The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2U Inc COM 90214J101 18,354 487,626 SH   SOLE   487,626 0 0
Aerojet Rocketdyne Holdings In COM 007800105 349 7,793 SH   SOLE   0 0 7,793
Aerovironment Inc COM 008073108 25,880 455,880 SH   SOLE   0 0 455,880
Agnico Eagle Mines Ltd COM 008474108 7,357 143,574 SH   SOLE   143,574 0 0
Alamos Gold Inc COM 011532108 6,310 1,042,931 SH   SOLE   1,042,931 0 0
Albemarle Corp COM 012653101 4,389 62,332 SH   SOLE   62,332 0 0
Alcoa Corp COM 013872106 1,575 67,280 SH   SOLE   67,280 0 0
Alibaba Group Holding Ltd COM 01609W102 131,014 773,171 SH   SOLE   0 0 773,171
Alphabet Inc COM 02079K107 14,507 13,421 SH   SOLE   0 0 13,421
Amazon.com Inc COM 023135106 171,635 90,638 SH   SOLE   0 0 90,638
AngloGold Ashanti Ltd COM 035128206 6,811 382,438 SH   SOLE   382,438 0 0
ANSYS Inc COM 03662Q105 10,189 49,744 SH   SOLE   0 0 49,744
Apple Inc COM 037833100 209,976 1,060,915 SH   SOLE   0 0 1,060,915
Aptiv PLC COM G6095L109 27,390 338,861 SH   SOLE   0 0 338,861
AquaBounty Technologies Inc COM 03842K200 976 317,925 SH   SOLE   0 0 317,925
Archer-Daniels-Midland Co COM 039483102 5,691 139,481 SH   SOLE   139,481 0 0
Arcturus Therapeutics Holdings COM 03969T109 1,227 129,974 SH   SOLE   0 0 129,974
Autodesk Inc COM 052769106 481 2,954 SH   SOLE   0 0 2,954
B2Gold Corp COM 11777Q209 6,666 2,200,060 SH   SOLE   2,200,060 0 0
Baidu Inc COM 056752108 99,372 846,728 SH   SOLE   202,598 0 644,130
Baker Hughes a GE Co COM 05722G100 7,327 297,469 SH   SOLE   295,205 0 2,264
Banco Bradesco SA COM 059460303 869 88,447 SH   SOLE   0 0 88,447
Barrick Gold Corp COM 067901108 7,553 478,977 SH   SOLE   478,977 0 0
Bellicum Pharmaceuticals Inc COM 079481107 3,580 2,105,649 SH   SOLE   0 0 2,105,649
BHP Group PLC COM 05545E209 28,568 558,948 SH   SOLE   558,948 0 0
Bluebird Bio Inc COM 09609G100 17,018 133,786 SH   SOLE   0 0 133,786
Boeing Co/The COM 097023105 404 1,109 SH   SOLE   0 0 1,109
BP PLC COM 055622104 12,304 295,070 SH   SOLE   295,070 0 0
Bristol-Myers Squibb Co COM 110122108 36,472 804,239 SH   SOLE   0 0 804,239
Bunge Ltd COM G16962105 2,801 50,279 SH   SOLE   50,279 0 0
Cabot Oil & Gas Corp COM 127097103 4,616 201,041 SH   SOLE   198,456 0 2,585
Cactus Inc COM 127203107 1,565 47,257 SH   SOLE   47,257 0 0
Callon Petroleum Co COM 13123X102 3,560 540,255 SH   SOLE   540,255 0 0
Calyxt Inc COM 13173L107 6,587 527,782 SH   SOLE   0 0 527,782
Canadian Natural Resources Ltd COM 136385101 4,411 163,557 SH   SOLE   163,557 0 0
Caterpillar Inc COM 149123101 7,389 54,217 SH   SOLE   0 0 54,217
Cellectis SA COM 15117K103 19,100 1,224,334 SH   SOLE   0 0 1,224,334
Cellular Biomedicine Group Inc COM 15117P102 8,799 532,318 SH   SOLE   0 0 532,318
Cerus Corp COM 157085101 28,378 5,049,385 SH   SOLE   3,201,944 0 1,847,441
CF Industries Holdings Inc COM 125269100 4,747 101,622 SH   SOLE   101,622 0 0
Charles Schwab Corp/The COM 808513105 32,065 797,838 SH   SOLE   0 0 797,838
Chevron Corp COM 166764100 14,977 120,354 SH   SOLE   119,126 0 1,228
China Biologic Products Holdin COM G21515104 10,445 109,599 SH   SOLE   0 0 109,599
