The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 28,737 391,719 SH   SOLE   391,719 0 0
AbbVie Inc. Common 00287Y109 46,541 492,078 SH   SOLE   492,078 0 0
ABIOMED, Inc. Common 003654100 1,687 3,750 SH   SOLE   3,750 0 0
AC Immune SA Shares H00263105 1,375 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Company, Inc. Common 00404A109 9,588 272,400 SH   SOLE   272,400 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 1,945 93,689 SH   SOLE   93,689 0 0
Acceleron Pharma Inc. Common 00434H108 9,773 170,766 SH   SOLE   170,766 0 0
Achillion Pharmaceuticals, Inc. Common 00448Q201 1,710 464,761 SH   SOLE   464,761 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 4,768 351,618 SH   SOLE   351,618 0 0
Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 9,740 13,000,000 PRN   SOLE   13,000,000 0 0
Aerie Pharmaceuticals, Inc. Common 00771V108 2,386 38,770 SH   SOLE   38,770 0 0
Aerpio Pharmaceuticals, Inc. Common 00810B105 2,364 765,000 SH   SOLE   765,000 0 0
Aetna Inc. Common 00817Y108 16,966 83,637 SH   SOLE   83,637 0 0
Affimed NV Common N01045108 1,105 254,000 SH   SOLE   254,000 0 0
Agilent Technologies, Inc. Common 00846U101 4,007 56,800 SH   SOLE   56,800 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 2,612 33,870 SH   SOLE   33,870 0 0
Akebia Therapeutics, Inc. Common 00972D105 2,354 266,612 SH   SOLE   266,612 0 0
Albireo Pharma, Inc. Common 01345P106 4,120 125,000 SH   SOLE   125,000 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 60,944 438,416 SH   SOLE   438,416 0 0
Align Technology, Inc. Common 016255101 4,399 11,244 SH   SOLE   11,244 0 0
Alkermes plc Shares G01767105 7,259 171,042 SH   SOLE   171,042 0 0
Allergan plc Shares G0177J108 47,398 248,836 SH   SOLE   248,836 0 0
Alliqua BioMedical, Inc. Common 019621309 375 165,000 SH   SOLE   165,000 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 11,043 126,176 SH   SOLE   126,176 0 0
Amarin Corporation plc Sponsored ADR 023111206 12,268 754,049 SH   SOLE   754,049 0 0
AmerisourceBergen Corporation Common 03073E105 10,311 111,807 SH   SOLE   111,807 0 0
Amgen Inc. Common 031162100 140,513 677,855 SH   SOLE   677,855 0 0
Amicus Therapeutics, Inc. Common 03152W109 10,582 875,304 SH   SOLE   875,304 0 0
AnaptysBio, Inc. Common 032724106 4,580 45,910 SH   SOLE   45,910 0 0
Anthem, Inc. Common 036752103 38,681 141,147 SH   SOLE   141,147 0 0
ARCA biopharma, Inc. Common 00211Y407 454 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 2,781 639,370 SH   SOLE   639,370 0 0
Arena Pharmaceuticals, Inc. Common 040047607 4,315 93,767 SH   SOLE   93,767 0 0
argenx SE Sponsored ADR 04016X101 1,152 15,188 SH   SOLE   15,188 0 0
ArQule, Inc. Common 04269E107 1,415 250,000 SH   SOLE   250,000 0 0
Array BioPharma Inc. Common 04269X105 5,535 364,166 SH   SOLE   364,166 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 4,656 65,714 SH   SOLE   65,714 0 0
Assertio Therapeutics, Inc. Common 04545L107 6 1,000 SH   SOLE   1,000 0 0
AstraZeneca PLC Sponsored ADR 046353108 28,436 718,624 SH   SOLE   718,624 0 0
Athenex, Inc. Common 04685N103 708 45,530 SH   SOLE   45,530 0 0
Audentes Therapeutics, Inc. Common 05070R104 1,534 38,740 SH   SOLE   38,740 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 3,576 814,588 SH   SOLE   814,588 0 0
