The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U Inc Common Stock 90214J101 28,351 570,214 SH   SOLE   467,347 4,126 98,741
3D Systems Corp Common Stock 88554D205 1,401 137,725 SH   SOLE   137,725 0 0
3M Co Common Stock 88579Y101 53 280 SH   SOLE   280 0 0
Adobe Inc Common Stock 00724F101 6,549 28,948 SH   SOLE   28,948 0 0
Advanced Micro Devices Inc Common Stock 007903107 10,613 574,938 SH   SOLE   574,938 0 0
Aerovironment Inc Common Stock 008073108 7,857 115,625 SH   SOLE   56,686 0 58,939
Alibaba Group Holding Ltd ADR 01609W102 13,240 96,591 SH   SOLE   60,003 6,749 29,839
Align Technology Inc Common Stock 016255101 3,961 18,914 SH   SOLE   18,914 0 0
Allegheny Technologies Inc Common Stock 01741R102 45 2,063 SH   SOLE   2,063 0 0
Alphabet Inc Common Stock 02079K107 3,100 2,993 SH   SOLE   2,993 0 0
Amazon.com Inc Common Stock 023135106 64,310 42,817 SH   SOLE   31,889 1,832 9,096
AMETEK Inc Common Stock 031100100 508 7,497 SH   SOLE   7,497 0 0
ANSYS Inc Common Stock 03662Q105 3,009 21,053 SH   SOLE   21,053 0 0
Apple Inc Common Stock 037833100 16,729 106,052 SH   SOLE   106,052 0 0
Aptiv PLC Common Stock G6095L109 5,753 93,442 SH   SOLE   90,939 2,503 0
AquaBounty Technologies Inc Common Stock 03842K200 605 294,914 SH   SOLE   294,914 0 0
Arconic Inc Common Stock 03965L100 353 20,958 SH   SOLE   20,958 0 0
Arcturus Therapeutics Ltd Common Stock M1492T105 3,693 815,176 SH   SOLE   815,176 0 0
Arkema SA Common Stock F0392W125 43 499 SH   SOLE   499 0 0
Arrk Corp Common Stock J0198N101 347 504,801 SH   SOLE   504,801 0 0
ASX Ltd Common Stock Q0604U105 65 1,579 SH   SOLE   1,579 0 0
Atlassian Corp PLC Common Stock G06242104 5,361 60,252 SH   SOLE   60,252 0 0
Attunity Ltd Common Stock M15332121 585 29,720 SH   SOLE   29,720 0 0
AudioCodes Ltd Common Stock M15342104 512 51,850 SH   SOLE   51,850 0 0
Autodesk Inc Common Stock 052769106 4,728 36,761 SH   SOLE   36,761 0 0
Baidu Inc ADR 056752108 115,689 729,440 SH   SOLE   536,743 37,184 155,513
Bayer AG Common Stock D0712D163 27 390 SH   SOLE   0 390 0
Bellicum Pharmaceuticals Inc Common Stock 079481107 3,018 1,033,491 SH   SOLE   1,033,491 0 0
Bertrandt AG Common Stock D1014N107 442 5,638 SH   SOLE   5,638 0 0
Bezeq The Israeli Telecommunic Common Stock M2012Q100 438 449,052 SH   SOLE   449,052 0 0
Bluebird Bio Inc Common Stock 09609G100 19,536 196,938 SH   SOLE   110,159 13,402 73,377
Camtek Ltd/Israel Common Stock M20791105 447 65,974 SH   SOLE   65,974 0 0
Carpenter Technology Corp Common Stock 144285103 38 1,072 SH   SOLE   1,072 0 0
Celgene Corp Common Stock 151020104 11,171 174,303 SH   SOLE   174,303 0 0
Cellcom Israel Ltd Common Stock M2196U109 469 79,461 SH   SOLE   79,461 0 0
Cellectis SA ADR 15117K103 11,894 714,336 SH   SOLE   628,390 75,257 10,689
Ceragon Networks Ltd Common Stock M22013102 508 134,337 SH   SOLE   134,337 0 0
Cerus Corp Common Stock 157085101 34,176 6,740,782 SH   SOLE   5,031,386 68,123 1,641,273
Charles Schwab Corp/The Common Stock 808513105 155 3,738 SH   SOLE   3,738 0 0
