The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
58.Com Inc Adr SPON ADR REP A 31680Q104 38,327 707,013 SH   DFND 1 707,013 0 0
58.Com Inc Adr SPON ADR REP A 31680Q104 78,126 1,441,171 SH   SOLE 0 1,395,637 0 45,534
58.Com Inc Adr SPON ADR REP A 31680Q104 143,916 2,654,786 SH   DFND 2 1,995,464 0 659,322
AJ Gallagher & Co COM 363576109 83,092 1,127,435 SH   DFND 1 1,127,435 0 0
AJ Gallagher & Co COM 363576109 282,190 3,828,911 SH   DFND 2 2,897,520 0 931,391
AJ Gallagher & Co COM 363576109 161,204 2,187,291 SH   SOLE 0 2,124,657 0 62,634
Abiomed COM 003654100 165,280 508,491 SH   DFND 1 508,491 0 0
Abiomed COM 003654100 115,631 355,743 SH   DFND 2 94,403 0 261,340
Abiomed COM 003654100 66,511 204,625 SH   SOLE 0 204,625 0 0
Acacia Reasearch Corp ACACIA TCH COM 003881307 428 143,640 SH   DFND 1 143,640 0 0
Acacia Reasearch Corp ACACIA TCH COM 003881307 662 222,180 SH   SOLE 0 222,180 0 0
Activision Blizzard Inc COM 00507V109 30,861 662,672 SH   DFND 1 662,672 0 0
Activision Blizzard Inc COM 00507V109 38,963 836,656 SH   DFND 2 341,004 0 495,652
Activision Blizzard Inc COM 00507V109 10,895 233,950 SH   SOLE 0 233,950 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 9,893 1,720,555 SH   DFND 1 1,720,555 0 0
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 5,805 1,009,503 SH   DFND 2 358,721 0 650,782
Adaptimmune Therapeutics ADR SPONDS ADR 00653A107 5,574 969,463 SH   SOLE 0 969,463 0 0
Aduro Biotechnology COM 00739L101 4,509 1,708,037 SH   DFND 1 1,708,037 0 0
Aduro Biotechnology COM 00739L101 2,307 873,848 SH   SOLE 0 873,848 0 0
Aduro Biotechnology COM 00739L101 2,849 1,079,288 SH   DFND 2 382,713 0 696,575
Advanced Micro Devices COM 007903107 59,608 3,229,043 SH   DFND 2 2,515,963 0 713,080
Advanced Micro Devices COM 007903107 17,718 959,829 SH   DFND 1 959,829 0 0
Advanced Micro Devices COM 007903107 37,125 2,011,128 SH   SOLE 0 1,953,497 0 57,631
Aerovironment COM 008073108 13,303 195,778 SH   DFND 2 69,461 0 126,317
Aerovironment COM 008073108 19,686 289,717 SH   DFND 1 289,717 0 0
Aerovironment COM 008073108 18,580 273,443 SH   SOLE 0 273,443 0 0
Agios Pharmaceuticals COM 00847X104 20,483 444,225 SH   DFND 1 444,225 0 0
Agios Pharmaceuticals COM 00847X104 11,707 253,899 SH   DFND 2 13,469 0 240,430
Agios Pharmaceuticals COM 00847X104 7,589 164,591 SH   SOLE 0 164,591 0 0
Albemarle Corp COM 012653101 104,065 1,350,270 SH   DFND 2 1,035,801 0 314,469
Albemarle Corp COM 012653101 35,565 461,462 SH   DFND 1 461,462 0 0
Albemarle Corp COM 012653101 63,528 824,279 SH   SOLE 0 802,061 0 22,218
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 453,381 3,307,663 SH   DFND 1 3,307,663 0 0
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 4,577,928 33,398,468 SH   DFND 2 11,584,128 0 21,814,340
Alibaba Group Holding Sponsored ADR SPONSORED ADS 01609W102 1,453,649 10,605,162 SH   SOLE 0 8,896,484 0 1,708,678
Align Technology Inc COM 016255101 1,817 8,677 SH   DFND 2 8,677 0 0
Alnylam Pharmaceuticals COM 02043Q107 91,420 1,253,871 SH   DFND 1 1,253,871 0 0
Alnylam Pharmaceuticals COM 02043Q107 151,905 2,083,465 SH   DFND 2 1,239,537 0 843,928
Alnylam Pharmaceuticals COM 02043Q107 102,768 1,409,514 SH   SOLE 0 1,392,126 0 17,388
Alphabet Inc Class A CAP STK CL A 02079K305 21,218 20,305 SH   DFND 2 17,474 0 2,831
Alphabet Inc Class A CAP STK CL A 02079K305 24,031 22,997 SH   DFND 1 22,997 0 0
Alphabet Inc Class A CAP STK CL A 02079K305 86,058 82,355 SH   SOLE 0 82,355 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 384,560 371,337 SH   DFND 1 371,337 0 0
Alphabet Inc Class C CAP STK CL C 02079K107 1,330,789 1,285,029 SH   DFND 2 634,392 0 650,637
Alphabet Inc Class C CAP STK CL C 02079K107 673,047 649,904 SH   SOLE 0 510,987 0 138,917
Amazon.Com COM 023135106 796,373 530,219 SH   DFND 1 530,219 0 0
Amazon.Com COM 023135106 3,969,484 2,642,852 SH   DFND 2 902,560 0 1,740,292
Amazon.Com COM 023135106 2,047,628 1,363,295 SH   SOLE 0 1,156,993 0 206,302
Ambarella SHS G037AX101 5,160 147,500 SH   DFND 1 147,500 0 0
Ambarella SHS G037AX101 3,610 103,193 SH   DFND 2 36,948 0 66,245
Ambarella SHS G037AX101 4,431 126,670 SH   SOLE 0 126,670 0 0
Ameren COM 023608102 21,067 322,964 SH   DFND 1 322,964 0 0
Ameren COM 023608102 31 470 SH   DFND 2 470 0 0
Ameren COM 023608102 952 14,602 SH   SOLE 0 14,602 0 0
American Express COM 025816109 3,306 34,687 SH   DFND 1 34,687 0 0
American Express COM 025816109 15,824 166,012 SH   DFND 2 166,012 0 0
American Express COM 025816109 3,669 38,490 SH   SOLE 0 38,490 0 0
Analog Devices COM 032654105 15,198 177,068 SH   DFND 1 177,068 0 0
Analog Devices COM 032654105 15,138 176,376 SH   SOLE 0 176,376 0 0
Anaplan Inc Common COM 03272L108 49,673 1,871,644 SH   SOLE 0 1,871,644 0 0
Annaly Capital Man. COM 035710409 137 13,963 SH   DFND 1 13,963 0 0
Anthem Inc COM 036752103 173,038 658,865 SH   DFND 1 658,865 0 0
Anthem Inc COM 036752103 643,402 2,449,841 SH   DFND 2 1,851,513 0 598,328
Anthem Inc COM 036752103 355,338 1,352,999 SH   SOLE 0 1,312,279 0 40,720
Apache Corp COM 037411105 97,676 3,720,975 SH   DFND 1 3,720,975 0 0
Apache Corp COM 037411105 347,972 13,256,092 SH   DFND 2 10,016,085 0 3,240,007
Apache Corp COM 037411105 193,920 7,387,412 SH   SOLE 0 7,164,088 0 223,324
Apollo Commercial Real Estate Finance REIT COM 03762U105 158 9,500 SH   DFND 1 9,500 0 0
Apple COM 037833100 10,147 64,325 SH   DFND 1 64,325 0 0
