The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Achillion Pharmaceuticals Inc COM 00448Q201 40,698 13,749,383 SH   SOLE 1, 2 13,749,383 0 0
Adverum Biotechnologies Inc COM 00773U108 32,786 6,256,840 SH   SOLE 1, 2 6,256,840 0 0
Agenus Inc COM NEW 00847G705 29,353 9,883,213 SH   SOLE 1, 2 9,883,213 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 78,112 835,873 SH   SOLE 1, 2 835,873 0 0
Anchiano Therapeutics Ltd SPONSORED ADS 03280X102 411 60,414 SH   SOLE 1, 2 60,414 0 0
Apyx Med Corp COM 03837C106 19,718 3,124,899 SH   SOLE 1, 2 3,124,899 0 0
Arbutus Biopharma Corp COM 03879J100 19,727 5,510,223 SH   SOLE 1, 2 5,510,223 0 0
argenx SE SPONSORED ADR 04016X101 3,834 30,714 SH   SOLE 1, 2 30,714 0 0
Arrowhead Pharmaceuticals In COM 04280A100 28,043 1,528,213 SH   SOLE 1, 2 1,528,213 0 0
Arvinas Inc COM 04335A105 13,528 916,514 SH   SOLE 1, 2 916,514 0 0
Axonics Modulation Tech Inc COM 05465P101 36,501 1,524,030 SH   SOLE 1, 2 1,524,030 0 0
Axsome Therapeutics Inc COM 05464T104 8,476 595,635 SH   SOLE 1, 2 595,635 0 0
Bristol Myers Squibb Co COM 110122108 72,780 1,525,464 SH   SOLE 1, 2 1,525,464 0 0
CareDx Inc COM 14167L103 6,987 221,663 SH   SOLE 1, 2 221,663 0 0
Chardan Healthcare Acquisiti UNIT 12/13/2023 15957A207 6,018 600,000 SH   SOLE 1, 2 600,000 0 0
Concert Pharmaceuticals Inc COM 206022105 20,380 1,688,448 SH   SOLE 1, 2 1,688,448 0 0
Cytomx Therapeutics Inc COM 23284F105 10,376 965,252 SH   SOLE 1, 2 965,252 0 0
Dicerna Pharmaceuticals Inc COM 253031108 91,167 6,223,036 SH   SOLE 1, 2 6,223,036 0 0
Electrocore inc COM 28531P103 3,626 518,010 SH   SOLE 1, 2 518,010 0 0
Establishment Labs Hldgs Inc COM G31249108 31,866 1,325,539 SH   SOLE 1, 2 1,325,539 0 0
Fluidigm Corp del COM 34385P108 25,662 1,930,934 SH   SOLE 1, 2 1,930,934 0 0
Homology Medicines Inc COM 438083107 48,159 1,736,719 SH   SOLE 1, 2 1,736,719 0 0
Johnson & Johnson COM 478160104 11,828 84,614 SH   SOLE 1, 2 84,614 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 1,936 301,166 SH   SOLE 1, 2 301,166 0 0
LivaNova PLC SHS G5509L101 42,317 435,136 SH   SOLE 1, 2 435,136 0 0
Masimo Corp COM 574795100 50,274 363,569 SH   SOLE 1, 2 363,569 0 0
Mirati Therapeutics Inc COM 60468T105 22,876 312,093 SH   SOLE 1, 2 312,093 0 0
Motus Gi hldgs Inc COM 62014P108 1,792 459,478 SH   SOLE 1, 2 459,478 0 0
Myokardia Inc COM 62857M105 36,735 706,570 SH   SOLE 1, 2 706,570 0 0
Myriad Genetics Inc COM 62855J104 8,881 267,491 SH   SOLE 1, 2 267,491 0 0
Neuronetics Inc COM 64131A105 2,540 166,561 SH   SOLE 1, 2 166,561 0 0
Odonate Therapeutics Inc COM 676079106 7,324 331,240 SH   SOLE 1, 2 331,240 0 0
Oncocyte Corporation COM 68235C107 5,091 1,288,873 SH   SOLE 1, 2 1,288,873 0 0
Optinose Inc COM 68404V100 851 82,645 SH   SOLE 1, 2 82,645 0 0
Orthopediatrics Corp COM 68752L100 18,937 428,142 SH   SOLE 1, 2 428,142 0 0
Principia Biopharma Inc COM 74257L108 15,502 455,948 SH   SOLE 1, 2 455,948 0 0
ProQR Thrapeutics N V SHS EURO N71542109 51,637 3,722,950 SH   SOLE 1, 2 3,722,950 0 0
PTC Therapeutics Inc COM 69366J200 94,637 2,514,271 SH   SOLE 1, 2 2,514,271 0 0
Regenxbio Inc COM 75901B107 25,857 451,182 SH   SOLE 1, 2 451,182 0 0
Rocket Pharmaceuticals Inc COM 77313F106 280,250 16,037,486 SH   SOLE 1, 2 16,037,486 0 0
Sarepta Therapeutics Inc COM 803607100 40,310 338,199 SH   SOLE 1, 2 338,199 0 0
Si bone Inc COM 825704109 23,912 1,269,194 SH   SOLE 1, 2 1,269,194 0 0
Solid Biosciences Inc COM 83422E105 1,305 141,836 SH   SOLE 1, 2 141,836 0 0
Translate Bio Inc COM 89374L104 13,787 1,352,970 SH   SOLE 1, 2 1,352,970 0 0
Uniqure NV SHS N90064101 9,190 154,058 SH   SOLE 1, 2 154,058 0 0
Vericel Corp COM 92346J108 43,564 2,487,922 SH   SOLE 1, 2 2,487,922 0 0
Viewray Inc COM 92672L107 1,177 159,247 SH   SOLE 1, 2 159,247 0 0
Viveve Med Inc COM NEW 92852W204 4,211 4,480,565 SH   SOLE 1, 2 4,480,565 0 0
Vivus Inc 4.5 05/01/2020 NOTE 4.500% 5/0 928551AA8 3,120 4,000,000 SH   SOLE 1 4,000,000 0 0
WAVE Life Sciences Ltd SHS Y95308105 16,969 436,777 SH   SOLE 1, 2 436,777 0 0