The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 83,185 1,040,587 SH   DFND 1 0 0 1,040,587
ABBVIE INC COM 00287Y109 9 200 SH Put DFND 1 0 0 200
ABIOMED INC COM 003654100 16,961 59,389 SH   DFND 1 0 0 59,389
ACADIA PHARMACEUTICALS INC COM 004225108 2,787 103,800 SH   DFND 1 0 0 103,800
AFFIMED N V COM N01045108 704 167,500 SH   DFND 1 0 0 167,500
AKCEA THERAPEUTICS INC COM 00972L107 14,290 504,411 SH   DFND 1 0 0 504,411
ALDER BIOPHARMACEUTICALS INC COM 014339105 17,564 1,286,748 SH   DFND 1 0 0 1,286,748
ALEXION PHARMACEUTICALS INC COM 015351109 23,136 171,150 SH   DFND 1 0 0 171,150
ALIGN TECHNOLOGY INC COM 016255101 95,159 334,679 SH   DFND 1 0 0 334,679
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 24,980 267,305 SH   DFND 1 0 0 267,305
AMEDISYS INC COM 023436108 4,148 33,656 SH   DFND 1 0 0 33,656
AMERISOURCEBERGEN CORP COM 03073E105 19,912 250,398 SH   DFND 1 0 0 250,398
AMGEN INC COM 031162100 2,755 14,500 SH   DFND 1 0 0 14,500
AMICUS THERAPEUTICS INC COM 03152W109 2,040 150,000 SH   DFND 1 0 0 150,000
AMNEAL PHARMACEUTICALS INC COM STK CL A 03168L105 1,417 100,000 SH   DFND 1 0 0 100,000
ANGIODYNAMICS INC COM 03475V101 1,731 75,700 SH   DFND 1 0 0 75,700
ANTHEM INC COM 036752103 73,185 255,017 SH   DFND 1 0 0 255,017
ARENA PHARMACEUTICALS INC COM NEW 040047607 2,103 46,917 SH   DFND 1 0 0 46,917
ARGENX SE SPONSORED ADR 04016X101 2,484 19,900 SH   DFND 1 0 0 19,900
ARRAY BIOPHARMA INC COM 04269X105 1,175 48,200 SH   DFND 1 0 0 48,200
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 2,142 18,200 SH   DFND 1 0 0 18,200
AVEDRO INC COM 05355N109 9,203 750,000 SH   DFND 1 0 0 750,000
BAXTER INTL INC COM 071813109 23,838 293,174 SH   DFND 1 0 0 293,174
BECTON DICKINSON & CO COM 075887109 32,208 128,972 SH   DFND 1 0 0 128,972
BEIGENE LTD SPONSORED ADR 07725L102 13,490 102,200 SH   DFND 1 0 0 102,200
BENEFITFOCUS INC COM 08180D106 1,138 22,979 SH   DFND 1 0 0 22,979
BIOGEN INC COM 09062X103 1,997 8,450 SH   DFND 1 0 0 8,450
BLUEBIRD BIO INC COM 09609G100 3,634 23,100 SH   DFND 1 0 0 23,100
BOSTON SCIENTIFIC CORP COM 101137107 44,041 1,147,487 SH   DFND 1 0 0 1,147,487
BRISTOL MYERS SQUIBB CO COM 110122108 33,198 695,824 SH   DFND 1 0 0 695,824
CAREDX INC COM 14167L103 13,603 431,568 SH   DFND 1 0 0 431,568
CASTLIGHT HEALTH INC CL B 14862Q100 6,827 1,820,470 SH   DFND 1 0 0 1,820,470
CELGENE CORP COM 151020104 1,678 17,788 SH   DFND 1 0 0 17,788
CENTENE CORP DEL COM 15135B101 9,292 174,988 SH   DFND 1 0 0 174,988