Apple COM 037833100 10,361 65,686 SH   SOLE 0 65,686 0 0
Aslan Pharmaceuticals ADR ADS 04522R101 1,157 292,885 SH   DFND 1 292,885 0 0
Aslan Pharmaceuticals ADR ADS 04522R101 621 157,248 SH   SOLE 0 157,248 0 0
Atlassian Corp Plc CL A G06242104 68,998 775,432 SH   DFND 1 775,432 0 0
Atlassian Corp Plc CL A G06242104 446,530 5,018,319 SH   DFND 2 1,821,085 0 3,197,234
Atlassian Corp Plc CL A G06242104 161,627 1,816,442 SH   SOLE 0 904,860 0 911,582
Autohome Inc - ADR SP ADR RP CL A 05278C107 37,961 485,253 SH   DFND 1 485,253 0 0
Autohome Inc - ADR SP ADR RP CL A 05278C107 144,625 1,848,705 SH   DFND 2 1,391,543 0 457,162
Autohome Inc - ADR SP ADR RP CL A 05278C107 81,722 1,044,643 SH   SOLE 0 1,013,004 0 31,639
Avangrid COM 05351W103 21,748 434,175 SH   DFND 1 434,175 0 0
Avangrid COM 05351W103 33 650 SH   DFND 2 650 0 0
Avangrid COM 05351W103 1,040 20,764 SH   SOLE 0 20,764 0 0
Axogen Inc COM 05463X106 4,196 205,400 SH   DFND 1 205,400 0 0
Axogen Inc COM 05463X106 4,202 205,700 SH   DFND 2 73,100 0 132,600
Axogen Inc COM 05463X106 4,611 225,700 SH   SOLE 0 225,700 0 0
Axon Enterprise Inc COM 05464C101 5,460 124,800 SH   DFND 1 124,800 0 0
Axon Enterprise Inc COM 05464C101 5,295 121,018 SH   DFND 2 42,818 0 78,200
Axon Enterprise Inc COM 05464C101 5,898 134,800 SH   SOLE 0 134,800 0 0
BRF SA-ADR SPONSORED ADR 10552T107 12,943 2,278,657 SH   DFND 1 2,278,657 0 0
BRF SA-ADR SPONSORED ADR 10552T107 85,526 15,057,475 SH   DFND 2 5,722,189 0 9,335,286
Baidu.com Sponsored ADR SPON ADR REP A 056752108 150,605 949,588 SH   DFND 1 949,588 0 0
Baidu.com Sponsored ADR SPON ADR REP A 056752108 2,119,772 13,365,522 SH   DFND 2 4,540,092 0 8,825,430
Baidu.com Sponsored ADR SPON ADR REP A 056752108 602,376 3,798,084 SH   SOLE 0 3,151,726 0 646,358
BanColombia Pref ADR SPON ADR PREF 05968L102 21,446 562,894 SH   DFND 2 0 0 562,894
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 22,443 2,269,253 SH   DFND 1 2,269,253 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 29,021 2,934,361 SH   SOLE 0 2,934,361 0 0
Banco Bradesco Pn ADR SP ADR PFD NEW 059460303 156,379 15,811,828 SH   DFND 2 5,908,664 0 9,903,164
Banco Macro ADR SPON ADR B 05961W105 3,931 88,898 SH   DFND 1 88,898 0 0
Banco Macro ADR SPON ADR B 05961W105 18,130 410,001 SH   DFND 2 225,525 0 184,476
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 8,577 293,640 SH   DFND 2 104,115 0 189,525
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 10,922 373,908 SH   DFND 1 373,908 0 0
Baozun Spn Adr 1:1 SPONSORED ADR 06684L103 9,387 321,363 SH   SOLE 0 321,363 0 0
Beigene Ltd SPONSORED ADR 07725L102 2,218 15,812 SH   DFND 1 15,812 0 0
Beigene Ltd SPONSORED ADR 07725L102 11,067 78,904 SH   SOLE 0 78,904 0 0
Benefitfocus Inc COM 08180D106 10,481 229,241 SH   DFND 2 65,008 0 164,233
Benefitfocus Inc COM 08180D106 14,011 306,448 SH   DFND 1 306,448 0 0
Benefitfocus Inc COM 08180D106 13,464 294,490 SH   SOLE 0 294,490 0 0
BitAuto Holdings Ltd - ADR SPONSORED ADS 091727107 1,350 54,492 SH   SOLE 0 54,492 0 0
BlackRock Floating Rate Income COM 091941104 9,265 802,170 SH   DFND 1 802,170 0 0
Blackline COM 09239B109 7,215 176,184 SH   DFND 2 63,120 0 113,064
Blackline COM 09239B109 10,012 244,505 SH   DFND 1 244,505 0 0
Blackline COM 09239B109 7,688 187,732 SH   SOLE 0 187,732 0 0
Blue Apron Holdings Inc CL A 09523Q101 1,340 1,313,400 SH   DFND 1 1,313,400 0 0
Blue Capital Reinsurance Holdings Fund (USD) COM G1190F107 3,462 629,438 SH   DFND 1 629,438 0 0
Bluebird Bio Inc COM 09609G100 35,445 357,309 SH   DFND 1 357,309 0 0
Bluebird Bio Inc COM 09609G100 229,298 2,311,476 SH   DFND 2 835,623 0 1,475,853
Bluebird Bio Inc COM 09609G100 184,546 1,860,338 SH   SOLE 0 1,438,659 0 421,679
British Amer.Tobacco - ADR SPONSORED ADR 110448107 3,432 107,723 SH   DFND 1 107,723 0 0
British Amer.Tobacco - ADR SPONSORED ADR 110448107 960 30,117 SH   SOLE 0 30,117 0 0
CEVA Inc COM 157210105 3,468 156,980 SH   DFND 1 156,980 0 0
CEVA Inc COM 157210105 2,654 120,149 SH   DFND 2 43,556 0 76,593
CEVA Inc COM 157210105 2,564 116,092 SH   SOLE 0 116,092 0 0
CH Robinson Worldwide COM NEW 12541W209 77,672 923,673 SH   DFND 1 923,673 0 0
CH Robinson Worldwide COM NEW 12541W209 221,809 2,637,755 SH   DFND 2 2,022,594 0 615,161
CH Robinson Worldwide COM NEW 12541W209 135,034 1,605,831 SH   SOLE 0 1,562,894 0 42,937
CarMax Inc COM 143130102 4,372 69,698 SH   DFND 1 69,698 0 0
CarMax Inc COM 143130102 19,747 314,794 SH   DFND 2 314,794 0 0
CarMax Inc COM 143130102 4,839 77,139 SH   SOLE 0 77,139 0 0
Celgene COM 151020104 28,283 441,298 SH   DFND 1 441,298 0 0
Celgene COM 151020104 27,418 427,805 SH   DFND 2 212,924 0 214,881
Celgene COM 151020104 12,139 189,408 SH   SOLE 0 189,408 0 0
Cemex ADR SPON ADR NEW 151290889 28,271 5,865,447 SH   DFND 1 5,865,447 0 0
Cemex ADR SPON ADR NEW 151290889 98,086 20,349,866 SH   DFND 2 6,216,155 0 14,133,711
Cemex ADR SPON ADR NEW 151290889 37,820 7,846,458 SH   SOLE 0 7,846,458 0 0
Chegg COM 163092109 78,682 2,768,529 SH   DFND 1 2,768,529 0 0
Chegg COM 163092109 83,799 2,948,589 SH   DFND 2 1,177,766 0 1,770,823
Chegg COM 163092109 71,436 2,513,590 SH   SOLE 0 2,498,268 0 15,322
China Rapid Finance ADR SPONSORED ADR 16953Q105 306 300,000 SH   SOLE 0 300,000 0 0
Chipotle Mexican Grill COM 169656105 31,646 73,291 SH   DFND 1 73,291 0 0
Chipotle Mexican Grill COM 169656105 120,805 279,778 SH   DFND 2 211,288 0 68,490
