The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 80,534 957,595 SH   DFND 6 957,595 0 0
ABIOMED INC COM 003654100 35,083 134,682 SH   DFND 6 134,682 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,775 103,800 SH   DFND 6 103,800 0 0
ADOBE INC COM 00724F101 352 1,193 SH   DFND 6 1,193 0 0
AFFIMED N V COM N01045108 481 167,500 SH   DFND 6 167,500 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 3,792 50,782 SH   DFND 6 50,782 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 156,031 3,128,134 SH   DFND 1,4,6 3,128,134 0 0
AKCEA THERAPEUTICS INC COM 00972L107 15,285 651,820 SH   DFND 6 651,820 0 0
AKCEA THERAPEUTICS INC COM 00972L107 57,428 2,448,948 SH   DFND 1,4,6 2,448,948 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 15,922 1,352,798 SH   DFND 6 1,352,798 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 32,556 2,766,008 SH   DFND 1,4,6 2,766,008 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 3,536 27,000 SH   DFND 6 27,000 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 172,164 1,314,428 SH   DFND 1,3,6 1,314,428 0 0
ALIGN TECHNOLOGY INC COM 016255101 83,915 306,595 SH   DFND 6 306,595 0 0
ALLERGAN PLC SHS G0177J108 5,375 32,100 SH   DFND 6 32,100 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 17,872 246,305 SH   DFND 6 246,305 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 121,980 1,681,089 SH   DFND 1.4,6 1,681,089 0 0
AMEDISYS INC COM 023436108 21,163 174,310 SH   DFND 6 174,310 0 0
AMERICAN EXPRESS CO COM 025816109 370 3,000 SH   DFND 6 3,000 0 0
AMGEN INC COM 031162100 8,587 46,600 SH   DFND 6 46,600 0 0
AMICUS THERAPEUTICS INC COM 03152W109 1,872 150,000 SH   DFND 6 150,000 0 0
ANALOG DEVICES INC COM 032654105 336 2,973 SH   DFND 6 2,973 0 0
ANAPTYSBIO INC COM 032724106 959 17,000 SH   DFND 6 17,000 0 0
ANSYS INC COM 03662Q105 369 1,802 SH   DFND 6 1,802 0 0
ANTHEM INC COM 036752103 101,804 360,739 SH   DFND 6 360,739 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 2,751 46,917 SH   DFND 6 46,917 0 0
ARGENX SE SPONSORED ADR 04016X101 2,817 19,900 SH   DFND 6 19,900 0 0
ARGENX SE SPONSORED ADR 04016X101 130,925 924,739 SH   DFND 1,4,6 924,739 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 2,096 18,200 SH   DFND 6 18,200 0 0
ASPEN TECHNOLOGY INC COM 045327103 373 3,000 SH   DFND 6 3,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 51,853 1,369,604 SH   DFND 1,4,6 1,369,604 0 0
AUTOLIV INC COM 052800109 253 3,582 SH   DFND 6 3,582 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100 547 34,000 SH   DFND 6 34,000 0 0
AVANTOR INC COM 05352A100 3,574 187,231 SH   DFND 6 187,231 0 0
AVEDRO INC COM 05355N109 15,798 804,379 SH   DFND 6 804,379 0 0
BAXTER INTL INC COM 071813109 25,736 314,237 SH   DFND 6 314,237 0 0
BECTON DICKINSON & CO COM 075887109 37,724 149,692 SH   DFND 6 149,692 0 0
BEIGENE LTD SPONSORED ADR 07725L102 11,527 93,000 SH   DFND 6 93,000 0 0
BENEFITFOCUS INC COM 08180D106 2,394 88,163 SH   DFND 6 88,163 0 0
BIOGEN INC COM 09062X103 6,911 29,550 SH   DFND 6 29,550 0 0
BLACKBAUD INC COM 09227Q100 343 4,107 SH   DFND 6 4,107 0 0
BLUEBIRD BIO INC COM 09609G100 2,315 18,200 SH   DFND 6 18,200 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 1,462 15,500 SH   DFND 6 15,500 0 0
