The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 70,627 976,451 SH   DFND 1 0 0 976,451
ABIOMED INC COM 003654100 12,619 38,822 SH   DFND 1 0 0 38,822
ACADIA PHARMACEUTICALS INC COM 004225108 1,549 95,800 SH   DFND 1 0 0 95,800
ACCELERON PHARMA INC COM 00434H108 623 14,300 SH   DFND 1 0 0 14,300
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 754 131,135 SH   DFND 1 0 0 131,135
AFFIMED N V COM N01045108 529 170,000 SH   DFND 1 0 0 170,000
AKCEA THERAPEUTICS INC COM 00972L107 13,813 458,296 SH   DFND 1 0 0 458,296
ALDER BIOPHARMACEUTICALS INC COM 014339105 11,519 1,123,813 SH   DFND 1 0 0 1,123,813
ALEXION PHARMACEUTICALS INC COM 015351109 15,157 155,680 SH   DFND 1 0 0 155,680
ALIGN TECHNOLOGY INC COM 016255101 65,090 310,795 SH   DFND 1 0 0 310,795
ALLERGAN PLC SHS G0177J108 2,139 16,000 SH   DFND 1 0 0 16,000
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 16,360 224,385 SH   DFND 1 0 0 224,385
AMEDISYS INC COM 023436108 2,952 25,204 SH   DFND 1 0 0 25,204
AMERISOURCEBERGEN CORP COM 03073E105 18,359 246,762 SH   DFND 1 0 0 246,762
AMGEN INC COM 031162100 8,750 44,950 SH   DFND 1 0 0 44,950
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 1,285 95,000 SH   DFND 1 0 0 95,000
ANGIODYNAMICS INC COM 03475V101 1,524 75,700 SH   DFND 1 0 0 75,700
ANTHEM INC COM 036752103 61,103 232,660 SH   DFND 1 0 0 232,660
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,181 30,317 SH   DFND 1 0 0 30,317
ARGENX SE SPONSORED ADR 04016X101 1,210 12,600 SH   DFND 1 0 0 12,600
BAXTER INTL INC COM 071813109 16,754 254,543 SH   DFND 1 0 0 254,543
BECTON DICKINSON & CO COM 075887109 27,460 121,872 SH   DFND 1 0 0 121,872
BEIGENE LTD SPONSORED ADR 07725L102 11,726 83,600 SH   DFND 1 0 0 83,600
BIOGEN INC COM 09062X103 7,598 25,250 SH   DFND 1 0 0 25,250
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,914 45,969 SH   DFND 1 0 0 45,969
BLUEBIRD BIO INC COM 09609G100 1,280 12,900 SH   DFND 1 0 0 12,900
BOSTON SCIENTIFIC CORP COM 101137107 37,350 1,056,889 SH   DFND 1 0 0 1,056,889
BRISTOL MYERS SQUIBB CO COM 110122108 25,305 486,824 SH   DFND 1 0 0 486,824
CAREDX INC COM 14167L103 13,487 536,488 SH   DFND 1 0 0 536,488
CASTLIGHT HEALTH INC CL B 14862Q100 2,299 1,059,515 SH   DFND 1 0 0 1,059,515
CELGENE CORP COM 151020104 42,146 657,601 SH   DFND 1 0 0 657,601
CELLECTIS S A SPONSORED ADS 15117K103 778 46,750 SH   DFND 1 0 0 46,750
CENTENE CORP DEL COM 15135B101 10,389 90,101 SH   DFND 1 0 0 90,101
CERNER CORP COM 156782104 3,102 59,146 SH   DFND 1 0 0 59,146
CIGNA CORPORATION COM 125509109 31,456 165,625 SH   DFND 1 0 0 165,625
COHERUS BIOSCIENCES INC COM 19249H103 3,248 358,935 SH   DFND 1 0 0 358,935
COOPER COS INC COM NEW 216648402 7,538 29,619 SH   DFND 1 0 0 29,619
CVS HEALTH CORP COM 126650100 1,692 25,825 SH   DFND 1 0 0 25,825
DANAHER CORP DEL COM 235851102 34,328 332,896 SH   DFND 1 0 0 332,896
DENTSPLY SIRONA INC COM 24906P109 4,126 110,878 SH   DFND 1 0 0 110,878
DEXCOM INC COM 252131107 9,321 77,808 SH   DFND 1 0 0 77,808
EDWARDS LIFESCIENCES CORP COM 28176E108 24,170 157,797 SH   DFND 1 0 0 157,797
ENDO INTL PLC SHS G30401106 1,244 170,392 SH   DFND 1 0 0 170,392
ESPERION THERAPEUTICS INC NEW COM 29664W105 20,791 451,972 SH   DFND 1 0 0 451,972
EVOLENT HEALTH INC CL A 30050B101 903 45,270 SH   DFND 1 0 0 45,270
EXELIXIS INC COM 30161Q104 1,849 94,000 SH   DFND 1 0 0 94,000