Check Point Software Technolog Common Stock M22465104 458 4,464 SH   SOLE   4,464 0 0
Codexis Inc Common Stock 192005106 3,579 214,298 SH   SOLE   214,298 0 0
Cognex Corp Common Stock 192422103 2,666 68,945 SH   SOLE   68,945 0 0
Compugen Ltd Common Stock M25722105 15,420 7,105,958 SH   SOLE   6,906,103 56,726 143,129
CRISPR Therapeutics AG Common Stock H17182108 37,858 1,325,110 SH   SOLE   944,753 77,477 302,880
CyberArk Software Ltd Common Stock M2682V108 522 7,046 SH   SOLE   7,046 0 0
Daimler AG ADR 233825207 1,692 129,032 SH   SOLE   129,032 0 0
Danel Adir Yeoshua Ltd Common Stock M27013107 492 10,126 SH   SOLE   10,126 0 0
Dassault Systemes SE Common Stock F2457H472 1,457 12,267 SH   SOLE   12,267 0 0
Deere & Co Common Stock 244199105 1,919 12,867 SH   SOLE   12,867 0 0
DowDuPont Inc Common Stock 26078J100 51 953 SH   SOLE   953 0 0
Eastman Chemical Co Common Stock 277432100 50 682 SH   SOLE   682 0 0
Eastman Kodak Co Common Stock 277461406 57 22,266 SH   SOLE   22,266 0 0
Editas Medicine Inc Common Stock 28106W103 68,807 3,024,489 SH   SOLE   2,211,222 163,610 649,657
Elbit Systems Ltd Common Stock M3760D101 2,275 19,952 SH   SOLE   19,952 0 0
Eventbrite Inc Common Stock 29975E109 4,243 152,573 SH   SOLE   152,573 0 0
Evogene Ltd Common Stock M4119S104 499 252,122 SH   SOLE   252,122 0 0
Evonik Industries AG Common Stock D2R90Y117 39 1,550 SH   SOLE   1,550 0 0
ExOne Co/The Common Stock 302104104 13,100 1,978,817 SH   SOLE   1,597,998 0 380,819
FANUC Corp Common Stock J13440102 33 220 SH   SOLE   0 220 0
FARO Technologies Inc Common Stock 311642102 406 9,988 SH   SOLE   9,988 0 0
FirstRand Ltd Common Stock S5202Z131 170 34,982 SH   SOLE   34,982 0 0
Fiserv Inc Common Stock 337738108 138 1,873 SH   SOLE   1,873 0 0
Foamix Pharmaceuticals Ltd Common Stock M46135105 339 94,378 SH   SOLE   94,378 0 0
Galmed Pharmaceuticals Ltd Common Stock M47238106 279 40,844 SH   SOLE   40,844 0 0
General Electric Co Common Stock 369604103 285 37,606 SH   SOLE   37,606 0 0
General Motors Co Common Stock 37045V100 1,678 50,179 SH   SOLE   50,179 0 0
Gilat Satellite Networks Ltd Common Stock M51474118 557 60,300 SH   SOLE   60,300 0 0
GMO internet Inc Common Stock J1822R104 37 2,700 SH   SOLE   2,700 0 0
Grayscale Bitcoin Trust BTC Open-End Fund 389637109 14,427 3,638,710 SH   SOLE   1,386,036 685,136 1,567,538
GrubHub Inc Common Stock 400110102 8,678 112,983 SH   SOLE   112,983 0 0
Guidewire Software Inc Common Stock 40171V100 315 3,922 SH   SOLE   3,922 0 0
HDFC Bank Ltd ADR 40415F101 134 1,297 SH   SOLE   1,297 0 0
Henkel AG & Co KGaA Common Stock D3207M102 50 508 SH   SOLE   508 0 0
Hexagon AB Common Stock W40063104 472 10,367 SH   SOLE   10,367 0 0
Hexcel Corp Common Stock 428291108 50 869 SH   SOLE   869 0 0
Hilan Ltd Common Stock M5299H123 493 21,003 SH   SOLE   21,003 0 0
Hortonworks Inc Common Stock 440894103 8,268 573,384 SH   SOLE   343,935 0 229,449
HP Inc Common Stock 40434L105 2,004 97,957 SH   SOLE   97,957 0 0
