The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 12,005 524,683 SH   DFND 2 524,683 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 13,479 456,142 SH   DFND 2 456,142 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 767 48,343 SH   DFND 2 48,343 0 0
ALGONQUIN PWR UTILS CORP COM 015857105 1,268 79,900 SH   DFND 1 79,900 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 12,520 73,885 SH   DFND 1 73,885 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 134,247 792,251 SH   DFND 2 245,844 0 546,407
ALIGN TECHNOLOGY INC COM 016255101 11,495 42,000 SH   DFND 2 42,000 0 0
ALLSTATE CORP COM 020002101 368 3,614 SH   DFND 2 3,614 0 0
ALLSTATE CORP COM 020002101 608 5,978 SH   DFND 1 5,978 0 0
ALPHABET INC CAP STK CL C 02079K107 508,602 470,531 SH   DFND 2 283,847 0 186,684
ALPHABET INC CAP STK CL C 02079K107 25,007 23,135 SH   DFND 1 23,135 0 0
ALPHABET INC CAP STK CL A 02079K305 941 869 SH   DFND 2 0 0 869
AMARIN CORP PLC SPONS ADR NEW 023111206 14,762 761,329 SH   DFND 2 761,329 0 0
AMAZON INC COM 023135106 521,960 275,640 SH   DFND 2 147,628 0 128,012
AMAZON INC COM 023135106 30,713 16,219 SH   DFND 1 16,219 0 0
AMDOCS LTD SHS G02602103 654 10,526 SH   DFND 2 10,526 0 0
AMDOCS LTD SHS G02602103 885 14,255 SH   DFND 1 14,255 0 0
AMERICAN TOWER CORP NEW COM 03027X100 392,748 1,920,998 SH   DFND 2 1,144,271 0 776,727
AMERICAN TOWER CORP NEW COM 03027X100 19,251 94,160 SH   DFND 1 94,160 0 0
ANTHEM INC COM 036752103 989 3,505 SH   DFND 1 3,505 0 0
ANTHEM INC COM 036752103 33,181 117,575 SH   DFND 2 117,575 0 0
AT&T INC COM 00206R102 805 24,029 SH   DFND 2 24,029 0 0
AT&T INC COM 00206R102 1,142 34,066 SH   DFND 1 34,066 0 0
ATLANTICA YIELD PLC SHS G0751N103 1,166 51,426 SH   DFND 1 51,426 0 0
ATLANTICA YIELD PLC SHS G0751N103 800 35,281 SH   DFND 2 35,281 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 117 1,361 SH   DFND 2 1,361 0 0
AUTOHOME INC SP ADR RP CL A 05278C107 91 1,062 SH   DFND 1 1,062 0 0
BAIDU INC SPON ADR REP A 056752108 26,245 223,629 SH   DFND 2 67,630 0 155,999
BAIDU INC SPON ADR REP A 056752108 2,387 20,342 SH   DFND 1 20,342 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 13,652 311,751 SH   DFND 2 311,751 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 14,034 163,851 SH   DFND 2 163,851 0 0
CARA THERAPEUTICS INC COM 140755109 15,124 703,460 SH   DFND 2 703,460 0 0
CENTENE CORP DEL COM 15135B101 16,640 317,306 SH   DFND 2 317,306 0 0
COCA COLA CO COM 191216100 376,036 7,384,833 SH   DFND 2 4,505,445 0 2,879,388
COCA COLA CO COM 191216100 19,692 386,719 SH   DFND 1 386,719 0 0
COHERUS BIOSCIENCES INC COM 19249H103 14,994 678,464 SH   DFND 2 678,464 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 677 5,197 SH   DFND 2 5,197 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 1,122 8,604 SH   DFND 1 8,604 0 0
CVS HEALTH CORP COM 126650100 28,118 516,015 SH   DFND 2 516,015 0 0
DEX INC COM 252131107 18,273 121,949 SH   DFND 2 121,949 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 3,976 996,412 SH   DFND 2 996,412 0 0
