The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 42,399 504,148 SH   SOLE   504,148 0 0
AbbVie Inc. Common 00287Y109 24,239 333,316 SH   SOLE   333,316 0 0
ABIOMED, Inc. Common 003654100 8,522 32,716 SH   SOLE   32,716 0 0
AC Immune SA Shares H00263105 954 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Co., Inc. Common 00404A109 6,052 173,155 SH   SOLE   173,155 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 4,281 160,147 SH   SOLE   160,147 0 0
Acceleron Pharma Inc. Common 00434H108 7,739 188,388 SH   SOLE   188,388 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 919 228,496 SH   SOLE   228,496 0 0
Aerie Pharmaceuticals, Inc. Common 00771V108 1,971 66,688 SH   SOLE   66,688 0 0
Aerpio Pharmaceuticals, Inc. Common 00810B105 673 740,000 SH   SOLE   740,000 0 0
Affimed N.V. Common N01045108 729 254,000 SH   SOLE   254,000 0 0
Agilent Technologies, Inc. Common 00846U101 2,509 33,600 SH   SOLE   33,600 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 7,250 145,342 SH   SOLE   145,342 0 0
Albireo Pharma, Inc. Common 01345P106 3,390 105,154 SH   SOLE   105,154 0 0
Alcon Inc. Ordinary Shares H01301128 3,436 55,369 SH   SOLE   55,369 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 52,394 400,014 SH   SOLE   400,014 0 0
Align Technology, Inc. Common 016255101 7,740 28,278 SH   SOLE   28,278 0 0
Alkermes plc Shares G01767105 4,464 198,048 SH   SOLE   198,048 0 0
Allakos Inc. Common 01671P100 1,058 24,414 SH   SOLE   24,414 0 0
Allergan plc Shares G0177J108 24,157 144,281 SH   SOLE   144,281 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 11,709 161,372 SH   SOLE   161,372 0 0
Amarin Corporation plc Sponsored ADR 023111206 10,728 553,295 SH   SOLE   553,295 0 0
AmerisourceBergen Corp. Common 03073E105 11,960 140,273 SH   SOLE   140,273 0 0
Amgen Inc. Common 031162100 134,461 729,658 SH   SOLE   729,658 0 0
Amicus Therapeutics, Inc. Common 03152W109 3,926 314,597 SH   SOLE   314,597 0 0
AnaptysBio, Inc. Common 032724106 4,220 74,798 SH   SOLE   74,798 0 0
Anthem, Inc. Common 036752103 29,196 103,456 SH   SOLE   103,456 0 0
ARCA biopharma, Inc. Common 00211Y506 264 36,068 SH   SOLE   36,068 0 0
Ardelyx, Inc. Common 039697107 1,720 639,370 SH   SOLE   639,370 0 0
Arena Pharmaceuticals, Inc. Common 040047607 1,642 28,002 SH   SOLE   28,002 0 0
argenx SE Sponsored ADR 04016X101 4,018 28,381 SH   SOLE   28,381 0 0
ArQule, Inc. Common 04269E107 1,675 152,110 SH   SOLE   152,110 0 0
Array BioPharma Inc. Common 04269X105 15,005 323,883 SH   SOLE   323,883 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100 814 30,700 SH   SOLE   30,700 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 8,480 73,647 SH   SOLE   73,647 0 0
AstraZeneca PLC Sponsored ADR 046353108 13,829 334,998 SH   SOLE   334,998 0 0
Atreca, Inc. Class A Common 04965G109 3,297 175,000 SH   SOLE   175,000 0 0
Audentes Therapeutics, Inc. Common 05070R104 1,990 52,574 SH   SOLE   52,574 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 2,354 814,588 SH   SOLE   814,588 0 0
