The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 4,910 27,600 SH   DFND 1 27,600 0 0
ACCELERON PHARMA INC COM 00434H108 51,567 1,305,174 SH   DFND 1 1,305,174 0 0
ADDUS HOMECARE CORP COM 006739106 20,051 252,915 SH   DFND 1 252,915 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 3,845 500,046 SH   DFND 1 500,046 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 87,813 4,568,824 SH   DFND 1 4,568,824 0 0
AGILE THERAPEUTICS INC COM 00847L100 1,886 1,591,652 SH   DFND 1 1,591,652 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 7,109 339,480 SH   DFND 1 339,480 0 0
ALECTOR INC COM 014442107 29,948 2,076,812 SH   DFND 1 2,076,812 0 0
ALIMERA SCIENCES INC COM 016259103 4,000 7,062,607 SH   DFND 1 7,062,607 0 0
ALPHATEC HOLDINGS INC COM NEW 02081G201 2,693 536,517 SH   DFND 1 536,517 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 1,611 406,926 SH   DFND 1 406,926 0 0
ANAPTYSBIO INC COM 032724106 14,886 425,443 SH   DFND 1 425,443 0 0
ARDELYX INC COM 039697107 15,982 3,400,410 SH   DFND 1 3,400,410 0 0
ARGENX SE SPONSORED ADR 04016X101 32,023 281,000 SH   DFND 1 281,000 0 0
ARVINAS INC COM 04335A105 19,853 921,234 SH   DFND 1 921,234 0 0
ATRICURE INC COM 04963C209 7,302 292,777 SH   DFND 1 292,777 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 13,874 493,901 SH   DFND 1 493,901 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 11,325 2,722,241 SH   DFND 1 2,722,241 0 0
AVROBIO INC COM 05455M100 7,060 500,000 SH   DFND 1 500,000 0 0
AXOGEN INC COM 05463X106 22,992 1,842,330 SH   DFND 1 1,842,330 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 7,949 2,774,643 SH   DFND 1 2,774,643 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 3,436 816,096 SH   DFND 1 816,096 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 27,713 377,200 SH   DFND 1 377,200 0 0
BRIDGEBIO PHARMA INC COM 10806X102 6,226 290,000 SH   DFND 1 290,000 0 0
BROOKDALE SR LIVING INC COM 112463104 54,631 7,207,239 SH   DFND 1 7,207,239 0 0
CASTLE BIOSCIENCES INC COM 14843C105 1,673 92,477 SH   DFND 1 92,477 0 0
CENTENE CORP DEL COM 15135B101 31,165 720,400 SH   DFND 1 720,400 0 0
CLOVIS ONCOLOGY INC NOTE 2.500% 9/1 189464AB6 42,262 49,064,000 PRN   DFND 1 49,064,000 0 0
COHERUS BIOSCIENCES INC COM 19249H103 31,207 1,540,305 SH   DFND 1 1,540,305 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 152 23,600 SH   DFND 1 23,600 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 27,531 3,201,222 SH   DFND 1 3,201,222 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 20,185 594,725 SH   DFND 1 594,725 0 0
DFB HEALTHCARE ACQUISTION CO UNIT 01/30/2023 23291E208 25,800 2,500,000 SH   DFND 1 2,500,000 0 0
DIPLOMAT PHARMACY INC COM 25456K101 14,682 2,996,328 SH   DFND 1 2,996,328 0 0
EDITAS MEDICINE INC COM 28106W103 26,352 1,158,841 SH   DFND 1 1,158,841 0 0
EHEALTH INC COM 28238P109 7,347 110,000 SH   DFND 1 110,000 0 0
EYENOVIA INC COM 30234E104 729 197,069 SH   DFND 1 197,069 0 0
FATE THERAPEUTICS INC COM 31189P102 30,328 1,952,897 SH   DFND 1 1,952,897 0 0
FORTY SEVEN INC COM 34983P104 4,815 750,000 SH   DFND 1 750,000 0 0
GALAPAGOS NV SPON ADR 36315X101 15,420 101,010 SH   DFND 1 101,010 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 13,008 268,100 SH   DFND 1 268,100 0 0
GUARDANT HEALTH INC COM 40131M109 8,043 126,000 SH   DFND 1 126,000 0 0
HARPOON THERAPEUTICS INC COM 41358P106 3,613 264,497 SH   DFND 1 264,497 0 0
HOMOLOGY MEDICINES INC COM 438083107 104,263 5,760,368 SH   DFND 1 5,760,368 0 0
HORIZON PHARMA INVT LTD NOTE 2.500% 3/1 44052TAB7 158,106 136,032,000 PRN   DFND 1 136,032,000 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 175,978 6,462,634 SH   DFND 1 6,462,634 0 0
HUMANA INC COM 444859102 17,130 67,000 SH   DFND 1 67,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 3,807 422,974 SH   DFND 1 422,974 0 0
