The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLION PHARMACEUTICALS IN COM 00448Q201 37,157 13,864,383 SH   SOLE 1,2 13,864,383 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 75,149 6,320,350 SH   SOLE 1,2 6,320,350 0 0
AGENUS INC COM NEW 00847G705 30,253 10,084,214 SH   SOLE 1,2 10,084,214 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 159,494 2,198,094 SH   SOLE 1,2 2,198,094 0 0
ANCHIANO THERAPEUTICS LTD SPONSORED ADS 03280X102 233 51,918 SH   SOLE 1,2 51,918 0 0
APYX MED CORP COM 03837C106 22,847 3,399,899 SH   SOLE 1,2 3,399,899 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 11,509 5,533,093 SH   SOLE 1,2 5,533,093 0 0
ARGENX SE SPONSORED ADR 04016X101 4,452 31,448 SH   SOLE 1,2 31,448 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 29,689 1,120,346 SH   SOLE 1,2 1,120,346 0 0
ARVINAS INC COM 04335A105 17,765 807,870 SH   SOLE 1,2 807,870 0 0
AXONICS MODULATION TECH INC COM 05465P101 62,873 1,534,605 SH   SOLE 1,2 1,534,605 0 0
AXSOME THERAPEUTICS INC COM 05464T104 21,740 844,289 SH   SOLE 1,2 844,289 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 6,263 597,216 SH   SOLE 1,2 597,216 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 70,833 1,561,918 SH   SOLE 1,2 1,561,918 0 0
CAREDX INC COM 14167L103 5,565 154,616 SH   SOLE 1,2 154,616 0 0
CHARDAN HEALTHCARE ACQUISITI UNIT 12/13/2023 15957A207 6,113 600,000 SH   SOLE 1,2 600,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 11,089 988,319 SH   SOLE 1,2 988,319 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 96,896 6,152,103 SH   SOLE 1,2 6,152,103 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 41,411 1,883,180 SH   SOLE 1,2 1,883,180 0 0
FLUIDIGM CORP DEL COM 34385P108 25,594 2,077,471 SH   SOLE 1,2 2,077,471 0 0
HOMOLOGY MEDICINES INC COM 438083107 40,215 2,054,932 SH   SOLE 1,2 2,054,932 0 0
ILLUMINA INC COM 452327109 30,188 82,000 SH   SOLE 1,2 82,000 0 0
JOHNSON & JOHNSON COM 478160104 13,080 93,912 SH   SOLE 1,2 93,912 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 18,605 2,011,340 SH   SOLE 1,2 2,011,340 0 0
MASIMO CORP COM 574795100 55,399 372,258 SH   SOLE 1,2 372,258 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 90,967 3,521,856 SH   SOLE 1,2 3,521,856 0 0
MIRATI THERAPEUTICS INC COM 60468T105 26,293 255,270 SH   SOLE 1,2 255,270 0 0
MOTUS GI HLDGS INC COM 62014P108 3,412 1,126,144 SH   SOLE 1,2 1,126,144 0 0
MYOKARDIA INC COM 62857M105 36,274 723,455 SH   SOLE 1,2 723,455 0 0
MYRIAD GENETICS INC COM 62855J104 10,462 376,586 SH   SOLE 1,2 376,586 0 0
NEURONETICS INC COM 64131A105 2,105 168,274 SH   SOLE 1,2 168,274 0 0
ODONATE THERAPEUTICS INC COM 676079106 12,444 339,156 SH   SOLE 1,2 339,156 0 0
OPTINOSE INC COM 68404V100 620 87,615 SH   SOLE 1,2 87,615 0 0
ORTHOPEDIATRICS CORP COM 68752L100 14,689 376,647 SH   SOLE 1,2 376,647 0 0
PERSONALIS INC COM 71535D106 6,109 225,000 SH   SOLE 1,2 225,000 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 8,993 270,948 SH   SOLE 1,2 270,948 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 33,879 3,722,950 SH   SOLE 1,2 3,722,950 0 0
PTC THERAPEUTICS INC COM 69366J200 141,181 3,137,361 SH   SOLE 1,2 3,137,361 0 0
QUOTIENT LTD SHS G73268107 14,437 1,544,047 SH   SOLE 1,2 1,544,047 0 0
REGENXBIO INC COM 75901B107 18,906 368,040 SH   SOLE 1,2 368,040 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 248,812 16,587,491 SH   SOLE 1,2,3 16,587,491 0 0
SAREPTA THERAPEUTICS INC COM 803607100 91,814 604,236 SH   SOLE 1,2 604,236 0 0
SILK ROAD MEDICAL INC COM 82710M100 10,842 223,722 SH   SOLE 1,2 223,722 0 0
SOLID BIOSCIENCES INC COM 83422E105 835 145,225 SH   SOLE 1,2 145,225 0 0
STOKE THERAPEUTICS INC COM 86150R107 92,570 3,355,466 SH   SOLE 1,2 3,355,466 0 0
TRANSLATE BIO INC COM 89374L104 30,808 2,439,250 SH   SOLE 1,2 2,439,250 0 0
TRANSMEDICS GROUP INC COM 89377M109 14,698 507,007 SH   SOLE 1,2 507,007 0 0
UNIQURE NV SHS N90064101 11,300 144,595 SH   SOLE 1,2 144,595 0 0
VERICEL CORP COM 92346J108 49,242 2,606,771 SH   SOLE 1,2 2,606,771 0 0
VIEWRAY INC COM 92672L107 1,403 159,247 SH   SOLE 1,2 159,247 0 0
VIVEVE MED INC COM NEW 92852W204 1,703 4,480,565 SH   SOLE 1,2 4,480,565 0 0
Vivus Inc 4.5 05/01/2020 NOTE 4.500% 5/0 928551AA8 3,128 4,000,000 SH   SOLE 1 4,000,000 0 0