The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
58.Com Inc Adr SPON ADR REP A 31680Q104 56,413 766,483 SH   DFND 1 766,483 0 0
58.Com Inc Adr SPON ADR REP A 31680Q104 105,006 1,426,716 SH   SOLE 0 1,381,182 0 45,534
58.Com Inc Adr SPON ADR REP A 31680Q104 189,574 2,575,737 SH   DFND 2 2,023,013 0 552,724
AJ Gallagher & Co COM 363576109 279,071 3,748,941 SH   DFND 2 2,979,074 0 769,867
AJ Gallagher & Co COM 363576109 89,450 1,201,636 SH   DFND 1 1,201,636 0 0
AJ Gallagher & Co COM 363576109 161,853 2,174,270 SH   SOLE 0 2,108,154 0 66,116
Abiomed COM 003654100 213,401 474,488 SH   DFND 1 474,488 0 0
Abiomed COM 003654100 62,871 139,792 SH   DFND 2 38,474 0 101,318
Abiomed COM 003654100 85,600 190,327 SH   SOLE 0 190,327 0 0
Acacia Reasearch Corp ACACIA TCH COM 003881307 460 143,640 SH   DFND 1 143,640 0 0
Acacia Reasearch Corp ACACIA TCH COM 003881307 711 222,180 SH   SOLE 0 222,180 0 0
Activision Blizzard Inc COM 00507V109 34,774 418,009 SH   DFND 1 418,009 0 0
Activision Blizzard Inc COM 00507V109 45,090 542,011 SH   DFND 2 341,814 0 200,197
Activision Blizzard Inc COM 00507V109 12,972 155,936 SH   SOLE 0 155,936 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 20,638 1,521,955 SH   DFND 1 1,521,955 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 16,204 1,194,975 SH   DFND 2 544,193 0 650,782
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 9,501 700,697 SH   SOLE 0 700,697 0 0
Aduro Biotechnology COM 00739L101 8,956 1,218,456 SH   DFND 1 1,218,456 0 0
Aduro Biotechnology COM 00739L101 4,302 585,293 SH   SOLE 0 585,293 0 0
Aduro Biotechnology COM 00739L101 9,357 1,273,076 SH   DFND 2 576,501 0 696,575
Advanced Micro Devices COM 007903107 121,124 3,921,125 SH   DFND 2 3,091,010 0 830,115
Advanced Micro Devices COM 007903107 35,568 1,151,452 SH   DFND 1 1,151,452 0 0
Advanced Micro Devices COM 007903107 73,949 2,393,937 SH   SOLE 0 2,324,800 0 69,137
Aerovironment COM 008073108 28,659 255,494 SH   DFND 2 116,064 0 139,430
Aerovironment COM 008073108 37,175 331,417 SH   DFND 1 331,417 0 0
Aerovironment COM 008073108 24,741 220,567 SH   SOLE 0 220,567 0 0
Agios Pharmaceuticals COM 00847X104 32,203 417,565 SH   DFND 1 417,565 0 0
Agios Pharmaceuticals COM 00847X104 7,370 95,566 SH   DFND 2 14,080 0 81,486
Agios Pharmaceuticals COM 00847X104 12,132 157,312 SH   SOLE 0 157,312 0 0
Albemarle Corp COM 012653101 133,307 1,336,005 SH   DFND 2 1,063,036 0 272,969
Albemarle Corp COM 012653101 47,299 474,037 SH   DFND 1 474,037 0 0
Albemarle Corp COM 012653101 81,069 812,482 SH   SOLE 0 790,264 0 22,218
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 5,353,051 32,489,993 SH   DFND 2 12,255,312 0 20,234,681
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 596,864 3,622,627 SH   DFND 1 3,622,627 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 1,517,276 9,209,007 SH   SOLE 0 7,578,178 0 1,630,829
Align Technology Inc COM 016255101 5,355 13,688 SH   DFND 2 13,688 0 0
Alnylam Pharmaceuticals COM 02043Q107 108,558 1,240,378 SH   DFND 1 1,240,378 0 0
Alnylam Pharmaceuticals COM 02043Q107 159,472 1,822,120 SH   DFND 2 1,226,985 0 595,135
Alnylam Pharmaceuticals COM 02043Q107 122,557 1,400,328 SH   SOLE 0 1,382,940 0 17,388
Alphabet Inc Class A CAP STK CL A 02079K305 27,030 22,393 SH   DFND 2 19,607 0 2,786
Alphabet Inc Class A CAP STK CL A 02079K305 27,995 23,192 SH   DFND 1 23,192 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 95,596 79,196 SH   SOLE 0 79,196 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 473,897 397,075 SH   DFND 1 397,075 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 1,471,041 1,232,575 SH   DFND 2 644,955 0 587,620
Alphabet Inc Class C CAP STK CL C 02079K107 812,402 680,706 SH   SOLE 0 541,526 0 139,180
Amazon.Com COM 023135106 1,157,127 577,697 SH   DFND 1 577,697 0 0
Amazon.Com COM 023135106 5,174,596 2,583,423 SH   DFND 2 926,188 0 1,657,235
Amazon.Com COM 023135106 2,753,290 1,374,583 SH   SOLE 0 1,167,612 0 206,971
Ambarella SHS G037AX101 4,701 121,543 SH   DFND 2 55,298 0 66,245
Ambarella SHS G037AX101 5,705 147,500 SH   DFND 1 147,500 0 0
Ambarella SHS G037AX101 3,775 97,605 SH   SOLE 0 97,605 0 0
Ameren COM 023608102 16,219 256,550 SH   DFND 1 256,550 0 0
Ameren COM 023608102 949 15,010 SH   DFND 2 15,010 0 0
American Express COM 025816109 3,694 34,687 SH   DFND 1 34,687 0 0
American Express COM 025816109 19,557 183,651 SH   DFND 2 183,651 0 0
American Express COM 025816109 3,578 33,604 SH   SOLE 0 33,604 0 0
Analog Devices COM 032654105 13,683 147,986 SH   DFND 1 147,986 0 0
Analog Devices COM 032654105 15,917 172,154 SH   SOLE 0 172,154 0 0
Annaly Capital Man. COM 035710409 117 11,433 SH   DFND 1 11,433 0 0
Anthem Inc COM 036752103 193,391 705,678 SH   DFND 1 705,678 0 0
Anthem Inc COM 036752103 657,608 2,399,591 SH   DFND 2 1,893,563 0 506,028
Anthem Inc COM 036752103 369,196 1,347,186 SH   SOLE 0 1,305,193 0 41,993
Apache Corp COM 037411105 189,134 3,967,562 SH   DFND 1 3,967,562 0 0
Apache Corp COM 037411105 623,346 13,076,264 SH   DFND 2 10,316,818 0 2,759,446
Apache Corp COM 037411105 350,594 7,354,615 SH   SOLE 0 7,124,004 0 230,611
Apollo Commercial Real Estate Finance REIT COM 03762U105 138 7,300 SH   DFND 1 7,300 0 0