BOOKING HLDGS INC COM 09857L108 304 162 SH   DFND 6 162 0 0
BOSTON SCIENTIFIC CORP COM 101137107 59,346 1,380,782 SH   DFND 6 1,380,782 0 0
BRISTOL MYERS SQUIBB CO COM 110122108 38,802 855,609 SH   DFND 6 855,609 0 0
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 365 2,862 SH   DFND 6 2,862 0 0
BROWN FORMAN CORP CL B 115637209 356 6,417 SH   DFND 6 6,417 0 0
CAREDX INC COM 14167L103 17,707 492,008 SH   DFND 6 492,008 0 0
CASTLIGHT HEALTH INC CL B 14862Q100 2,584 800,000 SH   DFND 6 800,000 0 0
CATALENT INC COM 148806102 2,033 37,500 SH   DFND 6 37,500 0 0
CELGENE CORP COM 151020104 171,014 1,850,000 SH   DFND 1,3,6 1,850,000 0 0
CENTENE CORP DEL COM 15135B101 35,372 674,525 SH   DFND 6 674,525 0 0
CERNER CORP COM 156782104 388 5,298 SH   DFND 6 5,298 0 0
CHANGE HEALTHCARE INC COM 15912K100 14,600 1,000,000 SH   DFND 6 1,000,000 0 0
CHINA BIOLOGIC PRODS HLDGS I COM G21515104 344 3,609 SH   DFND 6 3,609 0 0
CIDARA THERAPEUTICS INC COM 171757107 3,856 2,295,272 SH   DFND 1,4,6 2,295,272 0 0
CIGNA CORP NEW COM 125523100 33,204 210,754 SH   DFND 6 210,754 0 0
COHERUS BIOSCIENCES INC COM 19249H103 3,683 166,635 SH   DFND 6 166,635 0 0
COLGATE PALMOLIVE CO COM 194162103 333 4,651 SH   DFND 6 4,651 0 0
COOPER COS INC COM NEW 216648402 10,770 31,969 SH   DFND 6 31,969 0 0
COVETRUS INC COM 22304C100 37 1,520 SH   DFND 6 1,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 38,173 810,462 SH   DFND 1,4,6 810,462 0 0
CTRIP COM INTL LTD SPONSORED ADS 22943F100 333 9,032 SH   DFND 6 9,032 0 0
CVS HEALTH CORP COM 126650100 3,233 59,326 SH   DFND 6 59,326 0 0
DANAHER CORPORATION COM 235851102 50,122 350,698 SH   DFND 6 350,698 0 0
DENTSPLY SIRONA INC COM 24906P109 7,313 125,313 SH   DFND 6 125,313 0 0
DEXCOM INC COM 252131107 24,744 165,136 SH   DFND 6 165,136 0 0
DIREXION SHS ETF TR DAILY S&P BIOTEC 25460E539 2,018 112,000 SH   DFND 6 112,000 0 0
DOMINOS PIZZA INC COM 25754A201 362 1,300 SH   DFND 6 1,300 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 32,138 173,966 SH   DFND 6 173,966 0 0
ELECTRONIC ARTS INC COM 285512109 314 3,100 SH   DFND 6 3,100 0 0
ENTEGRIS INC COM 29362U104 325 8,706 SH   DFND 6 8,706 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 24,862 534,447 SH   DFND 6 534,447 0 0
ESPERION THERAPEUTICS INC NEW COM 29664W105 163,888 3,522,964 SH   DFND 1,4,6 3,522,964 0 0
EVOLENT HEALTH INC CL A 30050B101 18,675 2,349,000 SH   DFND 6 2,349,000 0 0
EXELIXIS INC COM 30161Q104 22,306 1,043,800 SH   DFND 6 1,043,800 0 0
EXELIXIS INC COM 30161Q104 60,584 2,835,000 SH   DFND 1,4,6 2,835,000 0 0
FASTENAL CO COM 311900104 319 9,798 SH   DFND 6 9,798 0 0
FATE THERAPEUTICS INC COM 31189P102 1,198 59,000 SH   DFND 6 59,000 0 0
FITBIT INC CL A 33812L102 16,265 3,696,530 SH   DFND 6 3,696,530 0 0
G1 THERAPEUTICS INC COM 3621LQ109 20,601 671,925 SH   DFND 1,4,6 671,925 0 0
GENMARK DIAGNOSTICS INC COM 372309104 15,271 2,353,067 SH   DFND 6 2,353,067 0 0
GILEAD SCIENCES INC COM 375558103 8,053 119,200 SH   DFND 6 119,200 0 0
GILEAD SCIENCES INC COM 375558103 64,182 950,000 SH   DFND 1,2,6 950,000 0 0
GLAUKOS CORP COM 377322102 8,086 107,235 SH   DFND 6 107,235 0 0
GLOBUS MED INC CL A 379577208 11,568 273,482 SH   DFND 6 273,482 0 0
