The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics COMM 00461U105 2,064 1,911,573 SH   SOLE   1,911,573 0 0
Amarin ADR 023111206 78,958 5,208,305 SH   SOLE   5,208,305 0 0
Apellis Pharmaceuticals, Inc COMM 03753U106 1,194 49,580 SH   SOLE   49,580 0 0
Ascendis Pharma A/S ADR 04351P101 106,903 1,109,874 SH   SOLE   1,109,874 0 0
Audentes Therapeutics COMM 05070R104 26,226 933,640 SH   SOLE   933,640 0 0
Chiasma COMM 16706W102 8,070 1,630,221 SH   SOLE   1,630,221 0 0
Coherus BioSciences COMM 19249H103 39,167 1,933,221 SH   SOLE   1,933,221 0 0
Entasis Therapeutics Holdings Inc. COMM 293614103 7,034 1,180,178 SH   SOLE   1,180,178 0 0
Iterum Therapeutics COMM G6333L101 9,962 1,726,514 SH   SOLE   1,726,514 0 0
Karuna Therapeutics, Inc. COMM 48576A100 28,223 1,729,352 SH   SOLE   1,729,352 0 0
Kiniksa Pharmaceuticals, Ltd COMM CL A G5269C101 7,852 922,700 SH   SOLE   922,700 0 0
Merus N.V. COMM N5749R100 34,946 1,961,039 SH   SOLE   1,961,039 0 0
Natera COMM 632307104 101,698 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure, Inc COMM 65343E108 77,799 2,521,856 SH   SOLE   2,521,856 0 0
Nucana Biomed Ltd ADR 67022C106 16,411 2,266,666 SH   SOLE   2,266,666 0 0
Nucana Biomed Ltd Ordinary Shares GB00BYWYV 17,376 2,400,000 SH   SOLE   2,400,000 0 0
ObsEva SA COMM H5861P103 39,564 4,749,623 SH   SOLE   4,749,623 0 0
PDS Biotechnology Corporation COMM 70465T107 482 142,635 SH   SOLE   142,635 0 0
Principia Biopharma COMM 74257L108 40,023 1,417,258 SH   SOLE   1,417,258 0 0
Spark Therapeutics COMM 84652J103 46,674 481,270 SH   SOLE   481,270 0 0
Synlogic Inc. COMM 87166L100 1,317 574,972 SH   SOLE   574,972 0 0
Y-mAbs Therapeutics, Inc COMM 984241109 54,837 2,104,278 SH   SOLE   2,104,278 0 0
Acceleron Pharma Inc COMM 00434H108 4,727 119,653 SH   SOLE   119,653 0 0
Aimmune Therapeutics Inc COMM 00900T107 2,128 101,630 SH   SOLE   101,630 0 0
Akebia Therapeutics Inc COMM 00972D105 1,452 370,288 SH   SOLE   370,288 0 0
Align Technology Inc COMM 016255101 546 3,017 SH   SOLE   3,017 0 0
Allergan plc COMM G0177J108 8,159 48,481 SH   SOLE   48,481 0 0
Amgen Inc COMM 031162100 5,235 27,051 SH   SOLE   27,051 0 0
Amicus Therapeutics Inc COMM 03152W109 2,677 333,834 SH   SOLE   333,834 0 0
Applied Therapeutics Inc COMM 03828A101 553 50,350 SH   SOLE   50,350 0 0
ArQule Inc COMM 04269E107 856 119,395 SH   SOLE   119,395 0 0
Beigene Ltd COMM 07725L902 1,861 15,200 SH Call SOLE   15,200 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 441 153,942 SH   SOLE   153,942 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 2,024 30,029 SH   SOLE   30,029 0 0
Bristol-Myers Squibb Co COMM 110122108 7,109 140,193 SH   SOLE   140,193 0 0
Calithera Biosciences Inc COMM 13089P101 885 286,326 SH   SOLE   286,326 0 0
Cytokinetics Inc COMM 23282W605 704 61,838 SH   SOLE   61,838 0 0
Dermira Inc COMM 24983L104 1,854 290,195 SH   SOLE   290,195 0 0
Dicerna Pharmaceuticals Inc COMM 253031108 1,443 100,454 SH   SOLE   100,454 0 0
Fate Therapeutics Inc COMM 31189P102 1,737 111,838 SH   SOLE   111,838 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 1,243 408,895 SH   SOLE   408,895 0 0