Bausch Health Companies Inc. Common 071734107 4,929 192,000 SH   SOLE   192,000 0 0
Baxter International Inc. Sponsored ADR 071813109 11,258 146,040 SH   SOLE   146,040 0 0
Becton, Dickinson and Company Common 075887109 16,750 64,178 SH   SOLE   64,178 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 14,769 85,755 SH   SOLE   85,755 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 370 60,000 SH   SOLE   60,000 0 0
Biogen Inc. Common 09062X103 138,286 391,402 SH   SOLE   391,402 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 13,628 140,538 SH   SOLE   140,538 0 0
bluebird bio, Inc. Common 09609G100 12,817 87,788 SH   SOLE   87,788 0 0
Blueprint Medicines Corporation Common 09627Y109 11,397 146,001 SH   SOLE   146,001 0 0
Boston Scientific Corporation Common 101137107 17,132 444,991 SH   SOLE   444,991 0 0
Bristol-Myers Squibb Company Common 110122108 22,725 366,064 SH   SOLE   366,064 0 0
Cardinal Health, Inc. Common 14149Y108 340 6,300 SH   SOLE   6,300 0 0
Celgene Corporation Common 151020104 117,442 1,312,350 SH   SOLE   1,312,350 0 0
Celldex Therapeutics, Inc. Common 15117B103 48 105,800 SH   SOLE   105,800 0 0
Cellectis SA Sponsored ADR 15117K103 7,873 278,988 SH   SOLE   278,988 0 0
Centene Corporation Common 15135B101 24,159 166,869 SH   SOLE   166,869 0 0
Charles River Laboratories International, Inc. Common 159864107 3,050 22,670 SH   SOLE   22,670 0 0
Cidara Therapeutics, Inc. Common 171757107 699 158,784 SH   SOLE   158,784 0 0
Cigna Corporation Common 125509109 8,426 40,461 SH   SOLE   40,461 0 0
Clearside Biomedical, Inc. Common 185063104 508 82,665 SH   SOLE   82,665 0 0
Clovis Oncology, Inc. Common 189464100 2,214 75,400 SH   SOLE   75,400 0 0
Coherus Biosciences, Inc. Common 19249H103 2,472 149,820 SH   SOLE   149,820 0 0
Community Health Systems, Inc. Common 203668108 706 203,935 SH   SOLE   203,935 0 0
Concert Pharmaceuticals, Inc. Common 206022105 1,346 90,724 SH   SOLE   90,724 0 0
CRISPR Therapeutics AG Common H17182108 7,910 178,348 SH   SOLE   178,348 0 0
CVS Health Corporation Common 126650100 31,575 401,101 SH   SOLE   401,101 0 0
CymaBay Therapeutics, Inc. Common 23257D103 1,883 169,962 SH   SOLE   169,962 0 0
Danaher Corporation Common 235851102 22,750 209,371 SH   SOLE   209,371 0 0
DENTSPLY SIRONA Inc. Common 24906P109 2,174 57,600 SH   SOLE   57,600 0 0
Dermira, Inc. Common 24983L104 2,553 234,200 SH   SOLE   234,200 0 0
Diplomat Pharmacy, Inc. Common 25456K101 8,521 439,001 SH   SOLE   439,001 0 0
Editas Medicine, Inc. Common 28106W103 2,440 76,668 SH   SOLE   76,668 0 0
Edwards Lifesciences Corporation Common 28176E108 13,353 76,696 SH   SOLE   76,696 0 0
Egalet Corporation Note 5.50% 4/1/20 28226BAB0 700 7,000,000 PRN   SOLE   7,000,000 0 0
Eidos Therapeutics, Inc. Common 28249H104 278 27,900 SH   SOLE   27,900 0 0
Eli Lilly and Company Common 532457108 23,226 216,442 SH   SOLE   216,442 0 0
Endo International plc Shares G30401106 17,151 1,019,048 SH   SOLE   1,019,048 0 0
Endocyte, Inc. Common 29269A102 746 41,980 SH   SOLE   41,980 0 0
Epizyme, Inc. Common 29428V104 5,144 485,325 SH   SOLE   485,325 0 0
Esperion Therapeutics, Inc. Common 29664W105 8,399 189,287 SH   SOLE   189,287 0 0
Evolent Health, Inc. Common 30050B101 2,394 84,300 SH   SOLE   84,300 0 0
Exelixis, Inc. Common 30161Q104 9,816 553,940 SH   SOLE   553,940 0 0