China Petroleum & Chemical Cor COM 16941R108 2,219 32,541 SH   SOLE   32,541 0 0
Codexis Inc COM 192005106 14,429 782,933 SH   SOLE   0 0 782,933
Compugen Ltd COM M25722105 6,263 1,631,037 SH   SOLE   310,976 0 1,320,061
Concho Resources Inc COM 20605P101 8,004 77,577 SH   SOLE   76,549 0 1,028
ConocoPhillips COM 20825C104 4,222 69,216 SH   SOLE   69,216 0 0
CRISPR Therapeutics AG COM H17182108 88,143 1,871,408 SH   SOLE   879,533 0 991,875
Deere & Co COM 244199105 20,347 122,789 SH   SOLE   0 0 122,789
Diamondback Energy Inc COM 25278X109 7,573 69,499 SH   SOLE   68,536 0 963
Domino's Pizza Inc COM 25754A201 7,206 25,894 SH   SOLE   0 0 25,894
Dow Inc COM 260557103 2,643 53,599 SH   SOLE   53,599 0 0
Dril-Quip Inc COM 262037104 2,053 42,764 SH   SOLE   42,764 0 0
DuPont de Nemours Inc COM 26614N102 3,991 53,170 SH   SOLE   53,170 0 0
Editas Medicine Inc COM 28106W103 76,983 3,111,700 SH   SOLE   1,617,870 0 1,493,830
Elbit Systems Ltd COM M3760D101 3,303 22,090 SH   SOLE   0 0 22,090
Ensco Rowan plc COM G3166L100 783 91,807 SH   SOLE   90,967 0 840
EOG Resources Inc COM 26875P101 5,594 60,051 SH   SOLE   59,107 0 944
EQT Corp COM 26884L109 2,681 169,593 SH   SOLE   166,971 0 2,622
Eventbrite Inc COM 29975E109 42,725 2,637,357 SH   SOLE   640,593 0 1,996,764
ExOne Co/The COM 302104104 6,607 708,874 SH   SOLE   708,874 0 0
Exxon Mobil Corp COM 30231G102 18,151 236,864 SH   SOLE   235,058 0 1,806
Facebook Inc COM 30303M102 66,271 343,374 SH   SOLE   53,059 0 290,315
Fate Therapeutics Inc COM 31189P102 10,329 508,841 SH   SOLE   0 0 508,841
FLIR Systems Inc COM 302445101 2,815 52,032 SH   SOLE   0 0 52,032
Freeport-McMoRan Inc COM 35671D857 8,440 726,981 SH   SOLE   726,981 0 0
Garmin Ltd COM H2906T109 122 1,525 SH   SOLE   0 0 1,525
General Motors Co COM 37045V100 10,506 272,669 SH   SOLE   0 0 272,669
Guardant Health Inc COM 40131M109 18,167 210,431 SH   SOLE   0 0 210,431
Guidewire Software Inc COM 40171V100 60,393 595,711 SH   SOLE   0 0 595,711
Halliburton Co COM 406216101 10,345 454,917 SH   SOLE   452,251 0 2,666
HDFC Bank Ltd COM 40415F101 37,747 290,273 SH   SOLE   0 0 290,273
HEICO Corp COM 422806109 471 3,520 SH   SOLE   0 0 3,520
Hess Corp COM 42809H107 2,689 42,297 SH   SOLE   42,297 0 0
Illumina Inc COM 452327109 153,262 416,303 SH   SOLE   180,116 0 236,187
Incyte Corp COM 45337C102 13,351 157,143 SH   SOLE   0 0 157,143
Inovio Pharmaceuticals Inc COM 45773H201 14,359 4,884,100 SH   SOLE   0 0 4,884,100
Intellia Therapeutics Inc COM 45826J105 84,487 5,161,098 SH   SOLE   2,995,043 0 2,166,055
Interactive Brokers Group Inc COM 45841N107 55,095 1,016,504 SH   SOLE   0 0 1,016,504
Intercontinental Exchange Inc COM 45866F104 49,630 577,494 SH   SOLE   0 0 577,494
International Paper Co COM 460146103 10,010 231,075 SH   SOLE   231,075 0 0
Intrexon Corp COM 46122T102 20,713 2,704,014 SH   SOLE   0 0 2,704,014
Intuit Inc COM 461202103 78,876 301,825 SH   SOLE   0 0 301,825
Invitae Corp COM 46185L103 125,321 5,332,788 SH   SOLE   3,354,922 0 1,977,866