FIBROGEN INC COM 31572Q808 1,481 32,000 SH   DFND 1 0 0 32,000
FITBIT INC CL A 33812L102 15,998 3,218,884 SH   DFND 1 0 0 3,218,884
GENMARK DIAGNOSTICS INC COM 372309104 9,718 1,999,540 SH   DFND 1 0 0 1,999,540
GILEAD SCIENCES INC COM 375558103 7,694 123,000 SH   DFND 1 0 0 123,000
GLOBUS MED INC CL A 379577208 6,623 153,031 SH   DFND 1 0 0 153,031
GUARDANT HEALTH INC COM 40131M109 4,102 109,117 SH   DFND 1 0 0 109,117
GW PHARMACEUTICALS PLC ADS 36197T103 626 6,429 SH   DFND 1 0 0 6,429
HCA HEALTHCARE INC COM 40412C101 5,853 47,034 SH   DFND 1 0 0 47,034
HEALTHCARE SVCS GRP INC COM 421906108 603 15,000 SH   DFND 1 0 0 15,000
SCHEIN HENRY INC COM 806407102 4,033 51,368 SH   DFND 1 0 0 51,368
HILL ROM HLDGS INC COM 431475102 18,153 205,008 SH   DFND 1 0 0 205,008
HMS HLDGS CORP COM 40425J101 6,099 216,817 SH   DFND 1 0 0 216,817
HOLOGIC INC COM 436440101 3,699 90,000 SH   DFND 1 0 0 90,000
HORIZON PHARMA PLC SHS G4617B105 3,292 168,500 SH   DFND 1 0 0 168,500
HUMANA INC COM 444859102 22,535 78,660 SH   DFND 1 0 0 78,660
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 10,164 440,169 SH   DFND 1 0 0 440,169
IDEXX LABS INC COM 45168D104 4,522 24,307 SH   DFND 1 0 0 24,307
ILLUMINA INC COM 452327109 75,550 251,893 SH   DFND 1 0 0 251,893
INCYTE CORP COM 45337C102 3,730 58,650 SH   DFND 1 0 0 58,650
INOGEN INC COM 45780L104 4,134 33,292 SH   DFND 1 0 0 33,292
INSMED INC COM PAR $.01 457669307 10,616 809,146 SH   DFND 1 0 0 809,146
INSPIRE MED SYS INC COM 457730109 3,913 92,616 SH   DFND 1 0 0 92,616
INSULET CORP COM 45784P101 1,428 18,000 SH   DFND 1 0 0 18,000
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 6,575 145,779 SH   DFND 1 0 0 145,779
INTELLIA THERAPEUTICS INC COM 45826J105 216 15,834 SH   DFND 1 0 0 15,834
INTERCEPT PHARMACEUTICALS IN COM 45845P108 2,333 23,148 SH   DFND 1 0 0 23,148
INTERSECT ENT INC COM 46071F103 6,691 237,444 SH   DFND 1 0 0 237,444
INTRA CELLULAR THERAPIES INC COM 46116X101 599 52,600 SH   DFND 1 0 0 52,600
INTUITIVE SURGICAL INC COM NEW 46120E602 66,473 138,797 SH   DFND 1 0 0 138,797
IONIS PHARMACEUTICALS INC COM 462222100 20,683 382,588 SH   DFND 1 0 0 382,588
IOVANCE BIOTHERAPEUTICS INC COM 462260100 142 16,000 SH   DFND 1 0 0 16,000
IRHYTHM TECHNOLOGIES INC COM 450056106 5,822 83,792 SH   DFND 1 0 0 83,792
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 793 76,500 SH   DFND 1 0 0 76,500
ISHARES TR NASDAQ BIOTECH CALL 464287906 70,000 200 SH   DFND 1 0 0 200
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 32,310 260,648 SH   DFND 1 0 0 260,648
JOHNSON & JOHNSON COM 478160104 2,581 20,000 SH   DFND 1 0 0 20,000
LABORATORY CORP AMER HLDGS COM NEW 50540R409 821 6,500 SH   DFND 1 0 0 6,500
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 3,239 23,870 SH   DFND 1 0 0 23,870
LIVANOVA PLC SHS G5509L101 11,663 127,510 SH   DFND 1 0 0 127,510
LOXO ONCOLOGY INC COM 548862101 1,205 8,600 SH   DFND 1 0 0 8,600
MACROGENICS INC COM 556099109 13,551 1,066,993 SH   DFND 1 0 0 1,066,993
MASIMO CORP COM 574795100 2,446 22,780 SH   DFND 1 0 0 22,780
MATERIALISE NV SPONSORED ADS 57667T100 4,310 215,192 SH   DFND 1 0 0 215,192
MCKESSON CORP COM 58155Q103 760 6,879 SH   DFND 1 0 0 6,879
MEDIDATA SOLUTIONS INC COM 58471A105 3,318 49,211 SH   DFND 1 0 0 49,211
MEDTRONIC PLC SHS G5960L103 45,157 496,446 SH   DFND 1 0 0 496,446
