The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 26,985 322,513 SH   SOLE   322,513 0 0
AbbVie Inc. Common 00287Y109 30,289 400,016 SH   SOLE   400,016 0 0
ABIOMED, Inc. Common 003654100 5,820 32,716 SH   SOLE   32,716 0 0
AC Immune SA Shares H00263105 850 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Company, Inc. Common 00404A109 4,233 136,200 SH   SOLE   136,200 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 5,764 160,147 SH   SOLE   160,147 0 0
Acceleron Pharma Inc. Common 00434H108 3,410 86,313 SH   SOLE   86,313 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 116 77,061 SH   SOLE   77,061 0 0
Aerie Pharmaceuticals, Inc. Common 00771V108 1,282 66,688 SH   SOLE   66,688 0 0
Aerpio Pharmaceuticals, Inc. Common 00810B105 175 257,554 SH   SOLE   257,554 0 0
Agilent Technologies, Inc. Common 00846U101 2,607 34,025 SH   SOLE   34,025 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 4,608 142,217 SH   SOLE   142,217 0 0
Alcon Inc. Ordinary Shares H01301128 3,227 55,369 SH   SOLE   55,369 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 44,454 453,887 SH   SOLE   453,887 0 0
Align Technology, Inc. Common 016255101 5,116 28,278 SH   SOLE   28,278 0 0
Alkermes plc Shares G01767105 3,864 198,048 SH   SOLE   198,048 0 0
Allakos Inc. Common 01671P100 960 12,207 SH   SOLE   12,207 0 0
Allergan plc Shares G0177J108 24,449 145,281 SH   SOLE   145,281 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 13,372 166,275 SH   SOLE   166,275 0 0
Amarin Corp. plc Sponsored ADR 023111206 4,375 288,557 SH   SOLE   288,557 0 0
AmerisourceBergen Corp. Common 03073E105 14,353 174,338 SH   SOLE   174,338 0 0
Amgen Inc. Common 031162100 122,354 632,287 SH   SOLE   632,287 0 0
Amicus Therapeutics, Inc. Common 03152W109 2,523 314,597 SH   SOLE   314,597 0 0
AnaptysBio, Inc. Common 032724106 2,362 67,496 SH   SOLE   67,496 0 0
Anthem, Inc. Common 036752103 29,084 121,132 SH   SOLE   121,132 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 2,380 98,784 SH   SOLE   98,784 0 0
ARCA biopharma, Inc. Common 00211Y506 192 36,068 SH   SOLE   36,068 0 0
Ardelyx, Inc. Common 039697107 2,739 582,698 SH   SOLE   582,698 0 0
Arena Pharmaceuticals, Inc. Common 040047607 1,282 28,002 SH   SOLE   28,002 0 0
Argenx SE Sponsored ADR 04016X101 3,880 34,048 SH   SOLE   34,048 0 0
ArQule, Inc. Common 04269E107 545 76,054 SH   SOLE   76,054 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100 865 30,700 SH   SOLE   30,700 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 7,433 77,167 SH   SOLE   77,167 0 0
AstraZeneca PLC Sponsored ADR 046353108 12,306 276,098 SH   SOLE   276,098 0 0
Atreca, Inc. Class A Common 04965G109 2,047 167,245 SH   SOLE   167,245 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 3,389 814,588 SH   SOLE   814,588 0 0
AVROBIO, Inc. Common 05455M100 285 20,176 SH   SOLE   20,176 0 0
Bausch Health Companies Inc. Common 071734107 3,689 168,812 SH   SOLE   168,812 0 0