CIGNA CORP NEW COM 125523100 26,641 165,657 SH   DFND 1 0 0 165,657
COHERUS BIOSCIENCES INC COM 19249H103 4,326 317,135 SH   DFND 1 0 0 317,135
COOPER COS INC COM NEW 216648402 8,772 29,619 SH   DFND 1 0 0 29,619
CVS HEALTH CORP COM 126650100 3,108 57,627 SH   DFND 1 0 0 57,627
DANAHER CORPORATION COM 235851102 45,122 341,784 SH   DFND 1 0 0 341,784
DENTSPLY SIRONA INC COM 24906P109 5,498 110,878 SH   DFND 1 0 0 110,878
DEXCOM INC COM 252131107 15,619 131,146 SH   DFND 1 0 0 131,146
DIREXION SHS ETF TR DAILY S&P BIOTEC 25460E539 1,380 75,000 SH   DFND 1 0 0 75,000
EDWARDS LIFESCIENCES CORP COM 28176E108 30,979 161,912 SH   DFND 1 0 0 161,912
ESPERION THERAPEUTICS INC NEW COM 29664W105 19,896 495,547 SH   DFND 1 0 0 495,547
EVOLENT HEALTH INC CL A 30050B101 17,716 1,408,237 SH   DFND 1 0 0 1,408,237
EXELIXIS INC COM 30161Q104 3,344 140,500 SH   DFND 1 0 0 140,500
FIBROGEN INC COM 31572Q808 2,652 48,800 SH   DFND 1 0 0 48,800
FITBIT INC CL A 33812L102 19,352 3,268,934 SH   DFND 1 0 0 3,268,934
GALAPAGOS NV SPON ADR 36315X101 23 190 SH Put DFND 1 0 0 190
GENMARK DIAGNOSTICS INC COM 372309104 16,683 2,353,067 SH   DFND 1 0 0 2,353,067
GILEAD SCIENCES INC COM 375558103 5,058 77,800 SH   DFND 1 0 0 77,800
GILEAD SCIENCES INC COM 375558103 112 350 SH Call DFND 1 0 0 0
GILEAD SCIENCES INC COM 375558103 62 250 SH Call DFND 1 0 0 0
GLOBUS MED INC CL A 379577208 11,785 238,510 SH   DFND 1 0 0 238,510
GUARDANT HEALTH INC COM 40131M109 8,410 109,652 SH   DFND 1 0 0 109,652
GW PHARMACEUTICALS PLC ADS 36197T103 2,082 12,353 SH   DFND 1 0 0 12,353
HCA HEALTHCARE INC COM 40412C101 7,875 60,397 SH   DFND 1 0 0 60,397
HENRY SCHEIN INC COM 806407102 3,045 50,662 SH   DFND 1 0 0 50,662
HILL ROM HLDGS INC COM 431475102 21,499 203,088 SH   DFND 1 0 0 203,088
HMS HLDGS CORP COM 40425J101 8,616 290,977 SH   DFND 1 0 0 290,977
HOLOGIC INC COM 436440101 4,356 90,000 SH   DFND 1 0 0 90,000
HORIZON PHARMA PLC SHS G4617B105 4,197 158,800 SH   DFND 1 0 0 158,800
HUMANA INC COM 444859102 40,559 152,477 SH   DFND 1 0 0 152,477
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 18,296 598,310 SH   DFND 1 0 0 598,310
IDEXX LABS INC COM 45168D104 6,127 27,402 SH   DFND 1 0 0 27,402
ILLUMINA INC COM 452327109 80,064 257,696 SH   DFND 1 0 0 257,696
INCYTE CORP COM 45337C102 4,171 48,500 SH   DFND 1 0 0 48,500
INOGEN INC COM 45780L104 6,650 69,727 SH   DFND 1 0 0 69,727
INSMED INC COM PAR $.01 457669307 19,170 659,434 SH   DFND 1 0 0 659,434