IGM BIOSCIENCES INC COM 449585108 4,438 250,000 SH   DFND 1 250,000 0 0
IMMUNOMEDICS INC COM 452907108 42,618 3,214,000 SH   DFND 1 3,214,000 0 0
INOGEN INC COM 45780L104 9,182 191,660 SH   DFND 1 191,660 0 0
INTERCEPT PHARMACEUTICALS IN NOTE 3.250% 7/0 45845PAA6 49,530 57,791,000 PRN   DFND 1 57,791,000 0 0
INTERSECT ENT INC COM 46071F103 52,884 3,109,004 SH   DFND 1 3,109,004 0 0
ITAMAR MED LTD SPONSORED ADS 465437101 2,749 314,136 SH   DFND 1 314,136 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 10,332 890,668 SH   DFND 1 890,668 0 0
KEMPHARM INC NOTE 5.500% 2/0 488445AB3 32,179 62,423,000 PRN   DFND 1 62,423,000 0 0
KEMPHARM INC COM 488445107 477 692,104 SH   DFND 1 692,104 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 10,842 1,274,086 SH   DFND 1 1,274,086 0 0
MALLINCKRODT PUB LTD CO SHS G5785G107 10,101 4,191,327 SH   DFND 1 4,191,327 0 0
MEDICINES CO COM 584688105 5,000 100,000 SH Put DFND 1 100,000 0 0
MENLO THERAPEUTICS INC COM 586858102 446 99,622 SH   DFND 1 99,622 0 0
MIRATI THERAPEUTICS INC COM 60468T105 18,153 233,000 SH   DFND 1 233,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 34,696 3,448,912 SH   DFND 1 3,448,912 0 0
MOLINA HEALTHCARE INC COM 60855R100 21,621 197,056 SH   DFND 1 197,056 0 0
MORPHOSYS AG SPONSORED ADS 617760202 3,426 124,701 SH   DFND 1 124,701 0 0
MYLAN N V SHS EURO N59465109 151,397 7,654,065 SH   DFND 1 7,654,065 0 0
MYOKARDIA INC COM 62857M105 51,182 981,430 SH   DFND 1 981,430 0 0
NEOS THERAPEUTICS INC COM 64052L106 475 320,993 SH   DFND 1 320,993 0 0
NEURONETICS INC COM 64131A105 2,821 339,512 SH   DFND 1 339,512 0 0
NEVRO CORP NOTE 1.750% 6/0 64157FAA1 131,363 115,776,000 PRN   DFND 1 115,776,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 106,012 8,923,600 SH   DFND 1 8,923,600 0 0
PROTEON THERAPEUTICS INC COM 74371L109 318 1,224,899 SH   DFND 1 1,224,899 0 0
PROVENTION BIO INC COM 74374N102 4,948 725,000 SH   DFND 1 725,000 0 0
PTC THERAPEUTICS INC COM 69366J200 15,929 471,000 SH   DFND 1 471,000 0 0
PTC THERAPEUTICS INC NOTE 3.000% 8/1 69366JAB7 25,902 24,877,000 PRN   DFND 1 24,877,000 0 0
RA PHARMACEUTICALS INC COM 74933V108 40,868 1,728,019 SH   DFND 1 1,728,019 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 15,817 197,000 SH   DFND 1 197,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 55,903 2,589,291 SH   DFND 1 2,589,291 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 20,666 1,773,938 SH   DFND 1 1,773,938 0 0
SAREPTA THERAPEUTICS INC COM 803607100 28,772 382,000 SH   DFND 1 382,000 0 0
SELECT MED HLDGS CORP COM 81619Q105 28,403 1,714,099 SH   DFND 1 1,714,099 0 0
SIENTRA INC COM 82621J105 26,811 4,137,470 SH   DFND 1 4,137,470 0 0
SILK ROAD MEDICAL INC COM 82710M100 31,862 979,480 SH   DFND 1 979,480 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 22,783 1,050,888 SH   DFND 1 1,050,888 0 0
SYNLOGIC INC COM 87166L100 2,537 1,107,643 SH   DFND 1 1,107,643 0 0
SYROS PHARMACEUTICALS INC COM 87184Q107 13,172 1,268,946 SH   DFND 1 1,268,946 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 26,797 454,334 SH   DFND 1 454,334 0 0
TELIGENT INC NEW NOTE 4.750% 5/0 87960WAA2 5,550 9,567,000 PRN   DFND 1 9,567,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 14,572 387,545 SH   DFND 1 387,545 0 0
VERICEL CORP COM 92346J108 31,506 2,081,000 SH   DFND 1 2,081,000 0 0
VIEWRAY INC COM 92672L107 1,098 378,623 SH   DFND 1 378,623 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 16,583 807,727 SH   DFND 1 807,727 0 0
WRIGHT MED GROUP N V NOTE 2.250%11/1 98236JAB4 15,941 13,625,000 PRN   DFND 1 13,625,000 0 0
X4 PHARMACEUTICALS INC COM 98420X103 7,165 563,741 SH   DFND 1 563,741 0 0
XERIS PHARMACEUTICALS INC COM 98422L107 22,694 2,308,666 SH   DFND 1 2,308,666 0 0