Apple COM 037833100 15,296 67,761 SH   SOLE 0 67,761 0 0
Apple COM 037833100 12,893 57,114 SH   DFND 1 57,114 0 0
Aslan Pharmaceuticals ADR ADS 04522R101 2,249 292,885 SH   DFND 1 292,885 0 0
Aslan Pharmaceuticals ADR ADS 04522R101 1,208 157,248 SH   SOLE 0 157,248 0 0
Atlassian Corp Plc CL A G06242104 94,097 978,751 SH   DFND 1 978,751 0 0
Atlassian Corp Plc CL A G06242104 483,401 5,028,092 SH   DFND 2 1,812,515 0 3,215,577
Atlassian Corp Plc CL A G06242104 176,722 1,838,172 SH   SOLE 0 926,590 0 911,582
Autohome Inc - ADR SP ADR RP CL A 05278C107 40,139 518,529 SH   DFND 1 518,529 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 140,950 1,820,820 SH   DFND 2 1,437,931 0 382,889
Autohome Inc - ADR SP ADR RP CL A 05278C107 80,095 1,034,681 SH   SOLE 0 1,003,042 0 31,639
Avangrid COM 05351W103 16,024 334,330 SH   DFND 1 334,330 0 0
Avangrid COM 05351W103 1,066 22,250 SH   DFND 2 22,250 0 0
Axogen Inc COM 05463X106 155 4,200 SH   DFND 1 4,200 0 0
Axogen Inc COM 05463X106 187 5,068 SH   DFND 2 2,300 0 2,768
Axogen Inc COM 05463X106 129 3,500 SH   SOLE 0 3,500 0 0
BRF SA-ADR SPONSORED ADR 10552T107 11,384 2,077,329 SH   DFND 1 2,077,329 0 0
BRF SA-ADR SPONSORED ADR 10552T107 65,987 12,041,394 SH   DFND 2 4,874,732 0 7,166,662
Baidu.com Sponsored ADR SPON ADR REP A 056752108 263,570 1,152,573 SH   DFND 1 1,152,573 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 3,125,575 13,667,897 SH   DFND 2 4,863,238 0 8,804,659
Baidu.com Sponsored ADR SPON ADR REP A 056752108 836,210 3,656,684 SH   SOLE 0 3,009,294 0 647,390
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 14,446 2,040,421 SH   DFND 1 2,040,421 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 126,299 17,838,862 SH   DFND 2 8,096,062 0 9,742,800
Banco Macro ADR SPON ADR B 05961W105 3,382 81,747 SH   DFND 1 81,747 0 0
Banco Macro ADR SPON ADR B 05961W105 15,538 375,594 SH   DFND 2 197,406 0 178,188
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 16,688 343,508 SH   DFND 1 343,508 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 16,840 346,645 SH   DFND 2 157,120 0 189,525
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 11,800 242,900 SH   SOLE 0 242,900 0 0
Beigene Ltd SPONSORED ADR 07725L102 2,657 15,428 SH   DFND 1 15,428 0 0
Beigene Ltd SPONSORED ADR 07725L102 11,427 66,350 SH   DFND 2 0 0 66,350
Benefitfocus Inc COM 08180D106 12,396 306,448 SH   DFND 1 306,448 0 0
Benefitfocus Inc COM 08180D106 9,157 226,368 SH   SOLE 0 226,368 0 0
Benefitfocus Inc COM 08180D106 11,103 274,498 SH   DFND 2 110,265 0 164,233
BitAuto Holdings Ltd - ADR SPONSORED ADS 091727107 1,337 58,113 SH   SOLE 0 58,113 0 0
BlackRock Floating Rate Income COM 091941104 10,595 802,669 SH   DFND 1 802,669 0 0
Blackline COM 09239B109 13,807 244,505 SH   DFND 1 244,505 0 0
Blackline COM 09239B109 11,763 208,310 SH   DFND 2 95,246 0 113,064
Blackline COM 09239B109 7,859 139,175 SH   SOLE 0 139,175 0 0
Blue Apron Holdings Inc CL A 09523Q101 2,259 1,313,400 SH   DFND 1 1,313,400 0 0
Blue Capital Reinsurance Holdings Fund (USD) COM G1190F107 6,420 629,438 SH   DFND 1 629,438 0 0
Bluebird Bio Inc COM 09609G100 66,621 456,306 SH   DFND 1 456,306 0 0
Bluebird Bio Inc COM 09609G100 338,229 2,316,634 SH   DFND 2 833,597 0 1,483,037
Bluebird Bio Inc COM 09609G100 273,106 1,870,588 SH   SOLE 0 1,448,909 0 421,679
British Amer.Tobacco - ADR SPONSORED ADR 110448107 4,998 107,189 SH   DFND 1 107,189 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 1,404 30,117 SH   SOLE 0 30,117 0 0
CEVA Inc COM 157210105 4,090 142,260 SH   DFND 2 65,667 0 76,593
CEVA Inc COM 157210105 4,513 156,980 SH   DFND 1 156,980 0 0
CEVA Inc COM 157210105 2,372 82,500 SH   SOLE 0 82,500 0 0
CH Robinson Worldwide COM NEW 12541W209 92,336 942,976 SH   DFND 1 942,976 0 0
CH Robinson Worldwide COM NEW 12541W209 252,269 2,576,275 SH   DFND 2 2,072,802 0 503,473
CH Robinson Worldwide COM NEW 12541W209 155,751 1,590,593 SH   SOLE 0 1,547,656 0 42,937
CarMax Inc COM 143130102 5,204 69,698 SH   DFND 1 69,698 0 0
CarMax Inc COM 143130102 24,782 331,891 SH   DFND 2 331,891 0 0
CarMax Inc COM 143130102 4,935 66,093 SH   SOLE 0 66,093 0 0
Celgene COM 151020104 37,653 420,749 SH   DFND 1 420,749 0 0
Celgene COM 151020104 27,848 311,187 SH   DFND 2 234,475 0 76,712
Celgene COM 151020104 15,968 178,433 SH   SOLE 0 178,433 0 0
Cemex ADR SPON ADR NEW 151290889 35,991 5,112,336 SH   DFND 1 5,112,336 0 0
Cemex ADR SPON ADR NEW 151290889 184,116 26,152,851 SH   DFND 2 5,968,698 0 20,184,153
Cemex ADR SPON ADR NEW 151290889 8,979 1,275,421 SH   SOLE 0 1,275,421 0 0
Chegg COM 163092109 66,138 2,326,354 SH   DFND 1 2,326,354 0 0
Chegg COM 163092109 32,305 1,136,292 SH   DFND 2 436,321 0 699,971
Chegg COM 163092109 59,367 2,088,195 SH   SOLE 0 2,088,195 0 0
China Biologic Products Holdings Inc COM G21515104 11,263 140,782 SH   DFND 1 140,782 0 0
China Biologic Products Holdings Inc COM G21515104 37,768 472,096 SH   DFND 2 371,279 0 100,817
China Biologic Products Holdings Inc COM G21515104 21,538 269,227 SH   SOLE 0 260,849 0 8,378
China Rapid Finance ADR SPONSORED ADR 16953Q105 858 300,000 SH   SOLE 0 300,000 0 0
Chipotle Mexican Grill COM 169656105 124,647 274,238 SH   DFND 2 216,183 0 58,055