Forty Seven Inc COMM 34983P104 998 155,394 SH   SOLE   155,394 0 0
Halozyme Therapeutics Inc COMM 40637H109 2,892 186,446 SH   SOLE   186,446 0 0
Health Care Select Sector SPDR COMM 81369Y950 8,202 91,000 SH Put SOLE   91,000 0 0
Heron Therapeutics Inc COMM 427746902 995 53,800 SH Call SOLE   53,800 0 0
Heron Therapeutics Inc COMM 427746102 562 30,358 SH   SOLE   30,358 0 0
Homology Medicines Inc COMM 438083107 776 42,877 SH   SOLE   42,877 0 0
Kadmon Holdings Inc COMM 48283N106 1,959 777,390 SH   SOLE   777,390 0 0
Kala Pharmaceuticals Inc COMM 483119103 549 144,378 SH   SOLE   144,378 0 0
MacroGenics Inc COMM 556099109 2,211 173,299 SH   SOLE   173,299 0 0
Mirati Therapeutics Inc COMM 60468T105 703 9,027 SH   SOLE   9,027 0 0
MyoKardia Inc COMM 62857M105 1,759 33,728 SH   SOLE   33,728 0 0
Neurocrine Biosciences Inc COMM 64125C109 5,070 56,260 SH   SOLE   56,260 0 0
Orchard Therapeutics PLC ADR 68570P101 1,022 85,987 SH   SOLE   85,987 0 0
Otonomy Inc COMM 68906L105 1,118 467,940 SH   SOLE   467,940 0 0
PTC Therapeutics Inc COMM 69366J200 2,847 84,185 SH   SOLE   84,185 0 0
Pfizer Inc COMM 717081103 4,480 124,684 SH   SOLE   124,684 0 0
Reata Pharmaceuticals Inc COMM 75615P953 3,581 44,600 SH Put SOLE   44,600 0 0
Reata Pharmaceuticals Inc COMM 75615P103 3,475 43,278 SH   SOLE   43,278 0 0
Sarepta Therapeutics Inc COMM 803607100 2,348 31,169 SH   SOLE   31,169 0 0
Savara Inc COMM 805111101 424 160,124 SH   SOLE   160,124 0 0
Sunesis Pharmaceuticals Inc COMM 867328700 248 344,373 SH   SOLE   344,373 0 0
Syndax Pharmaceuticals Inc COMM 87164F905 226 30,300 SH Call SOLE   30,300 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 548 73,313 SH   SOLE   73,313 0 0
Syndax Pharmaceuticals Inc COMM 87164F955 445 59,600 SH Put SOLE   59,600 0 0
TG Therapeutics Inc COMM 88322Q108 2,853 508,086 SH   SOLE   508,086 0 0
United Therapeutics Corp COMM 91307C102 4,535 56,861 SH   SOLE   56,861 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 5,933 35,022 SH   SOLE   35,022 0 0
XBiotech Inc COMM 98400H102 1,118 106,899 SH   SOLE   106,899 0 0
Zymeworks Inc COMM 98985W102 1,417 57,154 SH   SOLE   57,154 0 0
Acceleron Pharma Inc COMM 00434H108 2,884 72,988 SH   OTR 1 72,988 0 0
Aimmune Therapeutics Inc COMM 00900T107 1,298 61,995 SH   OTR 1 61,995 0 0
Akebia Therapeutics Inc COMM 00972D105 848 216,441 SH   OTR 1 216,441 0 0
Align Technology Inc COMM 016255101 320 1,767 SH   OTR 1 1,767 0 0
Allergan plc COMM G0177J108 4,843 28,776 SH   OTR 1 28,776 0 0
Amgen Inc COMM 031162100 3,193 16,501 SH   OTR 1 16,501 0 0
Amicus Therapeutics Inc COMM 03152W109 1,555 193,920 SH   OTR 1 193,920 0 0
Applied Therapeutics Inc COMM 03828A101 333 30,324 SH   OTR 1 30,324 0 0
ArQule Inc COMM 04269E107 498 69,485 SH   OTR 1 69,485 0 0
Beigene Ltd COMM 07725L902 1,078 8,800 SH Call OTR 1 8,800 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 262 91,299 SH   OTR 1 91,299 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 1,221 18,115 SH   OTR 1 18,115 0 0
