The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 224,131 689,550 SH   SOLE   689,550 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 32,761 2,026,063 SH   SOLE   2,026,063 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 33,191 1,387,589 SH   SOLE   1,387,589 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 19,082 1,861,630 SH   SOLE   1,861,630 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 117,253 1,204,328 SH   SOLE   1,204,328 0 0
ALIGN TECHNOLOGY INC COM 016255101 32,843 156,823 SH   SOLE   156,823 0 0
ALIMERA SCIENCES INC COM 016259103 2,164 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 51,350 3,380,506 SH   SOLE   3,380,506 0 0
AMICUS THERAPEUTICS INC COM 03152W109 70,905 7,401,321 SH   SOLE   7,401,321 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 217,961 2,559,733 SH   SOLE   2,559,733 0 0
CELGENE CORP COM 151020104 34,139 532,667 SH   SOLE   532,667 0 0
CLOVIS ONCOLOGY INC COM 189464100 94,098 5,239,304 SH   SOLE   5,239,304 0 0
CYTOKINETICS INC COM NEW 23282W605 782 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 5,355 500,913 SH   SOLE   500,913 0 0
EPIZYME INC COM 29428V104 42,720 6,935,074 SH   SOLE   6,935,074 0 0
EXACT SCIENCES CORP COM 30063P105 19,869 314,889 SH   SOLE   314,889 0 0
GILEAD SCIENCES INC COM 375558103 11,003 175,900 SH   SOLE   175,900 0 0
HISTOGENICS CORP COM 43358V109 27 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 213 77,044 SH   SOLE   77,044 0 0
IMMUNOMEDICS INC COM 452907108 74,008 5,186,255 SH   SOLE   5,186,255 0 0
INSMED INC COM PAR $.01 457669307 100,415 7,653,617 SH   SOLE   7,653,617 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 43,902 4,685,352 SH   SOLE   4,685,352 0 0
MELINTA THERAPEUTICS INC COM 58549G100 40 50,689 SH   SOLE   50,689 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 20,331 1,841,613 SH   SOLE   1,841,613 0 0
PROTHENA CORP PLC SHS G72800108 11,418 1,108,510 SH   SOLE   1,108,510 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 23,604 1,159,900 SH   SOLE   1,159,900 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 9,168 3,985,945 SH   SOLE   3,985,945 0 0
SAGE THERAPEUTICS INC COM 78667J108 81,515 850,977 SH   SOLE   850,977 0 0
SHIRE PLC SPONSORED ADR 82481R106 8,343 47,938 SH   SOLE   47,938 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 205 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 132,362 4,147,988 SH   SOLE   4,147,988 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 483 1,162,473 SH   SOLE   1,162,473 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 177,728 1,632,025 SH   SOLE   1,632,025 0 0
VANDA PHARMACEUTICALS INC COM 921659108 108,588 4,155,670 SH   SOLE   4,155,670 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 75,437 2,771,394 SH   SOLE   2,771,394 0 0
ZOGENIX INC COM NEW 98978L204 1,076 29,500 SH   SOLE   29,500 0 0