Chipotle Mexican Grill COM 169656105 36,508 80,321 SH   DFND 1 80,321 0 0
Chipotle Mexican Grill COM 169656105 68,782 151,329 SH   SOLE 0 146,518 0 4,811
CoStar Group COM 22160N109 59,452 141,270 SH   DFND 1 141,270 0 0
CoStar Group COM 22160N109 14,083 33,463 SH   DFND 2 4,816 0 28,647
CoStar Group COM 22160N109 22,947 54,527 SH   SOLE 0 54,527 0 0
Coca Cola COM 191216100 18,614 402,997 SH   DFND 1 402,997 0 0
Coca Cola COM 191216100 21,703 469,871 SH   SOLE 0 469,871 0 0
Codexis COM 192005106 18,595 1,084,273 SH   DFND 1 1,084,273 0 0
Codexis COM 192005106 19,162 1,117,329 SH   DFND 2 507,958 0 609,371
Codexis COM 192005106 10,284 599,635 SH   SOLE 0 599,635 0 0
Consolidated Edison COM 209115104 15,713 206,230 SH   DFND 1 206,230 0 0
Consolidated Edison COM 209115104 836 10,972 SH   DFND 2 10,972 0 0
Copa Holdings S A CL A P31076105 8,057 100,915 SH   DFND 1 100,915 0 0
Copa Holdings S A CL A P31076105 222,496 2,786,775 SH   DFND 2 1,550,249 0 1,236,526
Copa Holdings S A CL A P31076105 22,182 277,829 SH   SOLE 0 277,829 0 0
Credicorp COM G2519Y108 403,779 1,810,021 SH   DFND 2 769,811 0 1,040,210
Credicorp COM G2519Y108 16,599 74,409 SH   DFND 1 74,409 0 0
Credicorp COM G2519Y108 25,988 116,497 SH   SOLE 0 116,497 0 0
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 1,418,994 38,175,792 SH   DFND 2 15,391,279 0 22,784,513
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 144,424 3,885,495 SH   DFND 1 3,885,495 0 0
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 420,502 11,312,935 SH   SOLE 0 9,095,084 0 2,217,851
Cullen/Frost Bankers COM 229899109 6,793 65,039 SH   DFND 1 65,039 0 0
Cullen/Frost Bankers COM 229899109 7,885 75,495 SH   SOLE 0 75,495 0 0
CyberArk Software Ltd SHS M2862V108 8,790 110,100 SH   DFND 1 110,100 0 0
CyberArk Software Ltd SHS M2862V108 9,285 116,300 SH   DFND 2 52,700 0 63,600
CyberArk Software Ltd SHS M2862V108 6,427 80,500 SH   SOLE 0 80,500 0 0
Denali Therapeutics COM 24823R105 34,680 1,595,203 SH   DFND 1 1,595,203 0 0
Denali Therapeutics COM 24823R105 8,243 379,172 SH   DFND 2 53,745 0 325,427
Denali Therapeutics COM 24823R105 76,352 3,512,046 SH   SOLE 0 3,512,046 0 0
Dexcom Inc COM 252131107 102,813 718,770 SH   DFND 1 718,770 0 0
Dexcom Inc COM 252131107 461,916 3,229,276 SH   DFND 2 1,195,469 0 2,033,807
Dexcom Inc COM 252131107 163,945 1,146,151 SH   SOLE 0 616,053 0 530,098
Digimarc COM 25381B101 2,925 93,000 SH   DFND 1 93,000 0 0
Digimarc COM 25381B101 2,563 81,500 SH   SOLE 0 81,500 0 0
Digimarc COM 25381B101 8,838 281,023 SH   DFND 2 129,288 0 151,735
Dolby Laboratories 'A' COM 25659T107 7,276 103,987 SH   DFND 1 103,987 0 0
Dolby Laboratories 'A' COM 25659T107 8,323 118,951 SH   SOLE 0 118,951 0 0
Dropbox Inc Class A Common Stock CL A 26210C104 19,765 736,666 SH   SOLE 0 736,666 0 0
Dropbox Inc Class B Common Stock CL A 26210C104 38,884 1,449,275 SH   SOLE 0 1,449,275 0 0
EOG Resources COM 26875P101 97,568 764,821 SH   DFND 1 764,821 0 0
EOG Resources COM 26875P101 352,537 2,763,476 SH   DFND 2 2,226,928 0 536,548
EOG Resources COM 26875P101 181,652 1,423,943 SH   SOLE 0 1,380,772 0 43,171
Ecolab COM 278865100 2,186 13,942 SH   DFND 1 13,942 0 0
Ecolab COM 278865100 4,594 29,303 SH   DFND 2 17,680 0 11,623
Edison International COM 281020107 13,759 203,300 SH   DFND 1 203,300 0 0
Edison International COM 281020107 855 12,640 SH   DFND 2 12,640 0 0
Ellie Mae COM 28849P100 58,696 619,348 SH   DFND 1 619,348 0 0
Ellie Mae COM 28849P100 21,058 222,200 SH   DFND 2 63,978 0 158,222
Ellie Mae COM 28849P100 25,064 264,472 SH   SOLE 0 264,472 0 0
Embraer ADR SP ADR REP 4 COM 29082A107 1,540 78,613 SH   DFND 1 78,613 0 0
Embraer ADR SP ADR REP 4 COM 29082A107 17,295 882,841 SH   DFND 2 70,684 0 812,157
Estee Lauder 'A' COM 518439104 27,968 192,461 SH   DFND 2 192,461 0 0
Eversource Energy COM 30040W108 16,392 266,790 SH   DFND 1 266,790 0 0
Eversource Energy COM 30040W108 1,181 19,223 SH   DFND 2 19,223 0 0
Evolent Health Inc A CL A 30050B101 9,944 350,153 SH   DFND 2 159,910 0 190,243
Evolent Health Inc A CL A 30050B101 10,218 359,780 SH   DFND 1 359,780 0 0
Evolent Health Inc A CL A 30050B101 8,327 293,216 SH   SOLE 0 293,216 0 0
Exact Sciences COM 30063P105 26,820 339,836 SH   DFND 1 339,836 0 0
Exact Sciences COM 30063P105 22,211 281,436 SH   DFND 2 133,054 0 148,382
Exact Sciences COM 30063P105 19,166 242,857 SH   SOLE 0 242,857 0 0
Exelon Corporation COM 30161N101 17,920 410,440 SH   DFND 1 410,440 0 0
Exelon Corporation COM 30161N101 959 21,965 SH   DFND 2 21,965 0 0
Facebook Cl.A CL A 30303M102 457,001 2,778,795 SH   DFND 1 2,778,795 0 0
Facebook Cl.A CL A 30303M102 1,543,234 9,383,642 SH   DFND 2 4,266,420 0 5,117,222
Facebook Cl.A CL A 30303M102 794,626 4,831,729 SH   SOLE 0 3,516,540 0 1,315,189
Faro Technologies COM 311642102 5,110 79,415 SH   DFND 1 79,415 0 0
Faro Technologies COM 311642102 9,994 155,313 SH   DFND 2 69,736 0 85,577
Faro Technologies COM 311642102 6,942 107,880 SH   SOLE 0 107,880 0 0
Fastenal COM 311900104 20,389 351,406 SH   DFND 1 351,406 0 0
Fastenal COM 311900104 14,832 255,635 SH   DFND 2 255,635 0 0
Fastenal COM 311900104 22,448 386,897 SH   SOLE 0 386,897 0 0
Federal Realty Investment Trust REIT SH BEN INT NEW 313747206 266 2,100 SH   DFND 1 2,100 0 0
