The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADMA BIOLOGICS INC | COM | 000899104 | 2,893 | 747,500 | SH | DFND | 1 | 747,500 | 0 | 0 | |
| ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 2,735 | 441,088 | SH | DFND | 1 | 441,088 | 0 | 0 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 5,642 | 291,000 | SH | DFND | 1 | 291,000 | 0 | 0 | |
| ANTARES PHARMA INC | COM | 036642106 | 5,738 | 1,744,147 | SH | DFND | 1 | 1,744,147 | 0 | 0 | |
| ARATANA THERAPEUTICS INC | COM | 03874P101 | 37,452 | 7,258,135 | SH | DFND | 1 | 7,258,135 | 0 | 0 | |
| AVADEL PHARMACEUTICALS PLC | SPONSORED ADR | 05337M104 | 8,967 | 3,102,673 | SH | DFND | 1 | 3,102,673 | 0 | 0 | |
| BIODELIVERY SCIENCES INTL IN | COM | 09060J106 | 19,911 | 4,281,943 | SH | DFND | 1 | 4,281,943 | 0 | 0 | |
| CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 10,618 | 2,765,070 | SH | DFND | 1 | 2,765,070 | 0 | 0 | |
| DEXCOM INC | COM | 252131107 | 9,485 | 63,300 | SH | DFND | 1 | 63,300 | 0 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 17,555 | 1,656,137 | SH | DFND | 1 | 1,656,137 | 0 | 0 | |
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 16,654 | 316,619 | SH | DFND | 1 | 316,619 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 12,232 | 657,998 | SH | DFND | 1 | 657,998 | 0 | 0 | |
| HERON THERAPEUTICS INC | COM | 427746102 | 1,859 | 100,000 | SH | Call | DFND | 1 | 100,000 | 0 | 0 |
| INCYTE CORP | COM | 45337C102 | 5,658 | 66,600 | SH | DFND | 1 | 66,600 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 38,234 | 1,559,299 | SH | DFND | 1 | 1,559,299 | 0 | 0 | |
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 8,249 | 891,760 | SH | DFND | 1 | 891,760 | 0 | 0 | |
| MATINAS BIOPHARMA HLDGS INC | COM | 576810105 | 657 | 766,708 | SH | DFND | 1 | 766,708 | 0 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 20,600 | 200,000 | SH | Call | DFND | 1 | 200,000 | 0 | 0 |
| MYRIAD GENETICS INC | COM | 62855J104 | 3,439 | 123,785 | SH | DFND | 1 | 123,785 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 2,270 | 74,786 | SH | DFND | 1 | 74,786 | 0 | 0 | |
| NEVRO CORP | COM | 64157F103 | 31,654 | 488,265 | SH | DFND | 1 | 488,265 | 0 | 0 | |
| OPTINOSE INC | COM | 68404V100 | 4,219 | 595,900 | SH | DFND | 1 | 595,900 | 0 | 0 | |
| RECRO PHARMA INC | COM | 75629F109 | 15,882 | 1,561,617 | SH | DFND | 1 | 1,561,617 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 21,161 | 1,053,314 | SH | DFND | 1 | 1,053,314 | 0 | 0 | |
| RETROPHIN INC | COM | 761299106 | 3,014 | 150,000 | SH | Call | DFND | 1 | 150,000 | 0 | 0 |
| RETROPHIN INC | COM | 761299106 | 10,045 | 500,000 | SH | Put | DFND | 1 | 500,000 | 0 | 0 |
| SI BONE INC | COM | 825704109 | 6,364 | 312,898 | SH | DFND | 1 | 312,898 | 0 | 0 | |
| SIENTRA INC | COM | 82621J105 | 8,624 | 1,400,000 | SH | DFND | 1 | 1,400,000 | 0 | 0 | |
| STRATA SKIN SCIENCES INC | COM NEW | 86272A206 | 8,109 | 3,256,615 | SH | DFND | 1 | 3,256,615 | 0 | 0 | |
| VERICEL CORP | COM | 92346J108 | 4,876 | 258,150 | SH | DFND | 1 | 258,150 | 0 | 0 | |
| VIEWRAY INC | COM | 92672L107 | 7,634 | 866,500 | SH | DFND | 1 | 866,500 | 0 | 0 | |
| ZOGENIX INC | COM NEW | 98978L204 | 16,473 | 344,762 | SH | DFND | 1 | 344,762 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 29,641 | 676,879 | SH | DFND | 1 | 676,879 | 0 | 0 | |
| BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 17,516 | 400,000 | SH | Call | DFND | 1 | 400,000 | 0 | 0 |
| QUOTIENT LTD | SHS | G73268107 | 5,982 | 639,756 | SH | DFND | 1 | 639,756 | 0 | 0 | |
| STRONGBRIDGE BIOPHARMA PLC | SHS USD | G85347105 | 7,965 | 2,544,839 | SH | DFND | 1 | 2,544,839 | 0 | 0 | |
| SOL GEL TECHNOLOGIES | SHS | M8694L103 | 6,649 | 730,100 | SH | DFND | 1 | 730,100 | 0 | 0 | |
| WRIGHT MED GROUP N V | ORD SHS | N96617118 | 3,769 | 126,400 | SH | DFND | 1 | 126,400 | 0 | 0 | |
| ALLERGAN PLC | SHS | G0177J108 | 19,222 | 114,804 | SH | DFND | 1 | 114,804 | 0 | 0 | |