Ionis Pharmaceuticals Inc COM 462222100 19,795 308,002 SH   SOLE   0 0 308,002
Iovance Biotherapeutics Inc COM 462260100 30,996 1,264,096 SH   SOLE   0 0 1,264,096
Iridium Communications Inc COM 46269C102 728 31,277 SH   SOLE   0 0 31,277
Jagged Peak Energy Inc COM 47009K107 2,355 284,808 SH   SOLE   284,808 0 0
JD.com Inc COM 47215P106 13,790 455,256 SH   SOLE   0 0 455,256
Kratos Defense & Security Solu COM 50077B207 7,640 333,762 SH   SOLE   0 0 333,762
LendingClub Corp COM 52603A109 84,270 25,692,140 SH   SOLE   7,205,354 0 18,486,786
LendingTree Inc COM 52603B107 140,705 334,988 SH   SOLE   26,827 0 308,161
Liberty Oilfield Services Inc COM 53115L104 2,188 135,204 SH   SOLE   135,204 0 0
Linde PLC COM G5494J103 3,260 16,236 SH   SOLE   16,236 0 0
Lockheed Martin Corp COM 539830109 543 1,495 SH   SOLE   0 0 1,495
Marathon Petroleum Corp COM 56585A102 4,713 84,339 SH   SOLE   83,543 0 796
Materialise NV COM 57667T100 22,528 1,154,097 SH   SOLE   1,141,352 0 12,745
MercadoLibre Inc COM 58733R102 60,604 99,064 SH   SOLE   0 0 99,064
Mosaic Co/The COM 61945C103 2,640 105,468 SH   SOLE   105,468 0 0
NanoString Technologies Inc COM 63009R109 75,519 2,488,261 SH   SOLE   1,584,062 0 904,199
Nasdaq Inc COM 631103108 47,206 490,863 SH   SOLE   0 0 490,863
Netflix Inc COM 64110L106 20,191 54,968 SH   SOLE   28,142 0 26,826
Newmont Goldcorp Corp COM 651639106 3,466 90,095 SH   SOLE   90,095 0 0
Nucor Corp COM 670346105 7,373 133,803 SH   SOLE   133,803 0 0
Nutanix Inc COM 67059N108 11,564 445,808 SH   SOLE   445,808 0 0
Nutrien Ltd COM 67077M108 20,783 388,750 SH   SOLE   388,750 0 0
NVIDIA Corp COM 67066G104 202,400 1,232,418 SH   SOLE   282,044 0 950,374
NXP Semiconductors NV COM N6596X109 11,623 119,077 SH   SOLE   0 0 119,077
Occidental Petroleum Corp COM 674599105 6,256 124,426 SH   SOLE   123,138 0 1,288
Oceaneering International Inc COM 675232102 2,464 120,851 SH   SOLE   120,851 0 0
Oil States International Inc COM 678026105 5,730 313,099 SH   SOLE   310,506 0 2,593
ONEOK Inc COM 682680103 2,570 37,345 SH   SOLE   35,794 0 1,551
Organovo Holdings Inc COM 68620A104 5,703 10,904,563 SH   SOLE   6,931,873 0 3,972,690
Packaging Corp of America COM 695156109 4,322 45,343 SH   SOLE   45,343 0 0
Patterson-UTI Energy Inc COM 703481101 3,552 308,625 SH   SOLE   305,588 0 3,037
PayPal Holdings Inc COM 70450Y103 125,105 1,093,002 SH   SOLE   0 0 1,093,002
PerkinElmer Inc COM 714046109 13,375 138,827 SH   SOLE   0 0 138,827
PetroChina Co Ltd COM 71646E100 1,990 36,138 SH   SOLE   36,138 0 0
Petroleo Brasileiro SA COM 71654V408 1,866 119,844 SH   SOLE   119,844 0 0
Phillips 66 COM 718546104 4,175 44,635 SH   SOLE   44,635 0 0
Pinduoduo Inc COM 722304102 68,816 3,335,739 SH   SOLE   0 0 3,335,739
Pioneer Natural Resources Co COM 723787107 4,650 30,224 SH   SOLE   29,707 0 517
Pluristem Therapeutics Inc COM 72940R102 1,168 1,882,401 SH   SOLE   0 0 1,882,401
Proto Labs Inc COM 743713109 19,082 164,471 SH   SOLE   160,234 0 4,237
Regeneron Pharmaceuticals Inc COM 75886F107 38,716 123,692 SH   SOLE   0 0 123,692
