The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 15,017 2,103,164 SH   SOLE   2,103,164 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 642,173 39,713,842 SH   SOLE   39,713,842 0 0
Acceleron Pharma Inc. COM 00434H108 3,654 83,900 SH   SOLE   83,900 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 1,742 1,095,359 SH   SOLE   1,095,359 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 1,474 172,630 SH   SOLE   172,630 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 12,835 1,713,604 SH   SOLE   1,713,604 0 0
Aevi Genomic Medicine, Inc. COM 00835P105 2,765 3,950,419 SH   SOLE   3,950,419 0 0
Affimed N.V. COM N01045108 622 200,000 SH   SOLE   200,000 0 0
Aimmune Therapeutics, Inc. COM 00900T107 16,120 673,908 SH   SOLE   673,908 0 0
Albireo Pharma, Inc. COM 01345P106 6,133 250,000 SH   SOLE   250,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 833,002 8,555,894 SH   SOLE   8,555,894 0 0
Alkermes plc SHS G01767105 1,977 67,000 SH   SOLE   67,000 0 0
Amarin Corporation plc SPONSORED ADR 023111206 579,688 42,592,824 SH   SOLE   42,592,824 0 0
AnaptysBio, Inc. COM 032724106 7,214 113,086 SH   SOLE   113,086 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 2,586 196,078 SH   SOLE   196,078 0 0
Aquestive Therapeutics, Inc. COM 03843E104 627 99,600 SH   SOLE   99,600 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 23,618 10,934,154 SH   SOLE   10,934,154 0 0
Aravive, Inc. COM 03890D108 1,423 404,384 SH   SOLE   404,384 0 0
Arcus Biosciences, Inc. COM 03969F109 1,309 121,534 SH   SOLE   121,534 0 0
argenx SE SPONSORED ADR 04016X101 97,949 1,019,557 SH   SOLE   1,019,557 0 0
Array BioPharma Inc. COM 04269X105 71,844 5,041,696 SH   SOLE   5,041,696 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 177,760 2,837,352 SH   SOLE   2,837,352 0 0
Assembly Biosciences, Inc. COM 045396108 3,361 148,587 SH   SOLE   148,587 0 0
Audentes Therapeutics, Inc. COM 05070R104 19,411 910,463 SH   SOLE   910,463 0 0
Autolus Therapeutics plc SPON ADS 05280R100 5,148 156,773 SH   SOLE   156,773 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 1,677,485 11,959,824 SH   SOLE   11,959,824 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 7,819 2,677,818 SH   SOLE   2,677,818 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 121,882 15,103,081 SH   SOLE   15,103,081 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 646,228 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 3,968 40,000 SH   SOLE   40,000 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 5,568 2,900,000 SH   SOLE   2,900,000 0 0
Cerus Corporation COM 157085101 54,502 10,749,937 SH   SOLE   10,749,937 0 0
ChemoCentryx, Inc. COM 16383L106 2,259 207,029 SH   SOLE   207,029 0 0
Clementia Pharmaceuticals Inc. COM 185575107 43,799 3,724,445 SH   SOLE   3,724,445 0 0
ContraFect Corporation COM 212326102 10,944 7,153,076 SH   SOLE   7,153,076 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 535 133,333 SH   SOLE   133,333 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 3,936 131,250 SH   SOLE   131,250 0 0
CymaBay Therapeutics, Inc. COM 23257D103 38,702 4,917,700 SH   SOLE   4,917,700 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 35,371 5,509,560 SH   SOLE   5,509,560 0 0
Dynavax Technologies Corporation COM 268158201 686 75,000 SH   SOLE   75,000 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 1,788 498,189 SH   SOLE   498,189 0 0
Forty Seven, Inc. COM 34983P104 3,930 250,000 SH   SOLE   250,000 0 0
Fulgent Genetics, Inc. COM 359664109 396 125,000 SH   SOLE   125,000 0 0
G1 Therapeutics, Inc. COM 3621LQ109 2,437 127,236 SH   SOLE   127,236 0 0
Galapagos NV SPONSORED ADR 36315X101 2,300 25,072 SH   SOLE   25,072 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 1,473 215,594 SH   SOLE   215,594 0 0