Express Scripts Holding Company Common 30219G108 5,059 53,250 SH   SOLE   53,250 0 0
FibroGen, Inc. Common 31572Q808 10,826 178,207 SH   SOLE   178,207 0 0
Foamix Pharmaceuticals Ltd. Shares M46135105 4,167 727,205 SH   SOLE   727,205 0 0
Galapagos NV Sponsored ADR 36315X101 11,222 99,815 SH   SOLE   99,815 0 0
Genomic Health, Inc. Common 37244C101 2,439 34,740 SH   SOLE   34,740 0 0
Gilead Sciences, Inc. Common 375558103 149,966 1,942,317 SH   SOLE   1,942,317 0 0
GlaxoSmithKline plc Shares 37733W105 8,785 218,700 SH   SOLE   218,700 0 0
Global Blood Therapeutics, Inc. Common 37890U108 5,026 132,270 SH   SOLE   132,270 0 0
Global Medical REIT Inc. Common 37954A204 691 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals plc ADS 36197T103 7,531 43,598 SH   SOLE   43,598 0 0
HCA Healthcare, Inc. Common 40412C101 10,341 74,335 SH   SOLE   74,335 0 0
HCP, Inc. Common 40414L109 1,198 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Incorporated Common 421946104 1,990 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Common 42225P501 1,227 46,000 SH   SOLE   46,000 0 0
Henry Schein, Inc. Common 806407102 2,670 31,400 SH   SOLE   31,400 0 0
Hologic, Inc. Common 436440101 801 19,546 SH   SOLE   19,546 0 0
Horizon Pharma plc Shares G4617B105 3,190 162,900 SH   SOLE   162,900 0 0
Humana Inc. Common 444859102 23,184 68,487 SH   SOLE   68,487 0 0
IDEXX Laboratories, Inc. Common 45168D104 25,566 102,403 SH   SOLE   102,403 0 0
Illumina, Inc. Common 452327109 89,092 242,717 SH   SOLE   242,717 0 0
ImmunoGen, Inc. Common 45253H101 1,593 168,190 SH   SOLE   168,190 0 0
Immunomedics, Inc. Common 452907108 2,028 97,370 SH   SOLE   97,370 0 0
Incyte Corporation Common 45337C102 44,587 645,442 SH   SOLE   645,442 0 0
Innoviva, Inc. Common 45781M101 2,463 161,603 SH   SOLE   161,603 0 0
Inovalon Holdings, Inc. Common 45781D101 1,770 176,163 SH   SOLE   176,163 0 0
Intellia Therapeutics, Inc. Common 45826J105 1,965 68,671 SH   SOLE   68,671 0 0
Intersect ENT, Inc. Common 46071F103 240 8,356 SH   SOLE   8,356 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 756 34,850 SH   SOLE   34,850 0 0
Intuitive Surgical, Inc. Common 46120E602 14,137 24,629 SH   SOLE   24,629 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 4,273 82,838 SH   SOLE   82,838 0 0
Iovance Biotherapeutics, Inc. Common 462260100 2,440 216,908 SH   SOLE   216,908 0 0
IQVIA Holdings Inc. Common 46266C105 2,180 16,800 SH   SOLE   16,800 0 0
Jazz Pharmaceuticals plc Shares G50871105 18,570 110,452 SH   SOLE   110,452 0 0
Johnson & Johnson Common 478160104 137,751 996,968 SH   SOLE   996,968 0 0
Jounce Therapeutics, Inc. Common 481116101 66 10,127 SH   SOLE   10,127 0 0
Koninklijke Philips N.V. NY Reg Sh 500472303 1,506 33,100 SH   SOLE   33,100 0 0
Laboratory Corporation of America Holdings Sponsored ADR 50540R409 2,119 12,200 SH   SOLE   12,200 0 0
LeMaitre Vascular, Inc. Common 525558201 1,052 27,150 SH   SOLE   27,150 0 0
Lexicon Pharmaceuticals, Inc. Sponsored ADR 528872302 747 70,000 SH   SOLE   70,000 0 0
Ligand Pharmaceuticals Incorporated Common 53220K504 2,454 8,940 SH   SOLE   8,940 0 0
LivaNova plc Shares G5509L101 779 6,287 SH   SOLE   6,287 0 0
Loxo Oncology, Inc. Common 548862101 4,202 24,595 SH   SOLE   24,595 0 0
LTC Properties, Inc. Common 502175102 9,249 209,673 SH   SOLE   209,673 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105 1,428 6,670 SH   SOLE   6,670 0 0
