The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ADAMAS PHARMACEUTICALS INC COM 00548A106 2,742 536,000 SH   DFND 1 536,000 0 0
AETERNA ZENTARIS INC COM 007975402 494 480,000 SH   DFND 1 480,000 0 0
ALIMERA SCIENCES INC COM 016259103 3,362 5,936,000 SH   DFND 1 5,936,000 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 46,893 4,060,000 SH   DFND 1 4,060,000 0 0
AMAZON COM INC COM 023135106 5,208 3,000 SH   DFND 1 3,000 0 0
ANTARES PHARMA INC COM 036642106 18,812 5,624,000 SH   DFND 1 5,624,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 24,260 2,468,000 SH   DFND 1 2,468,000 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 17,865 636,000 SH   DFND 1 636,000 0 0
AVAYA HLDGS CORP COM 05351X101 5,320 520,000 SH   DFND 1 520,000 0 0
AYTU BIOSCIENCE INC COM PAR 054754700 6,195 5,120,064 SH   DFND 1 5,120,064 0 0
BELLEROPHON THERAPEUTICS INC COM 078771102 427 885,000 SH   DFND 1 885,000 0 0
BELLICUM PHARMACEUTICALS INC COM 079481107 1,087 1,034,962 SH   DFND 1 1,034,962 0 0
BIOGEN INC COM 09062X103 34,457 148,000 SH   DFND 1 148,000 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 24,114 578,000 SH   DFND 1 578,000 0 0
CAPSTONE TURBINE CORP COM NEW 14067D409 2,670 835,000 SH   DFND 1 835,000 0 0
CELGENE CORP COM 151020104 50,842 512,000 SH   DFND 1 512,000 0 0
CERECOR INC COM 15671L109 68,048 20,683,233 SH   DFND 1 20,683,233 0 0
CHIPOTLE MEXICAN GRILL INC COM 169656105 25,214 30,000 SH   DFND 1 30,000 0 0
CITIUS PHARMACEUTICALS INC COM NEW 17322U207 2,468 2,197,385 SH   DFND 1 2,197,385 0 0
CLOVIS ONCOLOGY INC COM 189464100 7,860 20,000 SH Call DFND 1 20,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 10,821 264,000 SH   DFND 1 264,000 0 0
DIPLOMAT PHARMACY INC COM 25456K101 26,460 5,400,000 SH   DFND 1 5,400,000 0 0
DROPBOX INC CL A 26210C104 20,170 1,000,000 SH   DFND 1 1,000,000 0 0
DYNATRONICS CORP COM NEW 268157401 1,309 536,000 SH   DFND 1 536,000 0 0
EDGEWELL PERS CARE CO COM 28035Q102 48,735 15,000 SH Call DFND 1 15,000 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 34,846 580,000 SH   DFND 1 580,000 0 0
ENERGIZER HLDGS INC NEW COM 29272W109 34,864 800,000 SH   DFND 1 800,000 0 0
EYEGATE PHARMACEUTICALS INC COM NEW 30233M503 8,438 1,792,500 SH   DFND 1 1,792,500 0 0
FOOT LOCKER INC COM 344849104 26,543 615,000 SH   DFND 1 615,000 0 0
FRONTDOOR INC COM 35905A109 19,039 392,000 SH   DFND 1 392,000 0 0
HAIN CELESTIAL GROUP INC COM 405217100 36,508 17,000 SH Call DFND 1 17,000 0 0
HOSTESS BRANDS INC CL A 44109J106 8,111 580,000 SH   DFND 1 580,000 0 0
INCYTE CORP COM 45337C102 31,770 428,000 SH   DFND 1 428,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 90,804 6,000 SH Put DFND 1 6,000 0 0
KRAFT HEINZ CO COM 500754106 41,903 1,500,000 SH   DFND 1 1,500,000 0 0
L BRANDS INC COM 501797104 8,032 410,000 SH   DFND 1 410,000 0 0
LOWES COS INC COM 548661107 12,755 116,000 SH   DFND 1 116,000 0 0
LULULEMON ATHLETICA INC COM 550021109 25,992 135,000 SH   DFND 1 135,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 9,312 108,000 SH   DFND 1 108,000 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 9,640 40,000 SH Call DFND 1 40,000 0 0
MEDIGUS LTD SPONSORED ADS 58471G300 809 1,285,715 SH   DFND 1 1,285,715 0 0
MERCK & CO INC COM 58933Y105 11,448 136,000 SH   DFND 1 136,000 0 0
O REILLY AUTOMOTIVE INC NEW COM 67103H107 26,899 67,500 SH   DFND 1 67,500 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 6,791 1,572,000 SH   DFND 1 1,572,000 0 0
PTC THERAPEUTICS INC COM 69366J200 4,600 136,000 SH   DFND 1 136,000 0 0
RALPH LAUREN CORP CL A 751212101 22,149 232,000 SH   DFND 1 232,000 0 0
REGENERON PHARMACEUTICALS COM 75886F107 41,055 148,000 SH   DFND 1 148,000 0 0
RESTAURANT BRANDS INTL INC COM 76131D103 12,805 180,000 SH   DFND 1 180,000 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 2,207 1,793,666 SH   DFND 1 1,793,666 0 0
SPARK THERAPEUTICS INC COM 84652J103 24,245 250,000 SH   DFND 1 250,000 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 237,416 8,000 SH Put DFND 1 8,000 0 0
TARGET CORP COM 87612E106 25,658 240,000 SH   DFND 1 240,000 0 0
TRACTOR SUPPLY CO COM 892356106 9,768 108,000 SH   DFND 1 108,000 0 0
ULTA BEAUTY INC COM 90384S303 11,655 46,500 SH   DFND 1 46,500 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 18,343 230,000 SH   DFND 1 230,000 0 0
UNITEDHEALTH GROUP INC COM 91324P102 19,124 88,000 SH   DFND 1 88,000 0 0
URBAN OUTFITTERS INC COM 917047102 4,775 170,000 SH   DFND 1 170,000 0 0
V F CORP COM 918204108 25,362 285,000 SH   DFND 1 285,000 0 0
VALERITAS HLDGS INC COM 91914N301 1,516 1,060,000 SH   DFND 1 1,060,000 0 0
VANDA PHARMACEUTICALS INC COM 921659108 47,117 3,548,000 SH   DFND 1 3,548,000 0 0
VAXART INC COM NEW 92243A200 8,616 24,000,000 SH   DFND 1 24,000,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 5,083 30,000 SH   DFND 1 30,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 18,862 1,096,000 SH   DFND 1 1,096,000 0 0
WELBILT INC COM 949090104 35,271 2,092,000 SH   DFND 1 2,092,000 0 0
WENDYS CO COM 95058W100 19,980 1,000,000 SH   DFND 1 1,000,000 0 0
WINGSTOP INC COM 974155103 12,917 148,000 SH   DFND 1 148,000 0 0