Genomic Health, Inc. COM 37244C101 756,432 11,744,010 SH   SOLE   11,744,010 0 0
GW Pharmaceuticals plc ADS 36197T103 41,717 428,345 SH   SOLE   428,345 0 0
Halozyme Therapeutics, Inc. COM 40637H109 4,389 299,969 SH   SOLE   299,969 0 0
Heron Therapeutics, Inc. COM 427746102 130,170 5,018,104 SH   SOLE   5,018,104 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 13,396 4,836,237 SH   SOLE   4,836,237 0 0
Incyte Corporation COM 45337C102 2,178,060 34,251,607 SH   SOLE   34,251,607 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 685 580,400 SH   SOLE   580,400 0 0
InflaRx N.V. COM N44821101 6,510 178,987 SH   SOLE   178,987 0 0
Insmed Incorporated COM PAR $.01 457669307 24,298 1,851,982 SH   SOLE   1,851,982 0 0
Intellia Therapeutics, Inc. COM 45826J105 1,755 128,538 SH   SOLE   128,538 0 0
Invitae Corporation COM 46185L103 43,161 3,902,421 SH   SOLE   3,902,421 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 84,270 3,000,000 SH   SOLE   3,000,000 0 0
Kodiak Sciences Inc. COM 50015M109 64,930 9,145,115 SH   SOLE   9,145,115 0 0
Krystal Biotech, Inc. COM 501147102 16,306 784,674 SH   SOLE   784,674 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 1,459 154,675 SH   SOLE   154,675 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 131,801 1,169,278 SH   SOLE   1,169,278 0 0
Marker Therapeutics, Inc. COM 57055L107 8,325 1,500,000 SH   SOLE   1,500,000 0 0
Menlo Therapeutics Inc. COM 586858102 2,884 700,000 SH   SOLE   700,000 0 0
Merus N.V. COM N5749R100 16,240 1,160,014 SH   SOLE   1,160,014 0 0
Mirati Therapeutics, Inc. COM 60468T105 106,621 2,513,462 SH   SOLE   2,513,462 0 0
Molecular Templates, Inc. COM 608550109 1,027 254,230 SH   SOLE   254,230 0 0
MyoKardia, Inc. COM 62857M105 15,403 315,243 SH   SOLE   315,243 0 0
Neurocrine Biosciences, Inc. COM 64125C109 52,155 730,355 SH   SOLE   730,355 0 0
Novavax, Inc. COM 670002104 8,682 4,718,318 SH   SOLE   4,718,318 0 0
Orchard Therapeutics plc ADS 68570P101 1,966 125,000 SH   SOLE   125,000 0 0
Principia Biopharma Inc. COM 74257L108 48,968 1,787,807 SH   SOLE   1,787,807 0 0
Proteon Therapeutics, Inc. COM 74371L109 678 298,591 SH   SOLE   298,591 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 14,981 823,113 SH   SOLE   823,113 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 72,796 2,708,200 SH   SOLE   2,708,200 0 0
Ritter Pharmaceuticals, Inc. COM 767836307 168 279,999 SH   SOLE   279,999 0 0
Sangamo Therapeutics, Inc. COM 800677106 11,478 999,823 SH   SOLE   999,823 0 0
Seattle Genetics, Inc. COM 812578102 2,892,270 51,046,060 SH   SOLE   51,046,060 0 0
Sierra Oncology, Inc. COM 82640U107 2,640 2,000,000 SH   SOLE   2,000,000 0 0
Solid Biosciences Inc. COM 83422E105 15,755 587,884 SH   SOLE   587,884 0 0
Spark Therapeutics, Inc. COM 84652J103 54,175 1,384,130 SH   SOLE   1,384,130 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 6,371 613,144 SH   SOLE   613,144 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 231 556,665 SH   SOLE   556,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 3,202 574,835 SH   SOLE   574,835 0 0
Tricida, Inc. COM 89610F101 37,728 1,600,000 SH   SOLE   1,600,000 0 0
Trillium Therapeutics Inc. COM 89620X506 864 505,262 SH   SOLE   505,262 0 0
uniQure N.V. SHS N90064101 17,436 605,000 SH   SOLE   605,000 0 0
Viking Therapeutics, Inc. COM 92686J106 3,251 425,000 SH   SOLE   425,000 0 0
Xencor, Inc. COM 98401F105 15,917 440,186 SH   SOLE   440,186 0 0
Y-mAbs Therapeutics, Inc. COM 984241109 2,091 102,800 SH   SOLE   102,800 0 0
Zymeworks Inc. COM 98985W102 25,080 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 14,911 15,000,000 PRN   SOLE   15,000,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 63,434 53,270,000 PRN   SOLE   53,270,000 0 0