INSPIRE MED SYS INC COM 457730109 6,990 123,105 SH   DFND 1 0 0 123,105
INSULET CORP COM 45784P101 1,712 18,000 SH   DFND 1 0 0 18,000
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 12,389 222,350 SH   DFND 1 0 0 222,350
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,927 17,227 SH   DFND 1 0 0 17,227
INTERSECT ENT INC COM 46071F103 10,558 328,387 SH   DFND 1 0 0 328,387
INTUITIVE SURGICAL INC COM NEW 46120E602 86,157 150,999 SH   DFND 1 0 0 150,999
IONIS PHARMACEUTICALS INC COM 462222100 24,566 302,643 SH   DFND 1 0 0 302,643
IRHYTHM TECHNOLOGIES INC COM 450056106 8,827 117,761 SH   DFND 1 0 0 117,761
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 38,230 267,438 SH   DFND 1 0 0 267,438
JOHNSON & JOHNSON COM 478160104 2,796 20,000 SH   DFND 1 0 0 20,000
KURA ONCOLOGY INC COM 50127T109 486 29,300 SH   DFND 1 0 0 29,300
LABORATORY CORP AMER HLDGS COM NEW 50540R409 894 5,845 SH   DFND 1 0 0 5,845
LIVANOVA PLC SHS G5509L101 16,236 166,956 SH   DFND 1 0 0 166,956
MACROGENICS INC COM 556099109 14,210 790,305 SH   DFND 1 0 0 790,305
MASIMO CORP COM 574795100 3,150 22,780 SH   DFND 1 0 0 22,780
MATERIALISE NV SPONSORED ADS 57667T100 4,225 268,409 SH   DFND 1 0 0 268,409
MCKESSON CORP COM 58155Q103 724 6,186 SH   DFND 1 0 0 6,186
MEDICINES CO COM 584688105 811 29,000 SH   DFND 1 0 0 29,000
MEDIDATA SOLUTIONS INC COM 58471A105 5,162 70,474 SH   DFND 1 0 0 70,474
MEDTRONIC PLC SHS G5960L103 44,712 490,906 SH   DFND 1 0 0 490,906
MERCK & CO INC COM 58933Y105 1,248 15,000 SH   DFND 1 0 0 15,000
MIRATI THERAPEUTICS INC COM 60468T105 1,063 14,500 SH   DFND 1 0 0 14,500
MOLINA HEALTHCARE INC COM 60855R100 10,198 71,840 SH   DFND 1 0 0 71,840
MYLAN N V SHS EURO N59465109 3,457 122,000 SH   DFND 1 0 0 122,000
NEKTAR THERAPEUTICS COM 640268108 14,449 430,026 SH   DFND 1 0 0 430,026
NEUROCRINE BIOSCIENCES INC COM 64125C109 1,780 20,200 SH   DFND 1 0 0 20,200
NEURONETICS INC COM 64131A105 4,504 295,337 SH   DFND 1 0 0 295,337
NEVRO CORP COM 64157F103 8,026 128,402 SH   DFND 1 0 0 128,402
OMNICELL INC COM 68213N109 11,628 143,839 SH   DFND 1 0 0 143,839
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 9,066 526,162 SH   DFND 1 0 0 526,162
PENUMBRA INC COM 70975L107 3,475 23,637 SH   DFND 1 0 0 23,637
PFIZER INC COM 717081103 1,699 40,000 SH   DFND 1 0 0 40,000
PORTOLA PHARMACEUTICALS INC COM 737010108 2,162 62,300 SH   DFND 1 0 0 62,300
PRA HEALTH SCIENCES INC COM 69354M108 16,489 149,507 SH   DFND 1 0 0 149,507
PREMIER INC CL A 74051N102 1,085 31,462 SH   DFND 1 0 0 31,462