GRACO INC COM 384109104 346 6,903 SH   DFND 6 6,903 0 0
GUARDANT HEALTH INC COM 40131M109 10,346 119,848 SH   DFND 6 119,848 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 2,130 12,353 SH   DFND 6 12,353 0 0
HALOZYME THERAPEUTICS INC COM 40637H109 141,698 8,247,860 SH   DFND 1,4,6 8,247,860 0 0
HCA HEALTHCARE INC COM 40412C101 25,242 186,745 SH   DFND 6 186,745 0 0
HENRY SCHEIN INC COM 806407102 4,048 57,917 SH   DFND 6 57,917 0 0
HILL ROM HLDGS INC COM 431475102 24,397 233,198 SH   DFND 6 233,198 0 0
HMS HLDGS CORP COM 40425J101 12,906 398,442 SH   DFND 6 398,442 0 0
HOLOGIC INC COM 436440101 7,085 147,548 SH   DFND 6 147,548 0 0
HOMOLOGY MEDICINES INC COM 438083107 27,440 1,402,122 SH   DFND 1,4,6 1,402,122 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 6,460 268,500 SH   DFND 6 268,500 0 0
HUAZHU GROUP LTD SPONSORED ADS 44332N106 339 9,344 SH   DFND 6 9,344 0 0
HUMANA INC COM 444859102 63,994 241,212 SH   DFND 6 241,212 0 0
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR 44842L103 13,163 598,310 SH   DFND 6 598,310 0 0
IDEXX LABS INC COM 45168D104 8,934 32,449 SH   DFND 6 32,449 0 0
ILLUMINA INC COM 452327109 84,009 228,191 SH   DFND 6 228,191 0 0
INCYTE CORP COM 45337C102 9,996 117,650 SH   DFND 6 117,650 0 0
INCYTE CORP COM 45337C102 304,157 3,580,000 SH   DFND 1,4,6 3,580,000 0 0
INOGEN INC COM 45780L104 6,465 96,843 SH   DFND 6 96,843 0 0
INSMED INC COM PAR $.01 457669307 15,884 620,459 SH   DFND 6 620,459 0 0
INSPIRE MED SYS INC COM 457730109 11,787 194,340 SH   DFND 6 194,340 0 0
INSULET CORP COM 45784P101 9,938 83,246 SH   DFND 6 83,246 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 10,708 191,733 SH   DFND 6 191,733 0 0
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 312 5,757 SH   DFND 6 5,757 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,180 14,827 SH   DFND 6 14,827 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 55,458 696,976 SH   DFND 1,4,6 696,976 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104 330 3,837 SH   DFND 6 3,837 0 0
INTERSECT ENT INC COM 46071F103 10,258 450,718 SH   DFND 6 450,718 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 591 45,500 SH   DFND 6 45,500 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 28,556 2,200,000 SH   DFND 1,4,6 2,200,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 88,377 168,482 SH   DFND 6 168,482 0 0
IONIS PHARMACEUTICALS INC COM 462222100 18,166 282,658 SH   DFND 6 282,658 0 0
IONIS PHARMACEUTICALS INC COM 462222100 493,238 7,674,470 SH   DFND 1,4,6 7,674,470 0 0
IPG PHOTONICS CORP COM 44980X109 330 2,141 SH   DFND 6 2,141 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 14,143 178,848 SH   DFND 6 178,848 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 47,355 332,173 SH   DFND 6 332,173 0 0
JD COM INC SPON ADR CL A 47215P106 371 12,263 SH   DFND 6 12,263 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 9,487 1,230,523 SH   DFND 1,5,6 1,230,523 0 0
KIRBY CORP COM 497266106 338 4,274 SH   DFND 6 4,274 0 0
KOSMOS ENERGY LTD COM 500688106 376 60,000 SH   DFND 6 60,000 0 0
KURA ONCOLOGY INC COM 50127T109 2,859 145,200 SH   DFND 6 145,200 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409 1,000 5,783 SH   DFND 6 5,783 0 0
