The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 56,246 766,710 SH   DFND 1 0 0 766,710
ABIOMED INC COM 003654100 14,902 33,135 SH   DFND 1 0 0 33,135
ACADIA PHARMACEUTICALS INC COM 004225108 1,183 57,000 SH   DFND 1 0 0 57,000
ACCELERON PHARMA INC COM 00434H108 927 16,200 SH   DFND 1 0 0 16,200
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 794 58,535 SH   DFND 1 0 0 58,535
AETNA INC NEW COM 00817Y108 1,440 7,100 SH   DFND 1 0 0 7,100
AGIOS PHARMACEUTICALS INC COM 00847X104 1,532 19,861 SH   DFND 1 0 0 19,861
AKCEA THERAPEUTICS INC COM 00972L107 14,656 418,496 SH   DFND 1 0 0 418,496
ALDER BIOPHARMACEUTICALS INC COM 014339105 15,072 905,254 SH   DFND 1 0 0 905,254
ALEXION PHARMACEUTICALS INC COM 015351109 25,450 183,080 SH   DFND 1 0 0 183,080
ALIGN TECHNOLOGY INC COM 016255101 57,239 146,310 SH   DFND 1 0 0 146,310
ALLERGAN PLC SHS G0177J108 2,476 13,000 SH   DFND 1 0 0 13,000
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 19,245 219,891 SH   DFND 1 0 0 219,891
AMEDISYS INC COM 023436108 3,149 25,204 SH   DFND 1 0 0 25,204
AMERISOURCEBERGEN CORP COM 03073E105 22,027 238,853 SH   DFND 1 0 0 238,853
AMGEN INC COM 031162100 7,659 36,950 SH   DFND 1 0 0 36,950
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 2,108 95,000 SH   DFND 1 0 0 95,000
ANGIODYNAMICS INC COM 03475V101 1,646 75,700 SH   DFND 1 0 0 75,700
ANTHEM INC COM 036752103 61,439 224,188 SH   DFND 1 0 0 224,188
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,418 30,817 SH   DFND 1 0 0 30,817
BAXTER INTL INC COM 071813109 20,301 263,348 SH   DFND 1 0 0 263,348
BECTON DICKINSON & CO COM 075887109 27,513 105,413 SH   DFND 1 0 0 105,413
BEIGENE LTD SPONSORED ADR 07725L102 2,001 11,620 SH   DFND 1 0 0 11,620
BIOGEN INC COM 09062X103 13,866 39,245 SH   DFND 1 0 0 39,245
BIOMARIN PHARMACEUTICAL INC COM 09061G101 4,642 47,869 SH   DFND 1 0 0 47,869
BLUEBIRD BIO INC COM 09609G100 1,664 11,400 SH   DFND 1 0 0 11,400
BOSTON SCIENTIFIC CORP COM 101137107 37,689 978,929 SH   DFND 1 0 0 978,929
BRISTOL MYERS SQUIBB CO COM 110122108 21,215 341,729 SH   DFND 1 0 0 341,729
CAREDX INC COM 14167l103 9,724 337,049 SH   DFND 1 0 0 337,049
CASTLIGHT HEALTH INC CL B 14862Q100 2,400 888,842 SH   DFND 1 0 0 888,842
CELGENE CORP COM 151020104 54,231 606,000 SH   DFND 1 0 0 606,000
CELLECTIS S A SPONSORED ADS 15117K103 1,400 49,600 SH   DFND 1 0 0 49,600
CENTENE CORP DEL COM 15135B101 31,565 218,021 SH   DFND 1 0 0 218,021
CERNER CORP COM 156782104 3,810 59,146 SH   DFND 1 0 0 59,146
CIGNA CORPORATION COM 125509109 35,291 169,463 SH   DFND 1 0 0 169,463
COHERUS BIOSCIENCES INC COM 19249H103 3,563 215,935 SH   DFND 1 0 0 215,935
COOPER COS INC COM NEW 216648402 6,322 22,811 SH   DFND 1 0 0 22,811
CVS HEALTH CORP COM 126650100 630 8,000 SH   DFND 1 0 0 8,000
DANAHER CORP DEL COM 235851102 27,493 253,016 SH   DFND 1 0 0 253,016
DENTSPLY SIRONA INC COM 24906P109 4,185 110,878 SH   DFND 1 0 0 110,878
DEXCOM INC COM 252131107 10,248 71,647 SH   DFND 1 0 0 71,647
EAGLE PHARMACEUTICALS INC COM 269796108 1,248 18,000 SH   DFND 1 0 0 18,000
EDWARDS LIFESCIENCES CORP COM 28176E108 44,105 253,333 SH   DFND 1 0 0 253,333
ENDO INTL PLC SHS G30401106 3,659 217,392 SH   DFND 1 0 0 217,392
ESPERION THERAPEUTICS INC NEW COM 29664W105 17,386 391,852 SH   DFND 1 0 0 391,852
EXPRESS SCRIPTS HLDG CO COM 30219G108 4,228 44,500 SH   DFND 1 0 0 44,500
