The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 36,536 457,048 SH   SOLE   457,048 0 0
AbbVie Inc. Common 00287Y109 25,806 320,213 SH   SOLE   320,213 0 0
ABIOMED, Inc. Common 003654100 6,850 23,986 SH   SOLE   23,986 0 0
AC Immune SA Shares H00263105 868 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Company, Inc. Common 00404A109 5,075 173,155 SH   SOLE   173,155 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 2,812 104,714 SH   SOLE   104,714 0 0
Acceleron Pharma Inc. Common 00434H108 8,773 188,388 SH   SOLE   188,388 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 983 228,496 SH   SOLE   228,496 0 0
Aerie Pharmaceuticals, Inc. Common 00771V108 3,254 68,496 SH   SOLE   68,496 0 0
Aerpio Pharmaceuticals, Inc. Common 00810B105 667 740,000 SH   SOLE   740,000 0 0
Affimed N.V. Common N01045108 1,067 254,000 SH   SOLE   254,000 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 6,189 91,776 SH   SOLE   91,776 0 0
Akebia Therapeutics, Inc. Common 00972D105 1,752 213,942 SH   SOLE   213,942 0 0
Albireo Pharma, Inc. Common 01345P106 4,026 125,000 SH   SOLE   125,000 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 50,788 375,705 SH   SOLE   375,705 0 0
Align Technology, Inc. Common 016255101 8,040 28,278 SH   SOLE   28,278 0 0
Alkermes plc Shares G01767105 7,227 198,048 SH   SOLE   198,048 0 0
Allakos Inc. Common 01671P100 989 24,414 SH   SOLE   24,414 0 0
Allergan plc Shares G0177J108 28,296 193,263 SH   SOLE   193,263 0 0
Alliqua BioMedical, Inc. Common 019621309 437 148,500 SH   SOLE   148,500 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 12,472 133,458 SH   SOLE   133,458 0 0
Amarin Corporation plc Sponsored ADR 023111206 12,692 611,352 SH   SOLE   611,352 0 0
AmerisourceBergen Corporation Common 03073E105 6,300 79,226 SH   SOLE   79,226 0 0
Amgen Inc. Common 031162100 133,819 704,383 SH   SOLE   704,383 0 0
Amicus Therapeutics, Inc. Common 03152W109 4,279 314,597 SH   SOLE   314,597 0 0
AnaptysBio, Inc. Common 032724106 4,810 65,845 SH   SOLE   65,845 0 0
Anthem, Inc. Common 036752103 40,567 141,358 SH   SOLE   141,358 0 0
ARCA biopharma, Inc. Common 00211Y407 303 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 1,790 639,370 SH   SOLE   639,370 0 0
Arena Pharmaceuticals, Inc. Common 040047607 2,343 52,262 SH   SOLE   52,262 0 0
argenx SE Sponsored ADR 04016X101 3,543 28,381 SH   SOLE   28,381 0 0
ArQule, Inc. Common 04269E107 1,198 250,000 SH   SOLE   250,000 0 0
Array BioPharma Inc. Common 04269X105 8,878 364,166 SH   SOLE   364,166 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100 563 30,700 SH   SOLE   30,700 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 7,222 61,360 SH   SOLE   61,360 0 0
AstraZeneca PLC Sponsored ADR 046353108 14,595 360,998 SH   SOLE   360,998 0 0
Athenex, Inc. Common 04685N103 558 45,530 SH   SOLE   45,530 0 0
Audentes Therapeutics, Inc. Common 05070R104 2,051 52,574 SH   SOLE   52,574 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 1,173 814,588 SH   SOLE   814,588 0 0