LAUDER ESTEE COS INC CL A 518439104 412 2,248 SH   DFND 6 2,248 0 0
LIVANOVA PLC SHS G5509L101 19,117 265,666 SH   DFND 6 265,666 0 0
LIVE NATION ENTERTAINMENT IN COM 538034109 331 5,000 SH   DFND 6 5,000 0 0
M & T BK CORP COM 55261F104 294 1,731 SH   DFND 6 1,731 0 0
MACROGENICS INC COM 556099109 14,839 874,405 SH   DFND 6 874,405 0 0
MACROGENICS INC COM 556099109 59,749 3,520,859 SH   DFND 1,4,6 3,520,859 0 0
MARKEL CORP COM 570535104 304 279 SH   DFND 6 279 0 0
MARKETAXESS HLDGS INC COM 57060D108 425 1,322 SH   DFND 6 1,322 0 0
MASIMO CORP COM 574795100 9,761 65,592 SH   DFND 6 65,592 0 0
MATERIALISE NV SPONSORED ADS 57667T100 4,700 240,770 SH   DFND 6 240,770 0 0
MCCORMICK & CO INC COM NON VTG 579780206 371 2,391 SH   DFND 6 2,391 0 0
MCKESSON CORP COM 58155Q103 826 6,149 SH   DFND 6 6,149 0 0
MEDICINES CO COM 584688105 1,586 43,500 SH   DFND 6 43,500 0 0
MEDTRONIC PLC SHS G5960L103 75,907 779,411 SH   DFND 6 779,411 0 0
MERCADOLIBRE INC COM 58733R102 511 835 SH   DFND 6 835 0 0
METTLER TOLEDO INTERNATIONAL COM 592688105 399 475 SH   DFND 6 475 0 0
MICROCHIP TECHNOLOGY INC COM 595017104 314 3,617 SH   DFND 6 3,617 0 0
MIRATI THERAPEUTICS INC COM 60468T105 2,215 21,500 SH   DFND 6 21,500 0 0
MODERNA INC COM 60770K107 69,163 4,724,246 SH   DFND 1,5,6 4,724,246 0 0
MOLINA HEALTHCARE INC COM 60855R100 11,689 81,661 SH   DFND 6 81,661 0 0
MOODYS CORP COM 615369105 363 1,858 SH   DFND 6 1,858 0 0
MSCI INC COM 55354G100 426 1,786 SH   DFND 6 1,786 0 0
MYOKARDIA INC COM 62857M105 63,423 1,264,913 SH   DFND 1,4,6 1,264,913 0 0
MYOVANT SCIENCES LTD COM G637AM102 35,386 3,910,109 SH   DFND 1,4,6 3,910,109 0 0
NEKTAR THERAPEUTICS COM 640268108 18,217 512,010 SH   DFND 6 512,010 0 0
NEKTAR THERAPEUTICS COM 640268108 75,454 2,120,676 SH   DFND 1,4,6 2,120,676 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 6,944 82,250 SH   DFND 6 82,250 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 292,482 3,464,194 SH   DFND 1,4,6 3,464,194 0 0
NEURONETICS INC COM 64131A105 4,063 324,779 SH   DFND 6 324,779 0 0
NEVRO CORP COM 64157F103 9,112 140,548 SH   DFND 6 140,548 0 0
OMNICELL INC COM 68213N109 14,342 166,715 SH   DFND 6 166,715 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 7,962 578,615 SH   DFND 6 578,615 0 0
PENUMBRA INC COM 70975L107 4,029 25,180 SH   DFND 6 25,180 0 0
PFIZER INC COM 717081103 1,733 40,000 SH   DFND 6 40,000 0 0
POLYONE CORP COM 73179P106 284 9,035 SH   DFND 6 9,035 0 0
POOL CORPORATION COM 73278L105 367 1,921 SH   DFND 6 1,921 0 0
PROSHARES TR ULTSH NASD BIOT 74347B789 426 25,000 SH   DFND 6 25,000 0 0
PTC THERAPEUTICS INC COM 69366J200 3,758 83,500 SH   DFND 6 83,500 0 0
QIAGEN NV SHS NEW N72482123 30,190 744,513 SH   DFND 6 744,513 0 0
QUANTERIX CORP COM 74766Q101 13,434 397,569 SH   DFND 6 397,569 0 0
QUIDEL CORP COM 74838J101 15,926 268,470 SH   DFND 6 268,470 0 0
QUOTIENT LTD SHS G73268107 6,858 733,441 SH   DFND 6 733,441 0 0
RADIUS HEALTH INC COM NEW 750469207 1,440 59,100 SH   DFND 6 59,100 0 0
RADIUS HEALTH INC COM NEW 750469207 165,202 6,781,685 SH   DFND 1,5,6 6,781,685 0 0
REGENXBIO INC COM 75901B107 1,700 33,100 SH   DFND 6 33,100 0 0
RESMED INC COM 761152107 6,422 52,626 SH   DFND 6 52,626 0 0
S&P GLOBAL INC COM 78409V104 352 1,544 SH   DFND 6 1,544 0 0