Chipotle Mexican Grill COM 169656105 65,455 151,589 SH   SOLE 0 146,778 0 4,811
CoStar Group COM 22160N109 51,303 152,080 SH   DFND 1 152,080 0 0
CoStar Group COM 22160N109 37,513 111,201 SH   DFND 2 28,541 0 82,660
CoStar Group COM 22160N109 19,093 56,598 SH   SOLE 0 56,598 0 0
Coca Cola COM 191216100 22,176 468,343 SH   SOLE 0 468,343 0 0
Coca Cola COM 191216100 21,782 460,026 SH   DFND 1 460,026 0 0
Codexis COM 192005106 18,107 1,084,273 SH   DFND 1 1,084,273 0 0
Codexis COM 192005106 15,803 946,278 SH   DFND 2 336,907 0 609,371
Codexis COM 192005106 14,261 853,939 SH   SOLE 0 853,939 0 0
Consolidated Edison COM 209115104 23,138 302,611 SH   DFND 1 302,611 0 0
Consolidated Edison COM 209115104 21 270 SH   DFND 2 270 0 0
Consolidated Edison COM 209115104 1,457 19,056 SH   SOLE 0 19,056 0 0
Copa Holdings S A CL A P31076105 178,846 2,272,216 SH   DFND 2 1,014,919 0 1,257,297
Copa Holdings S A CL A P31076105 8,305 105,514 SH   DFND 1 105,514 0 0
Copa Holdings S A CL A P31076105 64,642 821,268 SH   SOLE 0 821,268 0 0
Credicorp COM G2519Y108 360,024 1,624,142 SH   DFND 2 780,667 0 843,475
Credicorp COM G2519Y108 17,252 77,829 SH   DFND 1 77,829 0 0
Credicorp COM G2519Y108 72,855 328,664 SH   SOLE 0 328,664 0 0
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 896,094 33,115,088 SH   DFND 2 11,338,220 0 21,776,868
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 88,339 3,264,566 SH   DFND 1 3,264,566 0 0
Ctrip.com Intl Sponsored ADR AMERICAN DEP SHS 22943F100 320,154 11,831,256 SH   SOLE 0 9,613,405 0 2,217,851
Cullen/Frost Bankers COM 229899109 7,366 83,757 SH   DFND 1 83,757 0 0
Cullen/Frost Bankers COM 229899109 6,608 75,144 SH   SOLE 0 75,144 0 0
CyberArk Software Ltd SHS M2862V108 8,163 110,100 SH   DFND 1 110,100 0 0
CyberArk Software Ltd SHS M2862V108 7,318 98,700 SH   DFND 2 35,100 0 63,600
CyberArk Software Ltd SHS M2862V108 7,970 107,500 SH   SOLE 0 107,500 0 0
Denali Therapeutics COM 24823R105 20,120 973,842 SH   DFND 2 51,345 0 922,497
Denali Therapeutics COM 24823R105 35,402 1,713,550 SH   DFND 1 1,713,550 0 0
Denali Therapeutics COM 24823R105 73,143 3,540,332 SH   SOLE 0 3,540,332 0 0
Dexcom Inc COM 252131107 384,178 3,206,825 SH   DFND 2 1,200,765 0 2,006,060
Dexcom Inc COM 252131107 70,639 589,645 SH   DFND 1 589,645 0 0
Dexcom Inc COM 252131107 135,725 1,132,935 SH   SOLE 0 602,837 0 530,098
Digimarc COM 25381B101 1,348 93,000 SH   DFND 1 93,000 0 0
Digimarc COM 25381B101 3,443 237,475 SH   DFND 2 85,740 0 151,735
Digimarc COM 25381B101 2,137 147,345 SH   SOLE 0 147,345 0 0
Dolby Laboratories 'A' COM 25659T107 7,185 116,195 SH   DFND 1 116,195 0 0
Dolby Laboratories 'A' COM 25659T107 7,277 117,682 SH   SOLE 0 117,682 0 0
Dropbox Inc Class A Common Stock CL A 26210C104 44,659 2,185,941 SH   SOLE 0 2,185,941 0 0
EOG Resources COM 26875P101 244,199 2,800,127 SH   DFND 2 2,166,257 0 633,870
EOG Resources COM 26875P101 63,772 731,245 SH   DFND 1 731,245 0 0
EOG Resources COM 26875P101 124,799 1,431,023 SH   SOLE 0 1,387,852 0 43,171
Ecolab COM 278865100 2,200 14,929 SH   DFND 1 14,929 0 0
Ecolab COM 278865100 4,142 28,111 SH   DFND 2 16,228 0 11,883
Ecolab COM 278865100 661 4,488 SH   SOLE 0 4,488 0 0
Edison International COM 281020107 17,887 315,083 SH   DFND 1 315,083 0 0
Edison International COM 281020107 44 770 SH   DFND 2 770 0 0
Edison International COM 281020107 744 13,103 SH   SOLE 0 13,103 0 0
Edwards Lifesciences Corp COM 28176E108 203 1,327 SH   SOLE 0 1,327 0 0
Ellie Mae COM 28849P100 25,453 405,102 SH   DFND 2 45,287 0 359,815
Ellie Mae COM 28849P100 41,395 658,839 SH   DFND 1 658,839 0 0
Ellie Mae COM 28849P100 18,651 296,850 SH   SOLE 0 296,850 0 0
Estee Lauder 'A' COM 518439104 24,493 188,260 SH   DFND 2 188,260 0 0
Eversource Energy COM 30040W108 23,847 366,655 SH   DFND 1 366,655 0 0
Eversource Energy COM 30040W108 31 480 SH   DFND 2 480 0 0
Eversource Energy COM 30040W108 1,508 23,183 SH   SOLE 0 23,183 0 0
Evolent Health Inc A CL A 30050B101 5,915 296,506 SH   DFND 2 106,263 0 190,243
Evolent Health Inc A CL A 30050B101 7,178 359,780 SH   DFND 1 359,780 0 0
Evolent Health Inc A CL A 30050B101 7,471 374,467 SH   SOLE 0 374,467 0 0
Exact Sciences COM 30063P105 21,275 337,159 SH   DFND 1 337,159 0 0
Exact Sciences COM 30063P105 14,658 232,297 SH   DFND 2 83,915 0 148,382
Exact Sciences COM 30063P105 19,841 314,438 SH   SOLE 0 314,438 0 0
Exelon Corporation COM 30161N101 22,558 500,167 SH   DFND 1 500,167 0 0
Exelon Corporation COM 30161N101 32 710 SH   DFND 2 710 0 0
Exelon Corporation COM 30161N101 1,024 22,706 SH   SOLE 0 22,706 0 0
Facebook Cl.A CL A 30303M102 330,299 2,519,633 SH   DFND 1 2,519,633 0 0
Facebook Cl.A CL A 30303M102 1,267,667 9,670,209 SH   DFND 2 4,203,293 0 5,466,916
Facebook Cl.A CL A 30303M102 629,394 4,801,231 SH   SOLE 0 3,487,451 0 1,313,780
Faro Technologies COM 311642102 3,227 79,415 SH   DFND 1 79,415 0 0
Faro Technologies COM 311642102 5,360 131,899 SH   DFND 2 46,322 0 85,577
Faro Technologies COM 311642102 5,839 143,671 SH   SOLE 0 143,671 0 0
Fastenal COM 311900104 22,035 421,408 SH   DFND 1 421,408 0 0
Fastenal COM 311900104 10,763 205,825 SH   DFND 2 205,825 0 0
Fastenal COM 311900104 22,048 421,650 SH   SOLE 0 421,650 0 0
Ferrari NV COM N3167Y103 1,178,856 11,883,321 SH   DFND 2 3,610,820 0 8,272,501
Ferrari NV COM N3167Y103 238,086 2,400,000 SH   SOLE 0 2,400,000 0 0