Baxter International Inc. Common 071813109 14,429 164,958 SH   SOLE   164,958 0 0
Becton, Dickinson and Co. Common 075887109 14,782 58,438 SH   SOLE   58,438 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 11,547 94,289 SH   SOLE   94,289 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 63 60,000 SH   SOLE   60,000 0 0
Bio-Techne Corp. Common 09073M104 5,975 30,537 SH   SOLE   30,537 0 0
Biogen Inc. Common 09062X103 60,053 257,939 SH   SOLE   257,939 0 0
Biohaven Pharmaceutical Holding Company Ltd. Common G11196105 1,215 29,125 SH   SOLE   29,125 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 16,564 245,763 SH   SOLE   245,763 0 0
Bluebird Bio, Inc. Common 09609G100 12,881 140,286 SH   SOLE   140,286 0 0
Blueprint Medicines Corp. Common 09627Y109 7,414 100,916 SH   SOLE   100,916 0 0
Boston Scientific Corp. Common 101137107 22,988 564,950 SH   SOLE   564,950 0 0
Bristol-Myers Squibb Co. Common 110122108 37,426 738,044 SH   SOLE   738,044 0 0
Cardinal Health, Inc. Common 14149Y108 2,748 58,241 SH   SOLE   58,241 0 0
Celgene Corp. Common 151020104 146,339 1,473,710 SH   SOLE   1,473,710 0 0
Celldex Therapeutics, Inc. Common 15117B202 15 7,053 SH   SOLE   7,053 0 0
Cellectis S.A. Sponsored ADR 15117K103 1,146 110,147 SH   SOLE   110,147 0 0
Charles River Laboratories International, Inc. Common 159864107 3,318 25,067 SH   SOLE   25,067 0 0
Cidara Therapeutics, Inc. Common 171757107 317 158,784 SH   SOLE   158,784 0 0
Cigna Corp. Common 125523100 18,973 124,995 SH   SOLE   124,995 0 0
Clearside Biomedical, Inc. Common 185063104 104 165,330 SH   SOLE   165,330 0 0
Coherus Biosciences, Inc. Common 19249H103 3,954 195,146 SH   SOLE   195,146 0 0
Community Health Systems, Inc. Common 203668108 734 203,935 SH   SOLE   203,935 0 0
CRISPR Therapeutics AG Namen AKT H17182108 4,154 101,336 SH   SOLE   101,336 0 0
CVS Health Corp. Common 126650100 34,076 540,286 SH   SOLE   540,286 0 0
CymaBay Therapeutics, Inc. Common 23257D103 451 88,102 SH   SOLE   88,102 0 0
Danaher Corp. Common 235851102 22,008 152,376 SH   SOLE   152,376 0 0
DENTSPLY SIRONA Inc. Common 24906P109 7,300 136,936 SH   SOLE   136,936 0 0
Diplomat Pharmacy, Inc. Common 25456K101 1,053 214,845 SH   SOLE   214,845 0 0
Editas Medicine, Inc. Common 28106W103 3,364 147,939 SH   SOLE   147,939 0 0
Edwards Lifesciences Corp. Common 28176E108 14,347 65,240 SH   SOLE   65,240 0 0
Eli Lilly and Co. Common 532457108 17,553 156,958 SH   SOLE   156,958 0 0
Endo International plc Shares G30401106 1,706 531,570 SH   SOLE   531,570 0 0
Epizyme, Inc. Common 29428V104 4,122 399,604 SH   SOLE   399,604 0 0
Esperion Therapeutics, Inc. Common 29664W105 7,829 213,562 SH   SOLE   213,562 0 0
Evolent Health, Inc. Common 30050B101 1,661 231,027 SH   SOLE   231,027 0 0
Exelixis, Inc. Common 30161Q104 5,867 331,751 SH   SOLE   331,751 0 0
Fate Therapeutics, Inc. Common 31189P102 2,573 165,672 SH   SOLE   165,672 0 0
FibroGen, Inc. Common 31572Q808 8,622 233,142 SH   SOLE   233,142 0 0