ECOLAB INC COM 278865100 590,924 2,992,930 SH   DFND 2 1,832,377 0 1,160,553
ECOLAB INC COM 278865100 29,818 151,023 SH   DFND 1 151,023 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 22,343 120,943 SH   DFND 2 120,943 0 0
EQUINIX INC COM 29444U700 394 782 SH   DFND 2 782 0 0
EQUINIX INC COM 29444U700 651 1,291 SH   DFND 1 1,291 0 0
EXACT SCIENCES CORP COM 30063P105 21,121 178,932 SH   DFND 2 178,932 0 0
EXXON MOBIL CORP COM 30231G102 282,214 3,682,811 SH   DFND 2 2,162,637 0 1,520,174
EXXON MOBIL CORP COM 30231G102 14,362 187,422 SH   DFND 1 187,422 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 275 2,240 SH   DFND 1 2,240 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 166 1,357 SH   DFND 2 1,357 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 283,954 2,907,879 SH   DFND 2 1,848,217 0 1,059,662
FIRST REP BK SAN FRANCISCO C COM 33616C100 13,532 138,581 SH   DFND 1 138,581 0 0
FISERV INC COM 337738108 422 4,628 SH   DFND 1 4,628 0 0
FISERV INC COM 337738108 475 5,207 SH   DFND 2 5,207 0 0
FRANCO NEVADA CORP COM 351858105 1,716 20,219 SH   DFND 2 20,219 0 0
FRANCO NEVADA CORP COM 351858105 1,249 14,712 SH   DFND 1 14,712 0 0
GEOPARK LTD USD SHS G38327105 113 6,082 SH   DFND 1 6,082 0 0
GEOPARK LTD USD SHS G38327105 152 8,225 SH   DFND 2 8,225 0 0
GLAUKOS CORP COM 377322102 15,779 209,265 SH   DFND 2 209,265 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 4,047 23,473 SH   DFND 2 23,473 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 12,495 96,083 SH   DFND 1 96,083 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 192,327 1,478,983 SH   DFND 2 629,260 0 849,723
HERON THERAPEUTICS INC COM 427746102 13,051 702,069 SH   DFND 2 702,069 0 0
HOME DEPOT INC COM 437076102 574,259 2,761,260 SH   DFND 2 1,643,179 0 1,118,081
HOME DEPOT INC COM 437076102 30,200 145,211 SH   DFND 1 145,211 0 0
HORIZON PHARMA PLC SHS DELETED G4617B105 11,827 491,544 SH   DFND 2 491,544 0 0
HUMANA INC COM 444859102 14,592 55,000 SH   DFND 2 55,000 0 0
ICICI BK LTD ADR 45104G104 61,042 4,848,434 SH   DFND 2 1,476,786 0 3,371,648
ICICI BK LTD ADR 45104G104 5,615 446,025 SH   DFND 1 446,025 0 0
ILLUMINA INC COM 452327109 20,066 54,505 SH   DFND 2 54,505 0 0
IMMUNOMEDICS INC COM 452907108 6,103 440,000 SH   DFND 2 440,000 0 0
INSMED INC COM PAR $.01 457669307 10,064 393,110 SH   DFND 2 393,110 0 0
INSULET CORP COM 45784P101 18,226 152,672 SH   DFND 2 152,672 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 21,998 41,937 SH   DFND 2 41,937 0 0
JOHNSON & JOHNSON COM 478160104 162 1,161 SH   DFND 2 1,161 0 0
JOHNSON & JOHNSON COM 478160104 266 1,912 SH   DFND 1 1,912 0 0
LHC GROUP INC COM 50187A107 13,232 110,657 SH   DFND 2 110,657 0 0
MERCADOLIBRE INC COM 58733R102 210 343 SH   DFND 1 343 0 0
MERCADOLIBRE INC COM 58733R102 272 444 SH   DFND 2 444 0 0
MERCK & CO INC COM 58933Y105 22,216 264,955 SH   DFND 2 264,955 0 0
MICROSOFT CORP COM 594918104 507,697 3,789,912 SH   DFND 2 2,401,473 0 1,388,439
MICROSOFT CORP COM 594918104 22,495 167,925 SH   DFND 1 167,925 0 0