Bausch Health Companies Inc. Common 071734107 4,170 168,812 SH   SOLE   168,812 0 0
Baxter International Inc. Common 071813109 11,194 137,668 SH   SOLE   137,668 0 0
Becton, Dickinson and Company Common 075887109 15,414 61,721 SH   SOLE   61,721 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 12,525 94,889 SH   SOLE   94,889 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 202 60,000 SH   SOLE   60,000 0 0
Bio-Techne Corporation Common 09073M104 4,309 21,701 SH   SOLE   21,701 0 0
Biogen Inc. Common 09062X103 74,289 314,278 SH   SOLE   314,278 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 19,728 222,086 SH   SOLE   222,086 0 0
bluebird bio, Inc. Common 09609G100 14,322 91,029 SH   SOLE   91,029 0 0
Blueprint Medicines Corporation Common 09627Y109 9,263 115,720 SH   SOLE   115,720 0 0
Boston Scientific Corporation Common 101137107 18,177 473,619 SH   SOLE   473,619 0 0
Bristol-Myers Squibb Company Common 110122108 35,212 738,044 SH   SOLE   738,044 0 0
Cardinal Health, Inc. Common 14149Y108 303 6,300 SH   SOLE   6,300 0 0
Celgene Corporation Common 151020104 139,030 1,473,710 SH   SOLE   1,473,710 0 0
Celldex Therapeutics, Inc. Common 15117B202 35 7,053 SH   SOLE   7,053 0 0
Cellectis SA Sponsored ADR 15117K103 3,173 173,035 SH   SOLE   173,035 0 0
Centene Corporation Common 15135B101 6,812 128,295 SH   SOLE   128,295 0 0
Charles River Laboratories International, Inc. Common 159864107 1,545 10,640 SH   SOLE   10,640 0 0
Cidara Therapeutics, Inc. Common 171757107 421 158,784 SH   SOLE   158,784 0 0
Cigna Corporation Common 125523100 18,777 116,756 SH   SOLE   116,756 0 0
Clearside Biomedical, Inc. Common 185063104 228 165,330 SH   SOLE   165,330 0 0
Clovis Oncology, Inc. Common 189464100 1,871 75,400 SH   SOLE   75,400 0 0
Coherus Biosciences, Inc. Common 19249H103 4,299 315,162 SH   SOLE   315,162 0 0
Community Health Systems, Inc. Common 203668108 761 203,935 SH   SOLE   203,935 0 0
Concert Pharmaceuticals, Inc. Common 206022105 548 45,362 SH   SOLE   45,362 0 0
CRISPR Therapeutics AG Namen AKT H17182108 6,371 178,348 SH   SOLE   178,348 0 0
CVS Health Corporation Common 126650100 27,308 506,364 SH   SOLE   506,364 0 0
Danaher Corporation Common 235851102 20,982 158,931 SH   SOLE   158,931 0 0
Denali Therapeutics Inc. Common 24823R105 450 19,372 SH   SOLE   19,372 0 0
DENTSPLY SIRONA Inc. Common 24906P109 7,762 156,521 SH   SOLE   156,521 0 0
Diplomat Pharmacy, Inc. Common 25456K101 1,248 214,845 SH   SOLE   214,845 0 0
Dr. Reddy's Laboratories Ltd. Sponsored ADR 256135203 1,172 28,950 SH   SOLE   28,950 0 0
Editas Medicine, Inc. Common 28106W103 1,875 76,668 SH   SOLE   76,668 0 0
Edwards Lifesciences Corporation Common 28176E108 10,867 56,798 SH   SOLE   56,798 0 0
Eli Lilly and Company Common 532457108 38,321 295,320 SH   SOLE   295,320 0 0
Endo International plc Shares G30401106 4,269 531,570 SH   SOLE   531,570 0 0
Epizyme, Inc. Common 29428V104 3,586 289,404 SH   SOLE   289,404 0 0
Esperion Therapeutics, Inc. Common 29664W105 7,412 184,607 SH   SOLE   184,607 0 0