Foamix Pharmaceuticals Ltd Shares M46135105 914 300,781 SH   SOLE   300,781 0 0
Galapagos NV Sponsored ADR 36315X101 1,395 9,141 SH   SOLE   9,141 0 0
Gilead Sciences, Inc. Common 375558103 116,238 1,833,982 SH   SOLE   1,833,982 0 0
GlaxoSmithKline PLC Shares 37733W105 9,891 231,758 SH   SOLE   231,758 0 0
Global Blood Therapeutics, Inc. Common 37890U108 4,510 92,957 SH   SOLE   92,957 0 0
Global Medical REIT Inc. Common 37954A204 837 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals plc ADS 36197T103 7,419 64,499 SH   SOLE   64,499 0 0
HCA Healthcare, Inc. Common 40412C101 11,848 98,393 SH   SOLE   98,393 0 0
HCP, Inc. Common 40414L109 1,621 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Inc. Common 421946104 2,278 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Common 42225P501 1,351 46,000 SH   SOLE   46,000 0 0
HealthEquity, Inc. Common 42226A107 1,818 31,810 SH   SOLE   31,810 0 0
Hologic, Inc. Common 436440101 2,156 42,701 SH   SOLE   42,701 0 0
Horizon Therapeutics plc Shares G46188101 5,847 214,730 SH   SOLE   214,730 0 0
Humana Inc. Common 444859102 21,536 84,234 SH   SOLE   84,234 0 0
IDEXX Laboratories, Inc. Common 45168D104 13,536 49,776 SH   SOLE   49,776 0 0
Illumina, Inc. Common 452327109 73,359 241,139 SH   SOLE   241,139 0 0
ImmunoGen, Inc. Common 45253H101 407 168,190 SH   SOLE   168,190 0 0
Immunomedics, Inc. Common 452907108 6,459 487,103 SH   SOLE   487,103 0 0
Incyte Corp. Common 45337C102 29,227 393,730 SH   SOLE   393,730 0 0
Inogen, Inc. Common 45780L104 2,948 61,526 SH   SOLE   61,526 0 0
Insmed Inc. Common 457669307 2,907 164,786 SH   SOLE   164,786 0 0
Intellia Therapeutics, Inc. Common 45826J105 735 55,050 SH   SOLE   55,050 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108 2,284 34,414 SH   SOLE   34,414 0 0
Intra-Cellular Therapies, Inc. Common 46116X101 206 27,548 SH   SOLE   27,548 0 0
Intuitive Surgical, Inc. Common 46120E602 29,953 55,475 SH   SOLE   55,475 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 11,158 186,244 SH   SOLE   186,244 0 0
Iovance Biotherapeutics, Inc. Common 462260100 3,185 175,012 SH   SOLE   175,012 0 0
IQVIA Holdings Inc. Common 46266C105 4,460 29,857 SH   SOLE   29,857 0 0
iShares Nasdaq Biotechnology ETF Nasdaq Biotech 464287556 1,882 18,914 SH   SOLE   18,914 0 0
Jazz Pharmaceuticals plc Shares G50871105 9,602 74,936 SH   SOLE   74,936 0 0
Johnson & Johnson Common 478160104 105,862 818,227 SH   SOLE   818,227 0 0
Koninklijke Philips N.V. NY Reg Sh 500472303 1,970 42,700 SH   SOLE   42,700 0 0
Laboratory Corp. of America Holdings Sponsored ADR 50540R409 5,279 31,424 SH   SOLE   31,424 0 0
Ligand Pharmaceuticals Inc. Common 53220K504 4,385 44,055 SH   SOLE   44,055 0 0
LTC Properties, Inc. Common 502175102 7,448 145,421 SH   SOLE   145,421 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105 1,150 13,340 SH   SOLE   13,340 0 0
Magenta Therapeutics, Inc. Common 55910K108 172 16,757 SH   SOLE   16,757 0 0
Mallinckrodt plc Sponsored ADR G5785G107 79 32,980 SH   SOLE   32,980 0 0