HubSpot Inc Common Stock 443573100 6,766 53,812 SH   SOLE   53,812 0 0
Illumina Inc Common Stock 452327109 94,970 316,640 SH   SOLE   239,613 15,993 61,034
Incyte Corp Common Stock 45337C102 4,206 66,147 SH   SOLE   66,147 0 0
Infineon Technologies AG ADR 45662N103 15 738 SH   SOLE   738 0 0
Inovio Pharmaceuticals Inc Common Stock 45773H201 7,543 1,885,641 SH   SOLE   1,885,641 0 0
Intec Pharma Ltd Common Stock M53644106 727 96,370 SH   SOLE   96,370 0 0
Intellia Therapeutics Inc Common Stock 45826J105 92,847 6,801,952 SH   SOLE   5,450,752 383,308 967,892
Interactive Brokers Group Inc Common Stock 45841N107 255 4,674 SH   SOLE   4,674 0 0
Intercontinental Exchange Inc Common Stock 45866F104 169 2,248 SH   SOLE   2,248 0 0
Intuit Inc Common Stock 461202103 257 1,307 SH   SOLE   1,307 0 0
Intuitive Surgical Inc Common Stock 46120E602 2,359 4,926 SH   SOLE   4,926 0 0
Invitae Corp Common Stock 46185L103 96,997 8,770,073 SH   SOLE   6,990,238 153,433 1,626,402
Ionis Pharmaceuticals Inc Common Stock 462222100 13,099 242,312 SH   SOLE   181,000 0 61,312
Iovance Biotherapeutics Inc Common Stock 462260100 6,428 726,360 SH   SOLE   726,360 0 0
Ituran Location and Control Lt Common Stock M6158M104 468 14,601 SH   SOLE   14,601 0 0
JD.com Inc ADR 47215P106 1,745 83,383 SH   SOLE   83,383 0 0
Kamada Ltd Common Stock M6240T109 425 85,268 SH   SOLE   85,268 0 0
Koninklijke DSM NV Common Stock N5017D122 51 620 SH   SOLE   620 0 0
Kratos Defense & Security Solu Common Stock 50077B207 1,690 119,953 SH   SOLE   119,953 0 0
LendingClub Corp Common Stock 52603A109 46,096 17,526,970 SH   SOLE   14,108,403 173,719 3,244,848
LendingTree Inc Common Stock 52603B107 51,709 235,501 SH   SOLE   178,759 11,977 44,765
Linde PLC Common Stock G5494J103 55 351 SH   SOLE   351 0 0
LINE Corp ADR 53567X101 135 3,963 SH   SOLE   3,963 0 0
Loxo Oncology Inc Common Stock 548862101 5,664 40,440 SH   SOLE   33,143 6,538 759
Materialise NV ADR 57667T100 49,292 2,460,912 SH   SOLE   2,244,754 6,823 209,335
Matrix IT Ltd Common Stock M6859E153 479 43,384 SH   SOLE   43,384 0 0
Medidata Solutions Inc Common Stock 58471A105 63,143 936,559 SH   SOLE   723,869 46,940 165,750
Medtronic PLC Common Stock G5960L103 438 4,820 SH   SOLE   4,820 0 0
Mellanox Technologies Ltd Common Stock M51363113 633 6,857 SH   SOLE   6,857 0 0
MercadoLibre Inc Common Stock 58733R102 6,374 21,765 SH   SOLE   18,580 2,862 323
MGI Digital Graphic Technology Common Stock F4090S113 2,052 44,342 SH   SOLE   44,342 0 0
Microsoft Corp Common Stock 594918104 1,502 14,786 SH   SOLE   14,786 0 0
Moog Inc Common Stock 615394202 474 6,118 SH   SOLE   6,118 0 0
MSCI Inc Common Stock 55354G100 115 783 SH   SOLE   783 0 0
Nano Dimension Ltd ADR 63008G104 570 513,079 SH   SOLE   513,079 0 0
NanoString Technologies Inc Common Stock 63009R109 48,030 3,238,692 SH   SOLE   3,140,420 91,512 6,760
Nasdaq Inc Common Stock 631103108 182 2,232 SH   SOLE   2,232 0 0
Netflix Inc Common Stock 64110L106 70,187 262,225 SH   SOLE   199,401 15,204 47,620