Bausch Health Co. Inc. Common 071734107 4,257 168,812 SH   SOLE   168,812 0 0
Baxter International Inc. Common 071813109 14,472 176,698 SH   SOLE   176,698 0 0
Becton, Dickinson and Co. Common 075887109 14,727 58,438 SH   SOLE   58,438 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 11,761 94,889 SH   SOLE   94,889 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 102 60,000 SH   SOLE   60,000 0 0
Bio-Techne Corporation Common 09073M104 4,524 21,701 SH   SOLE   21,701 0 0
Biogen Inc. Common 09062X103 52,548 224,690 SH   SOLE   224,690 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 21,050 245,763 SH   SOLE   245,763 0 0
bluebird bio, Inc. Common 09609G100 12,964 101,918 SH   SOLE   101,918 0 0
Blueprint Medicines Corporation Common 09627Y109 8,959 94,976 SH   SOLE   94,976 0 0
Boston Scientific Corporation Common 101137107 27,174 632,250 SH   SOLE   632,250 0 0
Bristol-Myers Squibb Company Common 110122108 33,470 738,044 SH   SOLE   738,044 0 0
Cardinal Health, Inc. Common 14149Y108 297 6,300 SH   SOLE   6,300 0 0
Celgene Corp. Common 151020104 136,230 1,473,710 SH   SOLE   1,473,710 0 0
Celldex Therapeutics, Inc. Common 15117B202 19 7,053 SH   SOLE   7,053 0 0
Cellectis SA Sponsored ADR 15117K103 1,718 110,147 SH   SOLE   110,147 0 0
Charles River Laboratories International, Inc. Common 159864107 2,010 14,167 SH   SOLE   14,167 0 0
Chimerix, Inc. Common 16934W106 494 114,333 SH   SOLE   114,333 0 0
Cidara Therapeutics, Inc. Common 171757107 267 158,784 SH   SOLE   158,784 0 0
Cigna Corporation Common 125523100 18,395 116,756 SH   SOLE   116,756 0 0
Clearside Biomedical, Inc. Common 185063104 161 165,330 SH   SOLE   165,330 0 0
Clovis Oncology, Inc. Common 189464100 561 37,700 SH   SOLE   37,700 0 0
Coherus Biosciences, Inc. Common 19249H103 6,440 291,419 SH   SOLE   291,419 0 0
Community Health Systems, Inc. Common 203668108 545 203,935 SH   SOLE   203,935 0 0
Concert Pharmaceuticals, Inc. Common 206022105 1,330 110,853 SH   SOLE   110,853 0 0
CRISPR Therapeutics AG Namen AKT H17182108 8,400 178,348 SH   SOLE   178,348 0 0
CVS Health Corp. Common 126650100 31,354 575,401 SH   SOLE   575,401 0 0
CymaBay Therapeutics, Inc. Common 23257D103 631 88,102 SH   SOLE   88,102 0 0
Danaher Corp. Common 235851102 22,714 158,931 SH   SOLE   158,931 0 0
DENTSPLY SIRONA Inc. Common 24906P109 7,407 126,921 SH   SOLE   126,921 0 0
Diplomat Pharmacy, Inc. Common 25456K101 1,308 214,845 SH   SOLE   214,845 0 0
Editas Medicine, Inc. Common 28106W103 1,113 44,989 SH   SOLE   44,989 0 0
Edwards Lifesciences Corp. Common 28176E108 12,889 69,769 SH   SOLE   69,769 0 0
Eli Lilly and Co. Common 532457108 28,052 253,199 SH   SOLE   253,199 0 0
Endo International plc Shares G30401106 2,190 531,570 SH   SOLE   531,570 0 0
Epizyme, Inc. Common 29428V104 5,015 399,604 SH   SOLE   399,604 0 0
Esperion Therapeutics, Inc. Common 29664W105 8,588 184,607 SH   SOLE   184,607 0 0
Evolent Health, Inc. Common 30050B101 1,385 174,270 SH   SOLE   174,270 0 0
Exelixis, Inc. Common 30161Q104 14,499 678,467 SH   SOLE   678,467 0 0
Fate Therapeutics, Inc. Common 31189P102 495 24,379 SH   SOLE   24,379 0 0