Ferrari NV COM N3167Y103 1,631,489 11,843,504 SH   DFND 2 3,621,982 0 8,221,522
Ferrari NV COM N3167Y103 330,609 2,400,000 SH   SOLE 0 2,400,000 0 0
Fiat Chrysler Automobiles SHS N31738102 162,749 9,252,485 SH   SOLE 0 8,956,903 0 295,582
Fiat Chrysler Automobiles SHS N31738102 88,512 5,032,027 SH   DFND 1 5,032,027 0 0
Fiat Chrysler Automobiles SHS N31738102 1,022,386 58,123,968 SH   DFND 2 27,214,551 0 30,909,417
First Republic Bank COM 33616C100 264,015 2,750,161 SH   DFND 2 2,095,087 0 655,074
First Republic Bank COM 33616C100 161,150 1,678,641 SH   SOLE 0 1,641,101 0 37,540
First Republic Bank COM 33616C100 171,658 1,788,108 SH   DFND 1 1,788,108 0 0
Foamix Pharmaceuticals SHS M46135105 637 111,200 SH   SOLE 0 111,200 0 0
Foamix Pharmaceuticals SHS M46135105 620 108,200 SH   DFND 1 108,200 0 0
Fortive Corp COM 34959J108 29,696 352,686 SH   DFND 2 226,765 0 125,921
Fortive Corp COM 34959J108 56,492 670,927 SH   DFND 1 670,927 0 0
Fortive Corp COM 34959J108 23,780 282,417 SH   SOLE 0 282,417 0 0
Glaukos Corp COM 377322102 52,208 804,435 SH   DFND 1 804,435 0 0
Glaukos Corp COM 377322102 18,820 289,991 SH   SOLE 0 289,991 0 0
Glaukos Corp COM 377322102 16,686 257,105 SH   DFND 2 73,896 0 183,209
Grubhub Inc COM 400110102 381,248 2,750,310 SH   DFND 1 2,750,310 0 0
Grubhub Inc COM 400110102 438,955 3,166,607 SH   DFND 2 2,105,222 0 1,061,385
Grubhub Inc COM 400110102 362,281 2,613,481 SH   SOLE 0 2,571,912 0 41,569
Grupo Financiero Galicia ADR COM 399909100 23,094 908,139 SH   DFND 2 93,263 0 814,876
Grupo Financiero Galicia ADR COM 399909100 2,315 91,041 SH   DFND 1 91,041 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 70,031 744,217 SH   SOLE 0 744,217 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 56,003 595,145 SH   DFND 2 441,358 0 153,787
HEICO COM 422806109 14,380 155,274 SH   DFND 1 155,274 0 0
HEICO COM 422806109 8,642 93,311 SH   SOLE 0 93,311 0 0
HEICO 'A' CL A 422806208 33,511 443,850 SH   DFND 2 322,587 0 121,263
HEICO 'A' CL A 422806208 25,615 339,275 SH   DFND 1 339,275 0 0
HEICO 'A' CL A 422806208 5,391 71,406 SH   SOLE 0 71,406 0 0
Himax Technologies Adr SPONSORED ADR 43289P106 3,974 675,800 SH   DFND 2 0 0 675,800
Howard Hughes COM 44267D107 31,961 257,292 SH   DFND 1 257,292 0 0
Howard Hughes COM 44267D107 111,555 898,047 SH   DFND 2 711,534 0 186,513
Howard Hughes COM 44267D107 65,952 530,932 SH   SOLE 0 514,304 0 16,628
Hutchison China Meditech SPONSORED ADR 44842L103 1,664 51,696 SH   DFND 1 51,696 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 4,701 146,050 SH   DFND 2 0 0 146,050
ICICI Bank ADR ADR 45104G104 197,534 23,266,706 SH   DFND 2 19,496,980 0 3,769,726
ICICI Bank ADR ADR 45104G104 144,471 17,016,660 SH   DFND 1 17,016,660 0 0
ICICI Bank ADR ADR 45104G104 193,086 22,742,745 SH   SOLE 0 22,742,745 0 0
IPG Photonics Corp COM 44980X109 18,733 120,028 SH   DFND 2 54,400 0 65,628
IPG Photonics Corp COM 44980X109 12,477 79,947 SH   DFND 1 79,947 0 0
IPG Photonics Corp COM 44980X109 11,492 73,636 SH   SOLE 0 73,636 0 0
Illumina COM 452327109 600,770 1,636,708 SH   DFND 1 1,636,708 0 0
Illumina COM 452327109 3,535,510 9,631,967 SH   DFND 2 2,583,546 0 7,048,421
Illumina COM 452327109 1,787,152 4,868,829 SH   SOLE 0 3,835,651 0 1,033,178
Infosys Ltd ADR SPONSORED ADR 456788108 7,426 730,196 SH   DFND 1 730,196 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 4,163 409,343 SH   DFND 2 391,835 0 17,508
Interactive Brokers Group COM 45841N107 94,714 1,712,427 SH   DFND 1 1,712,427 0 0
Interactive Brokers Group COM 45841N107 161,840 2,926,057 SH   DFND 2 2,276,782 0 649,275
Interactive Brokers Group COM 45841N107 95,490 1,726,454 SH   SOLE 0 1,685,868 0 40,586
Intuitive Surgical COM NEW 46120E602 142,211 247,755 SH   DFND 1 247,755 0 0
Intuitive Surgical COM NEW 46120E602 733,493 1,277,862 SH   DFND 2 453,749 0 824,113
Intuitive Surgical COM NEW 46120E602 443,603 772,827 SH   SOLE 0 540,436 0 232,391
Invesco Senior Income Trust COM 46131H107 12,892 2,998,119 SH   DFND 1 2,998,119 0 0
Invesco Senior Income Trust COM 46131H107 1,344 312,581 SH   DFND 2 312,581 0 0
Ionis Pharmaceuticals COM 462222100 56,944 1,103,986 SH   DFND 1 1,103,986 0 0
Ionis Pharmaceuticals COM 462222100 108,667 2,106,771 SH   SOLE 0 1,065,152 0 1,041,619
Ionis Pharmaceuticals COM 462222100 296,449 5,747,356 SH   DFND 2 2,056,537 0 3,690,819
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 281,119 25,602,804 SH   DFND 2 8,507,691 0 17,095,113
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 13,772 1,254,318 SH   DFND 1 1,254,318 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 14,588 1,328,635 SH   SOLE 0 1,328,635 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 39,081 1,497,918 SH   DFND 1 1,497,918 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 216,269 8,289,351 SH   DFND 2 4,393,510 0 3,895,841
JD.Com Inc - ADR SPON ADR CL A 47215P106 16,859 646,177 SH   SOLE 0 646,177 0 0
Jefferies Financial Group Inc COM 47233W109 48,229 2,196,216 SH   DFND 1 2,196,216 0 0
Jefferies Financial Group Inc COM 47233W109 162,465 7,398,232 SH   DFND 2 5,800,211 0 1,598,021
Jefferies Financial Group Inc COM 47233W109 92,345 4,205,144 SH   SOLE 0 4,075,402 0 129,742
