The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AAC HLDGS INC COM 000307108 3,562 1,936,027 SH   DFND   1,936,027 0 0
ACCELERON PHARMA INC COM 00434H108 58,453 1,255,174 SH   DFND   1,255,174 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 35,302 5,893,416 SH   DFND   5,893,416 0 0
ADDUS HOMECARE CORP COM 006739106 16,083 252,915 SH   DFND   252,915 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 4,025 500,046 SH   DFND   500,046 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 76,417 1,608,785 SH   DFND   1,608,785 0 0
ALECTOR INC COM 014442107 36,634 1,956,923 SH   DFND   1,956,923 0 0
ALIMERA SCIENCES INC COM 016259103 6,416 6,052,935 SH   DFND   6,052,935 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 9,448 326,797 SH   DFND   326,797 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 3,262 475,450 SH   DFND   475,450 0 0
ANAPTYSBIO INC COM 032724106 54,308 743,439 SH   DFND   743,439 0 0
ANTHEM INC COM 036752103 15,210 53,000 SH   DFND   53,000 0 0
ARDELYX INC COM 039697107 9,196 3,284,298 SH   DFND   3,284,298 0 0
ARGENX SE SPONSORED ADR 04016X101 49,156 393,750 SH   DFND   393,750 0 0
ARVINAS INC COM 04335A105 13,597 921,234 SH   DFND   921,234 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 16,972 144,194 SH   DFND   144,194 0 0
ATHENEX INC COM 04685N103 7,618 621,859 SH   DFND   621,859 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 19,272 493,901 SH   DFND   493,901 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 3,920 2,722,241 SH   DFND   2,722,241 0 0
AXOGEN INC COM 05463X106 37,213 1,767,006 SH   DFND   1,767,006 0 0
AXOVANT SCIENCES LTD COM G0750W104 5,281 3,970,326 SH   DFND   3,970,326 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 53,216 6,537,566 SH   DFND   6,537,566 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 40,575 506,865 SH   DFND   506,865 0 0
BROOKDALE SR LIVING INC COM 112463104 33,962 5,161,355 SH   DFND   5,161,355 0 0
CENTENE CORP DEL COM 15135B101 35,418 667,000 SH   DFND   667,000 0 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 4,647 5,000,000 PRN   DFND   5,000,000 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 3,434 253,400 SH   DFND   253,400 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 13,116 1,701,222 SH   DFND   1,701,222 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 14,103 607,633 SH   DFND   607,633 0 0
DEXCOM INC NOTE 0.750% 5/1 252131AF4 26,865 20,000,000 PRN   DFND   20,000,000 0 0
DFB HEALTHCARE ACQUISTION CO UNIT 01/30/2023 23291E208 25,375 2,500,000 SH   DFND   2,500,000 0 0
DIPLOMAT PHARMACY INC COM 25456K101 40,956 7,049,297 SH   DFND   7,049,297 0 0
EDITAS MEDICINE INC COM 28106W103 28,334 1,158,841 SH   DFND   1,158,841 0 0
EHEALTH INC COM 28238P109 27,405 439,609 SH   DFND   439,609 0 0
EXACT SCIENCES CORP DBCV 1.000% 1/1 30063PAA3 20,483 15,000,000 PRN   DFND   15,000,000 0 0
EYENOVIA INC COM 30234E104 1,797 300,000 SH   DFND   300,000 0 0
EYEPOINT PHARMACEUTICALS INC COM 30233G100 406 226,802 SH   DFND   226,802 0 0
FATE THERAPEUTICS INC COM 31189P102 29,920 1,702,897 SH   DFND   1,702,897 0 0
GALAPAGOS NV SPON ADR 36315X101 20,842 176,958 SH   DFND   176,958 0 0
GLAUKOS CORP COM 377322102 17,850 227,762 SH   DFND   227,762 0 0
HARPOON THERAPEUTICS INC COM 41358P106 2,699 285,000 SH   DFND   285,000 0 0
HOMOLOGY MEDICINES INC COM 438083107 144,946 5,227,035 SH   DFND   5,227,035 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 131,460 116,032,000 PRN   DFND   116,032,000 0 0
HORIZON PHARMA PLC SHS G4617B105 170,807 6,462,634 SH   DFND   6,462,634 0 0
IGI LABORATORIES INC NOTE 3.750%12/1 449575AB5 1,688 1,733,000 PRN   DFND   1,733,000 0 0
IMMUNOMEDICS INC COM 452907108 72,898 3,794,783 SH   DFND   3,794,783 0 0