Fiat Chrysler Automobiles SHS N31738102 121,312 8,112,008 SH   SOLE 0 7,863,328 0 248,680
Fiat Chrysler Automobiles SHS N31738102 56,727 3,912,838 SH   DFND 1 3,912,838 0 0
Fiat Chrysler Automobiles SHS N31738102 755,244 52,350,790 SH   DFND 2 22,588,105 0 29,762,685
First Republic Bank COM 33616C100 277,298 3,191,000 SH   DFND 2 2,043,422 0 1,147,578
First Republic Bank COM 33616C100 147,201 1,693,913 SH   SOLE 0 1,658,237 0 35,676
First Republic Bank COM 33616C100 158,435 1,823,191 SH   DFND 1 1,823,191 0 0
Foamix Pharmaceuticals SHS M46135105 399 111,200 SH   SOLE 0 111,200 0 0
Foamix Pharmaceuticals SHS M46135105 388 108,200 SH   DFND 1 108,200 0 0
Fortive Corp COM 34959J108 36,174 534,651 SH   DFND 2 181,315 0 353,336
Fortive Corp COM 34959J108 48,476 716,469 SH   DFND 1 716,469 0 0
Fortive Corp COM 34959J108 20,260 299,433 SH   SOLE 0 299,433 0 0
Glaukos Corp COM 377322102 48,679 866,633 SH   DFND 1 866,633 0 0
Glaukos Corp COM 377322102 17,737 315,768 SH   SOLE 0 315,768 0 0
Glaukos Corp COM 377322102 30,505 543,082 SH   DFND 2 68,760 0 474,322
GrubHub Inc COM 400110102 217,277 2,828,761 SH   DFND 1 2,828,761 0 0
GrubHub Inc COM 400110102 299,040 3,893,235 SH   DFND 2 2,086,686 0 1,806,549
GrubHub Inc COM 400110102 202,013 2,630,034 SH   SOLE 0 2,590,557 0 39,477
Grupo Financiero Galicia ADR COM 399909100 2,510 91,041 SH   DFND 1 91,041 0 0
Grupo Financiero Galicia ADR COM 399909100 13,764 499,223 SH   SOLE 0 499,223 0 0
Grupo Financiero Galicia ADR COM 399909100 11,126 403,569 SH   DFND 2 71,617 0 331,952
HDFC Bank ADR ADR REPS 3 SHS 40415F101 77,872 751,733 SH   SOLE 0 751,733 0 0
HDFC Bank ADR ADR REPS 3 SHS 40415F101 60,037 579,567 SH   DFND 2 431,558 0 148,009
HEICO COM 422806109 11,986 154,699 SH   DFND 1 154,699 0 0
HEICO COM 422806109 7,230 93,311 SH   SOLE 0 93,311 0 0
HEICO 'A' CL A 422806208 34,910 554,128 SH   DFND 2 273,853 0 280,275
HEICO 'A' CL A 422806208 23,301 369,853 SH   DFND 1 369,853 0 0
HEICO 'A' CL A 422806208 4,956 78,665 SH   SOLE 0 78,665 0 0
Himax Technologies Adr SPONSORED ADR 43289P106 2,318 675,800 SH   SOLE 0 675,800 0 0
Howard Hughes COM 44267D107 25,117 257,292 SH   DFND 1 257,292 0 0
Howard Hughes COM 44267D107 91,099 933,198 SH   DFND 2 704,074 0 229,124
Howard Hughes COM 44267D107 52,326 536,012 SH   SOLE 0 519,384 0 16,628
Hutchison China Meditech SPONSORED ADR 44842L103 180 7,813 SH   DFND 1 7,813 0 0
Hutchison China Meditech SPONSORED ADR 44842L103 4,414 191,146 SH   SOLE 0 191,146 0 0
ICICI Bank ADR ADR 45104G104 236,965 23,028,737 SH   DFND 2 17,660,475 0 5,368,262
ICICI Bank ADR ADR 45104G104 161,540 15,698,748 SH   DFND 1 15,698,748 0 0
ICICI Bank ADR ADR 45104G104 237,835 23,113,137 SH   SOLE 0 23,113,137 0 0
IPG Photonics Corp COM 44980X109 9,886 87,260 SH   DFND 2 30,935 0 56,325
IPG Photonics Corp COM 44980X109 9,057 79,947 SH   DFND 1 79,947 0 0
IPG Photonics Corp COM 44980X109 11,008 97,169 SH   SOLE 0 97,169 0 0
Illumina COM 452327109 438,008 1,460,368 SH   DFND 1 1,460,368 0 0
Illumina COM 452327109 2,930,394 9,770,262 SH   DFND 2 2,563,032 0 7,207,230
Illumina COM 452327109 1,453,957 4,847,652 SH   SOLE 0 3,814,474 0 1,033,178
Infosys Ltd ADR SPONSORED ADR 456788108 6,951 730,196 SH   DFND 1 730,196 0 0
Infosys Ltd ADR SPONSORED ADR 456788108 2,526 265,315 SH   DFND 2 125,390 0 139,925
Infosys Ltd ADR SPONSORED ADR 456788108 2,124 223,158 SH   SOLE 0 223,158 0 0
Interactive Brokers Group COM 45841N107 94,734 1,741,748 SH   DFND 1 1,741,748 0 0
Interactive Brokers Group COM 45841N107 95,027 1,747,153 SH   SOLE 0 1,706,567 0 40,586
Interactive Brokers Group COM 45841N107 180,893 3,325,846 SH   DFND 2 2,219,154 0 1,106,692
Intuitive Surgical COM NEW 46120E602 94,985 198,332 SH   DFND 1 198,332 0 0
Intuitive Surgical COM NEW 46120E602 611,932 1,277,733 SH   DFND 2 457,419 0 820,314
Intuitive Surgical COM NEW 46120E602 338,551 706,904 SH   SOLE 0 474,513 0 232,391
Invesco Senior Income Trust COM 46131H107 11,723 2,998,119 SH   DFND 1 2,998,119 0 0
Invesco Senior Income Trust COM 46131H107 1,222 312,581 SH   SOLE 0 312,581 0 0
Ionis Pharmaceuticals COM 462222100 48,545 897,989 SH   DFND 1 897,989 0 0
Ionis Pharmaceuticals COM 462222100 112,655 2,083,879 SH   SOLE 0 1,042,260 0 1,041,619
Ionis Pharmaceuticals COM 462222100 311,826 5,768,146 SH   DFND 2 2,070,696 0 3,697,450
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 18,971 2,075,575 SH   DFND 1 2,075,575 0 0
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 278,948 30,519,496 SH   DFND 2 3,177,121 0 27,342,375
Itau Unibanco Holding SA-ADR SPON ADR REP PFD 465562106 107,691 11,782,394 SH   SOLE 0 11,782,394 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 23,581 1,126,655 SH   DFND 1 1,126,655 0 0
JD.Com Inc - ADR SPON ADR CL A 47215P106 136,792 6,535,678 SH   DFND 2 2,601,075 0 3,934,603
JD.Com Inc - ADR SPON ADR CL A 47215P106 46,329 2,213,513 SH   SOLE 0 2,213,513 0 0
Jefferies Financial Group Inc COM 47233W109 36,285 2,090,159 SH   DFND 1 2,090,159 0 0
Jefferies Financial Group Inc COM 47233W109 131,469 7,573,100 SH   DFND 2 5,680,275 0 1,892,825
Jefferies Financial Group Inc COM 47233W109 73,568 4,237,759 SH   SOLE 0 4,108,017 0 129,742
Jianpu Technology Inc- ADR ADR 47738D101 9,323 2,235,703 SH   DFND 1 2,235,703 0 0
Jianpu Technology Inc- ADR ADR 47738D101 6,188 1,484,017 SH   SOLE 0 1,484,017 0 0