Jianpu Technology Inc- ADR ADR 47738D101 4,546 929,638 SH   DFND 1 929,638 0 0
Jianpu Technology Inc- ADR ADR 47738D101 4,733 967,818 SH   SOLE 0 967,818 0 0
Johnson & Johnson COM 478160104 14,469 104,717 SH   DFND 1 104,717 0 0
Johnson & Johnson COM 478160104 16,188 117,160 SH   SOLE 0 117,160 0 0
Kirby COM 497266106 74,564 906,558 SH   DFND 1 906,558 0 0
Kirby COM 497266106 253,321 3,079,895 SH   DFND 2 2,430,464 0 649,431
Kirby COM 497266106 141,017 1,714,494 SH   SOLE 0 1,660,272 0 54,222
Korea Electric Power ADR SPONSORED ADR 500631106 860 65,300 SH   DFND 2 65,300 0 0
LendingTree COM 52603B107 66,114 287,328 SH   DFND 1 287,328 0 0
LendingTree COM 52603B107 153,056 665,170 SH   DFND 2 459,156 0 206,014
LendingTree COM 52603B107 100,405 436,354 SH   SOLE 0 428,345 0 8,009
Liberty Media Corp DEB 4.00011/1 530715AG6 8,606 13,068,000 SH   DFND 1 13,068,000 0 0
Liberty Media Corp DEB 4.00011/1 530715AG6 1,018 1,546,000 SH   DFND 2 1,546,000 0 0
Lincoln Electric Hdg. COM 533900106 6,714 71,858 SH   DFND 2 71,858 0 0
Lindblad Expeditions Holdings COM 535219109 15,951 1,072,701 SH   SOLE 0 1,072,701 0 0
Line Corp Sponsored Adr SPONSORED ADR 53567X101 14,236 337,899 SH   DFND 2 10,721 0 327,178
Luxoft Holding ORD SHS CL A G57279104 4,590 96,930 SH   DFND 2 0 0 96,930
M&T Bank COM 55261F104 17,160 104,293 SH   DFND 2 104,293 0 0
MRC Global COM 55345K103 12,201 650,000 SH   SOLE 0 650,000 0 0
MakeMyTrip SHS V5633W109 71,036 2,587,819 SH   DFND 2 1,951,554 0 636,265
Markel Corp COM 570535104 138,794 116,782 SH   DFND 1 116,782 0 0
Markel Corp COM 570535104 334,442 281,401 SH   DFND 2 221,340 0 60,061
Markel Corp COM 570535104 188,883 158,927 SH   SOLE 0 154,631 0 4,296
MarketAxess Holdings COM 57060D108 270,158 1,513,576 SH   DFND 2 1,068,209 0 445,367
MarketAxess Holdings COM 57060D108 205,729 1,152,606 SH   DFND 1 1,152,606 0 0
MarketAxess Holdings COM 57060D108 181,400 1,016,305 SH   SOLE 0 998,228 0 18,077
Martin Marietta Materials COM 573284106 123,094 676,529 SH   DFND 1 676,529 0 0
Martin Marietta Materials COM 573284106 302,281 1,661,342 SH   DFND 2 1,303,528 0 357,814
Martin Marietta Materials COM 573284106 173,609 954,156 SH   SOLE 0 927,497 0 26,659
Mastercard Inc-Class A CL A 57636Q104 284,190 1,276,628 SH   DFND 1 1,276,628 0 0
Mastercard Inc-Class A CL A 57636Q104 623,729 2,801,893 SH   DFND 2 2,175,910 0 625,983
Mastercard Inc-Class A CL A 57636Q104 356,231 1,600,245 SH   SOLE 0 1,557,117 0 43,128
McDonald's COM 580135101 11,748 70,225 SH   DFND 1 70,225 0 0
McDonald's COM 580135101 13,606 81,333 SH   SOLE 0 81,333 0 0
MercadoLibre COM 58733R102 55,894 164,167 SH   DFND 1 164,167 0 0
MercadoLibre COM 58733R102 1,591,441 4,674,247 SH   DFND 2 1,723,338 0 2,950,909
MercadoLibre COM 58733R102 85,886 252,258 SH   SOLE 0 252,258 0 0
Mettler-Toledo COM 592688105 50,712 83,274 SH   DFND 1 83,274 0 0
Mettler-Toledo COM 592688105 281,095 461,583 SH   DFND 2 346,622 0 114,961
Mettler-Toledo COM 592688105 31,039 50,969 SH   SOLE 0 50,969 0 0
Microchip Technology COM 595017104 6,523 82,660 SH   DFND 2 82,660 0 0
Microsoft COM 594918104 17,068 149,231 SH   DFND 1 149,231 0 0
Microsoft COM 594918104 38,159 333,643 SH   DFND 2 333,643 0 0
Microsoft COM 594918104 19,643 171,753 SH   SOLE 0 171,753 0 0
Mindbody Cl A COM CL A 60255W105 8,334 205,026 SH   DFND 1 205,026 0 0
Mindbody Cl A COM CL A 60255W105 9,487 233,378 SH   DFND 2 104,969 0 128,409
Mindbody Cl A COM CL A 60255W105 4,944 121,628 SH   SOLE 0 121,628 0 0
Mobile Telesystems ADR SPONSORED ADR 607409109 116 13,600 SH   DFND 1 13,600 0 0
Moody's Corp COM 615369105 156,149 933,906 SH   DFND 1 933,906 0 0
Moody's Corp COM 615369105 548,531 3,280,689 SH   DFND 2 2,608,909 0 671,780
Moody's Corp COM 615369105 296,675 1,774,375 SH   SOLE 0 1,718,978 0 55,397
Myriad Genetics Inc COM 62855J104 70,471 1,531,974 SH   DFND 1 1,531,974 0 0
Myriad Genetics Inc COM 62855J104 237,744 5,168,348 SH   DFND 2 4,055,476 0 1,112,872
Myriad Genetics Inc COM 62855J104 130,956 2,846,871 SH   SOLE 0 2,755,229 0 91,642
NIO Inc ADR SPON ADS 62914V106 359,651 51,525,869 SH   DFND 2 15,117,406 0 36,408,463
NIO Inc ADR SPON ADS 62914V106 26,136 3,744,374 SH   DFND 1 3,744,374 0 0
NIO Inc ADR SPON ADS 62914V106 209,589 30,027,145 SH   SOLE 0 26,535,378 0 3,491,767
NVIDIA COM 67066G104 1,022,080 3,637,035 SH   DFND 2 1,385,469 0 2,251,566
NVIDIA COM 67066G104 241,230 858,410 SH   DFND 1 858,410 0 0
NVIDIA COM 67066G104 609,573 2,169,146 SH   SOLE 0 1,568,360 0 600,786
National Instruments Corp COM 636518102 14,096 291,652 SH   DFND 1 291,652 0 0
National Instruments Corp COM 636518102 9,062 187,500 SH   DFND 2 85,963 0 101,537
National Instruments Corp COM 636518102 15,302 316,624 SH   SOLE 0 316,624 0 0
NetEase.com ADR SPONSORED ADR 64110W102 92,710 406,176 SH   DFND 1 406,176 0 0
NetEase.com ADR SPONSORED ADR 64110W102 405,706 1,777,464 SH   DFND 2 802,945 0 974,519
NetEase.com ADR SPONSORED ADR 64110W102 169,549 742,823 SH   SOLE 0 479,148 0 263,675
Netflix Inc COM 64110L106 479,975 1,282,911 SH   DFND 1 1,282,911 0 0
Netflix Inc COM 64110L106 1,385,214 3,702,494 SH   DFND 2 1,602,328 0 2,100,166
Netflix Inc COM 64110L106 938,459 2,508,378 SH   SOLE 0 1,969,921 0 538,457
New Relic COM 64829B100 10,620 112,704 SH   DFND 2 16,289 0 96,415