Mallinckrodt plc Shares G5785G107 1,571 53,600 SH   SOLE   53,600 0 0
Marinus Pharmaceuticals, Inc. Common 56854Q101 3,362 336,228 SH   SOLE   336,228 0 0
Masimo Corporation Common 574795100 4,237 34,020 SH   SOLE   34,020 0 0
McKesson Corporation Common 58155Q103 11,003 82,947 SH   SOLE   82,947 0 0
Medical Properties Trust, Inc. Common 58463J304 7,118 477,409 SH   SOLE   477,409 0 0
The Medicines Company Common 584688105 4,960 165,841 SH   SOLE   165,841 0 0
Medtronic plc Shares G5960L103 33,391 339,439 SH   SOLE   339,439 0 0
Menlo Therapeutics Inc. Common 586858102 244 24,784 SH   SOLE   24,784 0 0
Merck & Co., Inc. Common 58933Y105 45,771 645,208 SH   SOLE   645,208 0 0
Merus N.V. Common N5749R100 8,175 414,115 SH   SOLE   414,115 0 0
Mettler-Toledo International Inc. Common 592688105 2,131 3,500 SH   SOLE   3,500 0 0
Mirati Therapeutics, Inc. Common 60468T105 640 13,590 SH   SOLE   13,590 0 0
Molecular Templates, Inc. Common 608550109 777 144,110 SH   SOLE   144,110 0 0
Mylan N.V. Shares N59465109 60,647 1,657,017 SH   SOLE   1,657,017 0 0
MyoKardia, Inc. Common 62857M105 2,517 38,600 SH   SOLE   38,600 0 0
Nektar Therapeutics Common 640268108 12,952 212,469 SH   SOLE   212,469 0 0
Neurocrine Biosciences, Inc. Common 64125C109 26,143 212,630 SH   SOLE   212,630 0 0
Nevro Corp. Common 64157F103 3,919 68,760 SH   SOLE   68,760 0 0
New Senior Investment Group Inc. Common 648691103 3,121 528,919 SH   SOLE   528,919 0 0
NewLink Genetics Corporation Common 651511107 490 205,026 SH   SOLE   205,026 0 0
Nightstar Therapeutics plc ADR 65413A101 3,065 150,000 SH   SOLE   150,000 0 0
Novartis AG Sponsored ADR 66987V109 27,803 322,690 SH   SOLE   322,690 0 0
Novavax, Inc. Common 670002104 1,073 571,000 SH   SOLE   571,000 0 0
Novo Nordisk A/S Sponsored ADR 670100205 14,232 301,900 SH   SOLE   301,900 0 0
NuCana plc Sponsored ADR 67022C106 245 9,823 SH   SOLE   9,823 0 0
NuVasive, Inc. Common 670704105 1,390 19,580 SH   SOLE   19,580 0 0
Omega Healthcare Investors, Inc. Common 681936100 19,000 579,785 SH   SOLE   579,785 0 0
Ovid Therapeutics Inc. Common 690469101 3,038 535,824 SH   SOLE   535,824 0 0
Perrigo Company plc Shares G97822103 2,641 37,300 SH   SOLE   37,300 0 0
Pfizer Inc. Common 717081103 59,675 1,354,093 SH   SOLE   1,354,093 0 0
Physicians Realty Trust Common 71943U104 6,593 391,016 SH   SOLE   391,016 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 11,689 2,087,380 SH   SOLE   2,087,380 0 0
Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 3,074 115,448 SH   SOLE   115,448 0 0
PRA Health Sciences, Inc. Common 69354M108 3,577 32,460 SH   SOLE   32,460 0 0
Protagonist Therapeutics, Inc. Common 74366E102 2,254 219,042 SH   SOLE   219,042 0 0
PTC Therapeutics, Inc. Common 69366J200 2,274 48,390 SH   SOLE   48,390 0 0
Puma Biotechnology, Inc. Common 74587V107 3,821 83,340 SH   SOLE   83,340 0 0
Quest Diagnostics Incorporated Common 74834L100 4,208 39,000 SH   SOLE   39,000 0 0
Quorum Health Corporation Common 74909E106 139 23,725 SH   SOLE   23,725 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 59,086 146,237 SH   SOLE   146,237 0 0
Repligen Corporation Common 759916109 2,146 38,700 SH   SOLE   38,700 0 0
ResMed Inc. Common 761152107 6,762 58,630 SH   SOLE   58,630 0 0