PTC THERAPEUTICS INC COM 69366J200 1,306 34,700 SH   DFND 1 0 0 34,700
PUMA BIOTECHNOLOGY INC COM 74587V107 663 17,100 SH   DFND 1 0 0 17,100
QIAGEN NV SHS NEW N72482123 25,107 617,194 SH   DFND 1 0 0 617,194
QUANTERIX CORP COM 74766Q101 9,024 349,359 SH   DFND 1 0 0 349,359
QUIDEL CORP COM 74838J101 14,638 223,580 SH   DFND 1 0 0 223,580
QUOTIENT LTD SHS G73268107 7,164 795,065 SH   DFND 1 0 0 795,065
RADIUS HEALTH INC COM NEW 750469207 1,178 59,100 SH   DFND 1 0 0 59,100
REGENERON PHARMACEUTICALS COM 75886F107 8,377 20,400 SH   DFND 1 0 0 20,400
REGENXBIO INC COM 75901B107 1,897 33,100 SH   DFND 1 0 0 33,100
RESMED INC COM 761152107 5,684 54,667 SH   DFND 1 0 0 54,667
SAGE THERAPEUTICS INC COM 78667J108 2,593 16,300 SH   DFND 1 0 0 16,300
SAREPTA THERAPEUTICS INC COM 803607100 1,085 9,100 SH   DFND 1 0 0 9,100
SEATTLE GENETICS INC COM 812578102 3,354 45,800 SH   DFND 1 0 0 45,800
SHOCKWAVE MED INC COM 82489T104 3,347 100,000 SH   DFND 1 0 0 100,000
STRYKER CORP COM 863667101 29,411 148,900 SH   DFND 1 0 0 148,900
SUPERNUS PHARMACEUTICALS INC COM 868459108 10,197 291,000 SH   DFND 1 0 0 291,000
SYNEOS HEALTH INC CL A 87166B102 2,443 47,200 SH   DFND 1 0 0 47,200
TABULA RASA HEALTHCARE INC COM 873379101 6,514 115,462 SH   DFND 1 0 0 115,462
TANDEM DIABETES CARE INC COM NEW 875372203 8,099 127,541 SH   DFND 1 0 0 127,541
TELADOC HEALTH INC COM 87918A105 76,411 1,374,294 SH   DFND 1 0 0 1,374,294
TELEFLEX INC COM 879369106 5,967 19,748 SH   DFND 1 0 0 19,748
THERMO FISHER SCIENTIFIC INC COM 883556102 10,636 38,858 SH   DFND 1 0 0 38,858
ULTRAGENYX PHARMACEUTICAL INC COM 90400D108 2,067 29,800 SH   DFND 1 0 0 29,800
UNITEDHEALTH GROUP INC COM 91324P102 32,845 132,837 SH   DFND 1 0 0 132,837
UNIQURE NV SHS N90064101 2,285 38,300 SH   DFND 1 0 0 38,300
VARIAN MED SYS INC COM 92220P105 398 2,807 SH   DFND 1 0 0 2,807
VEEVA SYS INC CL A COM 922475108 6,611 52,110 SH   DFND 1 0 0 52,110
VERTEX PHARMACEUTICALS INC COM 92532F100 21,520 116,989 SH   DFND 1 0 0 116,989
VOCERA COMMUNICATONS INC COM 92857F107 5,004 158,214 SH   DFND 1 0 0 158,214
WALGREENS BOOTS ALLIANCE INC COM 931427108 14,666 231,802 SH   DFND 1 0 0 231,802
WELLCARE HEALTH PLANS INC COM 94946T106 28,976 107,419 SH   DFND 1 0 0 107,419
WRIGHT MED GROUP NV ORD SHS N96617118 18,040 573,595 SH   DFND 1 0 0 573,595
ZAI LAB LTD ADR 98887Q104 885 30,000 SH   DFND 1 0 0 30,000
ZIMMER BIOMET HLDGS INC COM 98956P102 14,679 114,951 SH   DFND 1 0 0 114,951