New Relic COM 64829B100 45,470 482,545 SH   DFND 1 482,545 0 0
New Relic COM 64829B100 17,224 182,792 SH   SOLE 0 182,792 0 0
Novocure Ltd ORD SHS G6674U108 42,194 805,221 SH   DFND 2 266,399 0 538,822
Novocure Ltd ORD SHS G6674U108 94,750 1,808,203 SH   DFND 1 1,808,203 0 0
Novocure Ltd ORD SHS G6674U108 47,877 913,676 SH   SOLE 0 913,676 0 0
Now Inc/DE COM 67011P100 60,490 3,654,956 SH   DFND 1 3,654,956 0 0
Now Inc/DE COM 67011P100 108,820 6,575,220 SH   DFND 2 4,922,460 0 1,652,760
Now Inc/DE COM 67011P100 73,477 4,439,724 SH   SOLE 0 4,342,228 0 97,496
Nucana Plc ADR SPONSORED ADR 67022C106 12,241 491,208 SH   DFND 1 491,208 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 8,376 336,100 SH   SOLE 0 336,100 0 0
Nuveen Senior Income Fund COM 67067Y104 3,614 586,755 SH   DFND 1 586,755 0 0
PG&E Corp COM 69331C108 778 16,909 SH   DFND 2 16,909 0 0
PG&E Corp COM 69331C108 11,512 250,200 SH   DFND 1 250,200 0 0
Pacira Pharmaceuticals COM 695127100 15,273 310,747 SH   DFND 2 139,986 0 170,761
Pacira Pharmaceuticals COM 695127100 13,987 284,585 SH   DFND 1 284,585 0 0
Pacira Pharmaceuticals COM 695127100 10,158 206,677 SH   SOLE 0 206,677 0 0
Penumbra Inc COM 70975L107 55,541 371,015 SH   DFND 1 371,015 0 0
Penumbra Inc COM 70975L107 20,247 135,251 SH   DFND 2 37,903 0 97,348
Penumbra Inc COM 70975L107 24,064 160,748 SH   SOLE 0 160,748 0 0
Pepsico COM 713448108 11,814 105,673 SH   DFND 1 105,673 0 0
Pepsico COM 713448108 13,689 122,444 SH   SOLE 0 122,444 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 19,949 1,652,763 SH   DFND 1 1,652,763 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 202,179 16,750,506 SH   DFND 2 3,949,106 0 12,801,400
Petrobras Pref ADR SP ADR NON VTG 71654V101 19,308 1,845,846 SH   DFND 2 974,268 0 871,578
Petrobras Pref ADR SP ADR NON VTG 71654V101 4,269 408,082 SH   DFND 1 408,082 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 48,029 1,826,911 SH   DFND 2 953,689 0 873,222
Pinduoduo Inc ADR SPONSORED ADS 722304102 21,841 830,787 SH   DFND 1 830,787 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 60,303 2,293,758 SH   SOLE 0 2,293,758 0 0
Pioneer Floating Rate Trust COM 72369J102 6,077 550,936 SH   DFND 1 550,936 0 0
PriceSmart COM 741511109 85,388 1,054,829 SH   DFND 2 767,574 0 287,255
PriceSmart COM 741511109 11,999 148,222 SH   SOLE 0 148,222 0 0
Procter & Gamble COM 742718109 14,421 173,272 SH   DFND 1 173,272 0 0
Procter & Gamble COM 742718109 16,807 201,939 SH   SOLE 0 201,939 0 0
RPM Inc. COM 749685103 9,470 145,833 SH   DFND 1 145,833 0 0
RPM Inc. COM 749685103 10,398 160,116 SH   SOLE 0 160,116 0 0
Redfin COM 75737F108 42,469 2,271,052 SH   DFND 1 2,271,052 0 0
Redfin COM 75737F108 9,997 534,573 SH   DFND 2 101,233 0 433,340
Redfin COM 75737F108 17,891 956,740 SH   SOLE 0 956,740 0 0
ResTORbio Inc COM 76133L103 7,664 506,234 SH   DFND 1 506,234 0 0
ResTORbio Inc COM 76133L103 7,228 477,384 SH   SOLE 0 477,384 0 0
Resmed Inc COM 761152107 88,544 767,675 SH   DFND 1 767,675 0 0
Resmed Inc COM 761152107 300,209 2,602,819 SH   DFND 2 2,061,109 0 541,710
Resmed Inc COM 761152107 169,663 1,470,984 SH   SOLE 0 1,426,030 0 44,954
Rio Tinto Spn.Adr 1:1 SPONSORED ADR 767204100 3,603 70,626 SH   DFND 2 70,626 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 40,743 1,127,678 SH   DFND 1 1,127,678 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 78,144 2,162,860 SH   SOLE 0 2,094,968 0 67,892
Ritchie Bros Auctioneers (USA) COM 767744105 208,373 5,767,324 SH   DFND 2 4,512,486 0 1,254,838
Ritchie Bros. Auctioneers COM 767744105 14,314 396,943 SH   SOLE 0 396,943 0 0
Ritchie Bros. Auctioneers COM 767744105 61,471 1,704,739 SH   DFND 2 726,903 0 977,836
Royal Crbn.Cruises COM V7780T103 328,056 2,524,670 SH   DFND 2 1,992,003 0 532,667
Royal Crbn.Cruises COM V7780T103 95,462 734,662 SH   DFND 1 734,662 0 0
Royal Crbn.Cruises COM V7780T103 184,315 1,418,459 SH   SOLE 0 1,373,838 0 44,621
Rubius Therapeutics Inc COM 78116T103 4,995 208,141 SH   DFND 1 208,141 0 0
Rubius Therapeutics Inc COM 78116T103 3,987 166,106 SH   DFND 2 75,255 0 90,851
Rubius Therapeutics Inc COM 78116T103 84,849 3,535,365 SH   SOLE 0 3,535,365 0 0
Ryanair ADR SPONSORED ADR NE 783513203 558,835 5,818,771 SH   DFND 2 4,012,681 0 1,806,090
Ryanair ADR SPONSORED ADR NE 783513203 5,081 52,904 SH   SOLE 0 52,904 0 0
SEA Ltd ADR ADR 81141R100 7,436 537,684 SH   DFND 1 537,684 0 0
SEA Ltd ADR ADR 81141R100 38,962 2,817,236 SH   DFND 2 0 0 2,817,236
SEA Ltd ADR ADR 81141R100 8,866 641,104 SH   SOLE 0 641,104 0 0
SINA Corp ORD G81477104 9,140 131,550 SH   DFND 2 0 0 131,550
SVMK INC COM 78489X103 28,369 1,769,756 SH   SOLE 0 1,769,756 0 0
Salesforce.com COM 79466L302 109,237 686,893 SH   DFND 1 686,893 0 0
Salesforce.com COM 79466L302 566,935 3,564,955 SH   DFND 2 1,265,579 0 2,299,376
Salesforce.com COM 79466L302 206,988 1,301,568 SH   SOLE 0 656,310 0 645,258
Schlumberger COM 806857108 7,257 119,127 SH   DFND 2 119,127 0 0
Seattle Genetics COM 812578102 610,642 7,918,074 SH   DFND 2 4,329,406 0 3,588,668
Seattle Genetics COM 812578102 148,130 1,920,779 SH   DFND 1 1,920,779 0 0
Seattle Genetics COM 812578102 281,225 3,646,593 SH   SOLE 0 2,792,170 0 854,423