INSPIRE MED SYS INC COM 457730109 7,892 139,000 SH   DFND   139,000 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 57,201 57,791,000 PRN   DFND   57,791,000 0 0
INTERSECT ENT INC COM 46071F103 64,492 2,005,964 SH   DFND   2,005,964 0 0
INVITAE CORP COM 46185L103 9,677 413,200 SH   DFND   413,200 0 0
ITAMAR MED LTD SPONSORED ADS 465437101 3,647 314,136 SH   DFND   314,136 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 18,603 650,000 SH   DFND   650,000 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 28,677 65,423,000 PRN   DFND   65,423,000 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 23,663 1,310,259 SH   DFND   1,310,259 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 4,032 234,000 SH   DFND   234,000 0 0
MELINTA THERAPEUTICS INC COM 58549G209 1,267 356,952 SH   DFND   356,952 0 0
MENLO THERAPEUTICS INC COM 586858102 1,558 198,451 SH   DFND   198,451 0 0
MIRATI THERAPEUTICS INC COM 60468T105 18,486 252,200 SH   DFND   252,200 0 0
MOLINA HEALTHCARE INC COM 60855R100 12,209 86,000 SH   DFND   86,000 0 0
MORPHOSYS AG SPONSORED ADS 617760202 13,632 600,000 SH   DFND   600,000 0 0
MYLAN N V SHS EURO N59465109 90,682 3,199,789 SH   DFND   3,199,789 0 0
MYOKARDIA INC COM 62857M105 51,834 997,000 SH   DFND   997,000 0 0
NATERA INC COM 632307104 27,277 1,322,834 SH   DFND   1,322,834 0 0
NEOS THERAPEUTICS INC COM 64052L106 4,696 1,799,141 SH   DFND   1,799,141 0 0
NEURONETICS INC COM 64131A105 2,425 159,000 SH   DFND   159,000 0 0
NEVRO CORP COM 64157F103 36,222 579,463 SH   DFND   579,463 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 100,936 100,000,000 PRN   DFND   100,000,000 0 0
NUVASIVE INC NOTE 2.250% 3/1 670704AG0 7,782 7,000,000 PRN   DFND   7,000,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 143,462 8,023,600 SH   DFND   8,023,600 0 0
ORTHOPEDIATRICS CORP COM 68752L100 1,415 32,000 SH   DFND   32,000 0 0
OSMOTICA PHARMACEUTICALS PLC SHS G6S41R101 3,046 846,048 SH   DFND   846,048 0 0
PFENEX INC COM 717071104 5,674 918,187 SH   DFND   918,187 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 90,829 2,617,543 SH   DFND   2,617,543 0 0
PROTEON THERAPEUTICS INC COM 74371L109 616 1,224,899 SH   DFND   1,224,899 0 0
PTC THERAPEUTICS INC COM 69366J200 8,921 237,000 SH   DFND   237,000 0 0
RA PHARMACEUTICALS INC COM 74933V108 33,645 1,502,000 SH   DFND   1,502,000 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 31,111 364,000 SH   DFND   364,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 7,976 291,005 SH   DFND   291,005 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 4,911 280,000 SH   DFND   280,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 46,007 386,000 SH   DFND   386,000 0 0
SAVARA INC COM 805111101 1,843 250,000 SH   DFND   250,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 28,793 2,043,527 SH   DFND   2,043,527 0 0
SHOCKWAVE MED INC COM 82489T104 10,448 312,146 SH   DFND   312,146 0 0
SIENTRA INC COM 82621J105 23,429 2,730,632 SH   DFND   2,730,632 0 0
SYNLOGIC INC COM 87166L100 8,407 1,107,643 SH   DFND   1,107,643 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 11,598 1,268,945 SH   DFND   1,268,945 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 2,254 35,500 SH   DFND   35,500 0 0
TELIGENT INC NEW NOTE 4.750% 5/0 87960WAA2 6,453 9,567,000 PRN   DFND   9,567,000 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 15,919 119,000 SH   DFND   119,000 0 0
VERICEL CORP COM 92346J108 29,574 1,689,000 SH   DFND   1,689,000 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 15,336 394,737 SH   DFND   394,737 0 0
WRIGHT MED GROUP N V NOTE 2.250%11/1 98236JAB4 21,065 13,625,000 PRN   DFND   13,625,000 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 23,646 2,355,136 SH   DFND   2,355,136 0 0