Johnson & Johnson COM 478160104 6,153 47,682 SH   DFND 1 47,682 0 0
Johnson & Johnson COM 478160104 6,089 47,184 SH   SOLE 0 47,184 0 0
Kirby COM 497266106 78,627 1,167,259 SH   DFND 1 1,167,259 0 0
Kirby COM 497266106 279,767 4,153,317 SH   DFND 2 3,232,120 0 921,197
Kirby COM 497266106 159,510 2,368,017 SH   SOLE 0 2,294,393 0 73,624
Korea Electric Power ADR SPONSORED ADR 500631106 25 1,700 SH   DFND 2 1,700 0 0
Korea Electric Power ADR SPONSORED ADR 500631106 1,081 73,300 SH   SOLE 0 73,300 0 0
LendingTree COM 52603B107 58,934 268,406 SH   DFND 1 268,406 0 0
LendingTree COM 52603B107 150,264 684,358 SH   DFND 2 462,857 0 221,501
LendingTree COM 52603B107 96,119 437,759 SH   SOLE 0 429,750 0 8,009
Liberty Media Corp DEB 4.00011/1 530715AG6 10,439 16,530,000 SH   DFND 1 16,530,000 0 0
Liberty Media Corp DEB 4.00011/1 530715AG6 6 9,000 SH   DFND 2 9,000 0 0
Liberty Media Corp DEB 4.00011/1 530715AG6 976 1,546,000 SH   SOLE 0 1,546,000 0 0
Lincoln Electric Hdg. COM 533900106 4,038 51,216 SH   DFND 2 51,216 0 0
Lindblad Expeditions Holdings COM 535219109 14,439 1,072,701 SH   SOLE 0 1,072,701 0 0
Line Corp Sponsored Adr SPONSORED ADR 53567X101 11,231 329,256 SH   DFND 2 10,721 0 318,535
Luxoft Holding ORD SHS CL A G57279104 2,949 96,930 SH   SOLE 0 96,930 0 0
M&T Bank COM 55261F104 13,850 96,766 SH   DFND 2 96,766 0 0
MRC Global COM 55345K103 7,949 650,000 SH   SOLE 0 650,000 0 0
MakeMyTrip SHS V5633W109 78,411 3,222,819 SH   DFND 2 2,024,949 0 1,197,870
Markel Corp COM 570535104 105,715 101,840 SH   DFND 1 101,840 0 0
Markel Corp COM 570535104 305,291 294,100 SH   DFND 2 214,517 0 79,583
Markel Corp COM 570535104 161,591 155,668 SH   SOLE 0 151,546 0 4,122
MarketAxess Holdings COM 57060D108 380,307 1,799,759 SH   DFND 2 1,061,088 0 738,671
MarketAxess Holdings COM 57060D108 251,662 1,190,959 SH   DFND 1 1,190,959 0 0
MarketAxess Holdings COM 57060D108 217,134 1,027,564 SH   SOLE 0 1,009,487 0 18,077
Martin Marietta Materials COM 573284106 74,668 434,447 SH   DFND 1 434,447 0 0
Martin Marietta Materials COM 573284106 279,490 1,626,172 SH   DFND 2 1,245,854 0 380,318
Martin Marietta Materials COM 573284106 149,650 870,716 SH   SOLE 0 845,261 0 25,455
Mastercard Inc-Class A CL A 57636Q104 238,223 1,262,780 SH   DFND 1 1,262,780 0 0
Mastercard Inc-Class A CL A 57636Q104 570,733 3,025,358 SH   DFND 2 2,107,461 0 917,897
Mastercard Inc-Class A CL A 57636Q104 302,525 1,603,628 SH   SOLE 0 1,562,421 0 41,207
McDonald's COM 580135101 15,552 87,582 SH   DFND 1 87,582 0 0
McDonald's COM 580135101 14,860 83,686 SH   SOLE 0 83,686 0 0
MercadoLibre COM 58733R102 1,323,420 4,519,106 SH   DFND 2 1,482,131 0 3,036,975
MercadoLibre COM 58733R102 54,402 185,769 SH   DFND 1 185,769 0 0
MercadoLibre COM 58733R102 147,522 503,745 SH   SOLE 0 503,745 0 0
Mettler-Toledo COM 592688105 53,019 93,742 SH   DFND 1 93,742 0 0
Mettler-Toledo COM 592688105 271,060 479,261 SH   DFND 2 313,659 0 165,602
Mettler-Toledo COM 592688105 30,601 54,105 SH   SOLE 0 54,105 0 0
Microsoft COM 594918104 17,313 170,449 SH   DFND 1 170,449 0 0
Microsoft COM 594918104 31,442 309,563 SH   DFND 2 309,563 0 0
Microsoft COM 594918104 17,156 168,909 SH   SOLE 0 168,909 0 0
Mindbody Cl A COM CL A 60255W105 7,463 205,026 SH   DFND 1 205,026 0 0
Mindbody Cl A COM CL A 60255W105 7,207 197,994 SH   DFND 2 69,585 0 128,409
Mindbody Cl A COM CL A 60255W105 6,365 174,862 SH   SOLE 0 174,862 0 0
Mobile Telesystems ADR SPONSORED ADR 607409109 116 16,600 SH   DFND 1 16,600 0 0
Moderna Inc COM 60770K107 13,515 885,082 SH   DFND 1 885,082 0 0
Moderna Inc COM 60770K107 7,965 521,614 SH   DFND 2 86,623 0 434,991
Moderna Inc COM 60770K107 4,873 319,148 SH   SOLE 0 319,148 0 0
Moody's Corp COM 615369105 120,894 863,281 SH   DFND 1 863,281 0 0
Moody's Corp COM 615369105 468,963 3,348,780 SH   DFND 2 2,547,813 0 800,967
Moody's Corp COM 615369105 249,676 1,782,887 SH   SOLE 0 1,727,490 0 55,397
Myriad Genetics Inc COM 62855J104 39,908 1,372,823 SH   DFND 1 1,372,823 0 0
Myriad Genetics Inc COM 62855J104 152,538 5,247,267 SH   DFND 2 3,930,534 0 1,316,733
Myriad Genetics Inc COM 62855J104 83,282 2,864,854 SH   SOLE 0 2,773,212 0 91,642
NIO Inc ADR SPON ADS 62914V106 328,964 51,642,683 SH   DFND 2 15,312,303 0 36,330,380
NIO Inc ADR SPON ADS 62914V106 20,259 3,180,307 SH   DFND 1 3,180,307 0 0
NIO Inc ADR SPON ADS 62914V106 162,011 25,433,404 SH   SOLE 0 21,941,637 0 3,491,767
NVIDIA COM 67066G104 493,074 3,693,437 SH   DFND 2 1,371,890 0 2,321,547
NVIDIA COM 67066G104 99,098 742,307 SH   DFND 1 742,307 0 0
NVIDIA COM 67066G104 288,214 2,158,909 SH   SOLE 0 1,558,123 0 600,786
National Instruments Corp COM 636518102 14,092 310,542 SH   DFND 1 310,542 0 0
National Instruments Corp COM 636518102 5,508 121,376 SH   DFND 2 42,939 0 78,437
National Instruments Corp COM 636518102 16,434 362,147 SH   SOLE 0 362,147 0 0
NetEase.com ADR SPONSORED ADR 64110W102 79,165 336,343 SH   DFND 1 336,343 0 0
NetEase.com ADR SPONSORED ADR 64110W102 421,385 1,790,309 SH   DFND 2 802,194 0 988,115
NetEase.com ADR SPONSORED ADR 64110W102 174,364 740,808 SH   SOLE 0 477,747 0 263,061
Netflix Inc COM 64110L106 321,488 1,201,105 SH   DFND 1 1,201,105 0 0
Netflix Inc COM 64110L106 1,049,585 3,921,334 SH   DFND 2 1,606,827 0 2,314,507
Netflix Inc COM 64110L106 671,141 2,507,440 SH   SOLE 0 1,968,983 0 538,457
New Relic COM 64829B100 23,877 294,887 SH   DFND 2 15,567 0 279,320