FITBIT INC CL A 33812L102 13,449 2,513,900 SH   DFND 1 0 0 2,513,900
GENMARK DIAGNOSTICS INC COM 372309104 9,845 1,339,502 SH   DFND 1 0 0 1,339,502
GILEAD SCIENCES INC COM 375558103 10,616 137,500 SH   DFND 1 0 0 137,500
GLOBUS MED INC CL A 379577208 8,585 151,251 SH   DFND 1 0 0 151,251
GW PHARMACEUTICALS PLC ADS 36197T103 1,145 6,629 SH   DFND 1 0 0 6,629
HCA HEALTHCARE INC COM 40412C101 5,132 36,888 SH   DFND 1 0 0 36,888
HEALTHCARE SVCS GRP INC COM 421906108 609 15,000 SH   DFND 1 0 0 15,000
SCHEIN HENRY INC COM 806407102 4,368 51,368 SH   DFND 1 0 0 51,368
HILL ROM HLDGS INC COM 431475102 17,529 185,689 SH   DFND 1 0 0 185,689
HMS HLDGS CORP COM 40425J101 7,449 227,020 SH   DFND 1 0 0 227,020
HOLOGIC INC COM 436440101 14,830 361,894 SH   DFND 1 0 0 361,894
HORIZON PHARMA PLC SHS G4617B105 4,340 221,678 SH   DFND 1 0 0 221,678
HUMANA INC COM 444859102 33,348 98,510 SH   DFND 1 0 0 98,510
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 12,877 400,029 SH   DFND 1 0 0 400,029
IDEXX LABS INC COM 45168D104 6,068 24,307 SH   DFND 1 0 0 24,307
ILLUMINA INC COM 452327109 54,217 147,707 SH   DFND 1 0 0 147,707
INCYTE CORP COM 45337C102 3,616 52,350 SH   DFND 1 0 0 52,350
INOGEN INC COM 45780L104 5,678 23,261 SH   DFND 1 0 0 23,261
INSMED INC COM PAR $.01 457669307 11,451 566,301 SH   DFND 1 0 0 566,301
INSPIRE MED SYS INC COM 457730109 3,816 90,696 SH   DFND 1 0 0 90,696
INSULET CORP COM 45784P101 1,907 18,000 SH   DFND 1 0 0 18,000
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 9,329 141,620 SH   DFND 1 0 0 141,620
INTELLIA THERAPEUTICS INC COM 45826J105 470 16,434 SH   DFND 1 0 0 16,434
INTERCEPT PHARMACEUTICALS IN COM 45845P108 3,051 24,148 SH   DFND 1 0 0 24,148
INTERSECT ENT INC COM 46071F103 6,734 234,227 SH   DFND 1 0 0 234,227
INTRA CELLULAR THERAPIES INC COM 46116X101 1,185 54,600 SH   DFND 1 0 0 54,600
INTUITIVE SURGICAL INC COM NEW 46120E602 50,436 87,868 SH   DFND 1 0 0 87,868
IONIS PHARMACEUTICALS INC COM 462222100 16,017 310,536 SH   DFND 1 0 0 310,536
IOVANCE BIOTHERAPEUTICS INC COM 462260100 281 25,000 SH   DFND 1 0 0 25,000
IRHYTHM TECHNOLOGIES INC COM 450056106 6,594 69,661 SH   DFND 1 0 0 69,661
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,466 79,400 SH   DFND 1 0 0 79,400
ISHARES TR NASDAQ BIOTECH 464287556 3,414 28,000 SH   DFND 1 0 0 28,000
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 35,939 213,758 SH   DFND 1 0 0 213,758
JOHNSON & JOHNSON COM 478160104 2,763 20,000 SH   DFND 1 0 0 20,000
K2M GROUP HLDGS INC COM 48273J107 15,110 552,054 SH   DFND 1 0 0 552,054
LABORATORY CORP AMER HLDGS COM NEW 50540R409 16,333 94,040 SH   DFND 1 0 0 94,040
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 3,094 11,270 SH   DFND 1 0 0 11,270
LIVANOVA PLC SHS G5509L101 14,435 116,443 SH   DFND 1 0 0 116,443
MACROGENICS INC COM 556099109 15,529 724,302 SH   DFND 1 0 0 724,302
MASIMO CORP COM 574795100 2,426 19,476 SH   DFND 1 0 0 19,476
MATERIALISE NV SPONSORED ADS 57667T100 2,908 210,731 SH   DFND 1 0 0 210,731
MCKESSON CORP COM 58155Q103 1,128 8,503 SH   DFND 1 0 0 8,503
MEDIDATA SOLUTIONS INC COM 58471A105 2,706 36,907 SH   DFND 1 0 0 36,907
MEDTRONIC PLC SHS G5960L103 48,835 496,446 SH   DFND 1 0 0 496,446
MERCK & CO INC COM 58933Y105 887 12,500 SH   DFND 1 0 0 12,500
MIRATI THERAPEUTICS INC COM 60468T105 1,178 25,000 SH   DFND 1 0 0 25,000
