Form 25

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 25

NOTIFICATION OF REMOVAL FROM LISTING

AND/OR REGISTRATION UNDER SECTION 12(b)

OF THE SECURITIES EXCHANGE ACT OF 1934.

Commission File Number:

001-37895

001-37896

Shire Acquisitions Investments Ireland Designated Activity Company

(as issuer)

Shire plc

(as guarantor)

New York Stock Exchange

(Exact name of Issuer as specified in its charter; and name of Exchange

where security is listed and/or registered)

Block 2, Miesian Plaza, 50-58 Baggot Street Lower, Dublin 2, Republic of Ireland

+353 1 609 6000

(Address, including zip code, and telephone number, including area code, of Issuer’s principal executive offices)

1.900% Senior Notes due 2019; 2.400% Senior Notes due 2021; 2.875% Senior Notes due 2023; 3.200% Senior Notes

due 2026 of Shire Acquisitions Investments Ireland Designated Activity Company

Guarantees of 1.900% Senior Notes due 2019; 2.400% Senior Notes due 2021; 2.875% Senior Notes due 2023;

3.200% Senior Notes due 2026 of Shire plc

(Description of class of securities)

Please place an X in the box to designate the rule provision relied upon to strike the class of securities from listing and registration:

☐	17 CFR 240.12d2-2(a)(1)

☐	17 CFR 240.12d2-(a)(2)

☐	17 CFR 240.12d2-2(a)(3)

☐	17 CFR 240.12d2-2(a)(4)

☐	Pursuant to 17 CFR 240.12d2-2(b), the Exchange has complied with its rules to strike the class of securities from listing and/or withdraw registration on the Exchange.

☒	Pursuant to 17 CFR 240.12d2-2(c), the Issuer has complied with the rules of the Exchange and the requirements of 17 CFR 240.12d2-2(c) governing the voluntary withdrawal of the class of securities from listing and registration on the Exchange.


	Shire Acquisitions Investments Ireland Designated Activity Company

Date: January 22, 2019	By:	/s/ Fiona Foley
	Name:	Fiona Foley
	Title:	Director