New Relic COM 64829B100 41,963 518,249 SH   DFND 1 518,249 0 0
New Relic COM 64829B100 15,434 190,609 SH   SOLE 0 190,609 0 0
Novocure Ltd ORD SHS G6674U108 50,817 1,517,845 SH   DFND 2 384,789 0 1,133,056
Novocure Ltd ORD SHS G6674U108 66,721 1,992,855 SH   DFND 1 1,992,855 0 0
Novocure Ltd ORD SHS G6674U108 33,072 987,824 SH   SOLE 0 986,069 0 1,755
Now Inc/DE COM 67011P100 44,679 3,838,415 SH   DFND 1 3,838,415 0 0
Now Inc/DE COM 67011P100 85,586 7,352,796 SH   DFND 2 4,776,073 0 2,576,723
Now Inc/DE COM 67011P100 52,384 4,500,285 SH   SOLE 0 4,402,789 0 97,496
Nucana Plc ADR SPONSORED ADR 67022C106 7,123 491,208 SH   DFND 1 491,208 0 0
Nucana Plc ADR SPONSORED ADR 67022C106 4,873 336,100 SH   SOLE 0 336,100 0 0
Nuveen Senior Income Fund COM 67067Y104 2,110 383,602 SH   DFND 1 383,602 0 0
Orchard Therapeutics PLC ADR ADS 68570P101 14,550 925,000 SH   SOLE 0 925,000 0 0
Pacira Pharmaceuticals COM 695127100 11,429 265,668 SH   DFND 2 94,907 0 170,761
Pacira Pharmaceuticals COM 695127100 14,414 335,060 SH   DFND 1 335,060 0 0
Pacira Pharmaceuticals COM 695127100 14,318 332,813 SH   SOLE 0 332,813 0 0
Penumbra Inc COM 70975L107 53,995 441,861 SH   DFND 1 441,861 0 0
Penumbra Inc COM 70975L107 32,545 266,326 SH   DFND 2 29,831 0 236,495
Penumbra Inc COM 70975L107 24,175 197,835 SH   SOLE 0 197,835 0 0
Pepsico COM 713448108 14,509 131,326 SH   DFND 1 131,326 0 0
Pepsico COM 713448108 14,044 127,118 SH   SOLE 0 127,118 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 308,355 23,701,353 SH   DFND 2 4,999,404 0 18,701,949
Petrobras Common ADR SPONSORED ADR 71654V408 46,947 3,608,502 SH   DFND 1 3,608,502 0 0
Petrobras Common ADR SPONSORED ADR 71654V408 10,386 798,273 SH   SOLE 0 798,273 0 0
Petrobras Pref ADR SP ADR NON VTG 71654V101 45,713 3,944,165 SH   DFND 2 1,135,973 0 2,808,192
Petrobras Pref ADR SP ADR NON VTG 71654V101 5,322 459,205 SH   DFND 1 459,205 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 23,025 1,026,059 SH   DFND 2 571,837 0 454,222
Pinduoduo Inc ADR SPONSORED ADS 722304102 6,459 287,845 SH   DFND 1 287,845 0 0
Pinduoduo Inc ADR SPONSORED ADS 722304102 46,840 2,087,330 SH   SOLE 0 2,087,330 0 0
Pioneer Floating Rate Trust COM 72369J102 5,421 550,936 SH   DFND 1 550,936 0 0
PriceSmart COM 741511109 63,011 1,066,174 SH   DFND 2 773,529 0 292,645
PriceSmart COM 741511109 8,760 148,222 SH   SOLE 0 148,222 0 0
Procter & Gamble COM 742718109 19,486 211,990 SH   DFND 1 211,990 0 0
Procter & Gamble COM 742718109 18,480 201,049 SH   SOLE 0 201,049 0 0
RPM Inc. COM 749685103 10,677 181,648 SH   DFND 1 181,648 0 0
RPM Inc. COM 749685103 10,407 177,053 SH   SOLE 0 177,053 0 0
Redfin COM 75737F108 34,504 2,396,101 SH   DFND 1 2,396,101 0 0
Redfin COM 75737F108 18,337 1,273,419 SH   DFND 2 74,144 0 1,199,275
Redfin COM 75737F108 14,609 1,014,529 SH   SOLE 0 1,014,529 0 0
ResMed Inc COM 761152107 81,951 719,686 SH   DFND 1 719,686 0 0
ResMed Inc COM 761152107 168,416 1,479,017 SH   SOLE 0 1,434,063 0 44,954
ResMed Inc COM 761152107 301,459 2,647,397 SH   DFND 2 2,006,504 0 640,893
ResTORbio Inc COM 76133L103 4,115 477,384 SH   SOLE 0 477,384 0 0
ResTORbio Inc COM 76133L103 4,364 506,234 SH   DFND 1 506,234 0 0
Rio Tinto Spn.Adr 1:1 SPONSORED ADR 767204100 3,424 70,626 SH   DFND 2 70,626 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 33,391 1,020,514 SH   DFND 1 1,020,514 0 0
Ritchie Bros Auctioneers (USA) COM 767744105 71,257 2,177,763 SH   SOLE 0 2,109,871 0 67,892
Ritchie Bros Auctioneers (USA) COM 767744105 189,072 5,778,501 SH   DFND 2 4,461,992 0 1,316,509
Ritchie Bros. Auctioneers COM 767744105 12,979 396,943 SH   SOLE 0 396,943 0 0
Ritchie Bros. Auctioneers COM 767744105 56,120 1,716,262 SH   DFND 2 728,957 0 987,305
Royal Crbn.Cruises COM V7780T103 249,825 2,554,718 SH   DFND 2 1,935,712 0 619,006
Royal Crbn.Cruises COM V7780T103 65,731 672,163 SH   DFND 1 672,163 0 0
Royal Crbn.Cruises COM V7780T103 138,878 1,420,159 SH   SOLE 0 1,377,797 0 42,362
Rubius Therapeutics Inc COM 78116T103 5,433 337,900 SH   DFND 1 337,900 0 0
Rubius Therapeutics Inc COM 78116T103 2,266 140,916 SH   DFND 2 50,065 0 90,851
Rubius Therapeutics Inc COM 78116T103 57,524 3,577,380 SH   SOLE 0 3,577,380 0 0
Ryanair ADR SPONSORED ADR NE 783513203 480,260 6,731,990 SH   DFND 2 4,507,818 0 2,224,172
Ryanair ADR SPONSORED ADR NE 783513203 4,304 60,329 SH   SOLE 0 60,329 0 0
SEA Ltd ADR ADR 81141R100 31,932 2,820,816 SH   DFND 2 0 0 2,820,816
SEA Ltd ADR ADR 81141R100 6,087 537,684 SH   DFND 1 537,684 0 0
SEA Ltd ADR ADR 81141R100 7,257 641,104 SH   SOLE 0 641,104 0 0
SINA Corp ORD G81477104 7,056 131,550 SH   SOLE 0 131,550 0 0
SVMK INC COM 78489X103 21,715 1,769,756 SH   SOLE 0 1,769,756 0 0
Salesforce.com COM 79466L302 75,314 549,860 SH   DFND 1 549,860 0 0
Salesforce.com COM 79466L302 487,441 3,558,749 SH   DFND 2 1,272,132 0 2,286,617
Salesforce.com COM 79466L302 175,727 1,282,956 SH   SOLE 0 637,698 0 645,258
Schlumberger COM 806857108 3,988 110,529 SH   DFND 2 110,529 0 0
Seattle Genetics COM 812578102 205,353 3,624,312 SH   DFND 2 2,708,203 0 916,109
Seattle Genetics COM 812578102 58,970 1,040,761 SH   DFND 1 1,040,761 0 0
Seattle Genetics COM 812578102 116,532 2,056,687 SH   SOLE 0 1,999,441 0 57,246
Service Corp.Intl. COM 817565104 70,748 1,757,275 SH   DFND 1 1,757,275 0 0
Service Corp.Intl. COM 817565104 264,681 6,574,301 SH   DFND 2 4,786,181 0 1,788,120