Evolent Health, Inc. Common 30050B101 530 42,150 SH   SOLE   42,150 0 0
Exelixis, Inc. Common 30161Q104 16,148 678,467 SH   SOLE   678,467 0 0
FibroGen, Inc. Common 31572Q808 9,552 175,742 SH   SOLE   175,742 0 0
Foamix Pharmaceuticals Ltd Shares M46135105 1,128 300,781 SH   SOLE   300,781 0 0
Galapagos NV Sponsored ADR 36315X101 5,715 48,525 SH   SOLE   48,525 0 0
Genomic Health, Inc. Common 37244C101 1,858 26,531 SH   SOLE   26,531 0 0
Gilead Sciences, Inc. Common 375558103 113,728 1,749,388 SH   SOLE   1,749,388 0 0
GlaxoSmithKline plc Shares 37733W105 9,139 218,700 SH   SOLE   218,700 0 0
Global Blood Therapeutics, Inc. Common 37890U108 4,551 85,988 SH   SOLE   85,988 0 0
Global Medical REIT Inc. Common 37954A204 721 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals plc ADS 36197T103 5,882 34,891 SH   SOLE   34,891 0 0
HCA Healthcare, Inc. Common 40412C101 11,678 89,569 SH   SOLE   89,569 0 0
HCP, Inc. Common 40414L109 1,424 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Incorporated Common 421946104 2,183 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Common 42225P501 1,315 46,000 SH   SOLE   46,000 0 0
Hologic, Inc. Common 436440101 946 19,546 SH   SOLE   19,546 0 0
Horizon Pharma plc Shares G4617B105 511 19,350 SH   SOLE   19,350 0 0
Humana Inc. Common 444859102 9,491 35,682 SH   SOLE   35,682 0 0
IDEXX Laboratories, Inc. Common 45168D104 14,233 63,654 SH   SOLE   63,654 0 0
Illumina, Inc. Common 452327109 73,793 237,514 SH   SOLE   237,514 0 0
ImmunoGen, Inc. Common 45253H101 456 168,190 SH   SOLE   168,190 0 0
Immunomedics, Inc. Common 452907108 5,526 287,687 SH   SOLE   287,687 0 0
Incyte Corporation Common 45337C102 45,511 529,133 SH   SOLE   529,133 0 0
Inogen, Inc. Common 45780L104 763 8,000 SH   SOLE   8,000 0 0
Intellia Therapeutics, Inc. Common 45826J105 2,567 150,290 SH   SOLE   150,290 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108 6,631 59,275 SH   SOLE   59,275 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 1,342 110,193 SH   SOLE   110,193 0 0
Intuitive Surgical, Inc. Common 46120E602 22,984 40,281 SH   SOLE   40,281 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 8,906 109,720 SH   SOLE   109,720 0 0
Iovance Biotherapeutics, Inc. Common 462260100 2,063 216,908 SH   SOLE   216,908 0 0
IQVIA Holdings Inc. Common 46266C105 2,358 16,391 SH   SOLE   16,391 0 0
Jazz Pharmaceuticals plc Shares G50871105 9,645 67,471 SH   SOLE   67,471 0 0
Johnson & Johnson Common 478160104 125,530 897,990 SH   SOLE   897,990 0 0
Jounce Therapeutics, Inc. Common 481116101 63 10,127 SH   SOLE   10,127 0 0
Koninklijke Philips N.V. NY Reg Sh 500472303 3,489 85,400 SH   SOLE   85,400 0 0
Laboratory Corporation of America Holdings Sponsored ADR 50540R409 6,985 45,657 SH   SOLE   45,657 0 0
Ligand Pharmaceuticals, Inc. Common 53220K504 3,758 29,895 SH   SOLE   29,895 0 0
LivaNova PLC Shares G5509L101 1,109 11,400 SH   SOLE   11,400 0 0
LTC Properties, Inc. Common 502175102 6,660 145,421 SH   SOLE   145,421 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105 1,671 13,340 SH   SOLE   13,340 0 0