Masimo Corp. Common 574795100 3,933 26,436 SH   SOLE   26,436 0 0
McKesson Corp. Common 58155Q103 14,659 107,266 SH   SOLE   107,266 0 0
Medical Properties Trust, Inc. Common 58463J304 3,659 187,063 SH   SOLE   187,063 0 0
The Medicines Company Common 584688105 6,784 135,675 SH   SOLE   135,675 0 0
Medtronic plc Shares G5960L103 43,380 399,370 SH   SOLE   399,370 0 0
Merck & Co., Inc. Common 58933Y105 101,974 1,211,384 SH   SOLE   1,211,384 0 0
Merus N.V. Common N5749R100 382 21,421 SH   SOLE   21,421 0 0
Milestone Pharmaceuticals, Inc. Common 59935V107 812 46,940 SH   SOLE   46,940 0 0
Mirati Therapeutics, Inc. Common 60468T105 6,208 79,687 SH   SOLE   79,687 0 0
Molecular Templates, Inc. Common 608550109 950 144,110 SH   SOLE   144,110 0 0
Mylan N.V. Shares N59465109 20,543 1,038,554 SH   SOLE   1,038,554 0 0
MyoKardia, Inc. Common 62857M105 1,006 19,300 SH   SOLE   19,300 0 0
Myriad Genetics, Inc. Common 62855J104 538 18,805 SH   SOLE   18,805 0 0
Nektar Therapeutics Common 640268108 5,167 283,679 SH   SOLE   283,679 0 0
Neurocrine Biosciences, Inc. Common 64125C109 18,637 206,822 SH   SOLE   206,822 0 0
New Senior Investment Group Inc. Common 648691103 1,056 158,047 SH   SOLE   158,047 0 0
Novartis AG Sponsored ADR 66987V109 21,677 249,447 SH   SOLE   249,447 0 0
Novavax, Inc. Common 670002401 143 28,550 SH   SOLE   28,550 0 0
Novo Nordisk A/S Sponsored ADR 670100205 12,460 241,000 SH   SOLE   241,000 0 0
Novocure Ltd. Ordinary Shares G6674U108 7,548 100,932 SH   SOLE   100,932 0 0
Omega Healthcare Investors, Inc. Common 681936100 11,399 272,766 SH   SOLE   272,766 0 0
Ovid Therapeutics Inc. Sponsored ADR 690469101 1,208 372,733 SH   SOLE   372,733 0 0
Pacific Biosciences of California, Inc. Common 69404D108 2,557 495,495 SH   SOLE   495,495 0 0
PerkinElmer, Inc. Common 714046109 1,619 19,011 SH   SOLE   19,011 0 0
Perrigo Company plc Shares G97822103 605 10,818 SH   SOLE   10,818 0 0
Pfizer Inc. Common 717081103 75,967 2,114,306 SH   SOLE   2,114,306 0 0
Physicians Realty Trust Common 71943U104 5,394 303,908 SH   SOLE   303,908 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 4,942 1,449,269 SH   SOLE   1,449,269 0 0
Portola Pharmaceuticals, Inc. Sponsored ADR 737010108 3,096 115,448 SH   SOLE   115,448 0 0
PRA Health Sciences, Inc. Common 69354M108 15,182 153,003 SH   SOLE   153,003 0 0
PTC Therapeutics, Inc. Common 69366J200 5,020 148,435 SH   SOLE   148,435 0 0
Puma Biotechnology, Inc. Common 74587V107 768 71,340 SH   SOLE   71,340 0 0
Quest Diagnostics Inc. Common 74834L100 2,784 26,012 SH   SOLE   26,012 0 0
Quorum Health Corp. Common 74909E106 29 23,725 SH   SOLE   23,725 0 0
Quotient Ltd. Common G73268107 2,020 260,030 SH   SOLE   260,030 0 0
Ra Pharmaceuticals, Inc. Common 74933V108 1,320 55,829 SH   SOLE   55,829 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 44,289 159,658 SH   SOLE   159,658 0 0
REGENXBIO Inc. Common 75901B107 3,889 109,248 SH   SOLE   109,248 0 0
