The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADMA BIOLOGICS INC COM 000899104 5,606 1,479,243 SH   DFND 1 1,479,243 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 12,165 2,030,925 SH   DFND 1 2,030,925 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 17,561 2,469,894 SH   DFND 1 2,469,894 0 0
ALPHATEC HOLDINGS INC COM NEW 02081G201 1,174 442,966 SH   DFND 1 442,966 0 0
ANTARES PHARMA INC COM 036642106 8,011 2,643,947 SH   DFND 1 2,643,947 0 0
ARATANA THERAPEUTICS INC COM 03874P101 26,129 7,258,135 SH   DFND 1 7,258,135 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 4,468 3,102,673 SH   DFND 1 3,102,673 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 23,188 4,375,066 SH   DFND 1 4,375,066 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 29,871 5,856,998 SH   DFND 1 5,856,998 0 0
DEXCOM INC COM 252131107 8,039 67,500 SH   DFND 1 67,500 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,702 193,300 SH   DFND 1 193,300 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 20,924 395,309 SH   DFND 1 395,309 0 0
HERON THERAPEUTICS INC COM 427746102 5,083 207,998 SH   DFND 1 207,998 0 0
HERON THERAPEUTICS INC COM 427746102 9,776 400,000 SH Call DFND 1 400,000 0 0
INCYTE CORP COM 45337C102 8,601 100,000 SH   DFND 1 100,000 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 7,888 141,572 SH   DFND 1 141,572 0 0
INTERSECT ENT INC COM 46071F103 8,472 263,500 SH   DFND 1 263,500 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 41,162 4,328,303 SH   DFND 1 4,328,303 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 12,827 1,994,911 SH   DFND 1 1,994,911 0 0
MATINAS BIOPHARMA HLDGS INC COM 576810105 2,973 2,727,272 SH   DFND 1 2,727,272 0 0
MIRATI THERAPEUTICS INC COM 60468T105 10,856 148,100 SH   DFND 1 148,100 0 0
MYRIAD GENETICS INC COM 62855J104 7,968 240,000 SH   DFND 1 240,000 0 0
MYRIAD GENETICS INC COM 62855J104 16,600 500,000 SH Call DFND 1 500,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 8,512 355,714 SH   DFND 1 355,714 0 0
NEOS THERAPEUTICS INC COM 64052L106 4,207 1,611,999 SH   DFND 1 1,611,999 0 0
NEVRO CORP COM 64157F103 38,920 622,615 SH   DFND 1 622,615 0 0
NOVELION THERAPEUTICS INC COM NEW 67001K202 897 729,301 SH   DFND 1 729,301 0 0
OPIANT PHARMACEUTICALS INC COM 683750103 1,122 85,484 SH   DFND 1 85,484 0 0
OPTINOSE INC COM 68404V100 6,032 585,600 SH   DFND 1 585,600 0 0
RECRO PHARMA INC COM 75629F109 11,193 1,909,995 SH   DFND 1 1,909,995 0 0
RETROPHIN INC COM 761299106 22,995 1,016,114 SH   DFND 1 1,016,114 0 0
SIERRA ONCOLOGY INC COM 82640U107 8,259 4,829,832 SH   DFND 1 4,829,832 0 0
STRATA SKIN SCIENCES INC COM NEW 86272A206 8,169 2,866,323 SH   DFND 1 2,866,323 0 0
TELIGENT INC NEW COM 87960W104 2,310 1,990,983 SH   DFND 1 1,990,983 0 0
VERICEL CORP COM 92346J108 4,772 272,550 SH   DFND 1 272,550 0 0
VIEWRAY INC COM 92672L107 6,403 866,500 SH   DFND 1 866,500 0 0
ZOGENIX INC COM NEW 98978L204 20,447 371,698 SH   DFND 1 371,698 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 12,708 246,900 SH   DFND 1 246,900 0 0
LIVANOVA PLC SHS G5509L101 4,668 48,000 SH   DFND 1 48,000 0 0
OSMOTICA PHARMACEUTICALS PLC SHS G6S41R101 1,108 307,854 SH   DFND 1 307,854 0 0
QUOTIENT LTD SHS G73268107 9,899 1,098,656 SH   DFND 1 1,098,656 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 13,904 2,792,049 SH   DFND 1 2,792,049 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 5,739 847,700 SH   DFND 1 847,700 0 0