The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Qiagen NV | SHS NEW | N72482123 | 29,369 | 775,324 | SH | SOLE | 1 | 775,324 | 0 | 0 | |
| PACIFIC BIOSCIENCES CALIF IN | COM | 69404D108 | 12,105 | 2,237,607 | SH | SOLE | 1 | 2,237,607 | 0 | 0 | |
| Agenus Inc | COM NEW | 00847G705 | 21,025 | 9,824,579 | SH | SOLE | 1 | 9,824,579 | 0 | 0 | |
| Arbutus Biopharma Corp | COM | 03879J100 | 38,602 | 4,084,904 | SH | SOLE | 1 | 4,084,904 | 0 | 0 | |
| PTC Therapeutics Inc | COM | 69366J200 | 153,953 | 3,275,591 | SH | SOLE | 1 | 3,275,591 | 0 | 0 | |
| ResMed Inc | COM | 761152107 | 17,001 | 147,400 | SH | SOLE | 1 | 147,400 | 0 | 0 | |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 72,358 | 3,739,406 | SH | SOLE | 1 | 3,739,406 | 0 | 0 | |
| Viking Therapeutics Inc | COM | 92686J106 | 8,710 | 500,000 | SH | SOLE | 1 | 500,000 | 0 | 0 | |
| Viewray Inc | COM | 92672L107 | 31,726 | 3,389,498 | SH | SOLE | 1 | 3,389,498 | 0 | 0 | |
| PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 2,721 | 1,129,121 | SH | SOLE | 1 | 1,129,121 | 0 | 0 | |
| Nuvectra Corp | COM | 67075N108 | 5,524 | 251,329 | SH | SOLE | 1 | 251,329 | 0 | 0 | |
| Myokardia Inc | COM | 62857M105 | 17,859 | 273,917 | SH | SOLE | 1 | 273,917 | 0 | 0 | |
| CareDx Inc | COM | 14167L103 | 10,322 | 357,766 | SH | SOLE | 1 | 357,766 | 0 | 0 | |
| Adverum Biotechnologies Inc | COM | 00773U108 | 1,118 | 184,821 | SH | SOLE | 1 | 184,821 | 0 | 0 | |
| Novus Therapeutics Inc | COM | 67011N105 | 1,477 | 316,257 | SH | SOLE | 1 | 316,257 | 0 | 0 | |
| Bellicum Pharmaceuticals Inc | COM | 079481107 | 970 | 157,489 | SH | SOLE | 1 | 157,489 | 0 | 0 | |
| Rocket Pharmaceuticals Inc | COM | 77313F106 | 368,555 | 14,969,744 | SH | SOLE | 1 | 14,969,744 | 0 | 0 | |
| VIVEVE MED INC | COM NEW | 92852W204 | 8,435 | 3,147,232 | SH | SOLE | 1 | 3,147,232 | 0 | 0 | |
| Regenxbio Inc | COM | 75901B107 | 110,164 | 1,459,128 | SH | SOLE | 1 | 1,459,128 | 0 | 0 | |
| LivaNova PLC | SHS | G5509L101 | 54,923 | 443,036 | SH | SOLE | 1 | 443,036 | 0 | 0 | |
| La Jolla Pharmaceutical Co | COM PAR $.0001 2 | 503459604 | 24,098 | 1,197,107 | SH | SOLE | 1 | 1,197,107 | 0 | 0 | |
| Dicerna Pharmaceuticals Inc | COM | 253031108 | 83,337 | 5,461,124 | SH | SOLE | 1 | 5,461,124 | 0 | 0 | |
| Uniqure NV | SHS | N90064101 | 15,611 | 428,980 | SH | SOLE | 1 | 428,980 | 0 | 0 | |
| CORIUM INTL INC | COM | 21887L107 | 34,337 | 3,610,632 | SH | SOLE | 1 | 3,610,632 | 0 | 0 | |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 58,787 | 946,961 | SH | SOLE | 1 | 946,961 | 0 | 0 | |
| Vericel Corp | COM | 92346J108 | 31,384 | 2,217,916 | SH | SOLE | 1 | 2,217,916 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc | COM | 02043Q107 | 34,052 | 389,072 | SH | SOLE | 1 | 389,072 | 0 | 0 | |
| Novavax Inc | COM | 670002104 | 5,210 | 2,771,023 | SH | SOLE | 1 | 2,771,023 | 0 | 0 | |
| ACHILLION PHARMACEUTICALS IN | COM | 00448Q201 | 50,032 | 13,595,704 | SH | SOLE | 1 | 13,595,704 | 0 | 0 | |
| Illumina Inc | COM | 452327109 | 30,327 | 82,621 | SH | SOLE | 1 | 82,621 | 0 | 0 | |
| Bovie Medical Corp | COM | 10211F100 | 15,872 | 2,235,547 | SH | SOLE | 1 | 2,235,547 | 0 | 0 | |
| Tapimmune Inc | COM PAR | 876033408 | 1,898 | 209,721 | SH | SOLE | 1 | 209,721 | 0 | 0 | |
| ARROWHEAD PHARMACEUTICALS IN | COM | 04280A100 | 145,773 | 7,604,225 | SH | SOLE | 1 | 7,604,225 | 0 | 0 | |
| Sarepta Therapeutics Inc | COM | 803607100 | 50,725 | 314,070 | SH | SOLE | 1 | 314,070 | 0 | 0 | |
| Solid Biosciences Inc | COM | 83422E105 | 12,376 | 262,318 | SH | SOLE | 1 | 262,318 | 0 | 0 | |
| MOTUS GI HLDGS INC | COM | 62014P108 | 303 | 59,478 | SH | SOLE | 1 | 59,478 | 0 | 0 | |
| Homology Medicines Inc | COM | 438083107 | 9,942 | 434,917 | SH | SOLE | 1 | 434,917 | 0 | 0 | |
| ELECTROCORE INC | COM | 28531P103 | 7,198 | 514,165 | SH | SOLE | 1 | 514,165 | 0 | 0 | |
| Neuronetics Inc | COM | 64131A105 | 5,049 | 157,487 | SH | SOLE | 1 | 157,487 | 0 | 0 | |
| ESTABLISHMENT LABS HLDGS INC | COM | G31249108 | 18,094 | 775,809 | SH | SOLE | 1 | 775,809 | 0 | 0 | |
| Principia Biopharma Inc | COM | 74257L108 | 17,369 | 644,448 | SH | SOLE | 1 | 644,448 | 0 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 2,037 | 26,853 | SH | SOLE | 1 | 26,853 | 0 | 0 | |
| Odonate Therapeutics Inc | COM | 676079106 | 5,621 | 289,608 | SH | SOLE | 1 | 289,608 | 0 | 0 | |
| RA MED SYS INC | COM | 74933X104 | 2,002 | 110,000 | SH | SOLE | 1 | 110,000 | 0 | 0 | |
| Masimo Corp | COM | 574795100 | 38,665 | 310,461 | SH | SOLE | 1 | 310,461 | 0 | 0 | |
| VIVUS INC | NOTE 4.500% 5/0 | 928551AB6 | 3,185 | 4,000,000 | SH | SOLE | 1 | 4,000,000 | 0 | 0 | |