Service Corp.Intl. COM 817565104 145,279 3,608,517 SH   SOLE 0 3,501,041 0 107,476
Severstal GDR Reg S COM 818150302 110 8,085 SH   DFND 1 8,085 0 0
Sherwin-Williams Co COM 824348106 7,706 19,584 SH   DFND 2 19,584 0 0
Ship Finance Intl SHS G81075106 106 10,100 SH   DFND 1 10,100 0 0
Shopify 'A' CL A 82509L107 104,993 758,344 SH   DFND 1 758,344 0 0
Shopify 'A' CL A 82509L107 287,650 2,077,652 SH   DFND 2 1,368,986 0 708,666
Shopify 'A' CL A 82509L107 131,806 952,013 SH   SOLE 0 936,319 0 15,694
SiteOne Landscape Supply COM 82982L103 19,738 357,122 SH   DFND 1 357,122 0 0
SiteOne Landscape Supply COM 82982L103 78,971 1,428,807 SH   DFND 2 1,083,699 0 345,108
SiteOne Landscape Supply COM 82982L103 45,150 816,899 SH   SOLE 0 792,289 0 24,610
Snap Inc CL A 83304A106 878 159,389 SH   DFND 2 159,389 0 0
Sohu.com COM 83410S108 675 38,720 SH   DFND 1 38,720 0 0
Sohu.com COM 83410S108 3,486 200,140 SH   SOLE 0 200,140 0 0
Solarcity Corp NOTE 1.625 11/0 83416TAC4 15,715 16,696,000 SH   DFND 1 16,696,000 0 0
Solarcity Corp NOTE 1.625 11/0 83416TAC4 7 7,000 SH   DFND 2 7,000 0 0
Solarcity Corp NOTE 1.625 11/0 83416TAC4 737 783,000 SH   SOLE 0 783,000 0 0
Splunk Inc COM 848637104 10,584 100,940 SH   DFND 1 100,940 0 0
Splunk Inc COM 848637104 10,947 104,406 SH   SOLE 0 104,406 0 0
Splunk Inc COM 848637104 11,837 112,891 SH   DFND 2 40,024 0 72,867
Spotify Technology SA SHS L8681T102 1,473,141 12,979,216 SH   DFND 2 5,289,954 0 7,689,262
Spotify Technology SA SHS L8681T102 114,577 1,009,491 SH   DFND 1 1,009,491 0 0
Spotify Technology SA SHS L8681T102 406,012 3,577,197 SH   SOLE 0 3,022,035 0 555,162
Staar Surgical COM PAR $0.01 852312305 21,862 685,108 SH   DFND 1 685,108 0 0
Staar Surgical COM PAR $0.01 852312305 14,175 444,214 SH   DFND 2 159,257 0 284,957
Staar Surgical COM PAR $0.01 852312305 18,387 576,199 SH   SOLE 0 576,199 0 0
Stericycle Inc COM 858912108 109,560 2,986,090 SH   DFND 2 2,253,864 0 732,226
Stericycle Inc COM 858912108 27,871 759,631 SH   DFND 1 759,631 0 0
Stericycle Inc COM 858912108 60,442 1,647,387 SH   SOLE 0 1,596,623 0 50,764
Stitch Fix COM CL A 860897107 18,021 1,054,479 SH   DFND 2 57,048 0 997,431
Stitch Fix COM CL A 860897107 31,710 1,855,497 SH   DFND 1 1,855,497 0 0
Stitch Fix COM CL A 860897107 11,795 690,155 SH   SOLE 0 690,155 0 0
Stratasys SHS M85548101 4,076 226,300 SH   DFND 1 226,300 0 0
Stratasys SHS M85548101 5,507 305,755 SH   DFND 2 107,402 0 198,353
Stratasys SHS M85548101 4,103 227,836 SH   SOLE 0 227,836 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 4,622 5,601,000 SH   DFND 1 5,601,000 0 0
Sunpower Corp DBCV 4.000 1/1 867652AL3 1,846 2,237,000 SH   SOLE 0 2,237,000 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 53,387 2,001,018 SH   DFND 1 2,001,018 0 0
TAL Education Group ADR ADS REPSTG COM 874080104 1,087,687 40,767,868 SH   DFND 2 10,332,316 0 30,435,552
TAL Education Group ADR ADS REPSTG COM 874080104 123,807 4,640,426 SH   SOLE 0 2,333,385 0 2,307,041
TD Ameritrade Holding Corp COM 87236Y108 55,637 1,136,368 SH   DFND 1 1,136,368 0 0
TD Ameritrade Holding Corp COM 87236Y108 219,158 4,476,262 SH   DFND 2 3,442,550 0 1,033,712
TD Ameritrade Holding Corp COM 87236Y108 110,433 2,255,590 SH   SOLE 0 2,188,047 0 67,543
TJX Companies COM 872540109 17,961 401,452 SH   DFND 2 401,452 0 0
TJX Companies COM 872540109 9,819 219,470 SH   DFND 1 219,470 0 0
TJX Companies COM 872540109 4,348 97,175 SH   SOLE 0 97,175 0 0
TSMC ADR SPONSORED ADR 874039100 89,255 2,418,166 SH   DFND 1 2,418,166 0 0
TSMC ADR SPONSORED ADR 874039100 727,637 19,713,835 SH   DFND 2 12,216,743 0 7,497,092
TSMC ADR SPONSORED ADR 874039100 163,695 4,434,984 SH   SOLE 0 4,308,622 0 126,362
Tableau Software Class A CL A 87336U105 83,618 696,819 SH   DFND 1 696,819 0 0
Tableau Software Class A CL A 87336U105 44,549 371,238 SH   DFND 2 21,287 0 349,951
Tableau Software Class A CL A 87336U105 119,100 992,503 SH   SOLE 0 992,503 0 0
Tandem Diabetes Care COM NEW 875372203 8,547 225,100 SH   DFND 1 225,100 0 0
Tandem Diabetes Care COM NEW 875372203 7,959 209,600 SH   SOLE 0 209,600 0 0
Targa Resources COM 87612G101 64 1,783 SH   DFND 1 1,783 0 0
Teladoc COM 87918A105 12,064 243,380 SH   DFND 2 86,671 0 156,709
Teladoc COM 87918A105 12,654 255,281 SH   DFND 1 255,281 0 0
Teladoc COM 87918A105 11,965 241,381 SH   SOLE 0 241,381 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 4,794 362,660 SH   DFND 1 362,660 0 0
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 95,297 7,208,517 SH   DFND 2 4,347,760 0 2,860,757
Tencent Music Entertainment ADR SPONSORED ADS 88034P109 8,261 624,912 SH   SOLE 0 624,912 0 0
Teradyne COM 880770102 32,251 1,027,763 SH   DFND 1 1,027,763 0 0
Teradyne COM 880770102 167,428 5,335,478 SH   DFND 2 4,340,669 0 994,809
Teradyne COM 880770102 69,045 2,200,298 SH   SOLE 0 2,130,486 0 69,812
TerraForm Power CL A COM 88104R209 45,306 4,037,995 SH   DFND 1 4,037,995 0 0
TerraForm Power CL A COM 88104R209 53 4,720 SH   DFND 2 4,720 0 0
TerraForm Power CL A COM 88104R209 2,470 220,105 SH   SOLE 0 220,105 0 0
Tesla Inc COM 88160R101 505,114 1,517,769 SH   DFND 1 1,517,769 0 0
Tesla Inc COM 88160R101 2,566,077 7,710,568 SH   DFND 2 2,330,145 0 5,380,423
Tesla Inc COM 88160R101 1,333,212 4,006,045 SH   SOLE 0 3,286,135 0 719,910
The Trade Desk COM CL A 88339J105 75,598 651,367 SH   DFND 1 651,367 0 0