Rio Tinto PLC COM 767204100 24,068 386,070 SH   SOLE   386,070 0 0
Royal Dutch Shell PLC COM 780259206 17,022 261,596 SH   SOLE   261,596 0 0
RPC Inc COM 749660106 1,855 257,235 SH   SOLE   255,165 0 2,070
Rubius Therapeutics Inc COM 78116T103 19,728 1,254,158 SH   SOLE   0 0 1,254,158
salesforce.com Inc COM 79466L302 101,345 667,928 SH   SOLE   126,664 0 541,264
Sarepta Therapeutics Inc COM 803607100 13,294 87,492 SH   SOLE   0 0 87,492
Schlumberger Ltd COM 806857108 16,787 422,417 SH   SOLE   419,855 0 2,562
Seres Therapeutics Inc COM 81750R102 15,595 4,843,074 SH   SOLE   2,389,790 0 2,453,284
Shopify Inc COM 82509L107 52,361 174,448 SH   SOLE   0 0 174,448
Southern Copper Corp COM 84265V105 3,442 88,608 SH   SOLE   88,608 0 0
Spirit AeroSystems Holdings In COM 848574109 330 4,054 SH   SOLE   0 0 4,054
Splunk Inc COM 848637104 108,672 864,193 SH   SOLE   137,017 0 727,176
Spotify Technology SA COM L8681T102 32,497 222,244 SH   SOLE   175,673 0 46,571
Square Inc COM 852234103 365,163 5,034,654 SH   SOLE   858,426 0 4,176,228
Steel Dynamics Inc COM 858119100 5,455 180,642 SH   SOLE   180,642 0 0
Stratasys Ltd COM M85548101 86,615 2,949,096 SH   SOLE   2,923,270 0 25,826
Suncor Energy Inc COM 867224107 8,422 270,274 SH   SOLE   267,466 0 2,808
Synopsys Inc COM 871607107 6,136 47,680 SH   SOLE   0 0 47,680
Syros Pharmaceuticals Inc COM 87184Q107 27,667 2,987,763 SH   SOLE   1,383,550 0 1,604,213
Taiwan Semiconductor Manufactu COM 874039100 61,731 1,575,979 SH   SOLE   0 0 1,575,979
TechnipFMC PLC COM G87110105 7,072 272,633 SH   SOLE   270,245 0 2,388
Teck Resources Ltd COM 878742204 7,491 324,863 SH   SOLE   324,863 0 0
Teladoc Health Inc COM 87918A105 47,933 721,771 SH   SOLE   238,394 0 483,377
Teledyne Technologies Inc COM 879360105 320 1,170 SH   SOLE   0 0 1,170
Tencent Music Entertainment Gr COM 88034P109 19 1,257 SH   SOLE   0 0 1,257
Teradyne Inc COM 880770102 36,879 769,746 SH   SOLE   437,398 0 332,348
Tesla Inc COM 88160R101 146,745 656,695 SH   SOLE   429,868 0 226,827
Thermo Fisher Scientific Inc COM 883556102 19,278 65,643 SH   SOLE   0 0 65,643
TOTAL SA COM 89151E109 15,560 278,904 SH   SOLE   278,904 0 0
TransUnion COM 89400J107 36,305 493,876 SH   SOLE   0 0 493,876
Trimble Inc COM 896239100 25,916 574,497 SH   SOLE   0 0 574,497
Twilio Inc COM 90138F102 35,378 259,468 SH   SOLE   0 0 259,468
Twitter Inc COM 90184L102 110,597 3,168,974 SH   SOLE   1,026,956 0 2,142,018
Univar Inc COM 91336L107 2,457 111,488 SH   SOLE   111,488 0 0
Valero Energy Corp COM 91913Y100 2,441 28,508 SH   SOLE   28,508 0 0
Veracyte Inc COM 92337F107 61,247 2,148,248 SH   SOLE   1,029,746 0 1,118,502
Verisk Analytics Inc COM 92345Y106 61,535 420,149 SH   SOLE   0 0 420,149
Vertex Pharmaceuticals Inc COM 92532F100 19,358 105,560 SH   SOLE   0 0 105,560
Weyerhaeuser Co COM 962166104 7,123 270,436 SH   SOLE   270,436 0 0
Williams Cos Inc/The COM 969457100 3,282 117,061 SH   SOLE   117,061 0 0
Xilinx Inc COM 983919101 39,004 330,765 SH   SOLE   126,465 0 204,300
Zillow Group Inc COM 98954M200 166,133 3,581,222 SH   SOLE   516,165 0 3,065,057