The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADMA BIOLOGICS INC | COM | 000899104 | 10,100 | 4,226,077 | SH | DFND | 1 | 4,226,077 | 0 | 0 | |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 13,875 | 1,877,502 | SH | DFND | 1 | 1,877,502 | 0 | 0 | |
| ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 22,328 | 2,614,468 | SH | DFND | 1 | 2,614,468 | 0 | 0 | |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 5,715 | 58,700 | SH | DFND | 1 | 58,700 | 0 | 0 | |
| ALPHATEC HOLDINGS INC | COM NEW | 02081G201 | 1,030 | 449,585 | SH | DFND | 1 | 449,585 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 9,368 | 3,444,147 | SH | DFND | 1 | 3,444,147 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 25,030 | 4,083,135 | SH | DFND | 1 | 4,083,135 | 0 | 0 | |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 8,005 | 3,102,673 | SH | DFND | 1 | 3,102,673 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 16,188 | 4,375,066 | SH | DFND | 1 | 4,375,066 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 12,035 | 6,268,298 | SH | DFND | 1 | 6,268,298 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 21,552 | 179,900 | SH | DFND | 1 | 179,900 | 0 | 0 | |
| DOVA PHARMACEUTICALS INC | COM | 25985T102 | 2,667 | 351,800 | SH | DFND | 1 | 351,800 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 1,456 | 143,300 | SH | DFND | 1 | 143,300 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 9,889 | 240,909 | SH | DFND | 1 | 240,909 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 14,368 | 350,000 | SH | Call | DFND | 1 | 350,000 | 0 | 0 |
| HERON THERAPEUTICS INC | COM | 427746102 | 3,094 | 119,294 | SH | DFND | 1 | 119,294 | 0 | 0 | |
| IDERA PHARMACEUTICALS INC | COM PAR | 45168K405 | 1,348 | 486,604 | SH | DFND | 1 | 486,604 | 0 | 0 | |
| INCYTE CORP | COM | 45337C102 | 11,656 | 183,300 | SH | DFND | 1 | 183,300 | 0 | 0 | |
| INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 8,865 | 196,572 | SH | DFND | 1 | 196,572 | 0 | 0 | |
| INTERSECT ENT INC | COM | 46071F103 | 8,113 | 287,900 | SH | DFND | 1 | 287,900 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 52,668 | 5,951,153 | SH | DFND | 1 | 5,951,153 | 0 | 0 | |
| KALA PHARMACEUTICALS INC | COM | 483119103 | 1,658 | 339,119 | SH | DFND | 1 | 339,119 | 0 | 0 | |
| KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 2,827 | 143,129 | SH | DFND | 1 | 143,129 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 18,365 | 1,947,541 | SH | DFND | 1 | 1,947,541 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 8,484 | 200,000 | SH | DFND | 1 | 200,000 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 10,686 | 720,600 | SH | DFND | 1 | 720,600 | 0 | 0 | |
| NEOS THERAPEUTICS INC | COM | 64052L106 | 4,321 | 2,618,819 | SH | DFND | 1 | 2,618,819 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 28,950 | 744,415 | SH | DFND | 1 | 744,415 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 11,667 | 300,000 | SH | Call | DFND | 1 | 300,000 | 0 | 0 |
| NOVELION THERAPEUTICS INC | COM NEW | 67001K202 | 1,033 | 1,229,301 | SH | DFND | 1 | 1,229,301 | 0 | 0 | |
| OPTINOSE INC | COM | 68404V100 | 4,406 | 710,600 | SH | DFND | 1 | 710,600 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 14,541 | 2,048,025 | SH | DFND | 1 | 2,048,025 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 22,995 | 1,016,114 | SH | DFND | 1 | 1,016,114 | 0 | 0 | |
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 174,944 | 700,000 | SH | Put | DFND | 1 | 700,000 | 0 | 0 |
| SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 50,225 | 700,000 | SH | Put | DFND | 1 | 700,000 | 0 | 0 |
| SIERRA ONCOLOGY INC | COM | 82640U107 | 6,442 | 4,880,327 | SH | DFND | 1 | 4,880,327 | 0 | 0 | |
| STRATA SKIN SCIENCES INC | COM NEW | 86272A206 | 5,646 | 2,171,363 | SH | DFND | 1 | 2,171,363 | 0 | 0 | |
| TANDEM DIABETES CARE INC | COM NEW | 875372203 | 3,383 | 89,100 | SH | DFND | 1 | 89,100 | 0 | 0 | |
| TELIGENT INC NEW | COM | 87960W104 | 3,868 | 2,823,383 | SH | DFND | 1 | 2,823,383 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 32,835 | 442,219 | SH | DFND | 1 | 442,219 | 0 | 0 | |
| TESARO INC | COM | 881569107 | 24,131 | 325,000 | SH | Call | DFND | 1 | 325,000 | 0 | 0 |
| VERICEL CORP | COM | 92346J108 | 3,306 | 190,000 | SH | DFND | 1 | 190,000 | 0 | 0 | |
| VIEWRAY INC | COM | 92672L107 | 5,260 | 866,500 | SH | DFND | 1 | 866,500 | 0 | 0 | |
| ZOGENIX INC | COM NEW | 98978L204 | 19,542 | 535,998 | SH | DFND | 535,998 | 0 | 0 | ||
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 4,782 | 129,300 | SH | DFND | 1 | 129,300 | 0 | 0 | |
| LIVANOVA PLC | SHS | G5509L101 | 4,665 | 51,000 | SH | DFND | 1 | 51,000 | 0 | 0 | |
| OSMOTICA PHARMACEUTICALS PLC | SHS | G6S41R101 | 4,096 | 528,571 | SH | DFND | 1 | 528,571 | 0 | 0 | |
| QUOTIENT LTD | SHS | G73268107 | 10,389 | 1,697,582 | SH | DFND | 1 | 1,697,582 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 12,641 | 2,821,722 | SH | DFND | 1 | 2,821,722 | 0 | 0 | |
| SOL GEL TECHNOLOGIES | SHS | M8694L103 | 5,103 | 847,700 | SH | DFND | 1 | 847,700 | 0 | 0 | |