FibroGen, Inc. Common 31572Q808 11,038 244,320 SH   SOLE   244,320 0 0
Foamix Pharmaceuticals Ltd Shares M46135105 716 300,781 SH   SOLE   300,781 0 0
Galapagos NV Sponsored ADR 36315X101 6,256 48,525 SH   SOLE   48,525 0 0
Genomic Health, Inc. Common 37244C101 1,543 26,531 SH   SOLE   26,531 0 0
Gilead Sciences, Inc. Common 375558103 124,048 1,836,112 SH   SOLE   1,836,112 0 0
GlaxoSmithKline PLC Shares 37733W105 8,752 218,700 SH   SOLE   218,700 0 0
Global Blood Therapeutics, Inc. Common 37890U108 3,551 67,516 SH   SOLE   67,516 0 0
Global Medical REIT Inc. Common 37954A204 771 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals PLC ADS 36197T103 11,119 64,499 SH   SOLE   64,499 0 0
HCA Healthcare, Inc. Common 40412C101 12,107 89,569 SH   SOLE   89,569 0 0
HCP, Inc. Common 40414L109 1,455 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Inc. Common 421946104 2,130 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Common 42225P501 1,262 46,000 SH   SOLE   46,000 0 0
HealthEquity, Inc. Common 42226A107 2,080 31,810 SH   SOLE   31,810 0 0
Hologic, Inc. Common 436440101 2,051 42,701 SH   SOLE   42,701 0 0
Horizon Therapeutics plc Shares G46188101 3,789 157,473 SH   SOLE   157,473 0 0
Humana Inc. Common 444859102 12,767 48,122 SH   SOLE   48,122 0 0
IDEXX Laboratories, Inc. Common 45168D104 17,003 61,754 SH   SOLE   61,754 0 0
Illumina, Inc. Common 452327109 73,067 198,471 SH   SOLE   198,471 0 0
ImmunoGen, Inc. Common 45253H101 365 168,190 SH   SOLE   168,190 0 0
Immunomedics, Inc. Common 452907108 5,400 389,313 SH   SOLE   389,313 0 0
Incyte Corp. Common 45337C102 43,409 510,933 SH   SOLE   510,933 0 0
Inogen, Inc. Common 45780L104 935 14,000 SH   SOLE   14,000 0 0
Intellia Therapeutics, Inc. Common 45826J105 2,460 150,290 SH   SOLE   150,290 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108 4,285 53,857 SH   SOLE   53,857 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 715 55,096 SH   SOLE   55,096 0 0
Intuitive Surgical, Inc. Common 46120E602 29,204 55,675 SH   SOLE   55,675 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 8,201 127,598 SH   SOLE   127,598 0 0
Iovance Biotherapeutics, Inc. Common 462260100 4,881 199,073 SH   SOLE   199,073 0 0
IQVIA Holdings Inc. Common 46266C105 2,637 16,391 SH   SOLE   16,391 0 0
Jazz Pharmaceuticals plc Shares G50871105 9,619 67,471 SH   SOLE   67,471 0 0
Johnson & Johnson Common 478160104 123,960 890,004 SH   SOLE   890,004 0 0
Koninklijke Philips N.V. NY Reg Sh 500472303 3,722 85,400 SH   SOLE   85,400 0 0
Laboratory Corporation of America Holdings Sponsored ADR 50540R409 5,433 31,424 SH   SOLE   31,424 0 0
Ligand Pharmaceuticals Inc. Common 53220K504 5,029 44,055 SH   SOLE   44,055 0 0
LivaNova PLC Shares G5509L101 3,287 45,681 SH   SOLE   45,681 0 0
LTC Properties, Inc. Common 502175102 6,640 145,421 SH   SOLE   145,421 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105 1,398 13,340 SH   SOLE   13,340 0 0
Mallinckrodt plc Sponsored ADR G5785G107 303 32,980 SH   SOLE   32,980 0 0
