The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 2,710 1,936,027 SH   DFND   1,936,027 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 15,966 621,000 SH   DFND   621,000 0 0
ACCELERON PHARMA INC COM 00434H108 60,384 1,386,541 SH   DFND   1,386,541 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 43,552 5,893,416 SH   DFND   5,893,416 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 54,821 1,518,596 SH   DFND   1,518,596 0 0
ADDUS HOMECARE CORP COM 006739106 15,809 232,900 SH   DFND   232,900 0 0
ALIMERA SCIENCES INC COM 016259103 4,347 6,052,935 SH   DFND   6,052,935 0 0
ALLERGAN PLC SHS G0177J108 24,059 180,000 SH   DFND   180,000 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 8,801 326,797 SH   DFND   326,797 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 1,750 475,450 SH   DFND   475,450 0 0
ANAPTYSBIO INC COM 032724106 47,424 743,439 SH   DFND   743,439 0 0
ANTHEM INC COM 036752103 24,950 95,000 SH   DFND   95,000 0 0
ARDELYX INC COM 039697107 5,304 2,962,922 SH   DFND   2,962,922 0 0
ARGENX SE SPONSORED ADR 04016X101 45,345 472,000 SH   DFND   472,000 0 0
ARVINAS INC COM 04335A105 11,838 921,234 SH   DFND   921,234 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 31,644 505,098 SH   DFND   505,098 0 0
ATHENEX INC COM 04685N103 7,750 610,700 SH   DFND   610,700 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 10,530 493,901 SH   DFND   493,901 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 7,736 235,576 SH   DFND   235,576 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 7,023 2,722,241 SH   DFND   2,722,241 0 0
AXOGEN INC COM 05463X106 2,138 104,674 SH   DFND   104,674 0 0
AXOVANT SCIENCES LTD COM G0750W104 9,960 10,000,000 SH   DFND   10,000,000 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 55,770 6,910,789 SH   DFND   6,910,789 0 0
BIOSCRIP INC COM 09069N108 2,738 767,000 SH   DFND   767,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 28,087 521,000 SH   DFND   521,000 0 0
BROOKDALE SR LIVING INC COM 112463104 28,414 4,240,855 SH   DFND   4,240,855 0 0
CENTENE CORP DEL COM 15135B101 32,976 286,000 SH   DFND   286,000 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 2,550 635,843 SH   DFND   635,843 0 0
CVS HEALTH CORP COM 126650100 37,137 566,800 SH Call DFND   566,800 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 10,571 1,343,181 SH   DFND   1,343,181 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 9,400 622,548 SH   DFND   622,548 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 12,754 607,633 SH   DFND   607,633 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 73,718 55,000,000 PRN   DFND   55,000,000 0 0
DFB HEALTHCARE ACQUISTION CO UNIT 01/30/2023 23291E208 25,250 2,500,000 SH   DFND   2,500,000 0 0
DIPLOMAT PHARMACY INC COM 25456K101 31,617 2,348,993 SH   DFND   2,348,993 0 0
EDITAS MEDICINE INC COM 28106W103 26,364 1,158,841 SH   DFND   1,158,841 0 0
EHEALTH INC COM 28238P109 41,355 1,076,402 SH   DFND   1,076,402 0 0
EXACT SCIENCES CORP COM 30063P105 8,140 129,000 SH   DFND   129,000 0 0
EXACT SCIENCES CORP DBCV 1.000% 1/1 30063PAA3 16,499 15,000,000 PRN   DFND   15,000,000 0 0
EYENOVIA INC COM 30234E104 855 300,000 SH   DFND   300,000 0 0
FATE THERAPEUTICS INC COM 31189P102 21,232 1,654,865 SH   DFND   1,654,865 0 0
GALAPAGOS NV SPON ADR 36315X101 26,458 288,407 SH   DFND   288,407 0 0
GLAUKOS CORP COM 377322102 28,310 504,000 SH   DFND   504,000 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 10,627 109,117 SH   DFND   109,117 0 0
HISTOGENICS CORP COM 43358V109 26 296,099 SH   DFND   296,099 0 0
HOMOLOGY MEDICINES INC COM 438083107 116,877 5,227,035 SH   DFND   5,227,035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 112,678 113,532,000 PRN   DFND   113,532,000 0 0
HORIZON PHARMA PLC SHS G4617B105 133,375 6,825,719 SH   DFND   6,825,719 0 0
IGI LABORATORIES INC NOTE 3.750%12/1 449575AB5 3,628 3,733,000 PRN   DFND   3,733,000 0 0