Service Corp.Intl. COM 817565104 57,011 1,289,849 SH   DFND 1 1,289,849 0 0
Service Corp.Intl. COM 817565104 193,577 4,379,577 SH   DFND 2 3,450,549 0 929,028
Service Corp.Intl. COM 817565104 108,362 2,451,626 SH   SOLE 0 2,374,487 0 77,139
Severstal GDR Reg S COM 818150302 109 6,555 SH   DFND 1 6,555 0 0
Sherwin-Williams Co COM 824348106 4,731 10,393 SH   DFND 1 10,393 0 0
Sherwin-Williams Co COM 824348106 11,882 26,103 SH   DFND 2 26,103 0 0
Sherwin-Williams Co COM 824348106 4,437 9,748 SH   SOLE 0 9,748 0 0
Ship Finance Intl SHS G81075106 115 8,300 SH   DFND 1 8,300 0 0
Shopify 'A' CL A 82509L107 111,330 676,942 SH   DFND 1 676,942 0 0
Shopify 'A' CL A 82509L107 265,406 1,613,802 SH   DFND 2 1,322,643 0 291,159
Shopify 'A' CL A 82509L107 135,288 822,617 SH   SOLE 0 810,631 0 11,986
SiteOne Landscape Supply COM 82982L103 105,763 1,403,808 SH   DFND 2 1,106,845 0 296,963
SiteOne Landscape Supply COM 82982L103 31,054 412,186 SH   DFND 1 412,186 0 0
SiteOne Landscape Supply COM 82982L103 61,020 809,928 SH   SOLE 0 785,318 0 24,610
Snap Inc CL A 83304A106 2,088 246,186 SH   DFND 2 246,186 0 0
Sohu.com COM 83410S108 2,398 120,609 SH   DFND 1 120,609 0 0
Sohu.com COM 83410S108 11,655 586,261 SH   DFND 2 198,472 0 387,789
Solarcity Corp NOTE 1.625 11/0 83416TAC4 11,528 13,040,000 SH   DFND 1 13,040,000 0 0
Solarcity Corp NOTE 1.625 11/0 83416TAC4 47 53,000 SH   DFND 2 53,000 0 0
Splunk Inc COM 848637104 12,205 100,940 SH   DFND 1 100,940 0 0
Splunk Inc COM 848637104 8,933 73,884 SH   SOLE 0 73,884 0 0
Splunk Inc COM 848637104 16,067 132,881 SH   DFND 2 60,014 0 72,867
Spotify Technology SA SHS L8681T102 2,033,264 11,244,063 SH   DFND 2 4,489,909 0 6,754,154
Spotify Technology SA SHS L8681T102 160,820 889,345 SH   DFND 1 889,345 0 0
Spotify Technology SA SHS L8681T102 550,371 3,043,583 SH   SOLE 0 2,650,541 0 393,042
Staar Surgical COM PAR $0.01 852312305 28,588 595,588 SH   DFND 1 595,588 0 0
Staar Surgical COM PAR $0.01 852312305 25,601 533,350 SH   DFND 2 248,393 0 284,957
Staar Surgical COM PAR $0.01 852312305 20,220 421,241 SH   SOLE 0 421,241 0 0
Stericycle Inc COM 858912108 170,423 2,904,281 SH   DFND 2 2,284,151 0 620,130
Stericycle Inc COM 858912108 50,283 856,906 SH   DFND 1 856,906 0 0
Stericycle Inc COM 858912108 95,833 1,633,150 SH   SOLE 0 1,582,386 0 50,764
Stitch Fix COM CL A 860897107 15,882 362,842 SH   DFND 2 52,002 0 310,840
Stitch Fix COM CL A 860897107 65,260 1,490,976 SH   DFND 1 1,490,976 0 0
Stitch Fix COM CL A 860897107 25,334 578,807 SH   SOLE 0 578,807 0 0
Stratasys SHS M85548101 5,230 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 8,311 359,621 SH   DFND 2 161,268 0 198,353
Stratasys SHS M85548101 3,342 144,600 SH   SOLE 0 144,600 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 7,610 8,922,000 SH   DFND 1 8,922,000 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 3,018 3,538,000 SH   DFND 2 3,538,000 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 1,045,062 40,648,088 SH   DFND 2 10,271,625 0 30,376,463
TAL Education Group ADR ADS REPSTG COM 874080104 65,074 2,531,069 SH   DFND 1 2,531,069 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 121,123 4,711,113 SH   SOLE 0 2,404,072 0 2,307,041
TD Ameritrade Holding Corp COM 87236Y108 105,594 1,998,748 SH   DFND 1 1,998,748 0 0
TD Ameritrade Holding Corp COM 87236Y108 237,159 4,489,089 SH   DFND 2 3,538,813 0 950,276
TD Ameritrade Holding Corp COM 87236Y108 134,406 2,544,116 SH   SOLE 0 2,476,573 0 67,543
TJX Companies COM 872540109 24,994 223,121 SH   DFND 2 223,121 0 0
TJX Companies COM 872540109 13,165 117,523 SH   DFND 1 117,523 0 0
TJX Companies COM 872540109 6,887 61,483 SH   SOLE 0 61,483 0 0
TSMC ADR SPONSORED ADR 874039100 191,114 4,327,754 SH   DFND 1 4,327,754 0 0
TSMC ADR SPONSORED ADR 874039100 1,179,998 26,720,977 SH   DFND 2 19,097,783 0 7,623,194
TSMC ADR SPONSORED ADR 874039100 323,880 7,334,229 SH   SOLE 0 7,095,731 0 238,498
Tableau Software Class A CL A 87336U105 73,278 655,793 SH   DFND 1 655,793 0 0
Tableau Software Class A CL A 87336U105 16,952 151,709 SH   DFND 2 30,363 0 121,346
Tableau Software Class A CL A 87336U105 108,915 974,719 SH   SOLE 0 974,719 0 0
Tandem Diabetes Care COM NEW 875372203 9,643 225,100 SH   DFND 1 225,100 0 0
Tandem Diabetes Care COM NEW 875372203 8,979 209,600 SH   SOLE 0 209,600 0 0
Targa Resources COM 87612G101 82 1,463 SH   DFND 1 1,463 0 0
Teladoc COM 87918A105 20,662 239,281 SH   DFND 1 239,281 0 0
Teladoc COM 87918A105 14,952 173,152 SH   SOLE 0 173,152 0 0
Teladoc COM 87918A105 24,816 287,394 SH   DFND 2 130,685 0 156,709
Teradyne COM 880770102 44,154 1,194,003 SH   DFND 1 1,194,003 0 0
Teradyne COM 880770102 193,916 5,243,798 SH   DFND 2 4,419,521 0 824,277
Teradyne COM 880770102 81,206 2,195,939 SH   SOLE 0 2,126,127 0 69,812
TerraForm Power CL A COM 88104R209 21,128 1,829,287 SH   DFND 1 1,829,287 0 0
TerraForm Power CL A COM 88104R209 1,948 168,647 SH   DFND 2 168,647 0 0
Tesla Inc COM 88160R101 433,467 1,637,147 SH   DFND 1 1,637,147 0 0
Tesla Inc COM 88160R101 1,990,244 7,516,877 SH   DFND 2 2,370,693 0 5,146,184
Tesla Inc COM 88160R101 1,051,515 3,971,427 SH   SOLE 0 3,251,517 0 719,910
The Trade Desk COM CL A 88339J105 55,602 368,446 SH   DFND 1 368,446 0 0