Nice Ltd ADR 653656108 508 4,691 SH   SOLE   4,691 0 0
Nintendo Co Ltd Common Stock J51699106 45 171 SH   SOLE   0 171 0
Nova Measuring Instruments Ltd Common Stock M7516K103 459 20,150 SH   SOLE   20,150 0 0
NuVasive Inc Common Stock 670704105 331 6,684 SH   SOLE   6,684 0 0
NVIDIA Corp Common Stock 67066G104 122,036 914,128 SH   SOLE   718,037 39,998 156,093
NXP Semiconductors NV Common Stock N6596X109 1,833 25,007 SH   SOLE   25,007 0 0
Opera Ltd ADR 68373M107 276 49,725 SH   SOLE   10,825 0 38,900
Orbotech Ltd Common Stock M75253100 505 8,940 SH   SOLE   8,940 0 0
Organovo Holdings Inc Common Stock 68620A104 17,285 18,059,829 SH   SOLE   17,929,634 130,195 0
Pacific Biosciences of Califor Common Stock 69404D108 4 590 SH   SOLE   590 0 0
Partner Communications Co Ltd Common Stock M78465107 497 101,428 SH   SOLE   101,428 0 0
PayPal Holdings Inc Common Stock 70450Y103 10,396 123,629 SH   SOLE   123,629 0 0
Pinduoduo Inc ADR 722304102 4,931 219,730 SH   SOLE   219,730 0 0
Pluristem Therapeutics Inc Common Stock 72940R102 2,669 3,387,094 SH   SOLE   3,387,094 0 0
Pointer Telocation Ltd Common Stock M7946T104 493 40,543 SH   SOLE   40,543 0 0
PolyOne Corp Common Stock 73179P106 43 1,510 SH   SOLE   1,510 0 0
Prodways Group SA Common Stock F7329W102 1,904 644,576 SH   SOLE   644,576 0 0
Proto Labs Inc Common Stock 743713109 8,794 77,966 SH   SOLE   42,362 0 35,604
PTC Inc Common Stock 69370C100 1,408 16,988 SH   SOLE   16,988 0 0
RADCOM Ltd Common Stock M81865111 390 52,585 SH   SOLE   52,585 0 0
Radware Ltd Common Stock M81873107 486 21,406 SH   SOLE   21,406 0 0
Rakuten Inc ADR 75102W108 1,792 269,521 SH   SOLE   269,521 0 0
Rakuten Inc Common Stock J64264104 165 24,600 SH   SOLE   24,600 0 0
Red Hat Inc Common Stock 756577102 28 160 SH   SOLE   160 0 0
Redfin Corp Common Stock 75737F108 124 8,638 SH   SOLE   8,638 0 0
Redhill Biopharma Ltd ADR 757468103 337 60,741 SH   SOLE   60,741 0 0
Regeneron Pharmaceuticals Inc Common Stock 75886F107 5,199 13,921 SH   SOLE   13,921 0 0
Renishaw PLC Common Stock G75006117 2,372 43,889 SH   SOLE   43,889 0 0
Rubius Therapeutics Inc Common Stock 78116T103 5,068 315,152 SH   SOLE   257,424 51,793 5,935
salesforce.com Inc Common Stock 79466L302 48,511 354,169 SH   SOLE   244,677 21,395 88,097
Sandvik AB Common Stock W74857165 49 3,484 SH   SOLE   3,484 0 0
Sapiens International Corp NV Common Stock G7T16G103 461 41,804 SH   SOLE   41,804 0 0
Sarepta Therapeutics Inc Common Stock 803607100 273 2,504 SH   SOLE   2,504 0 0
SBI Holdings Inc/Japan Common Stock J6991H100 310 16,100 SH   SOLE   16,100 0 0
Seres Therapeutics Inc Common Stock 81750R102 18,620 4,119,479 SH   SOLE   3,263,090 223,428 632,961
Shopify Inc Common Stock 82509L107 9,736 70,321 SH   SOLE   70,321 0 0
Siemens AG Common Stock D69671218 448 4,024 SH   SOLE   4,024 0 0
Silicom Ltd Common Stock M84116108 429 12,275 SH   SOLE   12,275 0 0
SLM Solutions Group AG Common Stock D6T690109 1,298 126,097 SH   SOLE   126,097 0 0
SoftBank Group Corp ADR 83404D109 212 6,517 SH   SOLE   6,517 0 0
