2,026 19,077 SH   SOLE   19,077 0 0
RADCOM Ltd Common Stock M81865111 287 25,497 SH   SOLE   25,497 0 0
Radware Ltd Common Stock M81873107 522 19,730 SH   SOLE   19,730 0 0
Rakuten Inc ADR 75102W108 2,087 269,520 SH   SOLE   269,520 0 0
Rakuten Inc Common Stock J64264104 78 10,000 SH   SOLE   10,000 0 0
Red Hat Inc Common Stock 756577102 59,141 433,968 SH   OTR   341,890 15,782 76,296
Redfin Corp Common Stock 75737F108 181 9,693 SH   SOLE   9,693 0 0
Redhill Biopharma Ltd ADR 757468103 434 49,121 SH   SOLE   49,121 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 9,390 23,240 SH   SOLE   23,240 0 0
Renishaw PLC Common Stock G75006117 2,318 37,465 SH   SOLE   37,465 0 0
Rockwell Automation Inc Common Stock 773903109 1,981 10,562 SH   SOLE   10,562 0 0
Rubius Therapeutics Inc Common Stock 78116T103 4,518 188,268 SH   OTR   147,490 40,778 0
salesforce.com Inc Common Stock 79466L302 39,997 251,509 SH   OTR   185,702 11,089 54,718
Sandvik AB Common Stock W74857165 65 3,672 SH   SOLE   3,672 0 0
Sapiens International Corp NV Common Stock G7T16G103 703 53,187 SH   SOLE   53,187 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 196 6,300 SH   SOLE   6,300 0 0
Seres Therapeutics Inc Common Stock 81750R102 30,669 4,040,735 SH   OTR   3,247,770 182,117 610,848
ServiceNow Inc Common Stock 81762P102 6,486 33,152 SH   SOLE   33,152 0 0
Shopify Inc Common Stock 82509L107 17,037 103,595 SH   SOLE   103,595 0 0
Siemens AG Common Stock D69671218 543 4,239 SH   SOLE   4,239 0 0
Silicom Ltd Common Stock M84116108 580 14,299 SH   SOLE   14,299 0 0
SLM Solutions Group AG Common Stock D6T690109 1,896 78,120 SH   SOLE   78,120 0 0
SoftBank Group Corp ADR 83404D109 7,749 155,768 SH   SOLE   155,768 0 0
SoftBank Group Corp Common Stock J75963108 56 555 SH   OTR   0 555 0
SolarEdge Technologies Inc Common Stock 83417M104 376 9,985 SH   SOLE   9,985 0 0
Spark Therapeutics Inc Common Stock 84652J103 7 129 SH   SOLE   129 0 0
Splunk Inc Common Stock 848637104 43,468 359,506 SH   OTR   284,727 17,042 57,737
Spotify Technology SA Common Stock L8681T102 50,186 277,532 SH   OTR   210,201 11,221 56,110
Square Inc Common Stock 852234103 102,154 1,031,750 SH   OTR   757,966 38,555 235,229
Starbucks Corp Common Stock 855244109 212 3,727 SH   SOLE   3,727 0 0
Stratasys Ltd Common Stock M85548101 159,673 6,909,266 SH   OTR   5,075,614 296,658 1,536,994
Stryker Corp Common Stock 863667101 599 3,370 SH   SOLE   3,370 0 0
Suny Cellular Communication Lt Common Stock M8708U107 515 1,061,983 SH   SOLE   1,061,983 0 0
Syros Pharmaceuticals Inc Common Stock 87184Q107 26,462 2,221,870 SH   OTR   1,937,207 23,615 261,048
Taiwan Semiconductor Manufactu ADR 874039100 43,649 988,428 SH   OTR   855,459 27,534 105,435
Taro Pharmaceutical Industries Common Stock M8737E108 466 4,743 SH   SOLE   4,743 0 0
Teladoc Health Inc Common Stock 87918A105 7,753 89,791 SH   SOLE   89,791 0 0
Tencent Holdings Ltd ADR 88032Q109 111,170 2,722,096 SH   OTR   2,193,489 92,136 436,471
Teradyne Inc Common Stock 880770102 64,026 1,731,366 SH   OTR   1,232,560 83,196 415,610
Tesla Inc Common Stock 88160R101 197,710 746,725 SH   OTR   710,245 36,480 0
Teva Pharmaceutical Industries ADR 881624209 497 23,063 SH   SOLE   23,063 0 0
Together Startup Network Ltd Common Stock M1499P106 513 285,181 SH   SOLE   285,181 0 0
Toray Industries Inc Common Stock J89494116 62 8,236 SH   SOLE   8,236 0 0
Tower Semiconductor Ltd Common Stock M87915274 524 24,089 SH   SOLE   24,089 0 0
Toyota Motor Corp ADR 892331307 2,091 16,816 SH   SOLE   16,816 0 0
Trade Me Group Ltd Common Stock Q9162N106 15 4,434 SH   SOLE   4,434 0 0
TransUnion Common Stock 89400J107 181 2,456 SH   SOLE   2,456 0 0
Trimble Inc Common Stock 896239100 7,971 183,417 SH   SOLE   183,417 0 0
Twitter Inc Common Stock 90184L102 117,342 4,123,045 SH   OTR   3,157,494 165,784 799,767
Ultra Clean Holdings Inc Common Stock 90385V107 456 36,310 SH   SOLE   36,310 0 0
United Parcel Service Inc Common Stock 911312106 603 5,164 SH   SOLE   5,164 0 0
UroGen Pharma Ltd Common Stock M96088105 532 11,258 SH   SOLE   11,258 0 0
Veracyte Inc Common Stock 92337F107 37,635 3,940,804 SH   OTR   3,913,590 27,214 0
Verisk Analytics Inc Common Stock 92345Y106 186 1,546 SH   SOLE   1,546 0 0
Visa Inc Common Stock 92826C839 180 1,198 SH   SOLE   1,198 0 0
Wirecard AG ADR 97654L108 72 663 SH   SOLE   663 0 0
Wix.com Ltd Common Stock M98068105 598 4,992 SH   SOLE   4,992 0 0
Workday Inc Common Stock 98138H101 195 1,334 SH   SOLE   1,334 0 0
Xero Ltd Common Stock Q98665104 51 1,434 SH   SOLE   1,434 0 0
Xilinx Inc Common Stock 983919101 50,939 635,388 SH   OTR   510,340 20,172 104,876
YY Inc ADR 98426T106 3,511 46,859 SH   SOLE   46,859 0 0
Zillow Group Inc Common Stock 98954M200 43,708 987,749 SH   OTR   779,271 36,089 172,389
Zuora Inc Common Stock 98983V106 6,916 299,269 SH   SOLE   299,269 0 0