Revance Therapeutics, Inc. Common 761330109 1,936 77,919 SH   SOLE   77,919 0 0
Rhythm Pharmaceuticals, Inc. Sponsored ADR 76243J105 726 24,890 SH   SOLE   24,890 0 0
The RMR Group Inc. Class A 74967R106 494 5,323 SH   SOLE   5,323 0 0
Sabra Health Care REIT, Inc. Common 78573L106 16,753 724,606 SH   SOLE   724,606 0 0
Sage Therapeutics, Inc. Common 78667J108 20,285 143,614 SH   SOLE   143,614 0 0
Sangamo Therapeutics, Inc. Common 800677106 2,914 171,889 SH   SOLE   171,889 0 0
Sanofi Sponsored ADR 80105N105 8,036 179,900 SH   SOLE   179,900 0 0
Sarepta Therapeutics, Inc. Common 803607100 36,046 223,182 SH   SOLE   223,182 0 0
Seattle Genetics, Inc. Common 812578102 21,549 279,417 SH   SOLE   279,417 0 0
Senior Housing Properties Trust Common 81721M109 11,353 646,554 SH   SOLE   646,554 0 0
Shire plc Shares 82481R106 6,565 36,216 SH   SOLE   36,216 0 0
Smith & Nephew plc Sponsored ADR 83175M205 6,879 185,478 SH   SOLE   185,478 0 0
Spark Therapeutics, Inc. Common 84652J103 1,203 22,046 SH   SOLE   22,046 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 12,367 129,000 SH   SOLE   129,000 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108 1,926 114,670 SH   SOLE   114,670 0 0
STERIS plc Shares G84720104 4,027 35,203 SH   SOLE   35,203 0 0
Stryker Corporation Common 863667101 28,506 160,432 SH   SOLE   160,432 0 0
Sutro Biopharma, Inc. Common 869367102 3,750 250,000 SH   SOLE   250,000 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105 1,616 200,000 SH   SOLE   200,000 0 0
Teleflex Incorporated Common 879369106 1,697 6,379 SH   SOLE   6,379 0 0
Teligent, Inc. Common 87960W104 401 101,458 SH   SOLE   101,458 0 0
Tenet Healthcare Corporation Common 88033G407 4,682 164,500 SH   SOLE   164,500 0 0
TESARO, Inc. Common 881569107 3,705 94,970 SH   SOLE   94,970 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N105 2,372 859,322 SH   SOLE   859,322 0 0
Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 20,096 932,948 SH   SOLE   932,948 0 0
Theravance Biopharma, Inc. Common G8807B106 264 8,083 SH   SOLE   8,083 0 0
Thermo Fisher Scientific Inc. Common 883556102 44,031 180,395 SH   SOLE   180,395 0 0
Trillium Therapeutics Inc. Common 89620X506 2,717 468,399 SH   SOLE   468,399 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 5,875 76,958 SH   SOLE   76,958 0 0
uniQure N.V. Shares N90064101 1,373 37,741 SH   SOLE   37,741 0 0
United Therapeutics Corporation Class B 91307C102 5,276 41,261 SH   SOLE   41,261 0 0
Unitedhealth Group Incorporated Common 91324P102 91,647 344,486 SH   SOLE   344,486 0 0
Varian Medical Systems, Inc. Common 92220P105 2,936 26,227 SH   SOLE   26,227 0 0
Ventas, Inc. Common 92276F100 5,356 98,496 SH   SOLE   98,496 0 0
Verona Pharma plc Sponsored ADR 925050106 3,440 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 78,683 408,235 SH   SOLE   408,235 0 0
Waters Corporation Common 941848103 2,103 10,800 SH   SOLE   10,800 0 0
Welltower Inc. Common 95040Q104 2,930 45,560 SH   SOLE   45,560 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 7,742 266,781 SH   SOLE   266,781 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 15,625 118,846 SH   SOLE   118,846 0 0
Zoetis Inc. Class A 98978V103 20,822 227,415 SH   SOLE   227,415 0 0
Zogenix, Inc. Common 98978L204 3,283 66,182 SH   SOLE   66,182 0 0