The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADMA BIOLOGICS INC COM 000899104 2,251 505,900 SH   DFND 1 505,900 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 1,155 100,000 SH   DFND 1 100,000 0 0
ABBVIE INC COM 00287Y109 11,699 154,500 SH   DFND 1 154,500 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 1,750 1,620,000 SH   DFND 1 1,620,000 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 23,786 1,569,011 SH   DFND 1 1,569,011 0 0
ANTARES PHARMA INC COM 036642106 4,471 1,336,700 SH   DFND 1 1,336,700 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 12,907 3,102,673 SH   DFND 1 3,102,673 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 18,103 4,300,066 SH   DFND 1 4,300,066 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 4,674 880,303 SH   DFND 1 880,303 0 0
DERMIRA INC COM 24983L104 3,704 579,600 SH   DFND 1 579,600 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 14,016 1,367,377 SH   DFND 1 1,367,377 0 0
EXAGEN INC COM 30068X103 4,822 311,284 SH   DFND 1 311,284 0 0
EXICURE INC COM 30205M101 5,849 2,311,906 SH   DFND 1 2,311,906 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 3,451 30,000 SH   DFND 1 30,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 8,589 177,016 SH   DFND 1 177,016 0 0
HERON THERAPEUTICS INC COM 427746102 1,817 98,237 SH   DFND 1 98,237 0 0
HERON THERAPEUTICS INC COM 427746102 1,850 100,000 SH Call DFND 1 100,000 0 0
ICU MED INC COM 44930G107 4,788 30,000 SH   DFND 1 30,000 0 0
INTERSECT ENT INC COM 46071F103 13,253 779,134 SH   DFND 1 779,134 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 20,586 1,131,101 SH   DFND 1 1,131,101 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 1,600 181,844 SH   DFND 1 181,844 0 0
MIRATI THERAPEUTICS INC COM 60468T105 15,582 200,000 SH Call DFND 1 200,000 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 2,392 110,800 SH   DFND 1 110,800 0 0
NEVRO CORP COM 64157F103 12,939 150,510 SH   DFND 1 150,510 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 952 1,047,310 SH   DFND 1 1,047,310 0 0
PROGENICS PHARMACEUTICALS IN COM 743187106 8,007 1,583,925 SH   DFND 1 1,583,925 0 0
RECRO PHARMA INC COM 75629F109 10,944 987,760 SH   DFND 1 987,760 0 0
RETROPHIN INC COM 761299106 7,075 610,414 SH   DFND 1 610,414 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 130,579 440,000 SH Put DFND 1 440,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 53,375 700,000 SH Put DFND 1 700,000 0 0
SI BONE INC COM 825704109 3,946 223,291 SH   DFND 1 223,291 0 0
SIENTRA INC COM 82621J105 12,972 2,001,895 SH   DFND 1 2,001,895 0 0
STRATA SKIN SCIENCES INC COM NEW 86272A206 6,271 2,916,915 SH   DFND 1 2,916,915 0 0
VERICEL CORP COM 92346J108 3,589 237,050 SH   DFND 1 237,050 0 0
VIEWRAY INC COM 92672L107 8,704 3,001,361 SH   DFND 1 3,001,361 0 0
ZOGENIX INC COM NEW 98978L204 5,527 138,037 SH   DFND 1 138,037 0 0
ALKERMES PLC SHS G01767105 4,858 249,000 SH   DFND 1 249,000 0 0
ALLERGAN PLC SHS G0177J108 16,241 96,504 SH   DFND 1 96,504 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 22,220 532,591 SH   DFND 1 532,591 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 20,860 500,000 SH Call DFND 1 500,000 0 0
QUOTIENT LTD SHS G73268107 4,766 613,429 SH   DFND 1 613,429 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 6,161 2,578,003 SH   DFND 1 2,578,003 0 0
SOL GEL TECHNOLOGIES SHS M8694L103 5,064 563,300 SH   DFND 1 563,300 0 0
WRIGHT MED GROUP N V ORD SHS N96617118 12,760 618,500 SH   DFND 1 618,500 0 0