The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 183,998 706,354 SH   SOLE   706,354 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 61,714 2,308,803 SH   SOLE   2,308,803 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 79,711 3,828,564 SH   SOLE   3,828,564 0 0
ALDER BIOPHARMACEUTICALS INC COM 014339105 21,911 1,861,630 SH   SOLE   1,861,630 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 441 73,500 SH   SOLE   73,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 134,095 1,023,780 SH   SOLE   1,023,780 0 0
ALIGN TECHNOLOGY INC COM 016255101 40,372 147,505 SH   SOLE   147,505 0 0
ALIMERA SCIENCES INC COM 016259103 2,682 3,013,793 SH   SOLE   3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 33,721 3,375,506 SH   SOLE   3,375,506 0 0
AMICUS THERAPEUTICS INC COM 03152W109 97,298 7,796,299 SH   SOLE   7,796,299 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 223,245 2,606,485 SH   SOLE   2,606,485 0 0
CELGENE CORP COM 151020104 9,880 106,883 SH   SOLE   106,883 0 0
CLOVIS ONCOLOGY INC COM 189464100 76,451 5,141,304 SH   SOLE   5,141,304 0 0
CYTOKINETICS INC COM NEW 23282W605 1,391 123,686 SH   SOLE   123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 5,226 331,813 SH   SOLE   331,813 0 0
EPIZYME INC COM 29428V104 87,035 6,935,074 SH   SOLE   6,935,074 0 0
EXACT SCIENCES CORP COM 30063P105 37,169 314,889 SH   SOLE   314,889 0 0
GILEAD SCIENCES INC COM 375558103 11,884 175,900 SH   SOLE   175,900 0 0
HISTOGENICS CORP COM 43358V109 58 302,922 SH   SOLE   302,922 0 0
IDERA PHARMACEUTICALS INC COM PAR 45168K405 206 77,044 SH   SOLE   77,044 0 0
IMMUNOMEDICS INC COM 452907108 92,607 6,676,755 SH   SOLE   6,676,755 0 0
INSMED INC COM PAR $.01 457669307 202,007 7,890,917 SH   SOLE   7,890,917 0 0
KALEIDO BIOSCIENCES INC COM 483347100 10,053 866,666 SH   SOLE   866,666 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 31,521 5,262,263 SH   SOLE   5,262,263 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 520 125,321 SH   SOLE   125,321 0 0
MELINTA THERAPEUTICS INC COM NEW 58549G209 67 10,137 SH   SOLE   10,137 0 0
MINERVA NEUROSCIENCES INC COM 603380106 204 36,319 SH   SOLE   36,319 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 23,895 1,919,313 SH   SOLE   1,919,313 0 0
PROTHENA CORP PLC SHS G72800108 11,717 1,108,510 SH   SOLE   1,108,510 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 17,866 1,405,680 SH   SOLE   1,405,680 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 10,403 3,985,945 SH   SOLE   3,985,945 0 0
SAGE THERAPEUTICS INC COM 78667J108 145,562 795,031 SH   SOLE   795,031 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 209 247,000 SH   SOLE   247,000 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 124,485 4,237,051 SH   SOLE   4,237,051 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 845 1,162,473 SH   SOLE   1,162,473 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 121,211 1,552,792 SH   SOLE   1,552,792 0 0
VANDA PHARMACEUTICALS INC COM 921659108 71,226 5,055,050 SH   SOLE   5,055,050 0 0
WRIGHT MED GROUP N V ORD SHS N96617118 82,643 2,771,394 SH   SOLE   2,771,394 0 0
ZOGENIX INC COM NEW 98978L204 1,410 29,500 SH   SOLE   29,500 0 0