SAGE THERAPEUTICS INC COM 78667J108 2,984 16,300 SH   DFND 6 16,300 0 0
SAGE THERAPEUTICS INC COM 78667J108 238,951 1,305,104 SH   DFND 1,4,6 1,305,104 0 0
SALESFORCE COM INC COM 79466L302 297 1,956 SH   DFND 6 1,956 0 0
SANGAMO THERAPEUTICS INC COM 800677106 39,311 3,650,000 SH   DFND 1,4,6 3,650,000 0 0
SCHOLAR ROCK HOLDING CORP COM 80706P103 30,956 1,951,839 SH   DFND 1,4,6 1,951,839 0 0
SEATTLE GENETICS INC COM 812578102 5,052 73,000 SH   DFND 6 73,000 0 0
SENSATA TECHNOLOGIES HLDNG P SHS G8060N102 302 6,162 SH   DFND 6 6,162 0 0
SHOCKWAVE MED INC COM 82489T104 5,569 97,547 SH   DFND 6 97,547 0 0
SILK RAOD MEDICAL INC COM 82710M100 6,145 126,810 SH   DFND 6 126,810 0 0
SKYWORKS SOLUTIONS INC COM 83088M102 307 3,978 SH   DFND 6 3,978 0 0
SOCIEDAD QUIMICA MINERA DE C SPON ADR SER B 833635105 217 6,990 SH   DFND 6 6,990 0 0
STARBUCKS CORP COM 855244109 363 4,334 SH   DFND 6 4,334 0 0
STRYKER CORP COM 863667101 32,721 159,163 SH   DFND 6 159,163 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 15,453 467,000 SH   DFND 6 467,000 0 0
SYNEOS HEALTH INC CL A 87166B102 3,168 62,000 SH   DFND 6 62,000 0 0
TABULA RASA HEALTHCARE INC COM 873379101 9,545 191,175 SH   DFND 6 191,175 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 10,829 167,847 SH   DFND 6 167,847 0 0
TELADOC HEALTH INC COM 87918A105 95,299 1,435,012 SH   DFND 6 1,435,012 0 0
TELEFLEX INC COM 879369106 12,175 36,766 SH   DFND 6 36,766 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 16,747 57,024 SH   DFND 6 57,024 0 0
TRIMBLE INC COM 896239100 359 7,958 SH   DFND 6 7,958 0 0
TYLER TECHNOLOGIES INC COM 902252105 329 1,525 SH   DFND 6 1,525 0 0
ULTRAGENYX PHARMACEUTICAL INC COM 90400D108 1,448 22,800 SH   DFND 6 22,800 0 0
UNIQURE NV SHS N90064101 2,157 27,600 SH   DFND 6 27,600 0 0
UNITEDHEALTH GROUP INC COM 91324P102 47,434 194,394 SH   DFND 6 194,394 0 0
US BANCORP DEL COM NEW 902973304 297 5,662 SH   DFND 6 5,662 0 0
VARIAN MED SYS INC COM 92220P105 380 2,791 SH   DFND 6 2,791 0 0
VEEVA SYS INC CL A COM 922475108 8,039 49,590 SH   DFND 6 49,590 0 0
VEONEER INCORPORATED COM 92336X109 167 9,658 SH   DFND 6 9,658 0 0
VERISIGN INC COM 92343E102 365 1,744 SH   DFND 6 1,744 0 0
VERISK ANALYTICS INC COM 92345Y106 365 2,489 SH   DFND 6 2,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 25,763 140,489 SH   DFND 6 140,489 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 234,726 1,280,000 SH   DFND 1,4,6 1,280,000 0 0
VIKING THERAPEUTICS INC COM 92686J106 797 96,000 SH   DFND 6 96,000 0 0
VOCERA COMMUNICATONS INC COM 92857F107 6,181 193,634 SH   DFND 6 193,634 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 72,957 2,680,283 SH   DFND 1,4,6 2,680,283 0 0
WABTEC CORP COM 929740108 314 4,382 SH   DFND 6 4,382 0 0
WATSCO INC COM 942622200 326 1,993 SH   DFND 6 1,993 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 39,526 1,515,002 SH   DFND 1,4,6 1,515,002 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 1,383 4,851 SH   DFND 6 4,851 0 0
WRIGHT MED GROUP NV ORD SHS N96617118 14,269 478,495 SH   DFND 6 478,495 0 0
ZAI LAB LTD ADR 98887Q104 3,487 100,000 SH   DFND 6 100,000 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 11,915 101,199 SH   DFND 6 101,199 0 0