Masimo Corp. Common 574795100 4,127 27,732 SH   SOLE   27,732 0 0
McKesson Corp. Common 58155Q103 12,860 95,691 SH   SOLE   95,691 0 0
Medical Properties Trust, Inc. Common 58463J304 3,262 187,063 SH   SOLE   187,063 0 0
The Medicines Company Common 584688105 10,142 278,092 SH   SOLE   278,092 0 0
Medtronic plc Shares G5960L103 46,751 480,035 SH   SOLE   480,035 0 0
Merck & Co., Inc. Common 58933Y105 84,998 1,013,695 SH   SOLE   1,013,695 0 0
Merus N.V. Common N5749R100 3,591 245,114 SH   SOLE   245,114 0 0
Milestone Pharmaceuticals, Inc. Common 59935V107 1,358 50,000 SH   SOLE   50,000 0 0
Mirati Therapeutics, Inc. Common 60468T105 1,400 13,590 SH   SOLE   13,590 0 0
Molecular Templates, Inc. Common 608550109 1,203 144,110 SH   SOLE   144,110 0 0
MorphoSys AG Sponsored ADS 617760202 957 39,643 SH   SOLE   39,643 0 0
Mylan N.V. Shares N59465109 17,958 943,152 SH   SOLE   943,152 0 0
MyoKardia, Inc. Common 62857M105 1,935 38,600 SH   SOLE   38,600 0 0
Myriad Genetics, Inc. Common 62855J104 571 20,549 SH   SOLE   20,549 0 0
Natus Medical Inc. Common 639050103 1,573 61,219 SH   SOLE   61,219 0 0
Nektar Therapeutics Common 640268108 10,093 283,679 SH   SOLE   283,679 0 0
Neurocrine Biosciences, Inc. Common 64125C109 17,484 207,078 SH   SOLE   207,078 0 0
New Senior Investment Group Inc. Common 648691103 1,062 158,047 SH   SOLE   158,047 0 0
Novartis AG Sponsored ADR 66987V109 25,297 277,047 SH   SOLE   277,047 0 0
Novavax, Inc. Common 670002401 167 28,550 SH   SOLE   28,550 0 0
Novo Nordisk A/S Sponsored ADR 670100205 12,301 241,000 SH   SOLE   241,000 0 0
Novocure Ltd. Ordinary Shares G6674U108 3,419 54,074 SH   SOLE   54,074 0 0
Omega Healthcare Investors, Inc. Common 681936100 10,024 272,766 SH   SOLE   272,766 0 0
Ovid Therapeutics Inc. Sponsored ADR 690469101 690 372,733 SH   SOLE   372,733 0 0
Perrigo Company plc Shares G97822103 1,034 21,718 SH   SOLE   21,718 0 0
Pfizer Inc. Common 717081103 89,597 2,068,265 SH   SOLE   2,068,265 0 0
Physicians Realty Trust Common 71943U104 5,300 303,908 SH   SOLE   303,908 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 6,812 1,449,269 SH   SOLE   1,449,269 0 0
Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 3,132 115,448 SH   SOLE   115,448 0 0
PRA Health Sciences, Inc. Common 69354M108 15,170 153,003 SH   SOLE   153,003 0 0
Protagonist Therapeutics, Inc. Common 74366E102 1,469 121,341 SH   SOLE   121,341 0 0
PTC Therapeutics, Inc. Common 69366J200 6,282 139,608 SH   SOLE   139,608 0 0
Puma Biotechnology, Inc. Common 74587V107 907 71,340 SH   SOLE   71,340 0 0
Quest Diagnostics Inc. Common 74834L100 2,648 26,012 SH   SOLE   26,012 0 0
Quorum Health Corp. Common 74909E106 33 23,725 SH   SOLE   23,725 0 0
Ra Pharmaceuticals, Inc. Common 74933V108 577 19,190 SH   SOLE   19,190 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 52,261 166,968 SH   SOLE   166,968 0 0
REGENXBIO Inc. Common 75901B107 658 12,801 SH   SOLE   12,801 0 0
ResMed Inc. Common 761152107 6,359 52,110 SH   SOLE   52,110 0 0
Rhythm Pharmaceuticals, Inc. Common 76243J105 548 24,890 SH   SOLE   24,890 0 0
