The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 14,146 1,853,998 SH   DFND 1 1,853,998 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 50,145 1,424,571 SH   DFND 1 1,424,571 0 0
ACCELERON PHARMA INC COM 00434H108 63,963 1,117,651 SH   DFND 1 1,117,651 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 44,916 3,093,416 SH   DFND 1 3,093,416 0 0
ADDUS HOMECARE CORP COM 006739106 4,601 65,590 SH   DFND 1 65,590 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 94,815 1,540,448 SH   DFND 1 1,540,448 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 26,853 348,200 SH   DFND 1 348,200 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 15,086 553,000 SH   DFND 1 553,000 0 0
ALBIREO PHARMA INC COM 01345P106 3,955 120,000 SH   DFND 1 120,000 0 0
ALIMERA SCIENCES INC COM 016259103 5,932 6,052,935 SH   DFND 1 6,052,935 0 0
ALLAKOS INC COM 01671P100 10,123 225,000 SH   DFND 1 225,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 3,879 612,867 SH   DFND 1 612,867 0 0
ANAPTYSBIO INC COM 032724106 64,598 647,466 SH   DFND 1 647,466 0 0
ANTHEM INC COM 036752103 26,035 95,000 SH   DFND 1 95,000 0 0
ARDELYX INC COM 039697107 15,190 3,491,922 SH   DFND 1 3,491,922 0 0
ARGENX SE SPONSORED ADR 04016X101 49,789 656,500 SH   DFND 1 656,500 0 0
ARVINAS INC COM 04335A105 20,813 1,233,734 SH   DFND 1 1,233,734 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 22,675 320,000 SH   DFND 1 320,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 19,554 493,901 SH   DFND 1 493,901 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 7,668 250,000 SH   DFND 1 250,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 11,951 2,722,241 SH   DFND 1 2,722,241 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 52,729 6,910,789 SH   DFND 1 6,910,789 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 8,974 239,000 SH   DFND 1 239,000 0 0
BIOSCRIP INC COM 09069N108 3,172 1,023,379 SH   DFND 1 1,023,379 0 0
BLUEBIRD BIO INC COM 09609G100 8,970 61,435 SH   DFND 1 61,435 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 40,982 525,000 SH   DFND 1 525,000 0 0
BROOKDALE SR LIVING INC COM 112463104 46,279 4,707,912 SH   DFND 1 4,707,912 0 0
CENTENE CORP DEL COM 15135B101 35,471 245,000 SH   DFND 1 245,000 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 4,279 635,843 SH   DFND 1 635,843 0 0
CVS HEALTH CORP COM 126650100 44,618 566,800 SH Call DFND 1 566,800 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 14,882 1,343,181 SH   DFND 1 1,343,181 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 13,504 729,948 SH   DFND 1 729,948 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 65,134 2,900,000 SH   DFND 1 2,900,000 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 84,160 55,000,000 PRN   DFND 1 55,000,000 0 0
DFB HEALTHCARE ACQUISTION CO UNIT 01/30/2023 23291E208 25,500 2,500,000 SH   DFND 1 2,500,000 0 0
DIPLOMAT PHARMACY INC COM 25456K101 16,570 853,687 SH   DFND 1 853,687 0 0
EDITAS MEDICINE INC COM 28106W103 36,874 1,158,841 SH   DFND 1 1,158,841 0 0
EHEALTH INC COM 28238P109 34,677 1,227,061 SH   DFND 1 1,227,061 0 0
EIDOS THERAPEUTICS INC COM 28249H104 4,196 420,409 SH   DFND 1 420,409 0 0
ENDOCYTE INC COM 29269A102 62,410 3,514,084 SH   DFND 1 3,514,084 0 0
EPIZYME INC COM 29428V104 18,858 1,779,094 SH   DFND 1 1,779,094 0 0
EYENOVIA INC COM 30234E104 1,206 300,000 SH   DFND 1 300,000 0 0
FATE THERAPEUTICS INC COM 31189P102 19,118 1,173,617 SH   DFND 1 1,173,617 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 1,345 234,745 SH   DFND 1 234,745 0 0
G1 THERAPEUTICS INC COM 3621LQ109 15,007 287,000 SH   DFND 1 287,000 0 0
GALAPAGOS NV SPON ADR 36315X101 29,239 260,064 SH   DFND 1 260,064 0 0
GLAUKOS CORP COM 377322102 36,951 569,356 SH   DFND 1 569,356 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 5,052 29,249 SH   DFND 1 29,249 0 0
HISTOGENICS CORP COM 43358V109 161 296,099 SH   DFND 1 296,099 0 0
HOMOLOGY MEDICINES INC COM 438083107 119,490 5,227,035 SH   DFND 1 5,227,035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 99,537 99,100,000 PRN   DFND 1 99,100,000 0 0