IMMUNOMEDICS INC COM 452907108 26,160 1,833,202 SH   DFND   1,833,202 0 0
INSPIRE MED SYS INC COM 457730109 16,933 400,781 SH   DFND   400,781 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 53,020 57,791,000 PRN   DFND   57,791,000 0 0
INTERSECT ENT INC COM 46071F103 58,569 2,078,375 SH   DFND   2,078,375 0 0
INVITAE CORP COM 46185L103 7,610 688,062 SH   DFND   688,062 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 12,838 650,000 SH   DFND   650,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 4,451 475,000 SH   DFND   475,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 39,363 65,423,000 PRN   DFND   65,423,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 31,709 1,128,822 SH   DFND   1,128,822 0 0
LIVANOVA PLC SHS G5509L101 6,540 71,500 SH   DFND   71,500 0 0
MANNKIND CORP COM NEW 56400P706 1,000 943,298 SH   DFND   943,298 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 2,256 234,000 SH   DFND   234,000 0 0
MELINTA THERAPEUTICS INC COM 58549G100 265 333,902 SH   DFND   333,902 0 0
MIRATI THERAPEUTICS INC COM 60468T105 37,096 874,486 SH   DFND   874,486 0 0
MOLINA HEALTHCARE INC COM 60855R100 17,639 151,772 SH   DFND   151,772 0 0
MORPHOSYS AG SPONSORED ADS 617760202 15,180 600,000 SH   DFND   600,000 0 0
MYLAN N V SHS EURO N59465109 77,645 2,833,741 SH   DFND   2,833,741 0 0
MYOKARDIA INC COM 62857M105 48,713 997,000 SH   DFND   997,000 0 0
NATERA INC COM 632307104 17,492 1,253,000 SH   DFND   1,253,000 0 0
NEOS THERAPEUTICS INC COM 64052L106 2,030 1,230,267 SH   DFND   1,230,267 0 0
NEURONETICS INC COM 64131A105 3,077 159,000 SH   DFND   159,000 0 0
NEVRO CORP COM 64157F103 35,556 914,273 SH   DFND   914,273 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 92,273 100,000,000 PRN   DFND   100,000,000 0 0
NUVASIVE INC NOTE 2.250% 3/1 670704AG0 7,352 7,000,000 PRN   DFND   7,000,000 0 0
NUVECTRA CORP COM 67075N108 2,108 129,000 SH   DFND   129,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 126,211 8,023,600 SH   DFND   8,023,600 0 0
ORTHOPEDIATRICS CORP COM 68752L100 2,032 58,247 SH   DFND   58,247 0 0
OSMOTICA PHARMACEUTICALS PLC SHS G6S41R101 8,821 1,138,256 SH   DFND   1,138,256 0 0
PFENEX INC COM 717071104 3,412 1,069,514 SH   DFND   1,069,514 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 32,743 1,677,414 SH   DFND   1,677,414 0 0
PROTEON THERAPEUTICS INC COM 74371L109 2,781 1,224,899 SH   DFND   1,224,899 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 1,358 419,000 SH   DFND   419,000 0 0
RA MED SYS INC COM 74933X104 862 108,400 SH   DFND   108,400 0 0
RA PHARMACEUTICALS INC COM 74933V108 27,336 1,502,000 SH   DFND   1,502,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 20,420 364,000 SH   DFND   364,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 7,822 291,005 SH   DFND   291,005 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 4,150 280,000 SH   DFND   280,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 37,301 341,800 SH   DFND   341,800 0 0
SAVARA INC COM 805111101 1,893 250,000 SH   DFND   250,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 21,227 1,382,890 SH   DFND   1,382,890 0 0
SIENTRA INC COM 82621J105 19,991 1,572,891 SH   DFND   1,572,891 0 0
SYNLOGIC INC COM 87166L100 7,765 1,107,643 SH   DFND   1,107,643 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 7,068 1,268,945 SH   DFND   1,268,945 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 21,026 553,765 SH   DFND   553,765 0 0
TELIGENT INC NEW NOTE 4.750% 5/0 87960WAA2 6,539 9,567,000 PRN   DFND   9,567,000 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 38,698 332,000 SH   DFND   332,000 0 0
VERICEL CORP COM 92346J108 64,831 3,725,900 SH   DFND   3,725,900 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 1,106 117,647 SH   DFND   117,647 0 0
WRIGHT MED GROUP N V NOTE 2.250%11/1 98236JAB4 32,195 23,625,000 PRN   DFND   23,625,000 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 42,477 2,498,666 SH   DFND   2,498,666 0 0