Bristol-Myers Squibb Co COMM 110122108 4,337 85,519 SH   OTR 1 85,519 0 0
Calithera Biosciences Inc COMM 13089P101 530 171,514 SH   OTR 1 171,514 0 0
Cytokinetics Inc COMM 23282W605 429 37,721 SH   OTR 1 37,721 0 0
Dermira Inc COMM 24983L104 1,131 177,021 SH   OTR 1 177,021 0 0
Dicerna Pharmaceuticals Inc COMM 253031108 880 61,277 SH   OTR 1 61,277 0 0
Fate Therapeutics Inc COMM 31189P102 1,059 68,222 SH   OTR 1 68,222 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 701 230,742 SH   OTR 1 230,742 0 0
Forty Seven Inc COMM 34983P104 587 91,363 SH   OTR 1 91,363 0 0
Halozyme Therapeutics Inc COMM 40637H109 1,764 113,733 SH   OTR 1 113,733 0 0
Health Care Select Sector SPDR COMM 81369Y950 4,759 52,800 SH Put OTR 1 52,800 0 0
Heron Therapeutics Inc COMM 427746102 577 31,200 SH Call OTR 1 31,200 0 0
Heron Therapeutics Inc COMM 427746102 343 18,523 SH   OTR 1 18,523 0 0
Homology Medicines Inc COMM 438083107 473 26,155 SH   OTR 1 26,155 0 0
Kadmon Holdings Inc COMM 48283N106 1,182 468,954 SH   OTR 1 468,954 0 0
Kala Pharmaceuticals Inc COMM 483119103 321 84,381 SH   OTR 1 84,381 0 0
MacroGenics Inc COMM 556099109 1,318 103,265 SH   OTR 1 103,265 0 0
Mirati Therapeutics Inc COMM 60468T105 429 5,506 SH   OTR 1 5,506 0 0
MyoKardia Inc COMM 62857M105 1,057 20,263 SH   OTR 1 20,263 0 0
Neurocrine Biosciences Inc COMM 64125C109 3,085 34,231 SH   OTR 1 34,231 0 0
Orchard Therapeutics PLC ADR 68570P101 595 50,089 SH   OTR 1 50,089 0 0
Otonomy Inc COMM 68906L105 678 283,853 SH   OTR 1 283,853 0 0
PTC Therapeutics Inc COMM 69366J200 1,737 51,353 SH   OTR 1 51,353 0 0
Pfizer Inc COMM 717081103 2,602 72,427 SH   OTR 1 72,427 0 0
Reata Pharmaceuticals Inc COMM 75615P953 2,071 25,800 SH Put OTR 1 25,800 0 0
Reata Pharmaceuticals Inc COMM 75615P103 2,139 26,647 SH   OTR 1 26,647 0 0
Sarepta Therapeutics Inc COMM 803607100 1,437 19,075 SH   OTR 1 19,075 0 0
Savara Inc COMM 805111101 246 93,014 SH   OTR 1 93,014 0 0
Sunesis Pharmaceuticals Inc COMM 867328700 144 200,133 SH   OTR 1 200,133 0 0
Syndax Pharmaceuticals Inc COMM 87164F905 131 17,600 SH Call OTR 1 17,600 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 321 42,941 SH   OTR 1 42,941 0 0
Syndax Pharmaceuticals Inc COMM 87164F955 263 35,200 SH Put OTR 1 35,200 0 0
TG Therapeutics Inc COMM 88322Q108 1,740 309,936 SH   OTR 1 309,936 0 0
United Therapeutics Corp COMM 91307C102 2,766 34,685 SH   OTR 1 34,685 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 3,713 21,918 SH   OTR 1 21,918 0 0
XBiotech Inc COMM 98400H102 661 63,236 SH   OTR 1 63,236 0 0
Zymeworks Inc COMM 98985W102 825 33,283 SH   OTR 1 33,283 0 0
Acceleron Pharma Inc COMM 00434H108 8,519 215,621 SH   OTR 2 215,621 0 0
Aimmune Therapeutics Inc COMM 00900T107 3,835 183,145 SH   OTR 2 183,145 0 0
Akebia Therapeutics Inc COMM 00972D105 2,511 640,462 SH   OTR 2 640,462 0 0
Align Technology Inc COMM 016255101 944 5,216 SH   OTR 2 5,216 0 0
Allergan plc COMM G0177J108 9,622 57,176 SH   OTR 2 57,176 0 0
Amgen Inc COMM 031162100 9,433 48,748 SH   OTR 2 48,748 0 0
Amicus Therapeutics Inc COMM 03152W109 1,566 195,220 SH   OTR 2 195,220 0 0