Sabra Health Care REIT, Inc. Common 78573L106 9,180 466,247 SH   SOLE   466,247 0 0
Sage Therapeutics, Inc. Common 78667J108 15,406 84,145 SH   SOLE   84,145 0 0
Sangamo Therapeutics, Inc. Common 800677106 1,301 120,768 SH   SOLE   120,768 0 0
Sanofi Sponsored ADR 80105N105 3,719 85,941 SH   SOLE   85,941 0 0
Sarepta Therapeutics, Inc. Common 803607100 22,465 147,847 SH   SOLE   147,847 0 0
Seattle Genetics, Inc. Common 812578102 20,066 289,925 SH   SOLE   289,925 0 0
Senior Housing Properties Trust Common 81721M109 2,958 357,720 SH   SOLE   357,720 0 0
Smith & Nephew plc Shares 83175M205 6,998 160,734 SH   SOLE   160,734 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 7,808 89,022 SH   SOLE   89,022 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108 987 114,670 SH   SOLE   114,670 0 0
STERIS plc Shares G8473T100 4,315 28,981 SH   SOLE   28,981 0 0
Stryker Corporation Common 863667101 21,164 102,950 SH   SOLE   102,950 0 0
Sutro Biopharma, Inc. Common 869367102 7,298 641,268 SH   SOLE   641,268 0 0
Syneos Health, Inc. Class A 87166B102 1,483 29,027 SH   SOLE   29,027 0 0
Takeda Pharmaceutical SP ADR Sponsored ADS 874060205 3,153 178,128 SH   SOLE   178,128 0 0
Teleflex Inc. Common 879369106 2,112 6,379 SH   SOLE   6,379 0 0
Tenet Healthcare Corp. Common 88033G407 3,774 182,671 SH   SOLE   182,671 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N105 413 859,322 SH   SOLE   859,322 0 0
Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 7,253 785,851 SH   SOLE   785,851 0 0
TherapeuticsMD, Inc. Common 88338N107 1,409 541,815 SH   SOLE   541,815 0 0
Thermo Fisher Scientific Inc. Common 883556102 39,999 136,198 SH   SOLE   136,198 0 0
Trillium Therapeutics Inc. Common 89620X506 146 446,099 SH   SOLE   446,099 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 2,443 38,480 SH   SOLE   38,480 0 0
uniQure N.V. Shares N90064101 1,544 19,751 SH   SOLE   19,751 0 0
United Therapeutics Corporation Class B 91307C102 4,223 54,094 SH   SOLE   54,094 0 0
Unitedhealth Group Inc. Common 91324P102 79,092 324,133 SH   SOLE   324,133 0 0
Varian Medical Systems, Inc. Common 92220P105 3,271 24,027 SH   SOLE   24,027 0 0
Ventas, Inc. Common 92276F100 6,732 98,496 SH   SOLE   98,496 0 0
Verona Pharma plc Sponsored ADR 925050106 1,471 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Inc. Common 92532F100 89,807 489,734 SH   SOLE   489,734 0 0
Viking Therapeutics, Inc. Common 92686J106 946 114,016 SH   SOLE   114,016 0 0
WaVe Life Sciences Ltd. Shares Y95308105 1,460 55,955 SH   SOLE   55,955 0 0
WellCare Health Plans, Inc. Common 94946T106 5,099 17,886 SH   SOLE   17,886 0 0
Welltower Inc. Common 95040Q104 12,419 152,322 SH   SOLE   152,322 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 2,043 68,506 SH   SOLE   68,506 0 0
Xencor, Inc. Common 98401F105 2,963 72,382 SH   SOLE   72,382 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 9,378 79,654 SH   SOLE   79,654 0 0
Zoetis Inc. Class A 98978V103 28,212 248,584 SH   SOLE   248,584 0 0
Zogenix, Inc. Common 98978L204 5,932 124,148 SH   SOLE   124,148 0 0