Mallinckrodt public limited company Sponsored ADR G5785G107 717 32,980 SH   SOLE   32,980 0 0
Marinus Pharmaceuticals, Inc. Common 56854Q101 1,373 328,436 SH   SOLE   328,436 0 0
Masimo Corporation Common 574795100 1,482 10,715 SH   SOLE   10,715 0 0
McKesson Corporation Common 58155Q103 8,278 70,720 SH   SOLE   70,720 0 0
Medical Properties Trust, Inc. Common 58463J304 6,035 326,063 SH   SOLE   326,063 0 0
The Medicines Company Common 584688105 8,200 293,392 SH   SOLE   293,392 0 0
Medtronic plc Shares G5960L103 44,812 492,002 SH   SOLE   492,002 0 0
Merck & Co., Inc. Common 58933Y105 82,595 993,083 SH   SOLE   993,083 0 0
Merus N.V. Common N5749R100 4,692 317,671 SH   SOLE   317,671 0 0
Mirati Therapeutics, Inc. Common 60468T105 996 13,590 SH   SOLE   13,590 0 0
Molecular Templates, Inc. Common 608550109 837 144,110 SH   SOLE   144,110 0 0
Mylan N.V. Shares N59465109 26,729 943,152 SH   SOLE   943,152 0 0
MyoKardia, Inc. Common 62857M105 2,007 38,600 SH   SOLE   38,600 0 0
Myriad Genetics, Inc. Common 62855J104 682 20,549 SH   SOLE   20,549 0 0
Nektar Therapeutics Common 640268108 9,532 283,679 SH   SOLE   283,679 0 0
Neurocrine Biosciences, Inc. Common 64125C109 19,530 221,678 SH   SOLE   221,678 0 0
New Senior Investment Group Inc. Common 648691103 1,437 263,647 SH   SOLE   263,647 0 0
Novartis AG Sponsored ADR 66987V109 26,616 276,847 SH   SOLE   276,847 0 0
Novavax, Inc. Common 670002104 315 571,000 SH   SOLE   571,000 0 0
Novo Nordisk A/S Sponsored ADR 670100205 13,161 251,600 SH   SOLE   251,600 0 0
Novocure Limited Ordinary Shares G6674U108 3,177 65,964 SH   SOLE   65,964 0 0
NuVasive, Inc. Common 670704105 217 3,816 SH   SOLE   3,816 0 0
Omega Healthcare Investors, Inc. Common 681936100 12,981 340,266 SH   SOLE   340,266 0 0
Ovid Therapeutics Inc. Sponsored ADR 690469101 880 496,977 SH   SOLE   496,977 0 0
Perrigo Company plc Shares G97822103 1,046 21,718 SH   SOLE   21,718 0 0
Pfizer Inc. Common 717081103 87,945 2,070,765 SH   SOLE   2,070,765 0 0
Physicians Realty Trust Common 71943U104 5,717 303,908 SH   SOLE   303,908 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 6,993 2,087,380 SH   SOLE   2,087,380 0 0
Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 4,006 115,448 SH   SOLE   115,448 0 0
PRA Health Sciences, Inc. Common 69354M108 15,831 143,537 SH   SOLE   143,537 0 0
Protagonist Therapeutics, Inc. Common 74366E102 2,230 177,425 SH   SOLE   177,425 0 0
PTC Therapeutics, Inc. Common 69366J200 2,584 68,652 SH   SOLE   68,652 0 0
Puma Biotechnology, Inc. Common 74587V107 2,767 71,340 SH   SOLE   71,340 0 0
Quest Diagnostics, Inc. Common 74834L100 5,980 66,500 SH   SOLE   66,500 0 0
Quorum Health Corporation Common 74909E106 33 23,725 SH   SOLE   23,725 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 58,116 141,532 SH   SOLE   141,532 0 0
ResMed Inc. Common 761152107 7,171 68,974 SH   SOLE   68,974 0 0
Rhythm Pharmaceuticals, Inc. Common 76243J105 682 24,890 SH   SOLE   24,890 0 0
Sabra Health Care REIT, Inc. Common 78573L106 9,078 466,247 SH   SOLE   466,247 0 0