ResMed Inc. Common 761152107 5,014 37,110 SH   SOLE   37,110 0 0
Rocket Pharmaceuticals, Inc. Common 77313F106 2,418 207,555 SH   SOLE   207,555 0 0
Sabra Health Care REIT, Inc. Common 78573L106 10,705 466,247 SH   SOLE   466,247 0 0
Sage Therapeutics Inc Common 78667J108 12,174 86,780 SH   SOLE   86,780 0 0
Sanofi Sponsored ADR 80105N105 3,982 85,941 SH   SOLE   85,941 0 0
Sarepta Therapeutics, Inc. Common 803607100 10,566 140,279 SH   SOLE   140,279 0 0
Seattle Genetics, Inc. Common 812578102 24,760 289,925 SH   SOLE   289,925 0 0
Senior Housing Properties Trust Common 81721M109 3,311 357,720 SH   SOLE   357,720 0 0
Smith & Nephew plc Shares 83175M205 5,855 121,645 SH   SOLE   121,645 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 6,788 89,022 SH   SOLE   89,022 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108 951 114,670 SH   SOLE   114,670 0 0
STERIS plc Shares G8473T100 3,536 24,473 SH   SOLE   24,473 0 0
Stryker Corp. Common 863667101 25,636 118,520 SH   SOLE   118,520 0 0
Sutro Biopharma, Inc. Common 869367102 5,829 641,268 SH   SOLE   641,268 0 0
Syneos Health, Inc. Class A 87166B102 2,447 45,982 SH   SOLE   45,982 0 0
Takeda Pharmaceutic Sponsored ADS 874060205 3,615 210,146 SH   SOLE   210,146 0 0
Teleflex Inc. Common 879369106 2,167 6,379 SH   SOLE   6,379 0 0
Tenet Healthcare Corp. Common 88033G407 3,122 141,136 SH   SOLE   141,136 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N204 229 42,966 SH   SOLE   42,966 0 0
Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 5,407 785,851 SH   SOLE   785,851 0 0
Theravance Biopharma, Inc. Common G8807B106 898 46,101 SH   SOLE   46,101 0 0
Thermo Fisher Scientific Inc. Common 883556102 26,013 89,310 SH   SOLE   89,310 0 0
Trillium Therapeutics Inc. Common 89620X506 137 446,099 SH   SOLE   446,099 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 4,170 97,480 SH   SOLE   97,480 0 0
uniQure B.V. Shares N90064101 1,726 43,849 SH   SOLE   43,849 0 0
United Therapeutics Corp. Class B 91307C102 4,314 54,094 SH   SOLE   54,094 0 0
Unitedhealth Group Inc. Common 91324P102 73,298 337,283 SH   SOLE   337,283 0 0
Ventas, Inc. Common 92276F100 10,306 141,119 SH   SOLE   141,119 0 0
Verona Pharma plc Sponsored ADR 925050106 1,257 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Inc. Common 92532F100 82,547 487,234 SH   SOLE   487,234 0 0
WaVe Life Sciences Ltd. Shares Y95308105 2,516 122,551 SH   SOLE   122,551 0 0
Welltower Inc. Common 95040Q104 13,808 152,322 SH   SOLE   152,322 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 2,558 124,006 SH   SOLE   124,006 0 0
Xencor, Inc. Common 98401F105 5,000 148,231 SH   SOLE   148,231 0 0
Zai Lab Ltd. ADR 98887Q104 1,214 37,523 SH   SOLE   37,523 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 10,648 77,571 SH   SOLE   77,571 0 0
Zoetis Inc. Class A 98978V103 31,026 249,024 SH   SOLE   249,024 0 0
Zogenix, Inc. Common 98978L204 2,485 62,074 SH   SOLE   62,074 0 0
Zymeworks Inc. Common 98985W102 377 15,192 SH   SOLE   15,192 0 0