MONDELEZ INTL INC CL A 609207105 34,516 640,378 SH   DFND 2 640,378 0 0
MONDELEZ INTL INC CL A 609207105 277 5,148 SH   DFND 1 5,148 0 0
MSCI INC COM 55354G100 172,039 720,460 SH   DFND 2 396,323 0 324,137
MSCI INC COM 55354G100 10,537 44,127 SH   DFND 1 44,127 0 0
NOVOCURE LTD ORD SHS G6674U108 13,156 208,059 SH   DFND 2 208,059 0 0
OPEN TEXT CORP COM 683715106 456 8,433 SH   DFND 2 8,433 0 0
OPEN TEXT CORP COM 683715106 752 13,919 SH   DFND 1 13,919 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 107 2,752 SH   DFND 2 2,752 0 0
PAGSEGURO DIGITAL LTD COM CL A G68707101 85 2,189 SH   DFND 1 2,189 0 0
PFIZER INC COM 717081103 352 8,125 SH   DFND 1 8,125 0 0
PFIZER INC COM 717081103 213 4,908 SH   DFND 2 4,908 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 9,071 334,366 SH   DFND 2 334,366 0 0
PROCTER AND GAMBLE CO COM 742718109 382,044 3,484,213 SH   DFND 2 2,081,008 0 1,403,205
PROCTER AND GAMBLE CO COM 742718109 17,809 162,421 SH   DFND 1 162,421 0 0
PROGRESSIVE CORP OHIO COM 743315103 690 8,630 SH   DFND 2 8,630 0 0
PROGRESSIVE CORP OHIO COM 743315103 1,140 14,268 SH   DFND 1 14,268 0 0
SAREPTA THERAPEUTICS INC COM 803607100 17,524 115,329 SH   DFND 2 115,329 0 0
STARBUCKS CORP COM 855244109 30,230 360,615 SH   DFND 2 360,615 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 13,146 858,082 SH   DFND 2 858,082 0 0
STORE CAP CORP COM 862121100 588 17,708 SH   DFND 2 17,708 0 0
STORE CAP CORP COM 862121100 796 23,979 SH   DFND 1 23,979 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 425 10,850 SH   DFND 1 10,850 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 4,938 126,061 SH   DFND 2 126,061 0 0
TELADOC HEALTH INC COM 87918A105 15,595 234,834 SH   DFND 2 234,834 0 0
TELEFLEX INC COM 879369106 14,902 45,000 SH   DFND 2 45,000 0 0
THERAPEUTICSMD INC COM 88338N107 8,294 3,189,834 SH   DFND 2 3,189,834 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 601,700 2,048,829 SH   DFND 2 1,351,135 0 697,694
THERMO FISHER SCIENTIFIC INC COM 883556102 28,945 98,558 SH   DFND 1 98,558 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 552 7,209 SH   DFND 1 7,209 0 0
TORONTO DOMINION BK ONT COM NEW 891160509 331 4,332 SH   DFND 2 4,332 0 0
UNITEDHEALTH GROUP INC COM 91324P102 918 3,763 SH   DFND 1 3,763 0 0
UNITEDHEALTH GROUP INC COM 91324P102 700 2,870 SH   DFND 2 2,870 0 0
US BANCORP DEL COM NEW 902973304 37,982 724,850 SH   DFND 2 724,850 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 12,572 68,557 SH   DFND 2 68,557 0 0
VISA INC COM CL A 92826C839 1,114,422 6,421,330 SH   DFND 2 3,846,301 0 2,575,029
VISA INC COM CL A 92826C839 57,065 328,812 SH   DFND 1 328,812 0 0
VOCERA MUNICATIONS INC COM 92857F107 8,141 255,058 SH   DFND 2 255,058 0 0
WELLS FARGO CO NEW COM 949746101 256,152 5,413,196 SH   DFND 2 3,338,678 0 2,074,518
WELLS FARGO CO NEW COM 949746101 12,490 263,945 SH   DFND 1 263,945 0 0
WEYERHAEUSER CO COM 962166104 28,350 1,076,306 SH   DFND 2 1,076,306 0 0
WORLDPAY INC CL A 981558109 353 2,880 SH   DFND 2 2,880 0 0
WORLDPAY INC CL A 981558109 584 4,765 SH   DFND 1 4,765 0 0