SoftBank Group Corp Common Stock J75963108 37 555 SH   SOLE   0 555 0
SolarEdge Technologies Inc Common Stock 83417M104 420 11,978 SH   SOLE   11,978 0 0
Spark Therapeutics Inc Common Stock 84652J103 5 129 SH   SOLE   129 0 0
Splunk Inc Common Stock 848637104 52,230 498,136 SH   SOLE   351,800 30,520 115,816
Spotify Technology SA Common Stock L8681T102 44,928 395,842 SH   SOLE   289,460 20,430 85,952
Square Inc Common Stock 852234103 119,804 2,135,920 SH   SOLE   1,567,249 110,253 458,418
Stratasys Ltd Common Stock M85548101 122,003 6,774,158 SH   SOLE   4,948,735 337,178 1,488,245
Stryker Corp Common Stock 863667101 797 5,084 SH   SOLE   5,084 0 0
Suny Cellular Communication Lt Common Stock M8708U107 485 1,040,415 SH   SOLE   1,040,415 0 0
Syros Pharmaceuticals Inc Common Stock 87184Q107 13,706 2,460,621 SH   SOLE   2,172,117 27,456 261,048
Taiwan Semiconductor Manufactu ADR 874039100 8,903 241,195 SH   SOLE   241,195 0 0
Taro Pharmaceutical Industries Common Stock M8737E108 434 5,132 SH   SOLE   5,132 0 0
Teladoc Health Inc Common Stock 87918A105 32,637 658,407 SH   SOLE   552,664 28,263 77,480
Tencent Holdings Ltd ADR 88032Q109 103,187 2,614,306 SH   SOLE   1,972,795 128,147 513,364
Teradyne Inc Common Stock 880770102 81,293 2,590,588 SH   SOLE   1,865,039 152,248 573,301
Tesla Inc Common Stock 88160R101 137,815 414,107 SH   SOLE   390,684 21,602 1,821
Teva Pharmaceutical Industries ADR 881624209 364 23,606 SH   SOLE   23,606 0 0
Toray Industries Inc Common Stock J89494116 55 7,836 SH   SOLE   7,836 0 0
Tower Semiconductor Ltd Common Stock M87915274 367 24,877 SH   SOLE   24,877 0 0
Trade Me Group Ltd Common Stock Q9162N106 35 10,506 SH   SOLE   10,506 0 0
TransUnion Common Stock 89400J107 118 2,082 SH   SOLE   2,082 0 0
Trimble Inc Common Stock 896239100 5,648 171,609 SH   SOLE   171,609 0 0
Twilio Inc Common Stock 90138F102 4,040 45,237 SH   SOLE   45,237 0 0
Twitter Inc Common Stock 90184L102 92,635 3,223,193 SH   SOLE   2,418,241 180,015 624,937
Ultra Clean Holdings Inc Common Stock 90385V107 334 39,400 SH   SOLE   39,400 0 0
United Parcel Service Inc Common Stock 911312106 394 4,038 SH   SOLE   4,038 0 0
UroGen Pharma Ltd Common Stock M96088105 486 11,298 SH   SOLE   11,298 0 0
Veracyte Inc Common Stock 92337F107 43,945 3,493,255 SH   SOLE   3,466,370 26,885 0
Verisk Analytics Inc Common Stock 92345Y106 218 2,003 SH   SOLE   2,003 0 0
Visa Inc Common Stock 92826C839 29 223 SH   SOLE   223 0 0
Wirecard AG ADR 97654L108 161 2,090 SH   SOLE   2,090 0 0
Wix.com Ltd Common Stock M98068105 440 4,875 SH   SOLE   4,875 0 0
Workday Inc Common Stock 98138H101 32 198 SH   SOLE   198 0 0
Xero Ltd Common Stock Q98665104 104 3,465 SH   SOLE   3,465 0 0
Xerox Corp Common Stock 984121608 41 2,092 SH   SOLE   2,092 0 0
Xilinx Inc Common Stock 983919101 8,866 104,098 SH   SOLE   104,098 0 0
Zillow Group Inc Common Stock 98954M200 57,518 1,821,356 SH   SOLE   1,357,310 97,936 366,110
Zuora Inc Common Stock 98983V106 5,616 309,589 SH   SOLE   309,589 0 0