Sage Therapeutics, Inc. Common 78667J108 12,701 79,856 SH   SOLE   79,856 0 0
Sangamo Therapeutics, Inc. Common 800677106 2,304 241,538 SH   SOLE   241,538 0 0
Sanofi Sponsored ADR 80105N105 7,966 179,900 SH   SOLE   179,900 0 0
Sarepta Therapeutics, Inc. Common 803607100 17,622 147,847 SH   SOLE   147,847 0 0
Seattle Genetics, Inc. Common 812578102 21,234 289,925 SH   SOLE   289,925 0 0
Senior Housing Properties Trust Common 81721M109 4,214 357,720 SH   SOLE   357,720 0 0
Smith & Nephew plc Shares 83175M205 7,440 185,478 SH   SOLE   185,478 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 8,060 89,022 SH   SOLE   89,022 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108 1,226 114,670 SH   SOLE   114,670 0 0
STERIS plc Shares G8473T100 6,146 48,003 SH   SOLE   48,003 0 0
Stryker Corporation Common 863667101 24,305 123,050 SH   SOLE   123,050 0 0
Sutro Biopharma, Inc. Common 869367102 7,304 641,268 SH   SOLE   641,268 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105 753 143,438 SH   SOLE   143,438 0 0
Syneos Health, Inc. Class A 87166B102 1,502 29,027 SH   SOLE   29,027 0 0
Takeda Pharmaceutical Company Limited Sponsored ADS 874060205 3,628 178,128 SH   SOLE   178,128 0 0
Teleflex Incorporated Common 879369106 1,927 6,379 SH   SOLE   6,379 0 0
Tenet Healthcare Corporation Common 88033G407 4,070 141,136 SH   SOLE   141,136 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N105 1,151 859,322 SH   SOLE   859,322 0 0
Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 13,971 890,989 SH   SOLE   890,989 0 0
Thermo Fisher Scientific Inc. Common 883556102 39,072 142,743 SH   SOLE   142,743 0 0
Trillium Therapeutics Inc. Common 89620X506 294 446,099 SH   SOLE   446,099 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 5,338 76,958 SH   SOLE   76,958 0 0
uniQure N.V. Shares N90064101 1,178 19,751 SH   SOLE   19,751 0 0
United Therapeutics Corporation Class B 91307C102 4,843 41,261 SH   SOLE   41,261 0 0
Unitedhealth Group Incorporated Common 91324P102 80,145 324,133 SH   SOLE   324,133 0 0
Varian Medical Systems, Inc. Common 92220P105 3,717 26,227 SH   SOLE   26,227 0 0
Ventas, Inc. Common 92276F100 6,285 98,496 SH   SOLE   98,496 0 0
Verona Pharma plc Sponsored ADR 925050106 1,719 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 81,621 443,712 SH   SOLE   443,712 0 0
Viking Therapeutics, Inc. Common 92686J106 1,133 114,016 SH   SOLE   114,016 0 0
WaVe Life Sciences Ltd. Shares Y95308105 1,179 30,336 SH   SOLE   30,336 0 0
WellCare Health Plans, Inc. Common 94946T106 5,202 19,286 SH   SOLE   19,286 0 0
Welltower Inc. Common 95040Q104 18,416 237,322 SH   SOLE   237,322 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 3,610 114,776 SH   SOLE   114,776 0 0
Xencor, Inc. Common 98401F105 2,248 72,382 SH   SOLE   72,382 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 10,172 79,654 SH   SOLE   79,654 0 0
Zoetis Inc. Class A 98978V103 25,872 257,001 SH   SOLE   257,001 0 0
Zogenix, Inc. Common 98978L204 4,938 89,762 SH   SOLE   89,762 0 0