HORIZON PHARMA PLC SHS G4617B105 129,422 6,609,894 SH   DFND 1 6,609,894 0 0
IGI LABORATORIES INC NOTE 3.750%12/1 449575AB5 3,555 3,733,000 PRN   DFND 1 3,733,000 0 0
IMMUNOMEDICS INC COM 452907108 33,120 1,590,000 SH   DFND 1 1,590,000 0 0
INSPIRE MED SYS INC COM 457730109 7,953 189,000 SH   DFND 1 189,000 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 36,248 36,000,000 PRN   DFND 1 36,000,000 0 0
INTERSECT ENT INC COM 46071F103 61,754 2,147,950 SH   DFND 1 2,147,950 0 0
INVITAE CORP COM 46185L103 11,511 688,062 SH   DFND 1 688,062 0 0
K2M GROUP HLDGS INC NOTE 4.125% 8/1 48273JAB3 30,080 20,000,000 PRN   DFND 1 20,000,000 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 14,372 650,000 SH   DFND 1 650,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 8,089 475,000 SH   DFND 1 475,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 48,281 75,000,000 PRN   DFND 1 75,000,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 27,080 1,061,956 SH   DFND 1 1,061,956 0 0
LIVANOVA PLC SHS G5509L101 8,864 71,500 SH   DFND 1 71,500 0 0
MELINTA THERAPEUTICS INC COM 58549G100 9,132 2,311,858 SH   DFND 1 2,311,858 0 0
MIRATI THERAPEUTICS INC COM 60468T105 39,607 840,911 SH   DFND 1 840,911 0 0
MORPHOSYS AG SPONSORED ADS 617760202 16,020 600,000 SH   DFND 1 600,000 0 0
MYLAN N V SHS EURO N59465109 67,421 1,842,111 SH   DFND 1 1,842,111 0 0
MYOKARDIA INC COM 62857M105 59,788 917,000 SH   DFND 1 917,000 0 0
NEVRO CORP COM 64157F103 29,927 525,040 SH   DFND 1 525,040 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 99,400 100,000,000 PRN   DFND 1 100,000,000 0 0
NIGHTSTAR THERAPEUTICS PLC ADR 65413A101 10,210 499,747 SH   DFND 1 499,747 0 0
NUVASIVE INC NOTE 2.250% 3/1 670704AG0 8,865 7,000,000 PRN   DFND 1 7,000,000 0 0
NUVECTRA CORP COM 67075N108 6,130 278,890 SH   DFND 1 278,890 0 0
ORTHOPEDIATRICS CORP COM 68752L100 2,134 58,247 SH   DFND 1 58,247 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 17,648 1,087,359 SH   DFND 1 1,087,359 0 0
PERNIX THERAPEUTICS HLDGS IN COM NEW 71426V306 635 658,826 SH   DFND 1 658,826 0 0
PFENEX INC COM 717071104 5,465 1,069,514 SH   DFND 1 1,069,514 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 65,392 2,455,586 SH   DFND 1 2,455,586 0 0
PROTEON THERAPEUTICS INC COM 74371L109 2,389 1,224,899 SH   DFND 1 1,224,899 0 0
RA MED SYS INC COM 74933X104 2,341 128,600 SH   DFND 1 128,600 0 0
RA PHARMACEUTICALS INC COM 74933V108 6,923 382,700 SH   DFND 1 382,700 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 24,037 294,000 SH   DFND 1 294,000 0 0
REGENXBIO INC COM 75901B107 20,763 275,000 SH   DFND 1 275,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 10,667 365,689 SH   DFND 1 365,689 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 6,894 280,000 SH   DFND 1 280,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 47,807 296,000 SH   DFND 1 296,000 0 0
SAVARA INC COM 805111101 2,790 250,000 SH   DFND 1 250,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 28,078 1,526,000 SH   DFND 1 1,526,000 0 0
SIENTRA INC COM 82621J105 14,179 593,769 SH   DFND 1 593,769 0 0
SYNLOGIC INC COM 87166L100 19,399 1,365,143 SH   DFND 1 1,365,143 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 15,113 1,268,945 SH   DFND 1 1,268,945 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 12,129 283,115 SH   DFND 1 283,115 0 0
TELIGENT INC NEW COM 87960W104 2,800 708,873 SH   DFND 1 708,873 0 0
TELIGENT INC NEW NOTE 4.750% 5/0 87960WAA2 10,401 9,567,000 PRN   DFND 1 9,567,000 0 0
UNIQURE NV SHS N90064101 8,786 241,430 SH   DFND 1 241,430 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 33,494 262,000 SH   DFND 1 262,000 0 0
VERICEL CORP COM 92346J108 22,891 1,617,730 SH   DFND 1 1,617,730 0 0
VIKING THERAPEUTICS INC COM 92686J106 8,013 460,000 SH   DFND 1 460,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 2,226 117,647 SH   DFND 1 117,647 0 0
WRIGHT MED GROUP N V NOTE 2.250%11/1 98236JAB4 45,572 31,500,000 PRN   DFND 1 31,500,000 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 43,927 2,498,666 SH   DFND 1 2,498,666 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 15,908 121,000 SH   DFND 1 121,000 0 0