The Trade Desk COM CL A 88339J105 21,132 140,030 SH   SOLE 0 140,030 0 0
The Trade Desk COM CL A 88339J105 13,203 87,490 SH   DFND 2 12,513 0 74,977
Thermo Fisher Scientific COM 883556102 92,129 377,455 SH   DFND 1 377,455 0 0
Thermo Fisher Scientific COM 883556102 313,148 1,282,974 SH   DFND 2 1,019,332 0 263,642
Thermo Fisher Scientific COM 883556102 175,907 720,696 SH   SOLE 0 698,227 0 22,469
Trupanion COM 898202106 7,060 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 11,973 335,092 SH   DFND 2 151,386 0 183,706
Trupanion COM 898202106 26,262 735,000 SH   SOLE 0 735,000 0 0
Under Armour Inc Class A CL A 904311107 249,111 11,739,434 SH   DFND 2 4,183,119 0 7,556,315
Under Armour Inc Class A CL A 904311107 47,552 2,240,909 SH   DFND 1 2,240,909 0 0
Under Armour Inc Class A CL A 904311107 89,921 4,237,579 SH   SOLE 0 2,143,327 0 2,094,252
Under Armour Inc Class C CL C 904311206 18,670 959,416 SH   DFND 2 629,328 0 330,088
Under Armour Inc Class C CL C 904311206 36,177 1,859,068 SH   DFND 1 1,859,068 0 0
Under Armour Inc Class C CL C 904311206 15,043 773,004 SH   SOLE 0 773,004 0 0
United Parcel Service CL B 911312106 11,629 99,609 SH   DFND 1 99,609 0 0
United Parcel Service CL B 911312106 13,581 116,325 SH   SOLE 0 116,325 0 0
Unity Biotechnology Inc COM 91381U101 4,040 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 57,911 3,555,014 SH   SOLE 0 3,555,014 0 0
Uxin ADR ADS 91818X108 924 136,100 SH   DFND 1 136,100 0 0
Uxin ADR ADS 91818X108 763 112,300 SH   SOLE 0 112,300 0 0
Varian Medical Systems Inc COM 92220P105 13,138 117,375 SH   DFND 2 117,375 0 0
Vector Group COM 92240M108 58 4,200 SH   DFND 1 4,200 0 0
Veeco Instruments COM 922417100 5,200 507,354 SH   DFND 1 507,354 0 0
Veeco Instruments COM 922417100 2,243 218,813 SH   DFND 2 101,414 0 117,399
Veeco Instruments COM 922417100 7,905 771,205 SH   SOLE 0 771,205 0 0
Verisk Analytics COM 92345Y106 294,121 2,439,824 SH   DFND 2 1,965,130 0 474,694
Verisk Analytics COM 92345Y106 79,786 661,852 SH   DFND 1 661,852 0 0
Verisk Analytics COM 92345Y106 151,892 1,259,988 SH   SOLE 0 1,221,069 0 38,919
Vertex Pharmaceuticals COM 92532F100 58,873 305,453 SH   DFND 1 305,453 0 0
Vertex Pharmaceuticals COM 92532F100 33,228 172,400 SH   DFND 2 110,590 0 61,810
Vertex Pharmaceuticals COM 92532F100 22,526 116,874 SH   SOLE 0 116,874 0 0
Visa Inc-Class A Shares COM CL A 92826C839 143,843 958,376 SH   DFND 1 958,376 0 0
Visa Inc-Class A Shares COM CL A 92826C839 491,891 3,277,309 SH   DFND 2 2,591,599 0 685,710
Visa Inc-Class A Shares COM CL A 92826C839 272,565 1,816,013 SH   SOLE 0 1,758,864 0 57,149
Voya Prime Rate Trust SH BEN INT 92913A100 2,844 571,000 SH   DFND 1 571,000 0 0
Voya Prime Rate Trust SH BEN INT 92913A100 963 193,400 SH   DFND 2 193,400 0 0
WEC Energy Group COM 92939U106 13,945 208,890 SH   DFND 1 208,890 0 0
WEC Energy Group COM 92939U106 926 13,867 SH   DFND 2 13,867 0 0
Wabtec COM 929740108 118,059 1,125,655 SH   DFND 1 1,125,655 0 0
Wabtec COM 929740108 252,046 2,403,188 SH   DFND 2 1,862,068 0 541,120
Wabtec COM 929740108 143,408 1,367,349 SH   SOLE 0 1,330,168 0 37,181
Waters COM 941848103 76,322 392,037 SH   DFND 1 392,037 0 0
Waters COM 941848103 279,625 1,436,332 SH   DFND 2 1,159,966 0 276,366
Waters COM 941848103 143,358 736,380 SH   SOLE 0 713,531 0 22,849
Watsco Inc COM 942622200 86,772 487,208 SH   DFND 1 487,208 0 0
Watsco Inc COM 942622200 41,969 235,649 SH   DFND 2 143,619 0 92,030
Watsco Inc COM 942622200 35,767 200,825 SH   SOLE 0 200,825 0 0
Wayfair Inc Class A CL A 94419L101 214,301 1,451,218 SH   DFND 1 1,451,218 0 0
Wayfair Inc Class A CL A 94419L101 103,554 701,252 SH   DFND 2 237,208 0 464,044
Wayfair Inc Class A CL A 94419L101 102,339 693,026 SH   SOLE 0 693,026 0 0
Weibo Corp SPON ADR SPONSORED ADR 948596101 1,924 26,310 SH   DFND 2 0 0 26,310
Wipro Ltd ADR SPON ADR 1 SH 97651M109 514 98,583 SH   DFND 2 75,632 0 22,951
Wix Com SHS M98068105 301,884 2,522,003 SH   DFND 2 714,657 0 1,807,346
Workday Inc CL A 98138H101 99,736 683,217 SH   DFND 1 683,217 0 0
Workday Inc CL A 98138H101 507,571 3,476,991 SH   DFND 2 1,234,018 0 2,242,973
Workday Inc CL A 98138H101 336,698 2,306,465 SH   SOLE 0 1,674,790 0 631,675
Xylem COM 98419M100 6,921 86,651 SH   DFND 2 52,231 0 34,420
Xylem COM 98419M100 3,328 41,669 SH   DFND 1 41,669 0 0
Yext Inc COM 98585N106 7,265 306,534 SH   DFND 1 306,534 0 0
Yext Inc COM 98585N106 6,341 267,547 SH   SOLE 0 267,547 0 0
Yext Inc COM 98585N106 9,371 395,413 SH   DFND 2 178,984 0 216,429
Zillow Group Inc Class A CL A 98954M101 6,267 141,792 SH   DFND 1 141,792 0 0
Zillow Group Inc Class A CL A 98954M101 30,390 687,553 SH   DFND 2 487,539 0 200,014
Zillow Group Inc Class A CL A 98954M101 18,508 418,726 SH   SOLE 0 405,907 0 12,819
Zillow Group Inc Class C CL C CAP STK 98954M200 85,755 1,937,977 SH   DFND 1 1,937,977 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 238,248 5,384,125 SH   DFND 2 4,103,662 0 1,280,463
Zillow Group Inc Class C CL C CAP STK 98954M200 135,087 3,052,821 SH   SOLE 0 2,968,412 0 84,409
iRobot COM 462726100 16,797 152,810 SH   DFND 1 152,810 0 0
iRobot COM 462726100 36,612 333,077 SH   SOLE 0 333,077 0 0
iRobot COM 462726100 23,205 211,112 SH   DFND 2 100,035 0 111,077