The Trade Desk COM CL A 88339J105 41,499 357,561 SH   DFND 2 19,185 0 338,376
The Trade Desk COM CL A 88339J105 26,793 230,858 SH   SOLE 0 230,858 0 0
Thermo Fisher Scientific COM 883556102 78,385 350,260 SH   DFND 1 350,260 0 0
Thermo Fisher Scientific COM 883556102 291,170 1,301,087 SH   DFND 2 989,014 0 312,073
Thermo Fisher Scientific COM 883556102 160,804 718,547 SH   SOLE 0 697,236 0 21,311
Trupanion COM 898202106 5,031 197,600 SH   DFND 1 197,600 0 0
Trupanion COM 898202106 7,237 284,254 SH   DFND 2 100,548 0 183,706
Trupanion COM 898202106 20,653 811,187 SH   SOLE 0 811,187 0 0
Under Armour Inc Class A CL A 904311107 205,775 11,645,451 SH   DFND 2 4,151,539 0 7,493,912
Under Armour Inc Class A CL A 904311107 31,431 1,778,775 SH   DFND 1 1,778,775 0 0
Under Armour Inc Class A CL A 904311107 73,618 4,166,300 SH   SOLE 0 2,072,048 0 2,094,252
Under Armour Inc Class C CL C 904311206 26,471 1,637,049 SH   DFND 2 573,852 0 1,063,197
Under Armour Inc Class C CL C 904311206 32,190 1,990,733 SH   DFND 1 1,990,733 0 0
Under Armour Inc Class C CL C 904311206 13,186 815,471 SH   SOLE 0 815,471 0 0
United Parcel Service CL B 911312106 10,794 110,675 SH   DFND 1 110,675 0 0
United Parcel Service CL B 911312106 10,811 110,852 SH   SOLE 0 110,852 0 0
Unity Biotechnology Inc COM 91381U101 4,032 248,000 SH   DFND 1 248,000 0 0
Unity Biotechnology Inc COM 91381U101 57,805 3,555,014 SH   SOLE 0 3,555,014 0 0
Uxin ADR ADS 91818X108 3,323 683,800 SH   DFND 1 683,800 0 0
Uxin ADR ADS 91818X108 2,744 564,600 SH   SOLE 0 564,600 0 0
Varian Medical Systems Inc COM 92220P105 12,340 108,904 SH   DFND 2 108,904 0 0
Vector Group COM 92240M108 50 5,100 SH   DFND 1 5,100 0 0
Veeco Instruments COM 922417100 3,759 507,354 SH   DFND 1 507,354 0 0
Veeco Instruments COM 922417100 1,368 184,605 SH   DFND 2 67,206 0 117,399
Veeco Instruments COM 922417100 6,125 826,627 SH   SOLE 0 826,627 0 0
Verisk Analytics COM 92345Y106 218,776 2,006,382 SH   DFND 2 1,543,461 0 462,921
Verisk Analytics COM 92345Y106 56,067 514,187 SH   DFND 1 514,187 0 0
Verisk Analytics COM 92345Y106 117,207 1,074,898 SH   SOLE 0 1,042,205 0 32,693
Vertex Pharmaceuticals COM 92532F100 54,039 326,104 SH   DFND 1 326,104 0 0
Vertex Pharmaceuticals COM 92532F100 46,456 280,343 SH   DFND 2 102,888 0 177,455
Vertex Pharmaceuticals COM 92532F100 20,004 120,715 SH   SOLE 0 120,715 0 0
Visa Inc-Class A Shares COM CL A 92826C839 117,975 894,154 SH   DFND 1 894,154 0 0
Visa Inc-Class A Shares COM CL A 92826C839 440,182 3,336,226 SH   DFND 2 2,522,241 0 813,985
Visa Inc-Class A Shares COM CL A 92826C839 239,279 1,813,544 SH   SOLE 0 1,758,670 0 54,874
Voya Prime Rate Trust SH BEN INT 92913A100 2,564 571,000 SH   DFND 1 571,000 0 0
Voya Prime Rate Trust SH BEN INT 92913A100 868 193,400 SH   SOLE 0 193,400 0 0
WEC Energy Group COM 92939U106 21,454 309,760 SH   DFND 1 309,760 0 0
WEC Energy Group COM 92939U106 31 450 SH   DFND 2 450 0 0
WEC Energy Group COM 92939U106 930 13,423 SH   SOLE 0 13,423 0 0
Wabtec COM 929740108 78,759 1,121,127 SH   DFND 1 1,121,127 0 0
Wabtec COM 929740108 182,942 2,604,156 SH   DFND 2 1,784,929 0 819,227
Wabtec COM 929740108 96,819 1,378,204 SH   SOLE 0 1,341,023 0 37,181
Waters COM 941848103 69,996 371,038 SH   DFND 1 371,038 0 0
Waters COM 941848103 264,060 1,399,734 SH   DFND 2 1,078,137 0 321,597
Waters COM 941848103 139,801 741,062 SH   SOLE 0 718,213 0 22,849
Watsco Inc COM 942622200 72,027 517,661 SH   DFND 1 517,661 0 0
Watsco Inc COM 942622200 53,200 382,348 SH   DFND 2 121,388 0 260,960
Watsco Inc COM 942622200 29,572 212,533 SH   SOLE 0 212,533 0 0
Wayfair Inc Class A CL A 94419L101 156,849 1,741,219 SH   DFND 1 1,741,219 0 0
Wayfair Inc Class A CL A 94419L101 103,563 1,149,683 SH   DFND 2 169,936 0 979,747
Wayfair Inc Class A CL A 94419L101 79,487 882,407 SH   SOLE 0 882,407 0 0
Weibo Corp SPON ADR SPONSORED ADR 948596101 1,537 26,310 SH   SOLE 0 26,310 0 0
Wipro Ltd ADR SPON ADR 1 SH 97651M109 506 98,583 SH   DFND 2 75,632 0 22,951
Wix Com SHS M98068105 237,284 2,626,561 SH   DFND 2 738,090 0 1,888,471
Workday Inc CL A 98138H101 86,603 542,356 SH   DFND 1 542,356 0 0
Workday Inc CL A 98138H101 555,946 3,481,625 SH   DFND 2 1,247,032 0 2,234,593
Workday Inc CL A 98138H101 335,918 2,103,698 SH   SOLE 0 1,472,023 0 631,675
Xylem COM 98419M100 2,940 44,060 SH   DFND 1 44,060 0 0
Xylem COM 98419M100 882 13,217 SH   SOLE 0 13,217 0 0
Xylem COM 98419M100 5,542 83,059 SH   DFND 2 47,941 0 35,118
Yext Inc COM 98585N106 7,760 522,534 SH   DFND 1 522,534 0 0
Yext Inc COM 98585N106 6,481 436,441 SH   SOLE 0 436,441 0 0
Yext Inc COM 98585N106 4,972 334,816 SH   DFND 2 118,387 0 216,429
Zillow Group Inc Class A CL A 98954M101 1,805 57,439 SH   DFND 1 57,439 0 0
Zillow Group Inc Class A CL A 98954M101 20,856 663,558 SH   DFND 2 473,592 0 189,966
Zillow Group Inc Class A CL A 98954M101 12,131 385,960 SH   SOLE 0 373,141 0 12,819
Zillow Group Inc Class C CL C CAP STK 98954M200 67,192 2,127,677 SH   DFND 1 2,127,677 0 0
Zillow Group Inc Class C CL C CAP STK 98954M200 185,129 5,862,202 SH   DFND 2 4,087,005 0 1,775,197
Zillow Group Inc Class C CL C CAP STK 98954M200 104,011 3,293,571 SH   SOLE 0 3,209,162 0 84,409
iRobot COM 462726100 12,629 150,815 SH   DFND 1 150,815 0 0
iRobot COM 462726100 32,285 385,538 SH   SOLE 0 385,538 0 0
iRobot COM 462726100 14,569 173,981 SH   DFND 2 62,904 0 111,077