MERCK & CO INC COM 58933Y105 1,146 15,000 SH   DFND 1 0 0 15,000
MIRATI THERAPEUTICS INC COM 60468T105 1,018 24,000 SH   DFND 1 0 0 24,000
MOLINA HEALTHCARE INC COM 60855R100 6,437 55,384 SH   DFND 1 0 0 55,384
MYLAN N V SHS EURO N59465109 5,396 196,950 SH   DFND 1 0 0 196,950
MYRIAD GENETICS INC COM 62855J104 927 31,900 SH   DFND 1 0 0 31,900
NEKTAR THERAPEUTICS COM 640268108 8,586 261,210 SH   DFND 1 0 0 261,210
NEUROCRINE BIOSCIENCES INC COM 64125C109 2,860 40,050 SH   DFND 1 0 0 40,050
NEURONETICS INC COM 64131A105 3,200 165,400 SH   DFND 1 0 0 165,400
NEVRO CORP COM 64157F103 3,167 81,438 SH   DFND 1 0 0 81,438
OMNICELL INC COM 68213N109 6,616 108,042 SH   DFND 1 0 0 108,042
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 3,918 306,606 SH   DFND 1 0 0 306,606
PENUMBRA INC COM 70975L107 2,939 24,050 SH   DFND 1 0 0 24,050
PORTOLA PHARMACEUTICALS INC COM 737010108 501 25,650 SH   DFND 1 0 0 25,650
PRA HEALTH SCIENCES INC COM 69354M108 13,086 142,300 SH   DFND 1 0 0 142,300
PREMIER INC CL A 74051N102 500 13,400 SH   DFND 1 0 0 13,400
PTC THERAPEUTICS INC COM 69366J200 745 21,700 SH   DFND 1 0 0 21,700
QIAGEN NV SHS NEW N72482123 14,996 435,299 SH   DFND 1 0 0 435,299
QUANTERIX CORP COM 74766Q101 5,235 285,907 SH   DFND 1 0 0 285,907
QUIDEL CORP COM 74838J101 6,103 125,000 SH   DFND 1 0 0 125,000
QUOTIENT LTD SHS G73268107 5,102 833,619 SH   DFND 1 0 0 833,619
REGENERON PHARMACEUTICALS COM 75886F107 5,677 15,200 SH   DFND 1 0 0 15,200
REGENXBIO INC COM 75901B107 977 23,300 SH   DFND 1 0 0 23,300
RESMED INC COM 761152107 6,307 55,392 SH   DFND 1 0 0 55,392
SAGE THERAPEUTICS INC COM 78667J108 1,015 10,600 SH   DFND 1 0 0 10,600
SAREPTA THERAPEUTICS INC COM 803607100 1,386 12,700 SH   DFND 1 0 0 12,700
SEATTLE GENETICS INC COM 812578102 1,983 35,000 SH   DFND 1 0 0 35,000
STRYKER CORP COM 863667101 23,643 150,834 SH   DFND 1 0 0 150,834
SUPERNUS PHARMACEUTICALS INC COM 868459108 11,464 345,100 SH   DFND 1 0 0 345,100
TABULA RASA HEALTHCARE INC COM 873379101 5,602 87,857 SH   DFND 1 0 0 87,857
TANDEM DIABETES CARE INC COM NEW 875372203 3,769 99,253 SH   DFND 1 0 0 99,253
TELADOC HEALTH INC COM 87918A105 53,230 1,073,839 SH   DFND 1 0 0 1,073,839
TELEFLEX INC COM 879369106 5,104 19,748 SH   DFND 1 0 0 19,748
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 925 60,000 SH   DFND 1 0 0 60,000
THERMO FISHER SCIENTIFIC INC COM 883556102 8,211 36,692 SH   DFND 1 0 0 36,692
ULTRAGENYX PHARMACEUTICAL INC COM 90400D108 965 22,200 SH   DFND 1 0 0 22,200
UNITEDHEALTH GROUP INC COM 91324P102 33,092 132,836 SH   DFND 1 0 0 132,836
UNIQURE NV SHS N90064101 288 10,000 SH   DFND 1 0 0 10,000
VARIAN MED SYS INC COM 92220P105 354 3,122 SH   DFND 1 0 0 3,122
VEEVA SYS INC CL A COM 922475108 3,402 38,092 SH   DFND 1 0 0 38,092
VERTEX PHARMACEUTICALS INC COM 92532F100 19,007 114,700 SH   DFND 1 0 0 114,700
VOCERA COMMUNICATONS INC COM 92857F107 1,297 32,950 SH   DFND 1 0 0 32,950
VOYAGER THERAPEUTICS INC COM 92915B106 262 27,900 SH   DFND 1 0 0 27,900
WALGREENS BOOTS ALLIANCE INC COM 931427108 15,224 222,802 SH   DFND 1 0 0 222,802
WELLCARE HEALTH PLANS INC COM 94946T106 19,644 83,204 SH   DFND 1 0 0 83,204
WRIGHT MED GROUP NV ORD SHS 0.03 PAR N96617118 18,458 678,114 SH   DFND 1 0 0 678,114
ZIMMER BIOMET HLDGS INC COM 98956P102 9,553 92,104 SH   DFND 1 0 0 92,104