Applied Therapeutics Inc COMM 03828A101 674 61,330 SH   OTR 2 61,330 0 0
ArQule Inc COMM 04269E107 1,466 204,507 SH   OTR 2 204,507 0 0
Beigene Ltd COMM 07725L902 3,184 26,000 SH Call OTR 2 26,000 0 0
BioCryst Pharmaceuticals Inc COMM 09058V103 778 271,493 SH   OTR 2 271,493 0 0
Biomarin Pharmaceutical Inc COMM 09061G101 2,477 36,752 SH   OTR 2 36,752 0 0
Bristol-Myers Squibb Co COMM 110122108 12,811 252,637 SH   OTR 2 252,637 0 0
Calithera Biosciences Inc COMM 13089P101 1,567 507,012 SH   OTR 2 507,012 0 0
Cytokinetics Inc COMM 23282W605 1,268 111,433 SH   OTR 2 111,433 0 0
Dermira Inc COMM 24983L104 3,342 522,952 SH   OTR 2 522,952 0 0
Dicerna Pharmaceuticals Inc COMM 253031108 2,600 181,024 SH   OTR 2 181,024 0 0
Fate Therapeutics Inc COMM 31189P102 3,130 201,540 SH   OTR 2 201,540 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 1,701 559,617 SH   OTR 2 559,617 0 0
Forty Seven Inc COMM 34983P104 1,750 272,541 SH   OTR 2 272,541 0 0
Halozyme Therapeutics Inc COMM 40637H109 5,211 335,988 SH   OTR 2 335,988 0 0
Health Care Select Sector SPDR COMM 81369Y950 14,078 156,200 SH Put OTR 2 156,200 0 0
Heron Therapeutics Inc COMM 427746102 1,706 92,200 SH Call OTR 2 92,200 0 0
Heron Therapeutics Inc COMM 427746102 1,012 54,721 SH   OTR 2 54,721 0 0
Homology Medicines Inc COMM 438083107 1,398 77,265 SH   OTR 2 77,265 0 0
Kadmon Holdings Inc COMM 48283N106 3,436 1,363,414 SH   OTR 2 1,363,414 0 0
Kala Pharmaceuticals Inc COMM 483119103 949 249,447 SH   OTR 2 249,447 0 0
MacroGenics Inc COMM 556099109 3,892 304,990 SH   OTR 2 304,990 0 0
Mirati Therapeutics Inc COMM 60468T105 1,267 16,267 SH   OTR 2 16,267 0 0
MyoKardia Inc COMM 62857M105 3,126 59,935 SH   OTR 2 59,935 0 0
Neurocrine Biosciences Inc COMM 64125C109 9,118 101,188 SH   OTR 2 101,188 0 0
Orchard Therapeutics PLC ADR 68570P101 1,750 147,330 SH   OTR 2 147,330 0 0
Otonomy Inc COMM 68906L105 1,640 686,172 SH   OTR 2 686,172 0 0
PTC Therapeutics Inc COMM 69366J200 5,131 151,707 SH   OTR 2 151,707 0 0
Pfizer Inc COMM 717081103 7,671 213,496 SH   OTR 2 213,496 0 0
Portola Pharmaceuticals Inc COMM 737010108 1,588 59,191 SH   OTR 2 59,191 0 0
Reata Pharmaceuticals Inc COMM 75615P953 6,279 78,200 SH Put OTR 2 78,200 0 0
Reata Pharmaceuticals Inc COMM 75615P103 6,322 78,744 SH   OTR 2 78,744 0 0
Sarepta Therapeutics Inc COMM 803607100 4,231 56,170 SH   OTR 2 56,170 0 0
Savara Inc COMM 805111101 727 274,180 SH   OTR 2 274,180 0 0
Sunesis Pharmaceuticals Inc COMM 867328700 424 589,441 SH   OTR 2 589,441 0 0
Syndax Pharmaceuticals Inc COMM 87164F905 389 52,100 SH Call OTR 2 52,100 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 948 126,896 SH   OTR 2 126,896 0 0
Syndax Pharmaceuticals Inc COMM 87164F955 786 105,200 SH Put OTR 2 105,200 0 0
TG Therapeutics Inc COMM 88322Q108 5,141 915,606 SH   OTR 2 915,606 0 0
United Therapeutics Corp COMM 91307C102 8,172 102,468 SH   OTR 2 102,468 0 0
Vertex Pharmaceuticals Inc COMM 92532F100 10,970 64,750 SH   OTR 2 64,750 0 0
XBiotech Inc COMM 98400H102 1,972 188,528 SH   OTR 2 188,528 0 0
Zymeworks Inc COMM 98985W102 2,430 98,001 SH   OTR 2 98,001 0 0