The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10x Genomics Inc CL A COM 88025U109 252 5,000 SH   SOLE 1, 2 5,000 0 0
Achillion Pharmaceuticals In COM 00448Q201 49,912 13,864,383 SH   SOLE 1, 2 13,864,383 0 0
Adverum Biotechnologies Inc COM 00773U108 34,231 6,281,003 SH   SOLE 1, 2 6,281,003 0 0
Agenus Inc COM NEW 00847G705 23,770 9,213,191 SH   SOLE 1, 2 9,213,191 0 0
Alnylam Pharmaceuticals Inc COM 02043Q107 142,153 1,767,628 SH   SOLE 1, 2 1,767,628 0 0
Apyx Med Corp COM 03837C106 22,817 3,370,279 SH   SOLE 1, 2 3,370,279 0 0
Arbutus Biopharma Corp COM 03879J100 8,484 5,562,967 SH   SOLE 1, 2 5,562,967 0 0
argenx SE SPONSORED ADR 04016X101 3,592 31,516 SH   SOLE 1, 2 31,516 0 0
Arvinas Inc COM 04335A105 17,447 809,623 SH   SOLE 1, 2 809,623 0 0
Axonics Modulation Tech Inc COM 05465P101 41,312 1,534,605 SH   SOLE 1, 2 1,534,605 0 0
Axsome Therapeutics Inc COM 05464T104 17,125 846,121 SH   SOLE 1, 2 846,121 0 0
Bellus Health Inc New COM NEW 07987C204 26,856 4,178,156 SH   SOLE 1, 2 4,178,156 0 0
Brainsway Ltd SPONSORED ADS 10501L106 7,604 834,687 SH   SOLE 1, 2 834,687 0 0
Bristol Myers Squibb Co COM 110122108 79,377 1,565,307 SH   SOLE 1, 2 1,565,307 0 0
CareDx Inc COM 14167L103 3,503 154,951 SH   SOLE 1, 2 154,951 0 0
Castle Biosciences Inc COM 14843C105 13,478 745,045 SH   SOLE 1, 2 745,045 0 0
Chardan Healthcare Acquisiti UNIT 12/13/2023 15957A207 7,182 600,000 SH   SOLE 1, 2 600,000 0 0
Clearside Biomedical Inc COM 185063104 2,361 3,747,699 SH   SOLE 1, 2 3,747,699 0 0
Cytomx Therapeutics Inc COM 23284F105 7,310 990,463 SH   SOLE 1, 2 990,463 0 0
DermTech Inc COM 24984K105 12,498 2,386,871 SH   SOLE 1, 2 2,386,871 0 0
Dicerna Pharmaceuticals Inc COM 253031108 89,067 6,202,425 SH   SOLE 1, 2 6,202,425 0 0
Establishment Labs Hldgs Inc COM G31249108 38,570 2,039,681 SH   SOLE 1, 2 2,039,681 0 0
Exagen Inc COM 30068X103 7,925 511,633 SH   SOLE 1, 2 511,633 0 0
Fluidigm Corp Del COM 34385P108 9,767 2,109,500 SH   SOLE 1, 2 2,109,500 0 0
Homology Medicines Inc COM 438083107 44,336 2,449,478 SH   SOLE 1, 2 2,449,478 0 0
Inmode Ltd SHS M5425M103 5,378 250,000 SH   SOLE 1, 2 250,000 0 0
Insulet Corp COM 45784P101 18,345 111,232 SH   SOLE 1, 2 111,232 0 0
Johnson & Johnson COM 478160104 15,119 116,858 SH   SOLE 1, 2 116,858 0 0
La Jolla Pharmaceutical Co COM PAR $.0001 2 503459604 17,743 2,016,269 SH   SOLE 1, 2 2,016,269 0 0
Livongo Health Inc COM 539183103 262 15,000 SH   SOLE 1, 2 15,000 0 0
Masimo Corp COM 574795100 55,224 371,155 SH   SOLE 1, 2 371,155 0 0
Milestone Pharmaceuticals In COM 59935V107 63,819 3,521,856 SH   SOLE 1, 2 3,521,856 0 0
MiMedx Group Inc COM 602496101 14,524 2,964,000 SH   SOLE 1, 2 2,964,000 0 0
Mirati Therapeutics Inc COM 60468T105 46,183 592,776 SH   SOLE 1, 2 592,776 0 0
Motus Gi Hldgs Inc COM 62014P108 1,338 675,640 SH   SOLE 1, 2 675,640 0 0
Myokardia Inc COM 62857M105 37,810 725,025 SH   SOLE 1, 2 725,025 0 0
Natera Inc COM 632307104 9,429 287,470 SH   SOLE 1, 2 287,470 0 0
Neuronetics Inc COM 64131A105 1,394 167,728 SH   SOLE 1, 2 167,728 0 0
Odonate Therapeutics Inc COM 676079106 8,847 339,892 SH   SOLE 1, 2 339,892 0 0
Optinose Inc COM 68404V100 615 87,805 SH   SOLE 1, 2 87,805 0 0
Personalis Inc COM 71535D106 3,742 255,000 SH   SOLE 1, 2 255,000 0 0
Principia Biopharma Inc COM 74257L108 7,652 270,948 SH   SOLE 1, 2 270,948 0 0
ProQR Thrapeutics N V SHS EURO N71542109 21,317 3,700,833 SH   SOLE 1, 2 3,700,833 0 0
Protagonist Therapeutics Inc COM 74366E102 9,155 762,283 SH   SOLE 1, 2 762,283 0 0
PTC Therapeutics Inc COM 69366J200 123,489 3,651,361 SH   SOLE 1, 2 3,651,361 0 0
Quidel Corp COM 74838J101 10,828 176,495 SH   SOLE 1, 2 176,495 0 0
Quotient Ltd SHS G73268107 9,954 1,281,143 SH   SOLE 1, 2 1,281,143 0 0
Regenxbio Inc COM 75901B107 10,366 291,168 SH   SOLE 1, 2 291,168 0 0
Rocket Pharmaceuticals Inc COM 77313F106 192,503 16,587,491 SH   SOLE 1, 2, 3, 4 16,587,491 0 0
Sarepta Therapeutics Inc COM 803607100 54,555 724,311 SH   SOLE 1, 2 724,311 0 0
Silk Road Medical Inc COM 82710M100 7,961 244,716 SH   SOLE 1, 2 244,716 0 0
Solid Biosciences Inc COM 83422E105 1,505 145,541 SH   SOLE 1, 2 145,541 0 0
Stoke Therapeutics Inc COM 86150R107 69,401 3,355,466 SH   SOLE 1, 2 3,355,466 0 0
Sunesis Pharmaceuticals Inc COM 867328700 5,000 6,946,074 SH   SOLE 1, 2 6,946,074 0 0
Translate Bio Inc COM 89374L104 31,203 3,148,628 SH   SOLE 1, 2 3,148,628 0 0
Transmedics Group Inc COM 89377M109 11,953 503,266 SH   SOLE 1, 2 503,266 0 0
Uniqure NV SHS N90064101 5,704 144,909 SH   SOLE 1, 2 144,909 0 0
Vericel Corp COM 92346J108 40,053 2,645,476 SH   SOLE 1, 2 2,645,476 0 0
Vivus Inc 4.5 05/01/2020 NOTE 4.500% 5/0 928551AA8 2,920 4,000,000 SH   SOLE 1 4,000,000 0 0
Zimmer Biomet Hldgs Inc COM 98956P102 55,320 403,000 SH   SOLE 1, 2 403,000 0 0