MOLINA HEALTHCARE INC COM 60855R100 7,506 50,478 SH   DFND 1 0 0 50,478
MYLAN N V SHS EURO N59465109 20,692 565,350 SH   DFND 1 0 0 565,350
NEKTAR THERAPEUTICS COM 640268108 3,384 55,520 SH   DFND 1 0 0 55,520
NEUROCRINE BIOSCIENCES INC COM 64125C109 5,109 41,550 SH   DFND 1 0 0 41,550
NEURONETICS INC COM 64131A105 3,588 111,907 SH   DFND 1 0 0 111,907
NEVRO CORP COM 64157F103 4,584 80,415 SH   DFND 1 0 0 80,415
OMNICELL INC COM 68213N109 7,524 104,650 SH   DFND 1 0 0 104,650
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 3,600 221,837 SH   DFND 1 0 0 221,837
PACIFIC BIOSCIENCES OF CALIF INC COM 69404D108 13,931 2,575,000 SH   DFND 1 0 0 2,575,000
PENUMBRA INC COM 70975L107 2,866 19,142 SH   DFND 1 0 0 19,142
PFIZER INC COM 717081103 1,287 29,200 SH   DFND 1 0 0 29,200
PORTOLA PHARMACEUTICALS INC COM 737010108 710 26,650 SH   DFND 1 0 0 26,650
PRA HEALTH SCIENCES INC COM 69354M108 18,336 166,400 SH   DFND 1 0 0 166,400
PREMIER INC CL A 74051N102 691 15,100 SH   DFND 1 0 0 15,100
PTC THERAPEUTICS INC COM 69366J200 1,058 22,500 SH   DFND 1 0 0 22,500
QIAGEN NV SHS NEW N72482123 5,083 134,189 SH   DFND 1 0 0 134,189
QUANTERIX CORP COM 74766Q101 6,709 313,230 SH   DFND 1 0 0 313,230
QUOTIENT LTD SHS G73268107 5,450 721,858 SH   DFND 1 0 0 721,858
REGENERON PHARMACEUTICALS COM 75886F107 10,295 25,480 SH   DFND 1 0 0 25,480
REGENXBIO INC COM 75901B107 1,759 23,300 SH   DFND 1 0 0 23,300
RESMED INC COM 761152107 10,749 93,192 SH   DFND 1 0 0 93,192
SAGE THERAPEUTICS INC COM 78667J108 1,582 11,200 SH   DFND 1 0 0 11,200
SAREPTA THERAPEUTICS INC COM 803607100 2,116 13,100 SH   DFND 1 0 0 13,100
SEATTLE GENETICS INC COM 812578102 3,621 46,950 SH   DFND 1 0 0 46,950
SHIRE PLC SPONSORED ADR 82481R106 11,635 64,185 SH   DFND 1 0 0 64,185
STRYKER CORP COM 863667101 25,120 141,380 SH   DFND 1 0 0 141,380
SUPERNUS PHARMACEUTICALS INC COM 868459108 19,460 386,500 SH   DFND 1 0 0 386,500
SYNEOS HEALTH INC CL A 87166B102 1,348 26,156 SH   DFND 1 0 0 26,156
TABULA RASA HEALTHCARE INC COM 873379101 7,054 86,884 SH   DFND 1 0 0 86,884
TANDEM DIABETES CARE INC COM NEW 875372203 4,164 97,195 SH   DFND 1 0 0 97,195
TELADOC HEALTH INC COM 87918A105 50,646 586,520 SH   DFND 1 0 0 586,520
TELEFLEX INC COM 879369106 4,734 17,792 SH   DFND 1 0 0 17,792
TESARO INC COM 881569107 1,504 38,550 SH   DFND 1 0 0 38,550
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 1,292 60,000 SH   DFND 1 0 0 60,000
THERMO FISHER SCIENTIFIC INC COM 883556102 8,414 34,471 SH   DFND 1 0 0 34,471
ULTRAGENYX PHARMACEUTICAL INC COM 90400D108 2,431 31,850 SH   DFND 1 0 0 31,850
UNITEDHEALTH GROUP INC COM 91324P102 32,949 123,848 SH   DFND 1 0 0 123,848
UNIQURE NV SHS N90064101 724 19,900 SH   DFND 1 0 0 19,900
VARIAN MED SYS INC COM 92220P105 705 6,300 SH   DFND 1 0 0 6,300
VEEVA SYS INC CL A COM 922475108 3,559 32,691 SH   DFND 1 0 0 32,691
VERTEX PHARMACEUTICALS INC COM 92532F100 7,805 40,494 SH   DFND 1 0 0 40,494
VOYAGER THERAPEUTICS INC COM 92915B106 822 43,422 SH   DFND 1 0 0 43,422
WALGREENS BOOTS ALLIANCE INC COM 931427108 16,477 226,018 SH   DFND 1 0 0 226,018
WELLCARE HEALTH PLANS INC COM 94946T106 9,060 28,269 SH   DFND 1 0 0 28,269
WRIGHT MED GROUP NV ORD SHS 0.03 PAR N96617118 18,071 622,692 SH   DFND 1 0 0 622,692
ZIMMER BIOMET HLDGS INC COM 98956P102 12,109 92,104 SH   DFND 1 0 0 92,104